메뉴 건너뛰기




Volumn 5, Issue 4, 2014, Pages 442-453

Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy

Author keywords

Experimental models; Hyperglycemia; Stroke; Thrombolysis; Tissue plasminogen activator (tPA); Vascular reactivity

Indexed keywords

FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84895607012     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-014-0336-z     Document Type: Review
Times cited : (103)

References (120)
  • 1
    • 47649085123 scopus 로고    scopus 로고
    • Management of hyperglycemia in acute stroke: how, when, and for whom?
    • PID: 1843688
    • McCormick MT, Muir KW, Gray CS, Walters MR. Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke. 2008;39(7):2177–85.
    • (2008) Stroke , vol.39 , Issue.7 , pp. 2177-2185
    • McCormick, M.T.1    Muir, K.W.2    Gray, C.S.3    Walters, M.R.4
  • 2
    • 65349175045 scopus 로고    scopus 로고
    • Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis
    • PID: 1913146
    • Poppe AY, Majumdar SR, Jeerakathil T, Ghali W, Buchan AM, Hill MD, et al. Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis. Diabetes Care. 2009;32(4):617–22.
    • (2009) Diabetes Care , vol.32 , Issue.4 , pp. 617-622
    • Poppe, A.Y.1    Majumdar, S.R.2    Jeerakathil, T.3    Ghali, W.4    Buchan, A.M.5    Hill, M.D.6
  • 3
    • 54049111024 scopus 로고    scopus 로고
    • Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial
    • PID: 1870381
    • Yong M, Kaste M. Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial. Stroke. 2008;39(10):2749–55.
    • (2008) Stroke , vol.39 , Issue.10 , pp. 2749-2755
    • Yong, M.1    Kaste, M.2
  • 4
    • 34250846386 scopus 로고    scopus 로고
    • Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke
    • PID: 1752514
    • Uyttenboogaart M, Koch MW, Stewart RE, Vroomen PC, Luijckx GJ, De Keyser J. Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke. Brain. 2007;130(Pt 6):1626–30.
    • (2007) Brain , vol.130 , pp. 1626-1630
    • Uyttenboogaart, M.1    Koch, M.W.2    Stewart, R.E.3    Vroomen, P.C.4    Luijckx, G.J.5    De Keyser, J.6
  • 5
    • 0037056360 scopus 로고    scopus 로고
    • Admission glucose level and clinical outcomes in the NINDS rt-PA stroke trial
    • PID: 12221155, COI: 1:CAS:528:DC%2BD38XnvVSnsbc%3
    • Bruno A, Levine SR, Frankel MR, Brott TG, Lin Y, Tilley BC, et al. Admission glucose level and clinical outcomes in the NINDS rt-PA stroke trial. Neurology. 2002;59(5):669–74.
    • (2002) Neurology , vol.59 , Issue.5 , pp. 669-674
    • Bruno, A.1    Levine, S.R.2    Frankel, M.R.3    Brott, T.G.4    Lin, Y.5    Tilley, B.C.6
  • 6
    • 0034800666 scopus 로고    scopus 로고
    • Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview
    • PID: 11588337, COI: 1:STN:280:DC%2BD3MrktFGrsQ%3D%3
    • Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32(10):2426–32.
    • (2001) Stroke , vol.32 , Issue.10 , pp. 2426-2432
    • Capes, S.E.1    Hunt, D.2    Malmberg, K.3    Pathak, P.4    Gerstein, H.C.5
  • 7
    • 84857097464 scopus 로고    scopus 로고
    • Insulin resistance is associated with a poor response to intravenous thrombolysis in acute ischemic stroke
    • PID: 21911778, COI: 1:CAS:528:DC%2BC3MXhsFCrsLr
    • Calleja AI, Garcia-Bermejo P, Cortijo E, Bustamante R, Rojo Martinez E, Gonzalez Sarmiento E, et al. Insulin resistance is associated with a poor response to intravenous thrombolysis in acute ischemic stroke. Diabetes Care. 2011;34(11):2413–7.
    • (2011) Diabetes Care , vol.34 , Issue.11 , pp. 2413-2417
    • Calleja, A.I.1    Garcia-Bermejo, P.2    Cortijo, E.3    Bustamante, R.4    Rojo Martinez, E.5    Gonzalez Sarmiento, E.6
  • 8
    • 60549096743 scopus 로고    scopus 로고
    • Impact of fasting glycemia and regional cerebral perfusion in diabetic subjects: a study with technetium-99 m-ethyl cysteinate dimer single photon emission computed tomography
    • PID: 18845804, COI: 1:CAS:528:DC%2BD1cXhsFWisrz
    • Cosentino F, Battista R, Scuteri A, De Sensi F, De Siati L, Di Russo C, et al. Impact of fasting glycemia and regional cerebral perfusion in diabetic subjects: a study with technetium-99 m-ethyl cysteinate dimer single photon emission computed tomography. Stroke. 2009;40(1):306–8.
    • (2009) Stroke , vol.40 , Issue.1 , pp. 306-308
    • Cosentino, F.1    Battista, R.2    Scuteri, A.3    De Sensi, F.4    De Siati, L.5    Di Russo, C.6
  • 9
    • 36048935090 scopus 로고    scopus 로고
    • Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia
    • PID: 18000605, COI: 1:CAS:528:DC%2BD2sXhsVWrsbn
    • Gentile NT, Vaidyula VR, Kanamalla U, DeAngelis M, Gaughan J, Rao AK. Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia. Thromb Haemost. 2007;98(5):1007–13.
    • (2007) Thromb Haemost , vol.98 , Issue.5 , pp. 1007-1013
    • Gentile, N.T.1    Vaidyula, V.R.2    Kanamalla, U.3    DeAngelis, M.4    Gaughan, J.5    Rao, A.K.6
  • 10
    • 0032910598 scopus 로고    scopus 로고
    • Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men
    • PID: 10331423, COI: 1:CAS:528:DyaK1MXjtFSgt7g%3
    • Rao AK, Chouhan V, Chen X, Sun L, Boden G. Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men. Diabetes. 1999;48(5):1156–61.
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1156-1161
    • Rao, A.K.1    Chouhan, V.2    Chen, X.3    Sun, L.4    Boden, G.5
  • 11
    • 0034761311 scopus 로고    scopus 로고
    • Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat
    • PID: 11757804, COI: 1:CAS:528:DC%2BD38Xhs1Kksw%3D%3
    • Pandolfi A, Giaccari A, Cilli C, Alberta MM, Morviducci L, De Filippis EA, et al. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol. 2001;38(2):71–6.
    • (2001) Acta Diabetol , vol.38 , Issue.2 , pp. 71-76
    • Pandolfi, A.1    Giaccari, A.2    Cilli, C.3    Alberta, M.M.4    Morviducci, L.5    De Filippis, E.A.6
  • 13
    • 77954176107 scopus 로고    scopus 로고
    • Off-label thrombolysis is not associated with poor outcome in patients with stroke
    • PID: 2053870
    • Meretoja A, Putaala J, Tatlisumak T, Atula S, Artto V, Curtze S, et al. Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke. 2010;41(7):1450–8.
    • (2010) Stroke , vol.41 , Issue.7 , pp. 1450-1458
    • Meretoja, A.1    Putaala, J.2    Tatlisumak, T.3    Atula, S.4    Artto, V.5    Curtze, S.6
  • 14
    • 78149431412 scopus 로고    scopus 로고
    • Post-thrombolytic hyperglycemia and 3-month outcome in acute ischemic stroke
    • PID: 21079397, COI: 1:CAS:528:DC%2BC3cXhsFOgtrn
    • Putaala J, Sairanen T, Meretoja A, Lindsberg PJ, Tiainen M, Liebkind R, et al. Post-thrombolytic hyperglycemia and 3-month outcome in acute ischemic stroke. Cerebrovasc Dis. 2011;31(1):83–92.
