Cerebral Neovascularization and Remodeling Patterns in Two Different Models of Type 2 Diabetes

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Prakash, Roshini ^a   Johnson, Maribeth ^b   Fagan, Susan C ^a   Ergul, Adviye ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; GLUCOSE; METFORMIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GLUCOSE MONITORING; BRAIN BLOOD VESSEL; BRAIN BLOOD VOLUME; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG DOSE ESCALATION; DRUG EFFECT; GLYCEMIC CONTROL; HYPERGLYCEMIA; MICROVASCULATURE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEUROANATOMY; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT;

ANIMALS; ASTROCYTES; BLOOD GLUCOSE; BRAIN; CEREBROVASCULAR CIRCULATION; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; MICE; MUSCLE, SKELETAL; NEOVASCULARIZATION, PATHOLOGIC; RATS; RETINAL VESSELS;

EID: 84874123482     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056264     Document Type: Article

References (37)

1. Silvestre JS and Levy BI. (2006) Molecular basis of angiopathy in diabetes mellitus. Circ Res. 98(1): p. 4-6.
2. Mankovsky BN, Metzger BE, Molitch ME, Biller J (1996) Cerebrovascular disorders in patients with diabetes mellitus. J Diabetes Complications, 10(4): p. 228-42.
3. McCuskey PA, and McCuskey RS (1984) In vivo and electron microscopic study of the development of cerebral diabetic microangiography. Microcirc Endothelium Lymphatics,. 1(2): p. 221-44.
4. Li W, Prakash R, Kelly-Cobbs AI, Ogbi S, Kozak A, et al. (2010) Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes. 59(1): p. 228-35.
5. Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, et al. (2012) Enhanced cerebral but not peripheral angiogenesis in the goto-kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes. 61(6): 1533-42.
6. Borowsky IW, Collins RC (1989) Metabolic anatomy of the brain: a comparison of regional capillary density, glucose metabolism, and enzyme activities. Journal of Comp. Neurology,. 288: p. 401-413.
7. Kassab GS (2006) Scaling laws of vascular trees: of form and function. Am J Physiol Heart Circ Physiol. 290(2): p. H894-903.
8. Dockery P and Fraher J (2007) The quantification of vascular beds: a stereological approach. Exp Mol Pathol. 82(2): p. 110-20.
9. Risser L, Plouraboué F, Cloetens P, Fonta C (2009) A 3D-investigation shows that angiogenesis in primate cerebral cortex mainly occurs at capillary level. Int J Dev Neurosci. 27(2): p. 185-96.
10. Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods. 9(7): p. 676-82.
11. Macia I, Grana M, Paloc C, (2012) Knowledge management in image-based analysis of blood vessel structures. Knowl Inf Syst. 30: p. 457-491.
12. Heinzer S, Kuhn G, Krucker T, Meyer E, Ulmann-Schuler A, et al. (2008) Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF(165) in the brain. Neuroimage. 39(4): p. 1549-58.
13. Soltanian-Zadeh H, Shahrokni A, Khalighi MM, Zhang ZG, Zoroofi RA, et al. (2005) 3-D quantification and visualization of vascular structures from confocal microscopic images using skeletonization and voxel-coding. Computers in Biology and Medicine. 35(9): p. 791-813.
14. Lokkegaard A, Nyengaard JR, and West MJ. (2001) Stereological estimates of number and length of capillaries in subdivisions of the human hippocampal region. Hippocampus. 11(6): p. 726-40.
15. Ergul A, Alhusban A, Fagan SC, (2012) Angiogenesis: A Harmonized Target for Recovery After Stroke. Stroke Aug 43(8): 2270-4.
16. Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, et al. (2007) Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol. 7: p. 33.
17. Lechuga-Sancho AM, Arroba AI, Frago LM, García-Cáceres C, de Célix AD, Argente J, Chowen JA (2006) Reduction in the number of astrocytes and their projections is associated with increased synaptic protein density in the hypothalamus of poorly controlled diabetic rats. Endocrinology Nov. 147(11): p. 5314-24.
18. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, et al. (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci. 6(1): p. 43-50.
19. Araque A (2006) Astrocyte-neuron signaling in the brain-implications for disease. Curr Opin Investig Drugs,. 7(7): p. 619-24.
20. Pellerin L (2005) How astrocytes feed hungry neurons. Molecular Neurobiology. 32(1): p. 59-72.
21. Rungger-Brandle E, Dosso AA, Leuenberger PM (2000) Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci. 41(7): p. 1971-80.
22. Saravia FE, Revsin Y, Gonzalez Deniselle MC, Gonzalez SL, Roig P, et al. (2002) Increased astrocyte reactivity in the hippocampus of murine models of type 1 diabetes: the nonobese diabetic (NOD) and streptozotocin-treated mice. Brain Res. 957(2): p. 345-53.
23. Muranyi M, Ding C, He Q, Lin Y, Li PA (2006) Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury. Diabetes. 55(2): p. 349-55.
24. Dore-Duffy P and LaManna JC (2007) Physiologic angiodynamics in the brain. Antioxid Redox Signal. 9(9): p. 1363-71.
25. Stapleton PA, James ME, Goodwill AG, Frisbee JC (2008) Obesity and vascular dysfunction. Pathophysiology. 15(2): p. 79-89.
26. Nishimura N, Schaffer CB, Friedman B, Lyden PD, Kleinfeld D (2007) Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proc Natl Acad Sci U S A. 104(1): p. 365-70.
27. Secomb TW (1995) Mechanics of blood flow in the microcirculation. Symp Soc Exp Biol. 49: p. 305-21.
28. McCall AL (1992) The impact of diabetes on the CNS. Diabetes. 41(5): p. 557-70.
29. Duckrow RB, Beard DC, Brennan RW (1987) Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke. 18(1): p. 52-8.
30. Kelly-Cobbs AI, Prakash R, Coucha M, Knight RA, Li W, et al. (2012) Cerebral Myogenic Reactivity and Blood Flow in Type 2 Diabetic Rats: Role of Peroxynitrite in Hypoxia-mediated Loss of Myogenic Tone. J Pharmacol Exp Ther. Aug 342(2): 407-15.
31. Skyler JS (2004) Effects of Glycemic Control on Diabetes Complications and on the Prevention of Diabetes. Clinical Diabetes. 22(4).
32. Skyler JS (1998) Targeted glycemic control in type 2 diabetes. J Fla Med Assoc. 85(2): p. 7-15.
33. Brown A, Reynolds LR, Bruemmer D (2010) Intensive glycemic control and cardiovascular disease: an update. Nat Rev Cardiol. 7(7): p. 369-75.
34. Elgebaly MM, Prakash R, Li W, Ogbi S, Johnson MH, et al. (2010) Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling. J Cereb Blood Flow Metab. 30(12): p. 1928-38.
35. Rosen P, Wiernsperger NF (2006) Metformin delays the manifestation of diabetes and in Goto-Kakizaki rats by rvascular dysfunction eduction of mitochondrial oxidative stress. Diabetes Metab Res Rev. 22(4): p. 323-30.
36. Faure P, Wiernsperger N, Polge C, Favier A, Halimi S (2008) Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin. Clin Sci (Lond). 114(3): p. 251-6.
37. Sachidanandam K, Hutchinson JR, Elgebaly MM, Mezzetti EM, Dorrance AM, et al. (2009) Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1. Am J Physiol Regul Integr Comp Physiol. 296(4): p. R952-9.