Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 1, 1998, Pages 362-369

  Lindmark, Tuulikki ^b   Kimura, Yukitaka ^a,b   Artursson, Per ^b  

^a KYOTO UNIVERSITY   (Japan)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CELL PROTEIN; CELL PROTEIN ZO 1; DECANOIC ACID; DIACYLGLYCEROL; FLUORESCEIN SODIUM; INOSITOL TRISPHOSPHATE; LAURIC ACID; MEDIUM CHAIN FATTY ACID; OCCLUDIN; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE PERMEABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG PENETRATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; TIGHT JUNCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; CACO-2 CELLS; CALCIUM; DECANOIC ACIDS; DIGLYCERIDES; HUMANS; INTESTINAL ABSORPTION; LAURIC ACIDS; PERMEABILITY; TIGHT JUNCTIONS;

EID: 0031885344     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Anderberg EK, Lindmark T and Artursson P (1993) Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm Res 10:857-864.
2. Anderberg EK, Nyström C and Artursson P (1992) Epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. J Pharm Sci 81:879-887.
3. Artursson P (1990) Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J Pharm Sci 79:476-482.
4. Artursson P and Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epitheliai (Caco-2) cells. Biochem Biophys Res Commun 175:880-885.
5. Artursson P, Karlsson J, Ocklind G and Schipper N (1996) Studying transport processes in absorptive epithelia, in Epithelial Cell Culture (Shaw AJ, ed) pp 111-133, Oxford Press, New York.
6. Artursson P, Lindmark T, Davis SS and Illum L (1994) Effect of Chitosan on the permeability of intestinal epithelial cell (Caco-2). Pharm Res 11:1358-1361.
7. Aungst BJ, Saitoh H, Burcham DL, Huang S-M, Mousa SA and Hussain MA (1996) Enhancement of the intestinal absorption of peptides and non-peptides. J Control Release 41:19-31.
8. Bacallo R, Garfinkel A, Monke S, Zampighi G and Mandel LJ (1994) ATP depletion: A novel method to study junctional properties in epithelial tissues. I: Rearrangement of the actin cytoskeleton. J Cell Sci 107:3301-3313.
9. Balda MS, González-Mariscal L, Contreras RG, Macias-Silva M, Torres-Marques ME, Garcia Sáinz JA and Ceredijo M (1991) Assembly and sealing of tight Junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin. J Cell Biol 122:193-202.
10. Balda MS, González-Mariscal L, Matter K, Ceredijo M and Anderson JM (1993) Assembly of the tight junction: The role of diacylglycerol. J Cell Biol 123:293-302.
11. Balda MS, Whitney JA, Flores C, Gonzalez S, Cereijido M and Matter K (1996) Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of mutant tight junction membrane protein. J Cell Biol 134: 1031-1049.
12. Bleasdale JE, Thakur NR, Gremban RS, Bundy GL, Fitzpatrick FA, Smith RJ and Bunting S (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther 255:756-768.
13. 2 from human platelet. Biochim Biophys Acta 920: 301-305.
14. 1 cells. Am J Physiol 261:F1038-F1045.
15. Citi S and Kendrick-Jones J (1987) Regulation of non-muscle myosin structure and function. BioEssays 7:155-159.
16. Dodane V and Kachar B (1996) Identification of isoforms of G-proteins and PKC that colocalize with tight junctions. J Membr Biol 149:199-209.
17. Ellis B, Schneeberger EE and Rabito CA (1992) Cellular variability in the development of tight junctions after activation of protein kinase C. Am J Physiol 263: F293-F300.
18. Fogh J, Fogh JM and Orfeo T (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59:221-22
19. Ghandehari H, Smith PL, Ellens H, Yeh P-Y and Kopecek J (1997) Size-dependen permeability of hydrophilic probes across rabbit colonic epithelium. J Pharmacol Exp Ther 280:747-753.
20. Hidaka H, Inagaki M, Kawamoto S and Sasaki Y (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-5041.
21. Hidaka H, Sasaki Y, Tanaka T, Endo T, Ohno S, Fujii Y and Nagata T (1981) N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci USA 78:4354-4357.
22. Hochman JH, Fix JA and LeCluyse EL (1994) In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine. J Pharmacol Exp Ther 269:813-822.
23. Hollander D, Ricketts D, Boyd CAR and Phil D (1988) Importance of 'probe' molecular geometry in determining intestinal permeability. Can J Gastroenterol 2:35A-38A.