    • (2011) Cerebrovasc Dis , vol.31 , Issue.1 , pp. 83-92
    • Putaala, J.1    Sairanen, T.2    Meretoja, A.3    Lindsberg, P.J.4    Tiainen, M.5    Liebkind, R.6
  • 15
    • 0037967223 scopus 로고    scopus 로고
    • Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator–treated patients
    • PID: 1267701
    • Alvarez-Sabin J, Molina CA, Montaner J, Arenillas JF, Huertas R, Ribo M, et al. Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator–treated patients. Stroke. 2003;34(5):1235–41.
    • (2003) Stroke , vol.34 , Issue.5 , pp. 1235-1241
    • Alvarez-Sabin, J.1    Molina, C.A.2    Montaner, J.3    Arenillas, J.F.4    Huertas, R.5    Ribo, M.6
  • 16
    • 60549108722 scopus 로고    scopus 로고
    • The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study
    • PID: 19095970, COI: 1:CAS:528:DC%2BD1MXmvVeisA%3D%3
    • Fuentes B, Castillo J, San Jose B, Leira R, Serena J, Vivancos J, et al. The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study. Stroke. 2009;40(2):562–8.
    • (2009) Stroke , vol.40 , Issue.2 , pp. 562-568
    • Fuentes, B.1    Castillo, J.2    San Jose, B.3    Leira, R.4    Serena, J.5    Vivancos, J.6
  • 17
    • 77951042561 scopus 로고    scopus 로고
    • Intensive insulin therapy in severe traumatic brain injury: a randomized trial
    • PID: 20032790, COI: 1:CAS:528:DC%2BC3cXks1Wksbg%3
    • Coester A, Neumann CR, Schmidt MI. Intensive insulin therapy in severe traumatic brain injury: a randomized trial. J Trauma. 2010;68(4):904–11.
    • (2010) J Trauma , vol.68 , Issue.4 , pp. 904-911
    • Coester, A.1    Neumann, C.R.2    Schmidt, M.I.3
  • 18
    • 56749174097 scopus 로고    scopus 로고
    • Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial
    • PID: 18373223, COI: 1:CAS:528:DC%2BD1cXhtlGisbr
    • Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care. 2008;9(2):159–66.
    • (2008) Neurocrit Care , vol.9 , Issue.2 , pp. 159-166
    • Bilotta, F.1    Caramia, R.2    Cernak, I.3    Paoloni, F.P.4    Doronzio, A.5    Cuzzone, V.6
  • 19
    • 34047255739 scopus 로고    scopus 로고
    • Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK)
    • PID: 17434094, COI: 1:CAS:528:DC%2BD2sXmtVyrsLc%3
    • Gray CS, Hildreth AJ, Sandercock PA, O’Connell JE, Johnston DE, Cartlidge NE, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol. 2007;6(5):397–406.
    • (2007) Lancet Neurol , vol.6 , Issue.5 , pp. 397-406
    • Gray, C.S.1    Hildreth, A.J.2    Sandercock, P.A.3    O’Connell, J.E.4    Johnston, D.E.5    Cartlidge, N.E.6
  • 20
    • 77951717563 scopus 로고    scopus 로고
    • Randomized, controlled trial of insulin for acute poststroke hyperglycemia
    • PID: 20437554, COI: 1:CAS:528:DC%2BC3cXmvF2lsr4%3
    • McCormick M, Hadley D, McLean JR, Macfarlane JA, Condon B, Muir KW. Randomized, controlled trial of insulin for acute poststroke hyperglycemia. Ann Neurol. 2010;67(5):570–8.
    • (2010) Ann Neurol , vol.67 , Issue.5 , pp. 570-578
    • McCormick, M.1    Hadley, D.2    McLean, J.R.3    Macfarlane, J.A.4    Condon, B.5    Muir, K.W.6
  • 21
    • 84892697797 scopus 로고    scopus 로고
    • The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke
    • Bruno A, Durkalski VL, Hall CE, Juneja R, Barsan WG, Janis S, et al. The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke. Int J Stroke. 2013. doi:10.1111/ijs.12045.
    • (2013) Int J Stroke
    • Bruno, A.1    Durkalski, V.L.2    Hall, C.E.3    Juneja, R.4    Barsan, W.G.5    Janis, S.6
  • 22
    • 84876231902 scopus 로고    scopus 로고
    • Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • PID: 2337020
    • Jauch EC, Saver JL, Adams Jr HP, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870–947.
    • (2013) Stroke , vol.44 , Issue.3 , pp. 870-947
    • Jauch, E.C.1    Saver, J.L.2    Adams, H.P.3    Bruno, A.4    Connors, J.J.5    Demaerschalk, B.M.6
  • 24
    • 82955243840 scopus 로고    scopus 로고
    • Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus
    • PID: 22094479, COI: 1:STN:280:DC%2BC387gs1GltQ%3D%3
    • Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, et al. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology. 2011;77(21):1866–72.
    • (2011) Neurology , vol.77 , Issue.21 , pp. 1866-1872
    • Mishra, N.K.1    Ahmed, N.2    Davalos, A.3    Iversen, H.K.4    Melo, T.5    Soinne, L.6
  • 25
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • PID: 18815396, COI: 1:CAS:528:DC%2BD1cXhtFGqu77
    • Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.
    • (2008) N Engl J Med , vol.359 , Issue.13 , pp. 1317-1329
    • Hacke, W.1    Kaste, M.2    Bluhmki, E.3    Brozman, M.4    Davalos, A.5    Guidetti, D.6
  • 26
    • 33847215407 scopus 로고    scopus 로고
    • Hyperglycemia in acute ischemic stroke: a vascular perspective
    • PID: 16804552, COI: 1:CAS:528:DC%2BD2sXjtlKitL0%3
    • Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab. 2007;27(3):435–51.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.3 , pp. 435-451
    • Martini, S.R.1    Kent, T.A.2
  • 27
    • 67349179497 scopus 로고    scopus 로고
    • Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature
    • COI: 1:CAS:528:DC%2BD1MXmtFCiurc%3
    • Ergul A, Li W, Elgebaly MM, Bruno A, Fagan SC. Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature. Vasc Pharmacol. 2009;51:44–9.
    • (2009) Vasc Pharmacol , vol.51 , pp. 44-49
    • Ergul, A.1    Li, W.2    Elgebaly, M.M.3    Bruno, A.4    Fagan, S.C.5
  • 29
    • 0023182295 scopus 로고
    • Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration
    • PID: 3604580, COI: 1:STN:280:DyaL2s3ms1Crtg%3D%3
    • Nedergaard M, Diemer NH. Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol. 1987;73(2):131–7.
    • (1987) Acta Neuropathol , vol.73 , Issue.2 , pp. 131-137
    • Nedergaard, M.1    Diemer, N.H.2
  • 30
    • 80053483438 scopus 로고    scopus 로고
    • Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetes
    • PID: 21699626, COI: 1:CAS:528:DC%2BC3MXhtlyrsr7
    • Ritter L, Davidson L, Henry M, Davis-Gorman G, Morrison H, Frye JB, et al. Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetes. Microcirculation. 2011;18(7):552–61.
