Hyperglycemia and focal brain ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 3, 1999, Pages 288-297

  Gisselsson, Lars ^a   Smith, Maj Lis ^a,b   Siesjö, Bo K ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acidosis; Brain damage; Cerebral blood flow; Focal ischemia; Hypercapnia; Hyperglycemia

Indexed keywords

GLUCOSE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERCAPNIA; HYPERGLYCEMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0033380698     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199903000-00007     Document Type: Article

References (16)

1. de Courten Myers GM, Myers RE, Schoolfield L (1988) Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats. Stroke 19:623-630
2. de Courten Myers GM, Kleinholz BS, Wagner KR, Myers RE (1989) Fatal strokes in hyperglycemic cats. Stroke 20:1707-1715
3. de Courten Myers GM, Kleinholz M, Wagner KR, Myers RE (1994) Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion. J Cereb Blood Flow Metab 14: 227-236
4. Duff H (1995) Clinical and in vivo antiarrhythmic potential of sodium-hydrogen exchange inhibitors. Cardiovasc Res 29:189-193
5. 2+ concentration in response to oxygen-glucose deprivation in rat hippocampal slices. Neurosci Lett 168:155-158
6. Folbergrová J, Norberg K, Quistorff B, Siesjö BK (1975) Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia. J Neurochem 25:457-462
7. Folbergrová J, Memezawa H, Smith M-L, Siesjö BK (1992) Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. J Cereb Blood Flow Metab 12:25-33
8. Ginsberg MD, Welsh FA, Budd WW (1980) Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization. Stroke 11:347-354
9. Ginsberg M, Prado R, Dietrich W, Busto R, Watson B (1987) Hyperglycemia reduces the extent of cerebral infarction in rats. Stroke 18:570-574
10. Gisselsson L, Smith M-L, Siesjö B (1992) Influence of preischemic hyperglycemia on osmolality and early postischemic edema in the rat brain. J Cereb Blood Flow Metab 12:809-816
11. Hank SI, La Manna JC (1988) Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia. J Neurochem 51:1924-1929
12. Huang NC, Wei J, Quast MJ (1996) A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging. Exp Brain Res 109:33-42
13. Hurn PD, Koehler RC, Norris SE, Schwentker AE, Traystman RJ (1991) Bicarbonate conservation during incomplete cerebral ischemia with superimposed hypercapnia. Am J Physiol 261:H853-H859
14. Kalimo H, Rehncrona S, Soderfeldt B, Olsson Y, Siesjö BK (1981) Brain lactic acidosis and ischemic cell damage: 2. Histopathology. J Cereb Blood Flow Metab 1:313-327
15. Karmazyn M (1996) The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications. Can J Cardiol 12:1074-1082
16. Katsura K, Kristián T, Smith M-L, Siesjö BK (1994) Acidosis induced by hypercapnia exaggerates ischemic brain damage. J Cereb Blood Flow Metab 14:243-250