메뉴 건너뛰기




Volumn 26, Issue 3, 2014, Pages 173-181

Mycophenolic acid-treated dendritic cells generate regulatory CD4+ T cells that suppress CD8+ T cells' allocytotoxicity

Author keywords

Cytotoxicity; Immune regulation; Organ transplantation

Indexed keywords

ANTIGEN INDUCED REGULATORY T LYMPHOCYTE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANZYME A; GRANZYME B; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; MYCOPHENOLIC ACID; PERFORIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GRANZYME; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 84895833556     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt054     Document Type: Article
Times cited : (5)

References (43)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
    • (1995) J. Immunol. , vol.155 , pp. 1151
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 2
    • 0035421654 scopus 로고    scopus 로고
    • Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    • Piccirillo, C. A. and Shevach, E. M. 2001. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 167:1137.
    • (2001) J. Immunol , vol.167 , pp. 1137
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 3
    • 34547655923 scopus 로고    scopus 로고
    • A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment
    • Strauss, L., Bergmann, C., Szczepanski, M., Gooding, W., Johnson, J. T. and Whiteside, T. L. 2007. A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin. Cancer Res. 13(15 Pt 1):4345.
    • (2007) Clin. Cancer Res , vol.13 , Issue.15 PART 1 , pp. 4345
    • Strauss, L.1    Bergmann, C.2    Szczepanski, M.3    Gooding, W.4    Johnson, J.T.5    Whiteside, T.L.6
  • 4
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage, U. K., Moore, T. T., Joo, H. G. et al. 2002. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169:2756.
    • (2002) J. Immunol. , vol.169 , pp. 2756
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3
  • 5
    • 34848850453 scopus 로고    scopus 로고
    • Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40
    • Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L. and Liew, F. Y. 2007. Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc. Natl Acad. Sci. USA 104:15478.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 15478
    • Niedbala, W.1    Cai, B.2    Liu, H.3    Pitman, N.4    Chang, L.5    Liew, F.Y.6
  • 6
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson, C. F., Oukka, M., Kuchroo, V. J. and Sacks, D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204:285.
    • (2007) J. Exp. Med. , vol.204 , pp. 285
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 7
    • 57549115852 scopus 로고    scopus 로고
    • Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases
    • Sojka, D., Franta, Z., Horn, M. et al. 2008. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit. Vectors 1:7.
    • (2008) Parasit. Vectors , vol.1 , pp. 7
    • Sojka, D.1    Franta, Z.2    Horn, M.3
  • 9
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi, T., Kuniyasu, Y., Toda, M. et al. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.
    • (1998) Int. Immunol , vol.10 , pp. 1969
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3
  • 10
    • 0033611160 scopus 로고    scopus 로고
    • CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice
    • Gao, Q., Rouse, T. M., Kazmerzak, K. and Field, E. H. 1999. CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice. Transplantation 68:1891.
    • (1999) Transplantation , vol.68 , pp. 1891
    • Gao, Q.1    Rouse, T.M.2    Kazmerzak, K.3    Field, E.H.4
  • 11
    • 40749116456 scopus 로고    scopus 로고
    • T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice
    • Fernandez, M. A., Puttur, F. K., Wang, Y. M., Howden, W., Alexander, S. I. and Jones, C. A. 2008. T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. J. Immunol. 180:1556.
    • (2008) J. Immunol , vol.180 , pp. 1556
    • Fernandez, M.A.1    Puttur, F.K.2    Wang, Y.M.3    Howden, W.4    Alexander, S.I.5    Jones, C.A.6
  • 12
    • 0037111521 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy
    • van Maurik, A., Herber, M., Wood, K. J. and Jones, N. D. 2002. Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169:5401.
    • (2002) J. Immunol. , vol.169 , pp. 5401
    • van Maurik, A.1    Herber, M.2    Wood, K.J.3    Jones, N.D.4
  • 13
    • 0036604283 scopus 로고    scopus 로고
    • Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
    • Graca, L., Thompson, S., Lin, C. Y., Adams, E., Cobbold, S. P. and Waldmann, H. 2002. Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
    • (2002) J. Immunol. , vol.168 , pp. 5558
    • Graca, L.1    Thompson, S.2    Lin, C.Y.3    Adams, E.4    Cobbold, S.P.5    Waldmann, H.6