    • (2011) Microcirculation , vol.18 , Issue.7 , pp. 552-561
    • Ritter, L.1    Davidson, L.2    Henry, M.3    Davis-Gorman, G.4    Morrison, H.5    Frye, J.B.6
  • 31
    • 81255135828 scopus 로고    scopus 로고
    • Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke
    • PID: 21923664, COI: 1:CAS:528:DC%2BC3MXhs1Gqtb%2F
    • Kumari R, Willing LB, Patel SD, Baskerville KA, Simpson IA. Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke. J Neurochem. 2011;119(5):1029–40.
    • (2011) J Neurochem , vol.119 , Issue.5 , pp. 1029-1040
    • Kumari, R.1    Willing, L.B.2    Patel, S.D.3    Baskerville, K.A.4    Simpson, I.A.5
  • 32
    • 79251615897 scopus 로고    scopus 로고
    • White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke
    • PID: 21193743, COI: 1:CAS:528:DC%2BC3MXhtFCjt7w%3
    • Chen J, Cui X, Zacharek A, Cui Y, Roberts C, Chopp M. White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke. 2011;42(2):445–52.
    • (2011) Stroke , vol.42 , Issue.2 , pp. 445-452
    • Chen, J.1    Cui, X.2    Zacharek, A.3    Cui, Y.4    Roberts, C.5    Chopp, M.6
  • 33
    • 76349124070 scopus 로고    scopus 로고
    • The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse
    • PID: 19861974, COI: 1:CAS:528:DC%2BC3cXhsVWjtLY%3
    • Kumari R, Willing LB, Patel SD, Krady JK, Zavadoski WJ, Gibbs EM, et al. The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. J Cereb Blood Flow Metab. 2010;30(2):352–60.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.2 , pp. 352-360
    • Kumari, R.1    Willing, L.B.2    Patel, S.D.3    Krady, J.K.4    Zavadoski, W.J.5    Gibbs, E.M.6
  • 35
    • 79551623322 scopus 로고    scopus 로고
    • Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia
    • PID: 21133923, COI: 1:CAS:528:DC%2BC3MXisFKlu7o%3
    • Tureyen K, Bowen K, Liang J, Dempsey RJ, Vemuganti R. Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia. J Neurochem. 2011;116(4):499–507.
    • (2011) J Neurochem , vol.116 , Issue.4 , pp. 499-507
    • Tureyen, K.1    Bowen, K.2    Liang, J.3    Dempsey, R.J.4    Vemuganti, R.5
  • 37
    • 77449105172 scopus 로고    scopus 로고
    • Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia
    • PID: 1980889
    • Li W, Prakash R, Kelly-Cobbs AI, Ogbi S, Kozak A, El-Remessy AB, et al. Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes. 2010;59:228–35.
    • (2010) Diabetes , vol.59 , pp. 228-235
    • Li, W.1    Prakash, R.2    Kelly-Cobbs, A.I.3    Ogbi, S.4    Kozak, A.5    El-Remessy, A.B.6
  • 38
    • 78649719674 scopus 로고    scopus 로고
    • Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling
    • PID: 20664613, COI: 1:CAS:528:DC%2BC3cXhsV2gtL3
    • Elgebaly MM, Prakash R, Li W, Ogbi S, Johnson MH, Mezzetti EM, et al. Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling. J Cereb Blood Flow Metab. 2010;30(12):1928–38.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.12 , pp. 1928-1938
    • Elgebaly, M.M.1    Prakash, R.2    Li, W.3    Ogbi, S.4    Johnson, M.H.5    Mezzetti, E.M.6
  • 39
    • 67651011803 scopus 로고    scopus 로고
    • Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats
    • PID: 19478137, COI: 1:CAS:528:DC%2BD1MXpsFClsbw%3
    • Elewa HF, Kozak A, El-Remessy AB, Frye RF, Johnson MH, Ergul A, et al. Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats. J Pharmacol Exp Ther. 2009;330(2):532–40.
    • (2009) J Pharmacol Exp Ther , vol.330 , Issue.2 , pp. 532-540
    • Elewa, H.F.1    Kozak, A.2    El-Remessy, A.B.3    Frye, R.F.4    Johnson, M.H.5    Ergul, A.6
  • 40
    • 36649002215 scopus 로고    scopus 로고
    • Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes
    • PID: 1793779
    • Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, et al. Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol. 2007;7:33.
    • (2007) BMC Neurol , vol.7 , pp. 33
    • Ergul, A.1    Elgebaly, M.M.2    Middlemore, M.L.3    Li, W.4    Elewa, H.5    Switzer, J.A.6
  • 41
    • 79960672283 scopus 로고    scopus 로고
    • Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia
    • PID: 2172573
    • Xing Y, Jiang X, Yang Y, Xi G. Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia. Acta Neurochir Suppl. 2011;111:49–54.
    • (2011) Acta Neurochir Suppl , vol.111 , pp. 49-54
    • Xing, Y.1    Jiang, X.2    Yang, Y.3    Xi, G.4
  • 42
    • 80052296902 scopus 로고    scopus 로고
    • Neurovascular injury in acute hyperglycemia and diabetes: a comparative analysis in experimental stroke
    • PID: 2190934
    • Elgebaly MM, Ogbi S, Li W, Mezzetti EM, Prakash R, Johnson MH, et al. Neurovascular injury in acute hyperglycemia and diabetes: a comparative analysis in experimental stroke. Transl Stroke Res. 2011;2(3):391–8.
    • (2011) Transl Stroke Res , vol.2 , Issue.3 , pp. 391-398
    • Elgebaly, M.M.1    Ogbi, S.2    Li, W.3    Mezzetti, E.M.4    Prakash, R.5    Johnson, M.H.6
  • 43
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • PID: 2981404, COI: 1:CAS:528:DyaL2MXptlOmtA%3D%3
    • McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312(3):159–63.
    • (1985) N Engl J Med , vol.312 , Issue.3 , pp. 159-163
    • McCord, J.M.1
  • 44
    • 84885299035 scopus 로고    scopus 로고
    • Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-beta
    • PID: 23617822, COI: 1:CAS:528:DC%2BC3sXhs1Slurj
    • Shao B, Bayraktutan U. Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-beta. Diabetes Obes Metab. 2013;15(11):993–9.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.11 , pp. 993-999
    • Shao, B.1    Bayraktutan, U.2
  • 46
    • 0032252366 scopus 로고    scopus 로고
    • Hyperglycemia induces progressive changes in the cerebral microvasculature and blood–brain barrier transport during focal cerebral ischemia
    • PID: 9779189, COI: 1:STN:280:DyaK1cvlt1aisw%3D%3
    • Kawai N, Keep RF, Betz AL, Nagao S. Hyperglycemia induces progressive changes in the cerebral microvasculature and blood–brain barrier transport during focal cerebral ischemia. Acta Neurochir Suppl. 1998;71:219–21.
    • (1998) Acta Neurochir Suppl , vol.71 , pp. 219-221
    • Kawai, N.1    Keep, R.F.2    Betz, A.L.3    Nagao, S.4
  • 47
    • 0031034091 scopus 로고    scopus 로고
    • Hyperglycemia and the vascular effects of cerebral ischemia
    • PID: 8996504, COI: 1:STN:280:DyaK2s7kvFKqtA%3D%3
    • Kawai N, Keep RF, Betz AL. Hyperglycemia and the vascular effects of cerebral ischemia. Stroke. 1997;28(1):149–54.
