Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 2, 2009, Pages 532-540

  Elewa, Hazem F ^a,b   Kozak, Anna ^a,b   El Remessy, Azza B ^a,b   Frye, Reginald F ^c   Johnson, Maribeth H ^d   Ergul, Adviye ^a,b,d   Fagan, Susan C ^a,b,d  

^a UNIVERSITY OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEMOGLOBIN; HEMOGLOBIN A1C; LIPID PEROXIDE; PROTEIN KINASE B;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN PERFUSION; BRAIN PROTECTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; GLYCEMIC CONTROL; GOTO KAKIZAKI RAT; HEMOGLOBIN DETERMINATION; LIPID PEROXIDATION; MALE; NEUROLOGIC EXAMINATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RISK FACTOR; STATISTICAL ANALYSIS; WEIGHT CHANGE; WESTERN BLOTTING; WISTAR RAT;

ACUTE DISEASE; ANIMALS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; DIABETES MELLITUS, TYPE 2; DRUG ADMINISTRATION SCHEDULE; HEPTANOIC ACIDS; MALE; PYRROLES; RATS; RATS, WISTAR; TIME FACTORS;

EID: 67651011803     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.146951     Document Type: Article

References (42)

1. 4S (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344: 1383-1389.
2. Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, et al. (2006) High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355:549-559.
3. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, and Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476. (Pubitemid 16085691)
4. Bruno A, Williams LS, and Kent TA (2004) How important is hyperglycemia during acute brain infarction? Neurologist 10:195-200. (Pubitemid 38944371)
5. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657.
6. Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, and Fuller JH (2004) Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364:685-696. (Pubitemid 39140624)
7. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241. (Pubitemid 27456390)
8. Elewa HF, Kozak A, Johnson MH, Ergul A, and Fagan SC (2007) Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection. J Hypertens 25:855-859. (Pubitemid 46398881)
9. Elgebaly MM, Kelly A, Harris AK, Elewa H, Portik-Dobos V, Ketsawatsomkron P, Marrero M, and Ergul A (2008) Impaired insulin-mediated vasorelaxation in a nonobese model of type 2 diabetes: role of endothelin-1. Can J Physiol Pharmacol 86:358-364. (Pubitemid 351821129)
10. Endres M (2005) Statins and stroke. J Cereb Blood Flow Metab 25:1093-1110.
11. Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, Hall C, Kozak A, and Fagan SC (2007) Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol 7:33. (Pubitemid 350193885)
12. Ergul A, Li W, Elgebaly MM, Bruno A, and Fagan SC (2009) Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature. Vascul Pharmacol 51:44-49.
13. Fagan SC, Hess DC, Hohnadel EJ, Pollock DM, and Ergul A (2004) Targets for vascular protection after acute ischemic stroke. Stroke 35:2220-2225. (Pubitemid 39129589)
14. Fagan SC, Hess DC, Machado LS, Hohnadel EJ, Pollock DM, and Ergul A (2005) Tactics for vascular protection after acute ischemic stroke. Pharmacotherapy 25: 387-395. (Pubitemid 40300326)
15. Fagan SC, Kozak A, Hill WD, Pollock DM, Xu L, Johnson MH, Ergul A, and Hess DC (2006) Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection. J Hypertens 24:535-539. (Pubitemid 43261918)
16. Folsom AR, Rasmussen ML, Chambless LE, Howard G, Cooper LS, Schmidt MI, and Heiss G (1999) Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Diabetes Care 22:1077-1083.
17. Golomb BA, Dimsdale JE, White HL, Ritchie JB, and Criqui MH (2008) Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial. Arch Intern Med 168:721-727.
18. Harris AK, Elgebaly MM, Li W, Sachidanandam K, and Ergul A (2008) Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 294:R1213-R1219.
19. Harris AK, Hutchinson JR, Sachidanandam K, Johnson MH, Dorrance AM, Stepp DW, Fagan SC, and Ergul A (2005) Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1. Diabetes 54:2638-2644. (Pubitemid 41233585)
