-
1
-
-
0034708598
-
A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
-
Kainulainen V, Sundvall M, Maatta JA, Santiestevan E, Klagsbrun M, et al. (2000) A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. J Biol Chem 275: 8641-8649.
-
(2000)
J Biol Chem
, vol.275
, pp. 8641-8649
-
-
Kainulainen, V.1
Sundvall, M.2
Maatta, J.A.3
Santiestevan, E.4
Klagsbrun, M.5
-
2
-
-
0029928763
-
Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells
-
Sepp-Lorenzino L, Eberhard I, Ma Z, Cho C, Serve H, et al. (1996) Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells. Oncogene 12: 1679-1687.
-
(1996)
Oncogene
, vol.12
, pp. 1679-1687
-
-
Sepp-Lorenzino, L.1
Eberhard, I.2
Ma, Z.3
Cho, C.4
Serve, H.5
-
3
-
-
0035824391
-
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni CY, Murphy MP, Golde TE, Carpenter G, (2001) gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294: 2179-2181.
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
4
-
-
0037155219
-
Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4
-
Lee HJ, Jung KM, Huang YZ, Bennett LB, Lee JS, et al. (2002) Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277: 6318-6323.
-
(2002)
J Biol Chem
, vol.277
, pp. 6318-6323
-
-
Lee, H.J.1
Jung, K.M.2
Huang, Y.Z.3
Bennett, L.B.4
Lee, J.S.5
-
5
-
-
0034616385
-
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
-
Rio C, Buxbaum JD, Peschon JJ, Corfas G, (2000) Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. J Biol Chem 275: 10379-10387.
-
(2000)
J Biol Chem
, vol.275
, pp. 10379-10387
-
-
Rio, C.1
Buxbaum, J.D.2
Peschon, J.J.3
Corfas, G.4
-
6
-
-
8444243682
-
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
-
Williams C, Allison J, Vidal G, Burow M, Beckman B, et al. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol 167: 469-478.
-
(2004)
J Cell Biol
, vol.167
, pp. 469-478
-
-
Williams, C.1
Allison, J.2
Vidal, G.3
Burow, M.4
Beckman, B.5
-
7
-
-
33748087796
-
Coregulation of Estrogen Receptor by ERBB4/HER4 Establishes a Growth-Promoting Autocrine Signal in Breast Tumor Cells
-
Zhu Y, Sullivan LL, Nair SS, Williams CC, Pandey AK, et al. (2006) Coregulation of Estrogen Receptor by ERBB4/HER4 Establishes a Growth-Promoting Autocrine Signal in Breast Tumor Cells. Cancer Res 66: 7991-7998.
-
(2006)
Cancer Res
, vol.66
, pp. 7991-7998
-
-
Zhu, Y.1
Sullivan, L.L.2
Nair, S.S.3
Williams, C.C.4
Pandey, A.K.5
-
8
-
-
33748757331
-
ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression
-
Linggi B, Carpenter G, (2006) ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. J Biol Chem 281: 25373-25380.
-
(2006)
J Biol Chem
, vol.281
, pp. 25373-25380
-
-
Linggi, B.1
Carpenter, G.2
-
9
-
-
78650132637
-
Cell death or survival promoted by alternative isoforms of ErbB4
-
Sundvall M, Veikkolainen V, Kurppa K, Salah Z, Tvorogov D, et al. (2010) Cell death or survival promoted by alternative isoforms of ErbB4. Mol Biol Cell 21: 4275-4286.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 4275-4286
-
-
Sundvall, M.1
Veikkolainen, V.2
Kurppa, K.3
Salah, Z.4
Tvorogov, D.5
-
10
-
-
33749072714
-
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
-
Sardi S, Murtie J, Koirala S, Patten B, Corfas G, (2006) Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127: 185-197.
-
(2006)
Cell
, vol.127
, pp. 185-197
-
-
Sardi, S.1
Murtie, J.2
Koirala, S.3
Patten, B.4
Corfas, G.5
-
11
-
-
0033579505
-
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
-
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, et al. (1999) Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem 274: 36801-36807.
-
(1999)
J Biol Chem
, vol.274
, pp. 36801-36807
-
-
Ray, W.J.1
Yao, M.2
Mumm, J.3
Schroeter, E.H.4
Saftig, P.5
-
12
-
-
0035909901
-
The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
-
Gao Y, Pimplikar SW, (2001) The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A 98: 14979-14984.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14979-14984
-
-
Gao, Y.1
Pimplikar, S.W.2
-
13
-
-
67649534694
-
Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
-
McCarthy JV, Twomey C, Wujek P, (2009) Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity. Cell Mol Life Sci 66: 1534-1555.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 1534-1555
-
-
McCarthy, J.V.1
Twomey, C.2
Wujek, P.3
-
14
-
-
0030685131
-
A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester
-
Elenius K, Corfas G, Paul S, Choi CJ, Rio C, et al. (1997) A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem 272: 26761-26768.