    • (1997) Stroke , vol.28 , Issue.1 , pp. 149-154
    • Kawai, N.1    Keep, R.F.2    Betz, A.L.3
  • 48
    • 0023944657 scopus 로고
    • Triple-tracer autoradiography demonstrates effects of hyperglycemia on cerebral blood flow, pH, and glucose utilization in cerebral ischemia of rats
    • PID: 3376169, COI: 1:CAS:528:DyaL1cXksFaltrY%3
    • Nakai H, Yamamoto YL, Diksic M, Worsley KJ, Takara E. Triple-tracer autoradiography demonstrates effects of hyperglycemia on cerebral blood flow, pH, and glucose utilization in cerebral ischemia of rats. Stroke. 1988;19(6):764–72.
    • (1988) Stroke , vol.19 , Issue.6 , pp. 764-772
    • Nakai, H.1    Yamamoto, Y.L.2    Diksic, M.3    Worsley, K.J.4    Takara, E.5
  • 49
    • 0030958957 scopus 로고    scopus 로고
    • Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats
    • PID: 9183293, COI: 1:STN:280:DyaK2szis1CksA%3D%3
    • Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzalez JM, et al. Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab. 1997;17(5):553–9.
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.5 , pp. 553-559
    • Quast, M.J.1    Wei, J.2    Huang, N.C.3    Brunder, D.G.4    Sell, S.L.5    Gonzalez, J.M.6
  • 50
    • 0023118941 scopus 로고
    • Regional cerebral blood flow decreases during chronic and acute hyperglycemia
    • PID: 2949400, COI: 1:STN:280:DyaL2s7itFentA%3D%3
    • Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke. 1987;18(1):52–8.
    • (1987) Stroke , vol.18 , Issue.1 , pp. 52-58
    • Duckrow, R.B.1    Beard, D.C.2    Brennan, R.W.3
  • 51
    • 0018966630 scopus 로고
    • Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization
    • PID: 7414662, COI: 1:CAS:528:DyaL3cXltFWrtrc%3
    • Ginsberg MD, Welsh FA, Budd WW. Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization. Stroke. 1980;11(4):347–54.
    • (1980) Stroke , vol.11 , Issue.4 , pp. 347-354
    • Ginsberg, M.D.1    Welsh, F.A.2    Budd, W.W.3
  • 52
    • 0021827417 scopus 로고
    • The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat
    • PID: 4031911, COI: 1:STN:280:DyaL2M3ptFymsA%3D%3
    • Venables GS, Miller SA, Gibson G, Hardy JA, Strong AJ. The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat. J Neurol Neurosurg Psychiatry. 1985;48(7):663–9.
    • (1985) J Neurol Neurosurg Psychiatry , vol.48 , Issue.7 , pp. 663-669
    • Venables, G.S.1    Miller, S.A.2    Gibson, G.3    Hardy, J.A.4    Strong, A.J.5
  • 53
    • 0026596006 scopus 로고
    • Hyperglycemic versus normoglycemic stroke: topography of brain metabolites, intracellular pH, and infarct size
    • PID: 1548294, COI: 1:CAS:528:DyaK38XitFahtbs%3
    • Wagner KR, Kleinholz M, de Courten-Myers GM, Myers RE. Hyperglycemic versus normoglycemic stroke: topography of brain metabolites, intracellular pH, and infarct size. J Cereb Blood Flow Metab. 1992;12(2):213–22.
    • (1992) J Cereb Blood Flow Metab , vol.12 , Issue.2 , pp. 213-222
    • Wagner, K.R.1    Kleinholz, M.2    de Courten-Myers, G.M.3    Myers, R.E.4
  • 54
    • 0033380698 scopus 로고    scopus 로고
    • Hyperglycemia and focal brain ischemia
    • PID: 10078881, COI: 1:STN:280:DyaK1M7ns1OltQ%3D%3
    • Gisselsson L, Smith ML, Siesjo BK. Hyperglycemia and focal brain ischemia. J Cereb Blood Flow Metab. 1999;19(3):288–97.
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.3 , pp. 288-297
    • Gisselsson, L.1    Smith, M.L.2    Siesjo, B.K.3
  • 55
    • 0032899216 scopus 로고    scopus 로고
    • Signaling mechanisms underlying the vascular myogenic response
    • PID: 10221985, COI: 1:CAS:528:DyaK1MXivFektLc%3
    • Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev. 1999;79(2):387–423.
    • (1999) Physiol Rev , vol.79 , Issue.2 , pp. 387-423
    • Davis, M.J.1    Hill, M.A.2
  • 56
    • 0032929322 scopus 로고    scopus 로고
    • The myogenic response: established facts and attractive hypotheses
    • COI: 1:STN:280:DyaK1M7ovFWluw%3D%3
    • Schubert R, Mulvany MJ. The myogenic response: established facts and attractive hypotheses. Clin Sci (Lond). 1999;96(4):313–26.
    • (1999) Clin Sci (Lond) , vol.96 , Issue.4 , pp. 313-326
    • Schubert, R.1    Mulvany, M.J.2
  • 57
    • 84885446597 scopus 로고    scopus 로고
    • Regulation of cerebral blood flow
    • PID: 2180873
    • Peterson EC, Wang Z, Britz G. Regulation of cerebral blood flow. Int J Vasc Med. 2011;2011:823525.
    • (2011) Int J Vasc Med , vol.2011 , pp. 823525
    • Peterson, E.C.1    Wang, Z.2    Britz, G.3
  • 58
    • 0025097985 scopus 로고
    • Regulation of large cerebral arteries and cerebral microvascular pressure
    • PID: 2403863, COI: 1:STN:280:DyaK3c7gs12huw%3D%3
    • Faraci FM, Heistad DD. Regulation of large cerebral arteries and cerebral microvascular pressure. Circ Res. 1990;66(1):8–17.
    • (1990) Circ Res , vol.66 , Issue.1 , pp. 8-17
    • Faraci, F.M.1    Heistad, D.D.2
  • 59
    • 0031893415 scopus 로고    scopus 로고
    • Regulation of the cerebral circulation: role of endothelium and potassium channels
    • PID: 9457169, COI: 1:CAS:528:DyaK1cXptlOjsg%3D%3
    • Faraci FM, Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev. 1998;78(1):53–97.
    • (1998) Physiol Rev , vol.78 , Issue.1 , pp. 53-97
    • Faraci, F.M.1    Heistad, D.D.2
  • 60
    • 84944486665 scopus 로고
    • On the local reactions of the arterial wall to changes of internal pressure
    • PID: 16992618, COI: 1:STN:280:DC%2BD2s%2FntFCrtA%3D%3
    • Bayliss WM. On the local reactions of the arterial wall to changes of internal pressure. J Physiol. 1902;28(3):220–31.
    • (1902) J Physiol , vol.28 , Issue.3 , pp. 220-231
    • Bayliss, W.M.1
  • 61
    • 84871413155 scopus 로고    scopus 로고
    • Vascular protection following cerebral ischemia and reperfusion
    • Palomares SM, Cipolla MJ. Vascular protection following cerebral ischemia and reperfusion. J Neurol Neurophysiol. 2011;2011.
    • (2011) J Neurol Neurophysiol , pp. 2011
    • Palomares, S.M.1    Cipolla, M.J.2
  • 62
    • 0031017446 scopus 로고    scopus 로고
    • High glucose concentrations dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism
    • PID: 9040698, COI: 1:CAS:528:DyaK2sXhs1Ons7s%3
    • Cipolla MJ, Porter JM, Osol G. High glucose concentrations dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism. Stroke. 1997;28(2):405–10.
