Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability

Molecular Therapy

Volumn 22, Issue 2, 2014, Pages 359-370

  He, Wei ^a,b   Bennett, Michael J ^a,c   Luistro, Leopoldo ^a   Carvajal, Daisy ^a   Nevins, Thomas ^a   Smith, Melissa ^a   Tyagi, Gaurav ^a   Cai, James ^a   Wei, Xin ^a   Lin, Tai An ^a   Heimbrook, David C ^a   Packman, Kathryn ^a   Boylan, John F ^a,d  

^a HOFFMANN LA ROCHE INC   (United States)

^b ABBVIE INC   (United States)

^c MONSANTO COMPANY   (United States)

^d CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; ANION; CATION; LIPID; NANOPARTICLE; POLYMER;

ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL ADHESION; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN; ANIMAL; CHEMISTRY; DISEASE MODEL; GENE EXPRESSION; GENE TRANSFER; GENETICS; LEUKEMIA; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANIONS; CATIONS; CAVEOLINS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; LEUKEMIA; LIPIDS; MICE; NANOPARTICLES; POLYMERS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84895904189     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.210     Document Type: Article

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