Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate

Pharmaceutical Research

Volumn 14, Issue 7, 1997, Pages 930-935

  Lindmark, Tuulikki ^a   Söderholm, Johan D ^b   Olaison, Gunnar ^b   Alván, Gunnar ^c   Ocklind, Göran ^a   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Absorption enhancement; Epithelial permeability; Human rectal morphology; Medium chain fatty acid; Rectal drug absorption; Sodium caprate; Suppository; Tight junction

Indexed keywords

AMPICILLIN; DECANOIC ACID;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MICROSCOPY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION; RECTUM BIOPSY; SUPPOSITORY;

EID: 0030749435     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012112219578     Document Type: Article

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