The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-Catalyzed translocation

Cell Reports

Volumn 6, Issue 2, 2014, Pages 357-365

  Bulkley, David ^a,e   Brandi, Letizia ^b   Polikanov, Yury S ^a,c   Fabbretti, Attilio ^b   O'Connor, Michael ^d   Gualerzi, Claudio O ^b   Steitz, Thomas A ^a,c  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF CAMERINO   (Italy)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; DITYROMYCIN; ELONGATION FACTOR G; GE 82832; RIBOSOMAL PROTEIN S12; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG PROTEIN BINDING; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN TRANSPORT; THERMUS THERMOPHILUS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; ESCHERICHIA COLI; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDE ELONGATION FACTOR 2; PEPTIDES; PROTEIN BINDING; THERMUS THERMOPHILUS;

EID: 84895903363     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.12.024     Document Type: Article

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