Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism

PLoS Computational Biology

Volumn 10, Issue 2, 2014, Pages

  Noor, Elad ^a   Bar Even, Arren ^a   Flamholz, Avi ^a,b   Reznik, Ed ^c   Liebermeister, Wolfram ^d   Milo, Ron ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b University of California Berkeley   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; IONIC STRENGTH; KINETICS; METABOLISM; PHYSIOLOGY; REACTION KINETICS;

CATALYSE; CENTRAL METABOLISMS; DRIVING FORCES; ENZYME CATALYSIS; MAX/MIN; REVERSE FLUXES; REVERSE REACTIONS; THERMODYNAMIC DRIVING FORCES; THERMODYNAMIC POTENTIALS; THERMODYNAMICS FLUXES;

THERMODYNAMICS;

CITRATE SYNTHASE; MALATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXALOACETIC ACID; QUINONE DERIVATIVE; ENZYME;

ARTICLE; CELL PH; CONCENTRATION (PARAMETERS); CONCEPTUAL FRAMEWORK; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; FERMENTATION; IONIC STRENGTH; METABOLITE; NONHUMAN; THERMODYNAMICS; BIOLOGICAL MODEL; BIOLOGY; CITRIC ACID CYCLE; ESCHERICHIA COLI; KINETICS; METABOLISM; OSMOLARITY; PHOSPHORYLATION;

CITRIC ACID CYCLE; COMPUTATIONAL BIOLOGY; ENZYMES; ESCHERICHIA COLI; FERMENTATION; KINETICS; MALATE DEHYDROGENASE; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PHOSPHORYLATION; THERMODYNAMICS;

EID: 84895727036     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003483     Document Type: Article

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