Effect of Hyperglycemia on Brain Penetrating Arterioles and Cerebral Blood Flow Before and After Ischemia/Reperfusion

Translational Stroke Research

Volumn 1, Issue 2, 2010, Pages 127-134

  Cipolla, Marilyn J ^a   Godfrey, Julie A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium activated potassium channels; Cerebral edema; Hyperglycemia; Ischemic stroke; Lenticulostriate arterioles

Indexed keywords

APAMIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; HYPERGLYCEMIA; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 77955853860     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-010-0014-8     Document Type: Article

References (42)

1. Kiers L, Davis SM, Larkins R, Hopper J, Tress B, Rossiter SC, Carlin J, Ratnaike S (1992) Stroke topography and outcome in relation to hyperglycaemia and diabetes. J Neurol Neurosurg Psychiatry 55: 263-270.
2. Scott JF, Robinson GM, French JM, O'Connell JE, Alberti KG, Gray CS (1999) Prevalence of admission hyperglycaemia across clinical subtypes of acute stroke. Lancet 353: 376-377.
3. Pulsinelli WA, Levy DE, Sigsbee B, Scherer P, Plum F (1983) Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus. Am J Med 74: 540-544.
4. Stead LG, Gilmore RM, Bellolio MF, Mishra S, Bhagra A, Vaidyanathan L, Decker WW, Brown RD Jr (2009) Hyperglycemia as an independent predictor of worse outcome in non-diabetic patients presenting with acute ischemic stroke. Neurocrit Care 10(2): 181-186.
5. Woo E, Chan YW, Yu YL, Huang CY (1988) Admission glucose level in relation to mortality and morbidity outcome in 252 stroke patients. Stroke 19: 185-191.
6. Weir CJ, Murray GD, Dyker AG, Lees KR (1997) Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study. BMJ 314: 1303.
7. Parsons MW, Barber PA, Desmond PM, Baird TA, Darby DG, Byrnes G et al (2002) Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 52: 20-28.
8. Bruno A, Biller J, Adams HP Jr, Clarke WR, Woolson RF, Williams LS et al (1999) Acute blood glucose level and outcome from ischemic stroke. Neurology 52: 280.
9. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC (2001) Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32: 2426-2432.
10. Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzalez JM, Hillman GR, Kent TA (1997) Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab 17(5): 553-559.
11. Kawai N, Keep RF, Betz AL (1997) Hyperglycemia and the vascular effects of cerebral ischemia. Stroke 28(1): 149-154.
12. Venables GS, Miller SA, Gibson G, Hardy JA, Strong AJ (1985) The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat. J Neurol Neurosurg Psychiatry 48: 663-669.
13. Gisselsson L, Smith ML, Siesjö BK (1999) Hyperglycemia and focal brain ischemia. J Cereb Blood Flow Metab 19(3): 288-297.
14. Martini SR, Kent TA (2007) Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab 27(3): 435-451.
15. Uyttenboogaart M, Koch MW, Stewart RE, Vroomen PC, Luijckx GJ, De Keyser J (2007) Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke. Brain 130(Pt 6): 1626-1630.
16. Sulter G, Elting JW, De Keyser J (1998) Increased serum neuron specific enolase concentrations in patients with hyperglycemic cortical ischemic stroke. Neurosci Lett 253: 71-73.
17. Ginsberg MD, Prado R, Dietrich WD, Busto R, Watson BD (1987) Hyperglycemia reduces the extent of cerebral infarction in rats. Stroke 18: 570-574.
18. Prado R, Ginsberg MD, Dietrich WD, Watson BD, Busto R (1988) Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories. J Cereb Blood Flow Metab 8: 186-192.
19. Feekes JA, Cassell MD (2006) The vascular supply of the functional compartments of the human striatum. Brain 129(Pt 8): 2189-2201.
20. Nishimura N, Schaffer CB, Friedman B, Lyden PD, Kleinfeld D (2007) Penetrating arterioles are the bottleneck in the perfusion of neocortex. Proc Natl Acad Sci USA 104: 365-370.
21. Cipolla MJ, Li R, Vitullo L (2004) Perivascular innervation of penetrating brain parenchymal arterioles. J Cardiovasc Pharmacol 44(1): 1-8.
22. You J, Johnson TD, Marrelli SP, Bryan RM Jr (1999) Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat. Am J Physiol 277(3 Pt 2): H893-H900.
23. Cipolla MJ, Smith J, Kohlmeyer MM, Godfrey JA (2009) SKCa and IKCa Channels, myogenic tone, and vasodilator responses in middle cerebral and parenchymal arterioles: effect of ischemia and reperfusion. Stroke 40(4): 1451-1457.
24. Cipolla MJ, Bullinger LV (2008) Reactivity of brain parenchymal arterioles after ischemia and reperfusion. Microcirculation 15(6): 495-501.
25. Duckrow RB (1995) Decreased cerebral blood flow during acute hyperglycemia. Brain Res 703(1-2): 145-150.
26. Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W, Siesjö BK (1998) Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res 804(1): 36-44.
27. Hannah R, Vitullo L, Cipolla MJ (2005) Preexisting hyperglycemia during stroke is associated with enhanced reactive oxygen species (ROS) production and worsened stroke outcome. FASEB J 19: A1230.
28. Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier J-M, Shakkottai V (2007) Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem 14: 1437-1457.
29. McNeish AJ, Sandow SL, Neylon CB, Chen MX, Dora KA, Garland CJ (2006) Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke 37: 1277-1282.
30. Andresen J, Shafi NI, Bryan RM Jr (2006) Endothelial influences on cerebrovascular tone. J Appl Physiol 100: 318-327.
31. Sieber FE, Brown PR, Wu Y, Koehler RC, Traystman RJ (1993) Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs. Am J Physiol 264(4 Pt 2): H1069-H1075.
32. Grill V, Gutniak M, Björkman O, Lindqvist M, Stone-Elander S, Seitz RJ, Blomqvist G, Reichard P, Widén L (1990) Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects. Am J Physiol 258(5 Pt 1): E813-E820.
33. Duckrow RB, Beard DC, Brennan RW (1987) Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 18(1): 52-58.
34. Duckrow RB (1990) Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats. Stroke 21(7): 1072-1076.
35. Kamada H, Yu F, Nito C, Chan PH (2007) Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. Stroke 38(3): 1044-1049.
36. Cipolla MJ, Curry AB (2002) Middle cerebral artery function after stroke: the threshold duration of reperfusion for myogenic activity. Stroke 33(8): 2094-2099.
37. Marrelli SP, Khorovets A, Johnson TD, Childres WF, Bryan RM Jr (1999) P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia-reperfusion. Am J Physiol 276: H33-H41.
38. Fujii K, Heistad DD, Faraci FM (1992) Effect of diabetes mellitus on flow-mediated and endothelium-dependent dilatation of the rat basilar artery. Stroke 23(10): 1494-1498.
39. Mayhan WG, Patel KP (1995) Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C. Am J Physiol 269(4 Pt 2): H1297-H1302.
40. Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V (2007) Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 6(3): 258-268.
41. Mayhan WG (1993) Cerebral circulation during diabetes mellitus. Pharmacol Ther 57(2-3): 377-391.
42. Ennis SR, Keep RF (2007) Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening. J Cereb Blood Flow Metab 27(9): 1573-1582.