  • 14
    • 0036911130 scopus 로고    scopus 로고
    • Dominant transplantation tolerance impairs CD8+ T cell function but not expansion
    • Lin, C. Y., Graca, L., Cobbold, S. P. and Waldmann, H. 2002. Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nat. Immunol. 3:1208.
    • (2002) Nat. Immunol , vol.3 , pp. 1208
    • Lin, C.Y.1    Graca, L.2    Cobbold, S.P.3    Waldmann, H.4
  • 15
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • Mempel, T. R., Pittet, M. J., Khazaie, K. et al. 2006. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25:129.
    • (2006) Immunity , vol.25 , pp. 129
    • Mempel, T.R.1    Pittet, M.J.2    Khazaie, K.3
  • 16
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    • Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. and Schuler, G. 2001. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 193:1303.
    • (2001) J. Exp. Med. , vol.193 , pp. 1303
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 17
    • 49849094011 scopus 로고    scopus 로고
    • Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    • Horwitz, D. A., Zheng, S. G. and Gray, J. D. 2008. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 29:429.
    • (2008) Trends Immunol , vol.29 , pp. 429
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 18
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille, M. A. and Lafaille, J. J. 2009. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30:626.
    • (2009) Immunity , vol.30 , pp. 626
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 20
    • 17644395221 scopus 로고    scopus 로고
    • Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways
    • Lagaraine, C., Hoarau, C., Chabot, V., Velge-Roussel, F. and Lebranchu, Y. 2005. Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways. Int. Immunol. 17:351.
    • (2005) Int. Immunol , vol.17 , pp. 351
    • Lagaraine, C.1    Hoarau, C.2    Chabot, V.3    Velge-Roussel, F.4    Lebranchu, Y.5
  • 21
    • 0035400281 scopus 로고    scopus 로고
    • A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity
    • Lecoeur, H., Février, M., Garcia, S., Rivière, Y. and Gougeon, M. L. 2001. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J. Immunol. Methods 253:177.
    • (2001) J. Immunol. Methods , vol.253 , pp. 177
    • Lecoeur, H.1    Février, M.2    Garcia, S.3    Rivière, Y.4    Gougeon, M.L.5
  • 22
    • 0025905925 scopus 로고
    • Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
    • Peters, P. J., Borst, J., Oorschot, V. et al. 1991. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 173:1099.
    • (1991) J. Exp. Med. , vol.173 , pp. 1099
    • Peters, P.J.1    Borst, J.2    Oorschot, V.3
  • 23
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani, J. A. and Smyth, M. J. 2002. Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2:735.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 735
    • Trapani, J.A.1    Smyth, M.J.2
  • 24
    • 21044442709 scopus 로고    scopus 로고
    • Evaluation of the CD107 cytotoxicity assay for the detection of cytolytic CD8+ cells recognizing HER2/neu vaccine peptides
    • Mittendorf, E. A., Storrer, C. E., Shriver, C. D., Ponniah, S. and Peoples, G. E. 2005. Evaluation of the CD107 cytotoxicity assay for the detection of cytolytic CD8+ cells recognizing HER2/neu vaccine peptides. Breast Cancer Res. Treat. 92:85.
    • (2005) Breast Cancer Res. Treat , vol.92 , pp. 85
    • Mittendorf, E.A.1    Storrer, C.E.2    Shriver, C.D.3    Ponniah, S.4    Peoples, G.E.5
  • 25
    • 0142185336 scopus 로고    scopus 로고
    • Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    • Betts, M. R., Brenchley, J. M., Price, D. A. et al. 2003. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281:65.
    • (2003) J. Immunol. Methods , vol.281 , pp. 65
    • Betts, M.R.1    Brenchley, J.M.2    Price, D.A.3
  • 26
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+) CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo, C. A., Letterio, J. J., Thornton, A. M. et al. 2002. CD4(+) CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196:237.
    • (2002) J. Exp. Med. , vol.196 , pp. 237
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3
  • 27
    • 0021997185 scopus 로고
    • Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
    • Sakaguchi, S., Fukuma, K., Kuribayashi, K. and Masuda, T. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72.
    • (1985) J. Exp. Med. , vol.161 , pp. 72
    • Sakaguchi, S.1    Fukuma, K.2    Kuribayashi, K.3    Masuda, T.4
  • 28
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
    • (1996) J. Exp. Med. , vol.184 , pp. 387
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 30
