The PPAR-γ agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 2, 2010, Pages 352-360

  Kumari, Rashmi ^a   Willing, Lisa B ^a   Patel, Shyama D ^a   Krady, J Kyle ^a   Zavadoski, William J ^b   Gibbs, E Michael ^b   Vannucci, Susan J ^c   Simpson, Ian A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cytokines; Microglia; Stroke; Thiazolidinediones; Type II diabetes

Indexed keywords

CORTICOSTERONE; DARGLITAZONE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BFL1 GENE; BRAIN DAMAGE; BRAIN HYPOXIA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; CONVALESCENCE; CORTICOSTERONE BLOOD LEVEL; DIABETES MELLITUS; GENE; GENE EXPRESSION; IN SITU HYBRIDIZATION; INFLAMMATION; LIPOPROTEIN BLOOD LEVEL; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; STROKE; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ASTROCYTES; BLOOD GLUCOSE; CORTICOSTERONE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; HYPOXIA-ISCHEMIA, BRAIN; IN SITU HYBRIDIZATION; INFLAMMATION; LIPOPROTEINS, VLDL; MALE; MICE; MICROGLIA; PPAR GAMMA; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZOLIDINEDIONES; TRIGLYCERIDES;

EID: 76349124070     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.221     Document Type: Article

References (43)

