Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia

Acta Neurochirurgica, Supplementum

Volumn , Issue 111, 2011, Pages 49-54

  Xing, Yingqi ^a,b   Jiang, Xinmei ^a   Yang, Yi ^a,b   Xi, Guohua ^b  

^a JILIN UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Hemorrhagic transformation; Hyperglycemia; Middle cerebral artery occlusion

Indexed keywords

EVANS BLUE; GLUCOSE; HEMOGLOBIN; DIAGNOSTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; CONFERENCE PAPER; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HEMISPHERE; HEMOGLOBIN BLOOD LEVEL; HYPERGLYCEMIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MORBIDITY; MORTALITY; NONHUMAN; RAT; REPERFUSION; TRANSIENT ISCHEMIC ATTACK; ANIMAL; ARTICLE; BLEEDING; CEREBRAL ARTERY DISEASE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; HEMISPHERIC DOMINANCE; MALE; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; DISEASE MODELS, ANIMAL; EVANS BLUE; FUNCTIONAL LATERALITY; GLUCOSE; HEMOGLOBINS; HEMORRHAGE; HYPERGLYCEMIA; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; TIME FACTORS;

EID: 79960672283     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0693-8_9     Document Type: Conference Paper

References (21)

1. Bozzao L, Angeloni U, Bastianello S, Fantozzi LM, Pierallini A, Fieschi C (1991) Early angiographic and CT fndings in patients with hemorrhagic infarction in the distribution of the middle cere¬bral artery. Am J Neuroradiol 12:1115-1121
2. Hornig CR, Dorndorf W, Agnoli AL (1986) Hemorrhagic cerebral infarction-a prospective study. Stroke 17:179-185 (Pubitemid 16125236)
3. Moulin T, Crepin-Leblond T, Chopard JL, Bogousslavsky J (1994) Hemorrhagic infarcts. Eur Neurol 34:64-77 (Pubitemid 24050245)
4. Paciaroni M, Agnelli G, Corea F, Ageno W, Alberti A, Lanari A, Caso V, Micheli S, Bertolani L, Venti M, Palmerini F, Biagini S, Comi G, Previdi P, Silvestrelli G (2008) Early hemorrhagic trans¬formation of brain infarction: rate, predictive factors, and infuence on clinical outcome: results of a prospective multicenter study. Stroke 39:2249-2256
5. Lyden PD, Zivin JA (1993) Hemorrhagic transformation after cere¬bral ischemia: mechanisms and incidence. Cerebrovasc Brain Metab Rev 5:1-16
6. Wang X, Lo EH (2003) Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol 28:229-244 (Pubitemid 38156421)
7. de Courten-Myers GM, Kleinholz M, Wagner KR, Myers RE (1989) Fatal strokes in hyperglycemic cats. Stroke 20:1707-1715 (Pubitemid 20030883)
8. Karabiyikoglu M, Hua Y, Keep RF, Ennis SR, Xi G (2004) Intracerebral hirudin injection attenuates ischemic damage and neu¬rologic defcits without altering local cerebral blood fow. J Cereb Blood Flow Metab 24:159-166 (Pubitemid 38199109)
9. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91 (Pubitemid 19040218)
10. Choudhri TF, Hoh BL, Solomon RA, Connolly ES Jr, Pinsky DJ (1997) Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice. Stroke 28:2296-2302 (Pubitemid 27497937)
11. Xi G, Keep RF, Hoff JT (1998) Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg 89:991-996 (Pubitemid 28544054)
12. Lin TN, He YY, Wu G, Khan M, Hsu CY (1993) Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24:117-121 (Pubitemid 23014393)
13. de Courten-Myers GM, Kleinholz M, Holm P, DeVoe G, Schmitt G, Wagner KR, Myers RE (1992) Hemorrhagic infarct conversion in experimental stroke. Ann Emerg Med 21:120-126
14. Siesjo BK, Bendek G, Koide T, Westerberg E, Wieloch T (1985) Infuence of acidosis on lipid peroxidation in brain tissues in vitro. J Cereb Blood Flow Metab 5:253-258 (Pubitemid 15123211)
15. Hillered L, Ernster L, Siesjo BK (1984) Infuence of in vitro lactic acidosis and hypercapnia on respiratory activity of isolated rat brain mitochondria. J Cereb Blood Flow Metab 4:430-437 (Pubitemid 14034636)
16. Kalimo H, Rehncrona S, Soderfeldt B, Olsson Y, Siesjo BK (1981) Brain lactic acidosis and ischemic cell damage: 2. Histopathology. J Cereb Blood Flow Metab 1:313-327 (Pubitemid 12246554)
17. OuYang YB, Mellergard P, Kristian T, Kristianova V, Siesjo BK (1994) Infuence of acid-base changes on the intracellular calcium concentra¬tion of neurons in primary culture. Exp Brain Res 101:265-271 (Pubitemid 24304451)
18. Kraig RP, Petito CK, Plum F, Pulsinelli WA (1987) Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab 7:379-386
19. Garg R, Chaudhuri A, Munschauer F, Dandona P (2006) Hyper-glycemia, insulin, and acute ischemic stroke: a mechanistic justif-cation for a trial of insulin infusion therapy. Stroke 37:267-273 (Pubitemid 43732090)
20. Kawai N, Keep RF, Betz AL (1997) Hyperglycemia and the vascu¬lar effects of cerebral ischemia. Acta Neurochir Suppl 70:27-29 (Pubitemid 127502041)
21. Venables GS, Miller SA, Gibson G, Hardy JA, Strong AJ (1985) The effects of hyperglycaemia on changes during reperfusion fol¬lowing focal cerebral ischaemia in the cat. J Neurol Neurosurg Psychiatry 48:663-669 (Pubitemid 15026242)