20. Hayashi A, Suzuki M, Ogawa Y, Sonoda R, and Sasamata M (2004) Post-stroke atorvastatin treatment reduces neurological deficits and mortality rate in the stroke-prone spontaneously hypertensive rat. J Pharm Pharmacol 56:893-898. (Pubitemid 38885983)
21. Hilali HM, Simpkins AN, Hill WD, Waller JL, Knight RA, and Fagan SC (2004) Single slice method for quantification of hemorrhagic transformation using direct ELISA. Neurol Res 26:93-98.
22. Hosomi N, Nishiyama A, Ban CR, Naya T, Takahashi T, Kohno M, and Koziol JA (2005) Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Neuroscience 134:225-231. (Pubitemid 40943649)
23. Idris I, Thomson GA, and Sharma JC (2006) Diabetes mellitus and stroke. Int J Clin Pract 60:48-56.
24. Jemal M, Ouyang Z, Chen BC, and Teitz D (1999) Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 13:1003-1015. (Pubitemid 29257202)
25. Kawai N, Keep RF, and Betz AL (1997) Hyperglycemia and the vascular effects of cerebral ischemia. Acta Neurochir Suppl 70:27-29. (Pubitemid 127502041)
26. Kilic U, Bassetti CL, Kilic E, Xing H, Wang Z, and Hermann DM (2005) Postischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2. Neuroscience 134:901-906. (Pubitemid 41133393)
27. Liao JK (2002) Beyond lipid lowering: the role of statins in vascular protection. Int J Cardiol 86:5-18.
28. Liao JK and Laufs U (2005) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118.
29. Lins RL, Matthys KE, Verpooten GA, Peeters PC, Dratwa M, Stolear JC, and Lameire NH (2003) Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients. Nephrol Dial Transplant 18:967-976. (Pubitemid 36592541)
30. Lo EH, Dalkara T, and Moskowitz MA (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399-415.
31. Longa EZ, Weinstein PR, Carlson S, and Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91. (Pubitemid 19040218)
32. Martini SR and Kent TA (2007) Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab 27:435-451. (Pubitemid 46310424)
33. Plehn JF, Davis BR, Sacks FM, Rouleau JL, Pfeffer MA, Bernstein V, Cuddy TE, Moyé LA, Piller LB, Rutherford J, et al. (1999) Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. The Care Investigators. Circulation 99:216-223. (Pubitemid 29056362)
34. Prinz V, Laufs U, Gertz K, Kronenberg G, Balkaya M, Leithner C, Lindauer U, and Endres M (2008) Intravenous rosuvastatin for acute stroke treatment: an animal study. Stroke 39:433-438. (Pubitemid 351619468)
35. Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzalez JM, Hillman GR, and Kent TA (1997) Perfusion deficit parallels exacerbation of cerebral ischemia/ reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab 17:553-559. (Pubitemid 27250982)
36. Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, et al. (2003) Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 361:1149-1158. (Pubitemid 36398384)
37. Sironi L, Cimino M, Guerrini U, Calvio AM, Lodetti B, Asdente M, Balduini W, Paoletti R, and Tremoli E (2003) Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol 23:322-327. (Pubitemid 36231947)
38. Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K, Klein HH, Dominiak P, and Richardt G (2004) Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol 44:348-355. (Pubitemid 39129454)
39. WOSCOPS (1998) Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 97:1440-1445.
40. Yrjänheikki J, Koistinaho J, Kettunen M, Kauppinen RA, Appel K, Hüll M, and Fiebich BL (2005) Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. Brain Res 1052:174-179. (Pubitemid 41116775)
41. Zhang L, Zhang ZG, Ding GL, Jiang Q, Liu X, Meng H, Hozeska A, Zhang C, Li L, Morris D, et al. (2005) Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Circulation 112:3486-3494. (Pubitemid 43739565)
42. Zhang L, Zhang ZG, Liu XS, Hozeska-Solgot A, and Chopp M (2007) The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat. Arterioscler Thromb Vasc Biol 27:2470-2475. (Pubitemid 350203966)