Molecular origin of the binding of WWOX tumor suppressor to erbb4 receptor tyrosine kinase

Biochemistry

Volumn 52, Issue 51, 2013, Pages 9223-9236

  Schuchardt, Brett J ^a   Bhat, Vikas ^a   Mikles, David C ^a   McDonald, Caleb B ^a   Sudol, Marius ^b,c   Farooq, Amjad ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b WEIS CENTER FOR RESEARCH   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; LIGANDS; TUMORS;

BIOPHYSICAL METHODS; CONSENSUS SEQUENCE; HYDROPHOBIC LIGAND; INTRACELLULAR DOMAIN; MOLECULAR ORIGINS; RECEPTOR TYROSINE KINASE; TRANSCRIPTIONAL FUNCTIONS; TUMOR SUPPRESSORS;

AMINO ACIDS;

EPIDERMAL GROWTH FACTOR RECEPTOR 4; PROTEIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; WWOX PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB4 PROTEIN, HUMAN; LIGAND; MUTANT PROTEIN; OXIDOREDUCTASE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; TUMOR SUPPRESSOR PROTEIN; WWOX PROTEIN, HUMAN; RECEPTOR TYROSINE PROTEIN KINASE ERBB 4; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4;

ARTICLE; BINDING AFFINITY; CONSENSUS SEQUENCE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; AMINO ACID SUBSTITUTION; BINDING SITE; CALORIMETRY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; DOWN REGULATION; GENETIC TRANSCRIPTION; GENETICS; KINETICS; METABOLISM; PROTEIN DOMAIN; PROTEIN MOTIF; SIGNAL TRANSDUCTION; TITRIMETRY;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; BINDING SITES; CALORIMETRY; CONSENSUS SEQUENCE; DOWN-REGULATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTANT PROTEINS; OXIDOREDUCTASES; PEPTIDE FRAGMENTS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-4; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TITRIMETRY; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 84895774982     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400987k     Document Type: Article

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