    • (1997) Stroke , vol.28 , Issue.2 , pp. 405-410
    • Cipolla, M.J.1    Porter, J.M.2    Osol, G.3
  • 63
    • 0027511823 scopus 로고
    • Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs
    • PID: 8476084, COI: 1:CAS:528:DyaK3sXkt1Grsb8%3
    • Sieber FE, Brown PR, Wu Y, Koehler RC, Traystman RJ. Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs. Am J Physiol. 1993;264(4 Pt 2):H1069–75.
    • (1993) Am J Physiol , vol.264 , pp. 1069-1075
    • Sieber, F.E.1    Brown, P.R.2    Wu, Y.3    Koehler, R.C.4    Traystman, R.J.5
  • 65
    • 0030780772 scopus 로고    scopus 로고
    • Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats
    • PID: 9400380, COI: 1:CAS:528:DyaK2sXnvFWrurw%3
    • Zimmermann PA, Knot HJ, Stevenson AS, Nelson MT. Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circ Res. 1997;81(6):996–1004.
    • (1997) Circ Res , vol.81 , Issue.6 , pp. 996-1004
    • Zimmermann, P.A.1    Knot, H.J.2    Stevenson, A.S.3    Nelson, M.T.4
  • 66
    • 37549010369 scopus 로고    scopus 로고
    • Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat
    • PID: 18036520, COI: 1:CAS:528:DC%2BD1cXivVKrtw%3D%3
    • Jarajapu YP, Guberski DL, Grant MB, Knot HJ. Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat. Eur J Pharmacol. 2008;579(1–3):298–307.
    • (2008) Eur J Pharmacol , vol.579 , Issue.1-3 , pp. 298-307
    • Jarajapu, Y.P.1    Guberski, D.L.2    Grant, M.B.3    Knot, H.J.4
  • 67
    • 84864142878 scopus 로고    scopus 로고
    • Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone
    • PID: 22570365, COI: 1:CAS:528:DC%2BC38XhtVOru7v
    • Kelly-Cobbs AI, Prakash R, Coucha M, Knight RA, Li W, Ogbi SN, et al. Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone. J Pharmacol Exp Ther. 2012;342(2):407–15.
    • (2012) J Pharmacol Exp Ther , vol.342 , Issue.2 , pp. 407-415
    • Kelly-Cobbs, A.I.1    Prakash, R.2    Coucha, M.3    Knight, R.A.4    Li, W.5    Ogbi, S.N.6
  • 68
    • 80051668327 scopus 로고    scopus 로고
    • Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control
    • COI: 1:CAS:528:DC%2BC3MXhtFeqtrv
    • Kelly-Cobbs A, Elgebaly MM, Li W, Ergul A. Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control. Acta Physiol (Oxf). 2011;203(1):245–51.
    • (2011) Acta Physiol (Oxf) , vol.203 , Issue.1 , pp. 245-251
    • Kelly-Cobbs, A.1    Elgebaly, M.M.2    Li, W.3    Ergul, A.4
  • 69
    • 84859713759 scopus 로고    scopus 로고
    • Impaired myogenic tone in isolated cerebral and coronary resistance arteries from the goto-kakizaki rat model of type 2 diabetes
    • PID: 22508433, COI: 1:CAS:528:DC%2BC38XmvV2nt7s%3
    • Kold-Petersen H, Brondum E, Nilsson H, Flyvbjerg A, Aalkjaer C. Impaired myogenic tone in isolated cerebral and coronary resistance arteries from the goto-kakizaki rat model of type 2 diabetes. J Vasc Res. 2012;49(3):267–78.
    • (2012) J Vasc Res , vol.49 , Issue.3 , pp. 267-278
    • Kold-Petersen, H.1    Brondum, E.2    Nilsson, H.3    Flyvbjerg, A.4    Aalkjaer, C.5
  • 70
    • 77955853860 scopus 로고    scopus 로고
    • Effect of hyperglycemia on brain penetrating arterioles and cerebral blood flow before and after ischemia/reperfusion
    • PID: 2056331
    • Cipolla MJ, Godfrey JA. Effect of hyperglycemia on brain penetrating arterioles and cerebral blood flow before and after ischemia/reperfusion. Transl Stroke Res. 2010;1(2):127–34.
    • (2010) Transl Stroke Res , vol.1 , Issue.2 , pp. 127-134
    • Cipolla, M.J.1    Godfrey, J.A.2
  • 71
    • 84861867415 scopus 로고    scopus 로고
    • Peroxynitrite decomposition with FeTMPyP improves plasma-induced vascular dysfunction and infarction during mild but not severe hyperglycemic stroke
    • PID: 22373645, COI: 1:CAS:528:DC%2BC38XnvFemtb4%3
    • Palomares SM, Gardner-Morse I, Sweet JG, Cipolla MJ. Peroxynitrite decomposition with FeTMPyP improves plasma-induced vascular dysfunction and infarction during mild but not severe hyperglycemic stroke. J Cereb Blood Flow Metab. 2012;32(6):1035–45.
    • (2012) J Cereb Blood Flow Metab , vol.32 , Issue.6 , pp. 1035-1045
    • Palomares, S.M.1    Gardner-Morse, I.2    Sweet, J.G.3    Cipolla, M.J.4
  • 72
    • 84900538783 scopus 로고    scopus 로고
    • The role of contralateral cerebrovascular myogenic dysfunction in hyperglycemic stroke
    • Abstrac
    • Coucha M, Li W, Hafez S, Fagan SC, Ergul A. The role of contralateral cerebrovascular myogenic dysfunction in hyperglycemic stroke. Stroke. 2013;44:A153. Abstract.
    • (2013) Stroke , vol.44 , pp. 153
    • Coucha, M.1    Li, W.2    Hafez, S.3    Fagan, S.C.4    Ergul, A.5
  • 73
    • 0037046216 scopus 로고    scopus 로고
    • Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey
    • PID: 11940547, COI: 1:CAS:528:DC%2BD38Xjs12ns7k%3
    • Tanne D, Kasner SE, Demchuk AM, Koren-Morag N, Hanson S, Grond M, et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey. Circulation. 2002;105(14):1679–85.
    • (2002) Circulation , vol.105 , Issue.14 , pp. 1679-1685
    • Tanne, D.1    Kasner, S.E.2    Demchuk, A.M.3    Koren-Morag, N.4    Hanson, S.5    Grond, M.6
  • 74
    • 0034117546 scopus 로고    scopus 로고
    • Postischemic attenuation of cerebral artery reactivity is increased in the presence of tissue plasminogen activator
    • PID: 10754003, COI: 1:CAS:528:DC%2BD3cXivFajtL4%3
    • Cipolla MJ, Lessov N, Clark WM, Haley Jr EC. Postischemic attenuation of cerebral artery reactivity is increased in the presence of tissue plasminogen activator. Stroke. 2000;31(4):940–5.
    • (2000) Stroke , vol.31 , Issue.4 , pp. 940-945
    • Cipolla, M.J.1    Lessov, N.2    Clark, W.M.3    Haley, E.C.4
  • 75
    • 85019241921 scopus 로고    scopus 로고
    • Dilation to tissue plasminogen activator of middle cerebral arteries is prevented by actin cytoskeletal stabilization
    • Abstrac
    • Cipolla MJ, Curry AB. Dilation to tissue plasminogen activator of middle cerebral arteries is prevented by actin cytoskeletal stabilization. Stroke. 2000;32:360. Abstract.
    • (2000) Stroke , vol.32 , pp. 360
    • Cipolla, M.J.1    Curry, A.B.2
  • 76
    • 79851508084 scopus 로고    scopus 로고
    • tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK
    • PID: 21182829, COI: 1:CAS:528:DC%2BC3MXhvFektbc%3
    • Armstead WM, Riley J, Cines DB, Higazi AA. tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK. Brain Res. 2011;1376:88–93.