1. Aleo MD, Lundeen GR, Blackwell DK, Smith WM, Cole-man GL, Stadnicki SW, Kluwe WM (2003) Mechanism and implications of brown adipose tissue proliferation in rats and monkeys treated with the thiazolidinedione darglitazone, a potent peroxisome proliferator-activated receptor-gamma agonist. J Pharmacol Exp Ther 305: 1173-1182
2. Berger J, Michael T, Elbrecht A, Hermanowski-Vosatka A, Moller D, Wright S, Thieringer R (2001) Peroxisome proliferators-activated receptor-y ligands inhibit adipocyte 11b-hydroxysteroid dehydrogenase type-1 expression and activity. J Biol Chem 276:12629-12635
3. Bernardo A, Minghetti L (2008) Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists. PPAR Res 2008:864140
4. Bernotiene E, Palmer G, Talabot-Ayer D, Szalay-Quinodoz I, Aubert ML, Gabay C (2004) Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. Arthritis Res Ther 6:R256-63
5. Bonow RO, Gheorghiade M (2004) The diabetes epidemic: a national and global crisis. Am J Med 116(Suppl 5A): 2S-10S
6. Bruce A, Boling W, Kindy M, Peschon J, Kraemer P, Carpenter M, Holtsberg F, Mattson M (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794
7. Butcher SK, Lord JM (2004) Stress responses and innate immunity: aging as a contributory factor. Aging Cell 3:151-160
8. Culman J, Zhao Y, Gohlke P, Herdegen T (2007) PPAR-gamma: therapeutic target for ischemic stroke. Trends Pharmacol Sci 28:244-249
9. Dasu MR, Park S, Devaraj S, Jialal I (2009) Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice. Endocrinology 150:3457-3464
10. Drew PD, Xu J, Storer PD, Chavis JA, Racke MK (2006) Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. Neurochem Int 49:183-189
11. Fiuza C, Suffredini AF (2001) Human models of innate immunity: local and systemic inflammatory responses. J Endotoxin Res 7:385-388
12. Folbergrova J, Memezawa H, Smith ML, Siesjo BK (1992) Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo-and hyperglycemic rats. J Cereb Blood Flow Metab 12:25-33
13. Glezer I, Rivest S (2004) Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist 10:538-552
14. Hallenbeck JM (2002) The many faces of tumor necrosis factor in stroke. Nat Med 8:1363-1368
15. Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y, Seethala R, Yang WP, Ren J, Zhou M, Ryono D, Biller S, Mookhtiar KA, Wetterau J, Gregg R, Cheng PT, Hariharan N (2006) Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice. Diabetes 55:240-248
16. Herx LM, Rivest S, Yong VW (2000) Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J Immunol 165:2232-2239
17. Hounoki H, Sugiyama E, Mohamed SG, Shinoda K, Taki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Miyahara T (2008) Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. Bone 42:765-774
18. Hulin B, McCarthy PA, Gibbs EM (1996a) The glitazone family of antidiabetic agents. Current Pharmaceutical Design 2:85-102
19. Hulin B, Newton LS, Lewis DM, Genereux PE, Gibbs EM, Clark DA (1996b) Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone. J Med Chem 39:3897-3907
20. Kapadia R, Yi JH, Vemuganti R (2008) Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 13:1813-1826
21. Kumari R, Willing LB, Krady JK, Vannucci SJ, Simpson IA (2007) Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse. J Cereb Blood Flow Metab 27:710-718
22. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, Smith PL, Marino RL, Rodriguez A, Hubbard WC, O'Donnell CP, Polotsky VY (2005) Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97:698-706
23. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC (2005) Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the pheno-type of type 2 diabetes in db/db mice. Diabetes 54:32-40
24. Luo Y, Yin W, Signore A, Zhang F, Hong Z, Wang S, Graham S, Chen J (2006) Neuroprotection against focal ischemic brain injury by the peroxisome proliferated-activated receptor-y agonist rosiglitazone. J Neurochem 97:435-448
25. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 94:8093-8098
26. Mason JL, Suzuki K, Chaplin DD, Matsushima GK (2001) Interleukin-1beta promotes repair of the CNS. J Neurosci 21:7046-7052
27. Murakami K, Bujo H, Unoki H, Saito Y (2007) Effect of PPARalpha activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes. Eur J Pharmacol 561:206-213
28. Nedergaard M (1987) Transient focal ischemia in hypergly-cemic rats is associated with increased cerebral infarction. Brain Res 408:79-85
29. Nedergaard M, Diemer NH (1987) Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol 73:131-137
30. O'Connor JC, Johnson DR, Freund GG (2006) Psychoneur-oimmune implications of type 2 diabetes. Neurol Clin 24:539-559
31. Oakes ND, Thalen PG, Jacinto SM, Ljung B (2001) Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes 50:1158-1165
32. Pereira MP, Hurtado O, Cardenas A, Bosca L, Castillo J, Davalos A, Vivancos J, Serena J, Lorenzo P, Lizasoain I, Moro MA (2006) Rosiglitazone and 15-deoxy-del-ta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. J Cereb Blood Flow Metab 26:218-229
33. Rosenson RS (2007) Effects of peroxisome proliferator-activated receptors on lipoprotein metabolism and glucose control in type 2 diabetes mellitus. Am J Cardiol 99:96B-104B
34. Shimazu T, Inoue I, Araki N, Asano Y, Sawada M, Furuya D, Nagoya H, Greenberg JH (2005) A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke 36:353-359
35. Stumvoll M, Haring HU (2002) Glitazones: clinical effects and molecular mechanisms. Ann Med 34:217-224
36. Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE (2005) Peroxisome proliferator-acti-vated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience 130:685-696
37. Tureyen K, Kapadia R, Bowen KK, Satriotomo I, Liang J, Feinstein DL, Vemuganti R (2007) Peroxisome prolif-erator-activated receptor-gamma agonists induce neuro-protection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem 101:41-56
38. Vannucci SJ, Maher F, Simpson IA (1997) Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:2-21
39. Vannucci SJ, Willing LB, Goto S, Alkayed NJ, Brucklacher RM, Wood TL, Towfighi J, Hurn PD, Simpson IA (2001a) Experimental stroke in the female diabetic, db/db, mouse. J Cereb Blood Flow Metab 21:52-60
40. Vannucci SJ, Willing LB, Goto S, Alkayed NJ, Brucklacher RM, Wood TL, Towfighi J, Hurn PD, Simpson IA (2001b) Experimental stroke in the female diabetic, db/db, mouse. J Cereb Blood Flow Metab 21:52-60
41. Woster AP, Combs CK (2007) Differential ability of a thiazolidinedione PPARgamma agonist to attenuate cytokine secretion in primary microglia and macro-phage-like cells. J Neurochem 103:67-76
42. Zhang L, Nair A, Krady K, Corpe C, Bonneau RH, Simpson IA, Vannucci SJ (2004) Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normo-glycemic but not diabetic female mice. J Clin Invest 113:85-95
43. Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J (2006) Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpres-sion after focal cerebral ischemia in rats. FASEB J 20:1162-1175