The role of osmotic polysorbitol-based transporter in RNAi silencing via caveolae-mediated endocytosis and COX-2 expression

Biomaterials

Volumn 33, Issue 34, 2012, Pages 8868-8880

  Islam, Mohammad Ariful ^a,b   Shin, Ji Young ^b   Firdous, Jannatul ^a,b   Park, Tae Eun ^a,b   Choi, Yun Jaie ^a,b   Cho, Myung Haing ^b,c   Yun, Cheol Heui ^a,b   Cho, Chong Su ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Cav 1; Caveolae mediated endocytosis; COX 2; Polysorbitol; RNAi silencing; Transporter

Indexed keywords

CAV-1; CAVEOLAE-MEDIATED ENDOCYTOSIS; COX-2; POLYSORBITOL; RNAI SILENCING; TRANSPORTER;

GENE TRANSFER; RNA;

MOLECULAR BIOLOGY;

CAVEOLIN 1; CYCLOOXYGENASE 2; GENE THERAPY AGENT; POLYSORBITOL BASED OSMOTICALLY ACTIVE TRANSPORTER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CAVEOLA MEDIATED ENDOCYTOSIS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; HYPEROSMOSIS; OSMOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA INTERFERENCE;

ANIMALS; CAVEOLAE; CAVEOLIN 1; CELL LINE, TUMOR; CYCLOOXYGENASE 2; DRUG CARRIERS; ENDOCYTOSIS; GENE EXPRESSION REGULATION; OSMOSIS; OSTEOPONTIN; POLYESTERS; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84866842301     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.049     Document Type: Article

References (52)

1. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
2. Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 2001, 15:188-200.
3. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
4. McCaffrey A.P., Meuse L., Pham T.T.T., Conklin D.S., Hannon G.J., Kay M.A. Gene expression - RNA interference in adult mice. Nature 2002, 418:38-39.
5. Leuschner F., Dutta P., Gorbatov R., Novobrantseva T.I., Donahoe J.S., Courties G., et al. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 2011, 29:1005-1010.
6. Love K.T., Mahon K.P., Levins C.G., Whitehead K.A., Querbes W., Dorkin J.R., et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A 2010, 107:1864-1869.
7. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
8. Kleinman M.E., Yamada K., Takeda A., Chandrasekaran V., Nozaki M., Baffi J.Z., et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008, 452:591-597.
9. Bitko V., Musiyenko A., Shulyayeva O., Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005, 11:50-55.
10. Islam M.A., Yun C.H., Choi Y.J., Shin J.Y., Arote R., Jiang H.L., et al. Accelerated gene transfer through a polysorbitol-based transporter mechanism. Biomaterials 2011, 32:9908-9924.
11. Ma M., Li F., Yuan Z.F., Zhuo R.X. Influence of hydroxyl groups on the biological properties of cationic polymethacrylates as gene vectors. Acta Biomater 2010, 6:2658-2665.
12. Park M.R., Han K.O., Han I.K., Cho M.H., Nah J.W., Choi Y.J., et al. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J Control Release 2005, 105:367-380.
13. Khalil I.A., Kogure K., Akita H., Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006, 58:32-45.
14. Rejman J., Conese M., Hoekstra D. Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosis. J Liposome Res 2006, 16:237-247.
15. Le Roy C., Wrana J.L. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005, 6:112-126.
16. Ferrari A., Pellegrini V., Arcangeli C., Fittipaldi A., Giacca M., Beltram F. Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. Mol Ther 2003, 8:284-294.
17. Pelkmans L., Helenius A. Endocytosis via caveolae. Traffic 2002, 3:311-320.
18. Chung Y.C., Cheng T.Y., Young T.H. The role of adenosine receptor and caveolae-mediated endocytosis in oligonucleotide-mediated gene transfer. Biomaterials 2011, 32:4471-4480.
19. Dokka S., Rojanasakul Y. Novel non-endocytic delivery of antisense oligonucleotides. Adv Drug Deliv Rev 2000, 44:35-49.
20. Rejman J., Bragonzi A., Conese M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Mol Therapy 2005, 12:468-474.
21. Ding H.M., Ma Y.Q. Role of physicochemical properties of coating ligands in receptor-mediated endocytosis of nanoparticles. Biomaterials 2012, 33:5798-5802.
22. Ding H.M., Tian W.D., Ma Y.Q. Designing nanoparticle translocation through membranes by computer simulations. Acs Nano 2012, 6:1230-1238.
23. Yang K., Ma Y.Q. Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer. Nat Nanotechnol 2010, 5:579-583.
24. Wang S.H., Singh R.D., Godin L., Pagano R.E., Hubmayr R.D. Endocytic response of type I alveolar epithelial cells to hypertonic stress. Am J Physiol Lung Cell Mol Physiol 2011, 300:L560-L568.
25. Drab M., Verkade P., Elger M., Kasper M., Lohn M., Lauterbach B., et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001, 293:2449-2452.
26. Iversen T.G., Skotland T., Sandvig K. Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies. Nano Today 2011, 6:176-185.
27. Razani B., Engelman J.A., Wang X.B., Schubert W., Zhang X.L., Marks C.B., et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 2001, 276:38121-38138.
28. Volonte D., Galbiati F., Pestell R.G., Lisanti M.P. Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase - evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. J Biol Chem 2001, 276:8094-8103.
29. Moeckel G.W., Zhang L., Fogo A.B., Hao C.M., Pozzi A., Breyer M.D. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem 2003, 278:19352-19357.
30. Yang T.X., Huang Y.N., Heasley L.E., Berl T., Schnermann J.B., Briggs J.P. MAPK mediation of hypertonicity-stimulated cyclooxygenase-2 expression in renal medullary collecting duct cells. J Biol Chem 2000, 275:23281-23286.
31. Yang D.J., Bryant J., Chang J.Y., Mendez R., Oh C.S., Yu D.F., et al. Assessment of cyclooxygense-2 expression with 99mTc-labeled celebrex. Anti-cancer Drugs 2004, 15:255-263.
32. Kiss A.L., Botos E. Endocytosis via caveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?. J Cell Mol Med 2009, 13:1228-1237.
33. Du X.L., Jiang T., Sheng X.G., Gao R., Li Q.S. Inhibition of osteopontin suppresses in vitro and in vivo angiogenesis in endometrial cancer. Gynecol Oncol 2009, 115:371-376.
34. Kumar V., Behera R., Lohite K., Karnik S., Kundu G.C. p38 Kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Cancer Res 2010, 70:10381-10391.
35. Mok H., Lee S.H., Park J.W., Park T.G. Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing. Nat Mater 2010, 9:272-278.
36. Barreto J.A., O'Malley W., Kubeil M., Graham B., Stephan H., Spiccia L. Nanomaterials: applications in cancer imaging and therapy. Adv Mater 2011, 23:H18-H40.
37. Ryser H.J.P. A membrane effect of basic polymers dependent on molecular size. Nature 1967, 215:934-936.
38. Schroeder A., Dahlman J.E., Sahay G., Love K.T., Jiang S., Eltoukhy A.A., et al. Alkane-modified short polyethyleneimine for siRNA delivery. J Control Release 2012, 160:172-176.
39. Bhattacharya S.D., Garrison J., Guo H.T., Mi Z.Y., Markovic J., Kim V.M., et al. Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines. Surgery 2010, 148:291-297.
40. Zhang A.M., Liu Y., Shen Y.Z., Xu Y.H., Li X.T. Osteopontin silencing by small interfering RNA induces apoptosis and suppresses invasion in human renal carcinoma Caki-1 cells. Med Oncol 2010, 27:1179-1184.
41. Robertson B.W., Chellaiah M.A. Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Exp Cell Res 2010, 316:1-11.
42. Robertson B.W., Bonsal L., Chellaiah M.A. Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells. Mol Cancer 2010, 9:260.
43. Zhang R.H., Wang J., Ma S.J., Huang Z.H., Zhang G.X. Requirement of osteopontin in the migration and protection against taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells. BMC Cell Biol 2011, 12:11.
44. Zhang R.H., Zhang Z.H., Pan X.L., Huang X.Y., Huang Z.H., Zhang G.X. ATX-LPA axis induces expression of OPN in hepatic cancer cell SMMC7721. Anat Rec 2011, 294:406-411.
45. Daukas G., Zigmond S.H. Inhibition of receptor-mediated but not fluid-phase pinocytosis in polymorphonuclear leukocytes. J Cell Biol 1985, 101:1673-1679.
46. Heuser J.E., Anderson R.G.W. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol 1989, 108:389-400.
47. Kuper C., Bartels H., Fraek M.L., Beck F.X., Neuhofer W. Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress. Am J Physiol Cell Physiol 2007, 293:C1971-C1982.
48. Zhao H.Y., Tian W., Tai C., Cohen D.M. Hypertonic induction of COX-2 expression in renal medullary epithelial cells requires transactivation of the EGFR. Am J Physiol Renal Physiol 2003, 285:F281-F288.
49. Kuper C., Steinert D., Fraek M.L., Beck F.X., Neuhofer W. EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions. Am J Physiol Renal Physiol 2009, 296:F1100-F1108.
50. O'Neill K.D., Chen N.X., Wang M., Cocklin R., Zhang Y., Moe S.M. Cellular uptake of beta2M and AGE-beta2M in synovial fibroblasts and macrophages. Nephrol Dial Transplant 2003, 18:46-53.
51. Rodriguez D.A., Tapia J.C., Fernandez J.G., Torres V.A., Munoz N., Galleguillos D., et al. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell 2009, 20:2297-2310.
52. Chen S.F., Liou J.Y., Huang T.Y., Lin Y.S., Yeh A.L., Tam K., et al. Caveolin-1 facilitates cyclooxygenase-2 protein degradation. J Cellular Biochem 2010, 109:356-362.