    • (2011) Brain Res , vol.1376 , pp. 88-93
    • Armstead, W.M.1    Riley, J.2    Cines, D.B.3    Higazi, A.A.4
  • 77
    • 26444544223 scopus 로고    scopus 로고
    • Plasminogen activators contribute to impairment of hypercapnic and hypotensive cerebrovasodilation after cerebral hypoxia/ischemia in the newborn pig
    • PID: 16141421, COI: 1:CAS:528:DC%2BD2MXhtVeisbn
    • Armstead WM, Cines DB, Higazi AA. Plasminogen activators contribute to impairment of hypercapnic and hypotensive cerebrovasodilation after cerebral hypoxia/ischemia in the newborn pig. Stroke. 2005;36(10):2265–9.
    • (2005) Stroke , vol.36 , Issue.10 , pp. 2265-2269
    • Armstead, W.M.1    Cines, D.B.2    Higazi, A.A.3
  • 78
    • 77953737057 scopus 로고    scopus 로고
    • PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia
    • PID: 20435843, COI: 1:CAS:528:DC%2BC3cXpsVOrs7w%3
    • Armstead WM, Riley J, Kiessling JW, Cines DB, Higazi AA. PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia. Am J Physiol Heart Circ Physiol. 2010;299(1):H76–80.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , Issue.1 , pp. 76-80
    • Armstead, W.M.1    Riley, J.2    Kiessling, J.W.3    Cines, D.B.4    Higazi, A.A.5
  • 79
    • 0027987849 scopus 로고    scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344(8934):1383–9
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344(8934):1383–9.
  • 80
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360(9326):7–22.
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 7-22
    • Heart Protection Study Collaborative Group1
  • 81
    • 33847613568 scopus 로고    scopus 로고
    • Statin pre-treatment protects brain against focal cerebral ischemia in diabetic mice
    • PID: 17275846, COI: 1:CAS:528:DC%2BD2sXis1yitLg%3
    • Cakmak A, Yemisci M, Koksoy C, Yazgan U, Dincer D, Dalkara T. Statin pre-treatment protects brain against focal cerebral ischemia in diabetic mice. J Surg Res. 2007;138(2):254–8.
    • (2007) J Surg Res , vol.138 , Issue.2 , pp. 254-258
    • Cakmak, A.1    Yemisci, M.2    Koksoy, C.3    Yazgan, U.4    Dincer, D.5    Dalkara, T.6
  • 82
    • 84874123482 scopus 로고    scopus 로고
    • Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes
    • PID: 23441170, COI: 1:CAS:528:DC%2BC3sXjsFSisbw%3
    • Prakash R, Johnson M, Fagan SC, Ergul A. Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes. PloS ONE. 2013;8(2):e56264.
    • (2013) PloS ONE , vol.8 , Issue.2 , pp. 56264
    • Prakash, R.1    Johnson, M.2    Fagan, S.C.3    Ergul, A.4
  • 83
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    • PID: 17394460, COI: 1:CAS:528:DC%2BD2sXksFSqsLk%3
    • Tureyen K, Kapadia R, Bowen KK, Satriotomo I, Liang J, Feinstein DL, et al. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem. 2007;101(1):41–56.
    • (2007) J Neurochem , vol.101 , Issue.1 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3    Satriotomo, I.4    Liang, J.5    Feinstein, D.L.6
  • 84
    • 33947538056 scopus 로고    scopus 로고
    • Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse
    • PID: 16926846, COI: 1:CAS:528:DC%2BD2sXkvFyntLs%3
    • Kumari R, Willing LB, Krady JK, Vannucci SJ, Simpson IA. Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse. J Cereb Blood Flow Metab. 2007;27(4):710–8.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.4 , pp. 710-718
    • Kumari, R.1    Willing, L.B.2    Krady, J.K.3    Vannucci, S.J.4    Simpson, I.A.5
  • 85
    • 0032589712 scopus 로고    scopus 로고
    • Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra
    • PID: 9880405, COI: 1:CAS:528:DyaK1MXmsVWqtg%3D%3
    • Anderson RE, Tan WK, Martin HS, Meyer FB. Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra. Stroke. 1999;30(1):160–70.
    • (1999) Stroke , vol.30 , Issue.1 , pp. 160-170
    • Anderson, R.E.1    Tan, W.K.2    Martin, H.S.3    Meyer, F.B.4
  • 86
    • 0023889707 scopus 로고
    • Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats
    • PID: 336359
    • de Courten-Myers G, Myers RE, Schoolfield L. Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats. Stroke. 1988;19(5):623–30.
    • (1988) Stroke , vol.19 , Issue.5 , pp. 623-630
    • de Courten-Myers, G.1    Myers, R.E.2    Schoolfield, L.3
  • 87
    • 0028140031 scopus 로고
    • Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion
    • PID: 811331
    • de Courten-Myers GM, Kleinholz M, Wagner KR, Myers RE. Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1994;14(2):227–36.
    • (1994) J Cereb Blood Flow Metab , vol.14 , Issue.2 , pp. 227-236
    • de Courten-Myers, G.M.1    Kleinholz, M.2    Wagner, K.R.3    Myers, R.E.4
  • 88
    • 0029056093 scopus 로고
    • Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats
    • PID: 8545055, COI: 1:CAS:528:DyaK2MXotVejt7c%3
    • Bomont L, MacKenzie ET. Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats. Neurosci Lett. 1995;197(1):53–6.
    • (1995) Neurosci Lett , vol.197 , Issue.1 , pp. 53-56
    • Bomont, L.1    MacKenzie, E.T.2
  • 89
    • 0028797405 scopus 로고
    • Insulin reduction of cerebral infarction due to transient focal ischemia
    • PID: 7815155, COI: 1:CAS:528:DyaK2MXktlais7s%3
    • Hamilton MG, Tranmer BI, Auer RN. Insulin reduction of cerebral infarction due to transient focal ischemia. J Neurosurg. 1995;82(2):262–8.
    • (1995) J Neurosurg , vol.82 , Issue.2 , pp. 262-268
    • Hamilton, M.G.1    Tranmer, B.I.2    Auer, R.N.3
  • 90
    • 0028939857 scopus 로고
    • Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats
    • PID: 7552244, COI: 1:CAS:528:DyaK2MXlt1Sqtrs%3
    • Quast MJ, Wei J, Huang NC. Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats. Brain Res. 1995;677(2):204–12.
    • (1995) Brain Res , vol.677 , Issue.2 , pp. 204-212
    • Quast, M.J.1    Wei, J.2    Huang, N.C.3
  • 91
    • 0025817655 scopus 로고
    • Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion
    • PID: 2046937, COI: 1:STN:280:DyaK3M3mtFWksw%3D%3
    • Yip PK, He YY, Hsu CY, Garg N, Marangos P, Hogan EL. Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion. Neurology. 1991;41(6):899–905.
    • (1991) Neurology , vol.41 , Issue.6 , pp. 899-905
    • Yip, P.K.1    He, Y.Y.2    Hsu, C.Y.3    Garg, N.4    Marangos, P.5    Hogan, E.L.6
  • 92
    • 7944227011 scopus 로고    scopus 로고
    • Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia
    • PID: 15481723, COI: 1:CAS:528:DC%2BD2cXptVeitro%3
    • Zhu CZ, Auer RN. Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia. J Neurosurg. 2004;101(4):664–8.