24. 2+/calmodulin dependent cyclic nucleotide phosphodiesterase. J Biochem 96: 1721-1726.
25. Karlsson J (1995) Drug absorption in cell culture models of the intestinal epithelium. Thesis, Uppsala University, Uppsala, Sweden.
26. ++-calmodulin-dependent phosphorylation of myosin, and its role in brush border contraction in vitro. J Cell Biol 95:943-959
27. Kobayashi E, Nakano H, Moritomo M and Tamaoki T (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
28. Lennernäs H, Palm K, Fagerholm U and Artursson P (1996) Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int J Pharm 127:103-107.
29. Lindmark T, Nikkilä T and Artursson P (1995) Mechanism of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 275:958-964.
30. Lindmark T, Schipper N, Lazorová L, de Boer AG and Artursson P (1997b) Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: Assessment of molecular weight dependence and demonstration of transport routes. J Drug Target, in press.
31. Lindmark T, Söderholm JD, Olaison G, Alván G, Ocklind G and Artursson P (1997a) Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate. Pharm Res 14:930-935.
32. Lundin A (1990) Clinical applications of luminometric ATP monitoring. Thesis, Karolinska Institutet, Stockholm, Sweden.
33. Madara JL, Barenberg D and Carlson S (1986) Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: Further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity. J Cell Biol 102:2125-2136.
34. Madara JL, Stafford J, Barenberg D and Carlson S (1988) Functional coupling of tight junctions and microfilaments in T84 monolayers. Am J Physiol 254:G416-G423.
35. Madsen KL, Yanchar NL, Sigalet DL, Reigel T and Fedorak RN (1995) FK506 increases permeability in rat intestine by inhibiting mitochondrial function. Gastnxnttrology 109:107-114.
36. Mandel JM, Bacallo R and Zampighi G (1993) Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctions. Nature 361:552-555.
37. Mosman T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
38. Nathanson MH, Gautam A, Ng OC, Bruck R and Boyer JL (1992) Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets. Am J Physiol 262:G1079-G1086.
39. Saitoh M, Ishikawa T, Matsushima S, Naka M and Hidaka H (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J Biol Chem 262:7796-7801.
40. Salzman AL, Menconi JM, Unno N, Ezzell RM, Casey DM, Gonzalez PK and Fink MP (1995) Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am J Physiol 268:G361-G373.
41. Sawada T, Ogawa T, Tomita M, Hayashi M and Awazu S (1991) Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate. Pharm Res 8:1365-1371.
42. Schipper NGM, Vårum KM and Artursson P (1996) Chitosans as absorption enhancers for poorly absorbed drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm Res 13:1686-1692.
43. 2+/calmodulin dependent protein kinases. Curr Opin Cell Biol 5:247-253.
44. Soboll S, Gründel S, Schwabe U and Scholz R (1984) Influence of fatty acids on energy metabolism. 2: Kinetics of changes in metabolic rates and changes in subcellular adenine nucleotide contents and pH gradients following addition of octanoate and oleate in perfused rat liver. Eur J Biochem 141:231-236.
45. Stenson WF, Easom RA, Riehl TE and Turk J (1993) Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C. Am J Physiol 265: G955-G962.
46. Stuart RO and Nigam SK (1995) Regulated assembly of tight junctions by protein kinase C. Proc Natl Acad Sci USA 92:6072-6076.
47. Söderholm JD, Hedman L and Olaison G (1995) Tight functional permeability in human ileal mucosa: Modulation with sodium caprate and cytochalasin B. Gut 37: suppl 2, A39.
48. 2+ levels: A protein kinase C effect. J Membr Biol 149:71-79.
49. Tansey MG, Word RA, Hidaka H, Singer HA, Schworer CM, Kamm KE and Stull JT (1992) Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells. J Biol Chem 267: 12511-12516.
50. Tomita M, Hayashi M and Awazu S (1995) Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells. J Pharmacol Exp Ther 272:739-743.
51. Walsh MP (1994) Calmodulin and the regulation of smooth muscle contraction. Mol Cell Biochem 135:21-41.
52. + in asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across rabbit colonic segments and Caco-2 cell monolayer. J Pharmacol Exp Ther 275:114-119.
53. 2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem 267:13830-13835.