Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Xue, Jinling ^a   Shang, Guodong ^a   Tanaka, Yoshinori ^b   Saihara, Yasuhiro ^b   Hou, Lingyan ^a   Velasquez, Natalia ^a   Liu, Wenjun ^a   Lu, Yun ^a  

^a TSINGHUA UNIVERSITY   (China)

^b PANASONIC CORPORATION   (Japan)

Author keywords

Alkaline electrolyzed water; Dose response; Gastric injury; Hydrogen; Oxidative stress

Indexed keywords

ACETYLSALICYLIC ACID; DRINKING WATER; HYDROGEN; MYELOPEROXIDASE; NITROGEN; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATMOSPHERIC PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING; ELECTROLYSIS; FLUID INTAKE; GASTRITIS; MALE; NONHUMAN; OXIDATIVE STRESS; PH; RAT; STOMACH EROSION; STOMACH INJURY; STOMACH MUCOSA; WEIGHT GAIN; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PATHOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; STOMACH; STOMACH DISEASES;

ANIMALS; DEOXYGUANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING WATER; HYDROGEN; HYDROGEN-ION CONCENTRATION; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH DISEASES;

EID: 84895546924     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-81     Document Type: Article

References (46)

1. Brown NJ, Rumsey RD, Read NW. Adaptation of hydrogen analysis to measure stomach to caecum transit time in the rat. Gut 1987, 28:849-854. 10.1136/gut.28.7.849, 1433076, 3653753.
2. Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med 1969, 281:122-127. 10.1056/NEJM196907172810303, 5790483.
3. Ebert A, Brune A. Hydrogen concentration profiles at the oxic-anoxic interface: a microsensor study of the hindgut of the wood-feeding lower termite reticulitermes flavipes (kollar). Appl Environ Microbiol 1997, 63:4039-4046. 1389272, 16535716.
4. Lemke T, Van AT, Hackstein JH, Brune A. Cross-epithelial hydrogen transfer from the midgut compartment drives methanogenesis in the hindgut of cockroaches. Appl Environ Microbiol 2001, 67:4657-4661. 10.1128/AEM.67.10.4657-4661.2001, 93216, 11571169.
5. Olson JW, Maier RJ. Molecular hydrogen as an energy source for Helicobacter pylori. Science 2002, 298:1788-1790. 10.1126/science.1077123, 12459589.
6. Maier RJ. Use of molecular hydrogen as an energy substrate by human pathogenic bacteria. Biochem Soc Trans 2005, 33:83-85.
7. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007, 13:688-694. 10.1038/nm1577, 17486089.
8. Fontanari P, Badier M, Guillot C, Tomei C, Burnet H, Gardette B, Jammes Y. Changes in maximal performance of inspiratory and skeletal muscles during and after the 7.1-MPa Hydra 10 record human dive. Eur J Appl Physiol 2000, 81:325-328. 10.1007/s004210050050, 10664092.
9. Abraini JH, Gardette-Chauffour MC, Martinez E, Rostain JC, Lemaire C. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol 1994, 76:1113-1118.
10. Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res 2011, 1:24. 10.1186/2045-9912-1-24, 3231939, 22146674.
11. Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, Katoh K, Satoh T, Ito S. Biological effects of electrolyzed water in hemodialysis. Nephron Clin Pract 2009, 112:c9-c15. 10.1159/000210569, 19342864.
12. Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant 2010, 25:3026-3033. 10.1093/ndt/gfq196, 20388631.
13. Ono H, Nishijima Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, Sakamoto M, Kudo Y, Nakazawa J, Kaneko K, Nawashiro H. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone: a non-controlled study. Med Gas Res 2011, 1:12. 10.1186/2045-9912-1-12, 3231971, 22146068.
14. Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res 2011, 1:11. 10.1186/2045-9912-1-11, 3231938, 22146004.
15. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr 2010, 46:140-149. 10.3164/jcbn.09-100, 2831093, 20216947.
16. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 2008, 28:137-143. 10.1016/j.nutres.2008.01.008, 19083400.
17. Ohno K, Ito M, Ichihara M, Ito M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev 2012, 353152. doi:10.1155/2012/353152.
18. Ohta S. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochim Biophys Acta 1820, 2012:586-594.
19. Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res 2010, 38:1893-1903. 10.1177/147323001003800602, 21226992.
20. Chuai YH, Qian LR, Sun XJ, Cai JM. Molecular hydrogen and radiation protection. Free Radic Res 2012, 46:1061-1067. 10.3109/10715762.2012.689429, 22537465.
21. Ohta S, Nakao A, Ohno K. The 2011 Medical Molecular Hydrogen Symposium: an inaugural symposium of the journal Medical Gas Research. Med Gas Res 2011, 1:10. 10.1186/2045-9912-1-10, 3231937, 22146082.
22. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M, Rubinsztein DC. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One 2009, 4:e7247. 10.1371/journal.pone.0007247, 2747267, 19789628.
23. Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver Int 2010, 30:958-968. 10.1111/j.1478-3231.2010.02254.x, 20492513.
24. Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Med Gas Res 2012, 2:15. 10.1186/2045-9912-2-15, 3407490, 22608009.
25. Li Y, Hamasaki T, Nakamichi N, Kashiwagi T, Komatsu T, Ye J, Teruya K, Abe M, Yan H, Kinjo T, Kabayama S, Kawamura M, Shirahata S. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology 2011, 63:119-131. 10.1007/s10616-010-9317-6, 3080478, 21063772.
26. Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N. Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res 2008, 17:247-255. 10.3727/096504008786991620, 19192719.
27. Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, Teruya K, Nishikawa R, Kawahara T, Osada K, Toh K, Abe M, Tian H, Kabayama S, Otsubo K, Morisawa S, Katakura Y, Shirahata S. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biol Pharm Bull 2008, 31:19-26. 10.1248/bpb.31.19, 18175936.
28. Yoon KS, Huang XZ, Yoon YS, Kim SK, Song SB, Chang BS, Kim DH, Lee KJ. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biol Pharm Bull 2011, 34:1671-1677. 10.1248/bpb.34.1671, 22040878.
29. Naito Y, Takagi T, Uchiyama K, Tomatsuri N, Matsuyama K, Fujii T, Yagi N, Yoshida N, Yoshikawa T. Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. J Clin Biochem Nutr 2002, 32:69-81.
30. Rylander R. Drinking water constituents and disease. J Nutr 2008, 138:423s-425s.
31. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A. Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int 2009, 77(2):101-109.
32. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi H, Maruyama N, Ishigami A. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 2008, 375:346-350. 10.1016/j.bbrc.2008.08.020, 18706888.
33. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2009, 34(2):501-508. 10.1038/npp.2008.95, 18563058.
34. Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr 2010, 46(3):269-276. 10.3164/jcbn.10-19, 2872234, 20490324.
35. Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett 2011, 487(1):12-16. 10.1016/j.neulet.2010.09.064, 20888392.
36. Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K. Experimental verification of pretective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radio 2010, 83(990):509-514.
37. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 2008, 377(4):1195-1198. 10.1016/j.bbrc.2008.10.156, 18996093.
38. Kamimura N, Nishimaki K, Ohsawa I, Ohta S. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) 2011, 19:1396-1403. 10.1038/oby.2011.6, 21293445.
39. Asako H, Kubes P, Wallace J, Wolf RE, Granger DN. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 1992, 103:146-152.
40. Yoshida N, Takemura T, Granger DN, Anderson DC, Wolf RE, McIntire LV, Kvietys PR. Molecular determinants of aspirin-induced neutrophil adherence to endothelial cells. Gastroenterology 1993, 105:715-724.
41. Fiorucci S, Santucci L, Gerli R, Brunori PM, Federici B, Ugolini B, Fabbri C, Morelli A. NSAIDs upregulate beta 2-integrin expression on human neutrophils through a calcium-dependent pathway. Aliment Pharmacol Ther 1997, 11:619-630. 10.1046/j.1365-2036.1997.00190.x, 9218092.
42. Andrews FJ, Malcontenti-Wilson C, O'Brien PE. Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. Am J Physiol 1994, 266:G657-664.
43. Fiorucci S, Santucci L, Federici B, Antonelli E, Distrutti E, Morelli O, Renzo GD, Coata G, Cirino G, Soldato PD, Morelli A. Nitric oxide-releasing NSAIDs inhibit interleukin-1β converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNF-α. Aliment Pharmacol Ther 1994, 13:412-435.
44. Fiorucci S, Antonelli E, Santucci L, Morelli O, Migilietti M, Federici M, Mannucci R, Del Soldato P, Morelli A. Gastrointestinal safety of nitric oxide-derives aspirin is related to inhibition of ICE-like cysteine protease in rats. Gastroenterology 1999, 116:1089-1106. 10.1016/S0016-5085(99)70012-0, 10220501.
45. Naito Y, Handa O, Takagi T, Ishikawa T, Imamoto E, Nakagawa S, Yamaguchi T, Yoshida N, Matsui H, Yoshikawa T. Ubiquitin-proteasome inhibitor enhances tumor necrosis factor-α-induced apoptosis of rat gastric epithelial cells. Aliment Pharmacol Ther 2002, 16:59-66.
46. Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, Wang H. The protective role of hydrogen-rich saline in experimental liver injury in mice. J Hepatol 2011, 54:471-480. 10.1016/j.jhep.2010.08.011, 21145612.