    • (2004) J Neurosurg , vol.101 , Issue.4 , pp. 664-668
    • Zhu, C.Z.1    Auer, R.N.2
  • 93
    • 0035987094 scopus 로고    scopus 로고
    • The effects of early insulin treatment combined with thrombolysis in rat embolic stroke
    • PID: 12069290, COI: 1:CAS:528:DC%2BD38XltFSgur8%3
    • Meden P, Andersen M, Overgaard K, Rasmussen RS, Boysen G. The effects of early insulin treatment combined with thrombolysis in rat embolic stroke. Neurol Res. 2002;24(4):399–404.
    • (2002) Neurol Res , vol.24 , Issue.4 , pp. 399-404
    • Meden, P.1    Andersen, M.2    Overgaard, K.3    Rasmussen, R.S.4    Boysen, G.5
  • 94
    • 0026482164 scopus 로고
    • Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats
    • PID: 1448829, COI: 1:CAS:528:DyaK3sXhs1Knu7k%3
    • Warner DS, Gionet TX, Todd MM, McAllister AM. Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats. Stroke. 1992;23(12):1775–80.
    • (1992) Stroke , vol.23 , Issue.12 , pp. 1775-1780
    • Warner, D.S.1    Gionet, T.X.2    Todd, M.M.3    McAllister, A.M.4
  • 95
    • 0030211123 scopus 로고    scopus 로고
    • Glucose modulation of ischemic brain injury: review and clinical recommendations
    • PID: 8691903, COI: 1:STN:280:DyaK28zhtVOjtQ%3D%3
    • Wass CT, Lanier WL. Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc. 1996;71(8):801–12.
    • (1996) Mayo Clin Proc , vol.71 , Issue.8 , pp. 801-812
    • Wass, C.T.1    Lanier, W.L.2
  • 96
    • 0019997673 scopus 로고
    • Hyperglycemic ischemia of rat brain: the effect of post-ischemic insulin on metabolic rate
    • PID: 7049325, COI: 1:CAS:528:DyaL38XkvFSjsr8%3
    • Siemkowicz E, Hansen AJ, Gjedde A. Hyperglycemic ischemia of rat brain: the effect of post-ischemic insulin on metabolic rate. Brain Res. 1982;243(2):386–90.
    • (1982) Brain Res , vol.243 , Issue.2 , pp. 386-390
    • Siemkowicz, E.1    Hansen, A.J.2    Gjedde, A.3
  • 97
    • 0023732112 scopus 로고
    • The effect of postischemic blood glucose levels on ischemic brain damage in the rat
    • PID: 3059989, COI: 1:CAS:528:DyaL1MXjsleluw%3D%3
    • Voll CL, Auer RN. The effect of postischemic blood glucose levels on ischemic brain damage in the rat. Ann Neurol. 1988;24(5):638–46.
    • (1988) Ann Neurol , vol.24 , Issue.5 , pp. 638-646
    • Voll, C.L.1    Auer, R.N.2
  • 98
    • 0024337626 scopus 로고
    • Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats
    • PID: 2655186, COI: 1:CAS:528:DyaL1MXktFyjuro%3
    • Voll CL, Whishaw IQ, Auer RN. Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. Stroke. 1989;20(5):646–51.
    • (1989) Stroke , vol.20 , Issue.5 , pp. 646-651
    • Voll, C.L.1    Whishaw, I.Q.2    Auer, R.N.3
  • 99
    • 0027420017 scopus 로고
    • Metabolic changes associated with altering blood glucose levels in short duration forebrain ischemia
    • PID: 8495363, COI: 1:CAS:528:DyaK3sXisFalsrs%3
    • Tyson R, Peeling J, Sutherland G. Metabolic changes associated with altering blood glucose levels in short duration forebrain ischemia. Brain Res. 1993;608(2):288–98.
    • (1993) Brain Res , vol.608 , Issue.2 , pp. 288-298
    • Tyson, R.1    Peeling, J.2    Sutherland, G.3
  • 100
    • 33745252164 scopus 로고    scopus 로고
    • Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide
    • PID: 16729987, COI: 1:CAS:528:DC%2BD28Xmt1yisrk%3
    • Rizk NN, Rafols JA, Dunbar JC. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain Res. 2006;1096(1):204–12.
    • (2006) Brain Res , vol.1096 , Issue.1 , pp. 204-212
    • Rizk, N.N.1    Rafols, J.A.2    Dunbar, J.C.3
  • 101
    • 35248833162 scopus 로고    scopus 로고
    • Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats
    • PID: 17709900, COI: 1:CAS:528:DC%2BD2sXotlCitbY%3
    • Rizk NN, Myatt-Jones J, Rafols J, Dunbar JC. Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats. Endocrine. 2007;31(1):66–71.
    • (2007) Endocrine , vol.31 , Issue.1 , pp. 66-71
    • Rizk, N.N.1    Myatt-Jones, J.2    Rafols, J.3    Dunbar, J.C.4
  • 102
    • 69249240342 scopus 로고    scopus 로고
    • Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia
    • PID: 19631616, COI: 1:CAS:528:DC%2BD1MXhtVKls77
    • Xing Y, Hua Y, Keep RF, Xi G. Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. Brain Res. 2009;1291:113–21.
    • (2009) Brain Res , vol.1291 , pp. 113-121
    • Xing, Y.1    Hua, Y.2    Keep, R.F.3    Xi, G.4
  • 103
    • 77953810543 scopus 로고    scopus 로고
    • Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model
    • PID: 20423721, COI: 1:CAS:528:DC%2BC3cXnvVOms7c%3
    • Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, et al. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 2010;169(1):402–14.
    • (2010) Neuroscience , vol.169 , Issue.1 , pp. 402-414
    • Chen, C.H.1    Manaenko, A.2    Zhan, Y.3    Liu, W.W.4    Ostrowki, R.P.5    Tang, J.6
  • 104
    • 84856237050 scopus 로고    scopus 로고
    • Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia
    • PID: 22197649, COI: 1:CAS:528:DC%2BC38Xhs1Ggtr0%3
    • Huang M, Qian Y, Guan T, Huang L, Tang X, Li Y. Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia. Eur J Pharmacol. 2012;677(1–3):71–6.
    • (2012) Eur J Pharmacol , vol.677 , Issue.1-3 , pp. 71-76
    • Huang, M.1    Qian, Y.2    Guan, T.3    Huang, L.4    Tang, X.5    Li, Y.6
  • 105
    • 80055000205 scopus 로고    scopus 로고
    • Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats
    • PID: 21963653, COI: 1:CAS:528:DC%2BC3MXhtlOmu7f
    • Ye X, Chopp M, Cui X, Zacharek A, Cui Y, Yan T, et al. Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp Neurol. 2011;232(2):299–308.
    • (2011) Exp Neurol , vol.232 , Issue.2 , pp. 299-308
    • Ye, X.1    Chopp, M.2    Cui, X.3    Zacharek, A.4    Cui, Y.5    Yan, T.6
  • 106
    • 84862824846 scopus 로고    scopus 로고
    • Niaspan increases axonal remodeling after stroke in type 1 diabetes rats
    • PID: 22266016, COI: 1:CAS:528:DC%2BC38Xjs1OntLg%3
    • Yan T, Chopp M, Ye X, Liu Z, Zacharek A, Cui Y, et al. Niaspan increases axonal remodeling after stroke in type 1 diabetes rats. Neurobiol Dis. 2012;46(1):157–64.