-
(1997)
J Biol Chem
, vol.272
, pp. 26761-26768
-
-
Elenius, K.1
Corfas, G.2
Paul, S.3
Choi, C.J.4
Rio, C.5
-
15
-
-
70249096642
-
ErbB4 splice variants Cyt1 and Cyt2 differ by sixteen amino acids and exert opposing effects on the mammary epithelium in vivo
-
Muraoka-Cook R, Sandahl M, Strunk K, Miraglia L, Husted C, et al. (2009) ErbB4 splice variants Cyt1 and Cyt2 differ by sixteen amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol.
-
(2009)
Mol Cell Biol
-
-
Muraoka-Cook, R.1
Sandahl, M.2
Strunk, K.3
Miraglia, L.4
Husted, C.5
-
16
-
-
30044432092
-
Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth
-
Määttä JA, Sundvall M, Junttila TT, Peri L, Laine VJ, et al. (2006) Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth. Mol Biol Cell 17: 67-79.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 67-79
-
-
Määttä, J.A.1
Sundvall, M.2
Junttila, T.T.3
Peri, L.4
Laine, V.J.5
-
17
-
-
80051764374
-
Function of ERBB4 is determined by alternative splicing
-
Veikkolainen V, Vaparanta K, Halkilahti K, Iljin K, Sundvall M, et al. (2011) Function of ERBB4 is determined by alternative splicing. Cell Cycle 10: 2647-2657.
-
(2011)
Cell Cycle
, vol.10
, pp. 2647-2657
-
-
Veikkolainen, V.1
Vaparanta, K.2
Halkilahti, K.3
Iljin, K.4
Sundvall, M.5
-
18
-
-
35848968668
-
ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis
-
Zeng F, Zhang M, Singh A, Zent R, Harris R, (2007) ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell 18: 4446-4456.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4446-4456
-
-
Zeng, F.1
Zhang, M.2
Singh, A.3
Zent, R.4
Harris, R.5
-
19
-
-
0032718015
-
Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo
-
Tang CK, Concepcion XZ, Milan M, Gong X, Montgomery E, et al. (1999) Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res 59: 5315-5322.
-
(1999)
Cancer Res
, vol.59
, pp. 5315-5322
-
-
Tang, C.K.1
Concepcion, X.Z.2
Milan, M.3
Gong, X.4
Montgomery, E.5
-
20
-
-
62249111362
-
Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms
-
Hollmén M, Määttä J, Bald L, Sliwkowski M, Elenius K, (2009) Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms. Oncogene 28: 1309-1319.
-
(2009)
Oncogene
, vol.28
, pp. 1309-1319
-
-
Hollmén, M.1
Määttä, J.2
Bald, L.3
Sliwkowski, M.4
Elenius, K.5
-
21
-
-
0034654554
-
Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers
-
Srinivasan R, Gillett C, Barnes D, Gullick W, (2000) Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 60: 1483-1487.
-
(2000)
Cancer Res
, vol.60
, pp. 1483-1487
-
-
Srinivasan, R.1
Gillett, C.2
Barnes, D.3
Gullick, W.4
-
22
-
-
75149192831
-
Potential of ErbB4 antibodies for cancer therapy
-
Hollmén M, Elenius K, (2010) Potential of ErbB4 antibodies for cancer therapy. Future Oncol 6: 37-53.
-
(2010)
Future Oncol
, vol.6
, pp. 37-53
-
-
Hollmén, M.1
Elenius, K.2
-
23
-
-
13944269873
-
Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells
-
Junttila TT, Sundvall M, Lundin M, Lundin J, Tanner M, et al. (2005) Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells. Cancer Res 65: 1384-1393.
-
(2005)
Cancer Res
, vol.65
, pp. 1384-1393
-
-
Junttila, T.T.1
Sundvall, M.2
Lundin, M.3
Lundin, J.4
Tanner, M.5
-
24
-
-
73649135726
-
Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients
-
Thor A, Edgerton S, Jones F, (2009) Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients. Am J Pathol 175: 1802-1809.
-
(2009)
Am J Pathol
, vol.175
, pp. 1802-1809
-
-
Thor, A.1
Edgerton, S.2
Jones, F.3
-
25
-
-
67349199171
-
Short-term outcome of primary operated early breast cancer by hormone and HER-2 receptors
-
Brouckaert O, Pintens S, Van Belle V, Van Huffel S, Camerlynck E, et al. (2009) Short-term outcome of primary operated early breast cancer by hormone and HER-2 receptors. Breast Cancer Res Treat 115: 349-358.