    • 0348013075 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation
    • Câmara, N. O., Sebille, F. and Lechler, R. I. 2003. Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation. Eur. J. Immunol. 33:3473.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3473
    • Câmara, N.O.1    Sebille, F.2    Lechler, R.I.3
  • 31
    • 33646397029 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence
    • Trzonkowski, P., Szmit, E., Myśliwska, J. and Myśliwski, A. 2006. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence. Clin. Immunol. 119:307.
    • (2006) Clin. Immunol , vol.119 , pp. 307
    • Trzonkowski, P.1    Szmit, E.2    Myśliwska, J.3    Myśliwski, A.4
  • 32
    • 0035806323 scopus 로고    scopus 로고
    • Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings, M. K., Sangregorio, R. and Roncarolo, M. G. 2001. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295.
    • (2001) J. Exp. Med. , vol.193 , pp. 1295
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 33
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi, T., Tagami, T., Yamazaki, S. et al. 2000. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
    • (2000) J. Exp. Med. , vol.192 , pp. 303
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 34
    • 28544444024 scopus 로고    scopus 로고
    • Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
    • Kearley, J., Barker, J. E., Robinson, D. S. and Lloyd, C. M. 2005. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J. Exp. Med. 202:1539.
    • (2005) J. Exp. Med. , vol.202 , pp. 1539
    • Kearley, J.1    Barker, J.E.2    Robinson, D.S.3    Lloyd, C.M.4
  • 35
    • 0035881234 scopus 로고    scopus 로고
    • Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance
    • Gregori, S., Casorati, M., Amuchastegui, S., Smiroldo, S., Davalli, A. M. and Adorini, L. 2001. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 167:1945.
    • (2001) J. Immunol. , vol.167 , pp. 1945
    • Gregori, S.1    Casorati, M.2    Amuchastegui, S.3    Smiroldo, S.4    Davalli, A.M.5    Adorini, L.6
  • 36
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist, H. R., Raimondi, G., Zahorchak, A. F., Fischer, R. T., Wang, Z. and Thomson, A. W. 2007. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178:7018.
    • (2007) J. Immunol. , vol.178 , pp. 7018
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 37
    • 36348975870 scopus 로고    scopus 로고
    • Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells
    • Fujita, S., Sato, Y., Sato, K. et al. 2007. Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells. Blood 110:3793.
    • (2007) Blood , vol.110 , pp. 3793
    • Fujita, S.1    Sato, Y.2    Sato, K.3
  • 38
    • 13144256708 scopus 로고    scopus 로고
    • Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival
    • Taner, T., Hackstein, H., Wang, Z., Morelli, A. E. and Thomson, A. W. 2005. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival. Am. J. Transplant. 5:228.
    • (2005) Am. J. Transplant. , vol.5 , pp. 228
    • Taner, T.1    Hackstein, H.2    Wang, Z.3    Morelli, A.E.4    Thomson, A.W.5
  • 39
    • 0141678976 scopus 로고    scopus 로고
    • Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo
    • Jiang, S., Camara, N., Lombardi, G. and Lechler, R. I. 2003. Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 102:2180.
    • (2003) Blood , vol.102 , pp. 2180
    • Jiang, S.1    Camara, N.2    Lombardi, G.3    Lechler, R.I.4
  • 40
    • 34347389658 scopus 로고    scopus 로고
    • Induction of antigenspecific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper
    • Hamdi, H., Godot, V., Maillot, M. C. et al. 2007. Induction of antigenspecific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper. Blood 110:211.
    • (2007) Blood , vol.110 , pp. 211
    • Hamdi, H.1    Godot, V.2    Maillot, M.C.3
  • 41
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor, P. A., Lees, C. J. and Blazar, B. R. 2002. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493.
    • (2002) Blood , vol.99 , pp. 3493
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 42
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood
    • Yamagiwa, S., Gray, J. D., Hashimoto, S. and Horwitz, D. A. 2001. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 166:7282.
    • (2001) J. Immunol. , vol.166 , pp. 7282
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 43
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease
    • Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D. and Salomon, B. L. 2002. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196:401.
    • (2002) J. Exp. Med. , vol.196 , pp. 401
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.