    • (2012) Neurobiol Dis , vol.46 , Issue.1 , pp. 157-164
    • Yan, T.1    Chopp, M.2    Ye, X.3    Liu, Z.4    Zacharek, A.5    Cui, Y.6
  • 107
    • 34547738951 scopus 로고    scopus 로고
    • Niaspan increases angiogenesis and improves functional recovery after stroke
    • PID: 17557352, COI: 1:CAS:528:DC%2BD2sXhtVajsrr
    • Chen J, Cui X, Zacharek A, Jiang H, Roberts C, Zhang C, et al. Niaspan increases angiogenesis and improves functional recovery after stroke. Ann Neurol. 2007;62(1):49–58.
    • (2007) Ann Neurol , vol.62 , Issue.1 , pp. 49-58
    • Chen, J.1    Cui, X.2    Zacharek, A.3    Jiang, H.4    Roberts, C.5    Zhang, C.6
  • 108
    • 84888341499 scopus 로고    scopus 로고
    • Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery
    • PID: 2392001
    • Prakash R, Li W, Qu Z, Johnson MA, Fagan SC, Ergul A. Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery. Stroke. 2013;44(10):2875–82.
    • (2013) Stroke , vol.44 , Issue.10 , pp. 2875-2882
    • Prakash, R.1    Li, W.2    Qu, Z.3    Johnson, M.A.4    Fagan, S.C.5    Ergul, A.6
  • 109
    • 0035075998 scopus 로고    scopus 로고
    • Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    • PID: 11283404, COI: 1:STN:280:DC%2BD3M3ivVylug%3D%3
    • Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32(4):1005–11.
    • (2001) Stroke , vol.32 , Issue.4 , pp. 1005-1011
    • Chen, J.1    Li, Y.2    Wang, L.3    Zhang, Z.4    Lu, D.5    Lu, M.6
  • 110
    • 84856214781 scopus 로고    scopus 로고
    • Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats
    • PID: 2194096
    • Chen J, Ye X, Yan T, Zhang C, Yang XP, Cui X, et al. Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats. Stroke. 2011;42(12):3551–8.
    • (2011) Stroke , vol.42 , Issue.12 , pp. 3551-3558
    • Chen, J.1    Ye, X.2    Yan, T.3    Zhang, C.4    Yang, X.P.5    Cui, X.6
  • 111
    • 84855362074 scopus 로고    scopus 로고
    • Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production
    • PID: 22002675, COI: 1:CAS:528:DC%2BC3MXhtlKjtLn
    • Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production. Ann Neurol. 2011;70(4):583–90.
    • (2011) Ann Neurol , vol.70 , Issue.4 , pp. 583-590
    • Won, S.J.1    Tang, X.N.2    Suh, S.W.3    Yenari, M.A.4    Swanson, R.A.5
  • 112
    • 84865629675 scopus 로고    scopus 로고
    • Tissue plasminogen activator treatment of stroke in type-1 diabetes rats
    • PID: 22820263, COI: 1:CAS:528:DC%2BC38XhtlShtbb
    • Ning R, Chopp M, Yan T, Zacharek A, Zhang C, Roberts C, et al. Tissue plasminogen activator treatment of stroke in type-1 diabetes rats. Neuroscience. 2012;222:326–32.
    • (2012) Neuroscience , vol.222 , pp. 326-332
    • Ning, R.1    Chopp, M.2    Yan, T.3    Zacharek, A.4    Zhang, C.5    Roberts, C.6
  • 113
    • 84856454145 scopus 로고    scopus 로고
    • A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes
    • PID: 22052516, COI: 1:CAS:528:DC%2BC38XhtlSqtr0%3
    • Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, et al. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012;43(2):567–70.
    • (2012) Stroke , vol.43 , Issue.2 , pp. 567-570
    • Fan, X.1    Qiu, J.2    Yu, Z.3    Dai, H.4    Singhal, A.B.5    Lo, E.H.6
  • 114
    • 84876280524 scopus 로고    scopus 로고
    • Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats
    • PID: 23422086, COI: 1:CAS:528:DC%2BC3sXms1yltrc%3
    • Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke. 2013;44(3):745–52.
    • (2013) Stroke , vol.44 , Issue.3 , pp. 745-752
    • Fan, X.1    Lo, E.H.2    Wang, X.3
  • 115
    • 84872072700 scopus 로고    scopus 로고
    • Early insulin glycemic control combined with tPA thrombolysis reduces acute brain tissue damages in a focal embolic stroke model of diabetic rats
    • PID: 23117722, COI: 1:CAS:528:DC%2BC3sXis1e
    • Fan X, Ning M, Lo EH, Wang X. Early insulin glycemic control combined with tPA thrombolysis reduces acute brain tissue damages in a focal embolic stroke model of diabetic rats. Stroke. 2013;44(1):255–9.
    • (2013) Stroke , vol.44 , Issue.1 , pp. 255-259
    • Fan, X.1    Ning, M.2    Lo, E.H.3    Wang, X.4
  • 116
    • 1542466786 scopus 로고    scopus 로고
    • Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice
    • PID: 14702112, COI: 1:CAS:528:DC%2BD2cXjsVGlsA%3D%3
    • Zhang L, Nair A, Krady K, Corpe C, Bonneau RH, Simpson IA, et al. Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice. J Clin Invest. 2004;113(1):85–95.
    • (2004) J Clin Invest , vol.113 , Issue.1 , pp. 85-95
    • Zhang, L.1    Nair, A.2    Krady, K.3    Corpe, C.4    Bonneau, R.H.5    Simpson, I.A.6
  • 117
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • PID: 11259643, COI: 1:CAS:528:DC%2BD3MXis1Khtrg%3
    • Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci U S A. 2001;98(7):4044–9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.7 , pp. 4044-4049
    • Siren, A.L.1    Fratelli, M.2    Brines, M.3    Goemans, C.4    Casagrande, S.5    Lewczuk, P.6
  • 118
    • 34547880688 scopus 로고    scopus 로고
    • Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia
    • PID: 17603558, COI: 1:CAS:528:DC%2BD2sXovFehsrw%3
    • Wang Y, Zhang ZG, Rhodes K, Renzi M, Zhang RL, Kapke A, et al. Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br J Pharmacol. 2007;151(8):1377–84.
    • (2007) Br J Pharmacol , vol.151 , Issue.8 , pp. 1377-1384
    • Wang, Y.1    Zhang, Z.G.2    Rhodes, K.3    Renzi, M.4    Zhang, R.L.5    Kapke, A.6
  • 119
    • 70949095435 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the treatment of acute ischemic stroke
    • PID: 19834012, COI: 1:CAS:528:DC%2BD1MXhsValtbr
    • Ehrenreich H, Weissenborn K, Prange H, Schneider D, Weimar C, Wartenberg K, et al. Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke. 2009;40(12):e647–56.
    • (2009) Stroke , vol.40 , Issue.12 , pp. 647-656
    • Ehrenreich, H.1    Weissenborn, K.2    Prange, H.3    Schneider, D.4    Weimar, C.5    Wartenberg, K.6
  • 120
    • 77956413296 scopus 로고    scopus 로고
    • Erythropoietin in combination of tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6 hours after stroke
    • PID: 20671252, COI: 1:CAS:528:DC%2BC3cXht1egsLn
    • Jia L, Chopp M, Zhang L, Lu M, Zhang Z. Erythropoietin in combination of tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6 hours after stroke. Stroke. 2010;41(9):2071–6.
    • (2010) Stroke , vol.41 , Issue.9 , pp. 2071-2076
    • Jia, L.1    Chopp, M.2    Zhang, L.3    Lu, M.4    Zhang, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.