-
(2009)
Breast Cancer Res Treat
, vol.115
, pp. 349-358
-
-
Brouckaert, O.1
Pintens, S.2
van Belle, V.3
van Huffel, S.4
Camerlynck, E.5
-
26
-
-
36849001338
-
Isotype selection in antibody engineering
-
Salfeld J, (2007) Isotype selection in antibody engineering. Nat Biotechnol 25: 1369-1372.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1369-1372
-
-
Salfeld, J.1
-
27
-
-
0141755325
-
Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment
-
Cheng QC, Tikhomirov O, Zhou W, Carpenter G, (2003) Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem 278: 38421-38427.
-
(2003)
J Biol Chem
, vol.278
, pp. 38421-38427
-
-
Cheng, Q.C.1
Tikhomirov, O.2
Zhou, W.3
Carpenter, G.4
-
28
-
-
0043095391
-
TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation
-
Doedens J, Mahimkar R, Black R, (2003) TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. Biochem Biophys Res Commun 308: 331-338.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 331-338
-
-
Doedens, J.1
Mahimkar, R.2
Black, R.3
-
29
-
-
27244461099
-
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
-
Bouyain S, Longo P, Li S, Ferguson K, Leahy D, (2005) The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proc Natl Acad Sci U S A 102: 15024-15029.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15024-15029
-
-
Bouyain, S.1
Longo, P.2
Li, S.3
Ferguson, K.4
Leahy, D.5
-
30
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, et al. (2003) Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421: 756-760.
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
Stanley, A.M.4
Gabelli, S.B.5
-
31
-
-
35648994903
-
Molecular basis for passive immunotherapy of Alzheimer's disease
-
Gardberg A, Dice L, Ou S, Rich R, Helmbrecht E, et al. (2007) Molecular basis for passive immunotherapy of Alzheimer's disease. Proc Natl Acad Sci U S A 104: 15659-15664.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 15659-15664
-
-
Gardberg, A.1
Dice, L.2
Ou, S.3
Rich, R.4
Helmbrecht, E.5
-
32
-
-
51049101061
-
The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis
-
Naresh A, Thor A, Edgerton S, Torkko K, Kumar R, et al. (2008) The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis. Cancer Res 68: 6387-6395.
-
(2008)
Cancer Res
, vol.68
, pp. 6387-6395
-
-
Naresh, A.1
Thor, A.2
Edgerton, S.3
Torkko, K.4
Kumar, R.5
-
33
-
-
0034654554
-
Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers
-
Srinivasan R, Gillett CE, Barnes DM, Gullick WJ, (2000) Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 60: 1483-1487.
-
(2000)
Cancer Res
, vol.60
, pp. 1483-1487
-
-
Srinivasan, R.1
Gillett, C.E.2
Barnes, D.M.3
Gullick, W.J.4
-
34
-
-
0030043293
-
Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors
-
Bacus S, Chin D, Yarden Y, Zelnick C, Stern D, (1996) Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. Am J Pathol 148: 549-558.
-
(1996)
Am J Pathol
, vol.148
, pp. 549-558
-
-
Bacus, S.1
Chin, D.2
Yarden, Y.3
Zelnick, C.4
Stern, D.5
-
35
-
-
16844369407
-
Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast
-
Barnes N, Khavari S, Boland G, Cramer A, Knox W, et al. (2005) Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. Clin Cancer Res 11: 2163-2168.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2163-2168
-
-
Barnes, N.1
Khavari, S.2
Boland, G.3
Cramer, A.4
Knox, W.5
-
36
-
-
0036145181
-
EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival
-
Suo Z, Risberg B, Kalsson MG, Willman K, Tierens A, et al. (2002) EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival. J Pathol 196: 17-25.
-
(2002)
J Pathol
, vol.196
, pp. 17-25
-
-
Suo, Z.1
Risberg, B.2
Kalsson, M.G.3
Willman, K.4
Tierens, A.5
-
37
-
-
44149089008
-
Role of ErbB4 in Breast Cancer
-
Sundvall M, Iljin K, Kilpinen S, Sara H, Kallioniemi O, et al. (2008) Role of ErbB4 in Breast Cancer. J Mammary Gland Biol Neoplasia 13: 259-268.
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 259-268
-
-
Sundvall, M.1
Iljin, K.2
Kilpinen, S.3
Sara, H.4
Kallioniemi, O.5
|