Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study

Medical Gas Research

Volumn 1, Issue 1, 2011, Pages

  Ono, Hirohisa ^a   Nishijima, Yoji ^a   Adachi, Naoto ^a   Tachibana, Shigekuni ^a   Chitoku, Shiroh ^a   Mukaihara, Shigeo ^a   Sakamoto, Masaki ^a   Kudo, Yohei ^a   Nakazawa, Jun ^a   Kaneko, Kumi ^a   Nawashiro, Hiroshi ^b  

^a Nishijima Hospital   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; HYDROXYL RADICAL; NORPHENAZONE;

ABSENCE OF SIDE EFFECTS; ARTICLE; BRAIN STEM INFARCTION; CLINICAL ARTICLE; CLINICAL EVALUATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; MONOTHERAPY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; RELATIVE APPARENT DIFFUSION COEFFICIENT; RELATIVE DIFFUSION WEIGHTED IMAGE; TREATMENT OUTCOME;

EID: 84863648678     PISSN: None     EISSN: 20459912     Source Type: Journal    
DOI: 10.1186/2045-9912-1-12     Document Type: Article

References (35)

1. Study of apparent diffusion coefficient and anisotropy in patients with Acute Stroke. Yang Q, Brian M, Tress BM, Barber PA, Desmond PM, Darby DG, Gerraty RP, Li T, Davis SM, Stroke 1999 30 2382 2390 10.1161/01.STR.30.11.2382 10548675 (Pubitemid 29517739)
2. Serial Diffusion-and Hemodynamic-Weighted Magnetic Resonance Imaging. Schwamm LH, Koroshetz WJ, Sorensen GA, Wang B, Copen WA, Rordorf G, Buonanno FS, Schaefer PW, Gonzalez GR, Stroke 1998 29 2268 2276 10.1161/01.STR.29.11.2268 9804633
3. Time Course of Cerebral Infarction in the Middle Cerebral Arterial Territory: Deep Watershed versus Territorial Subtypes on Diffusion-weighted MR Images. Huang IJ, Chen CY, Chung HW, Chang DC, Lee CC, Chin SC, Liou M, Radiology 2001 221 35 42 10.1148/radiol.2211001412 11568318 (Pubitemid 32880368)
4. Serial analysis of the apparent diffusion coefficient time course in human stroke. Fiebach JB, Schellinger JO, Sartor HW, Neuroradiology 2002 44 294 298 10.1007/s00234-001-0720-8 11914803 (Pubitemid 36097172)
5. Serial Measurements of the Apparent Diffusion Coefficient in Human Stroke on Five Time Points over Three Months. Liu S, Karonen JO, Liu Y, Vanninen Ft, Partanen K, Cinbnen MK, Vainio P, Aronen HJ, Proc Intl Sot Mag Reson Med 2000 8 1203
6. The application of DWI and ADC map in cerebral infarction. Huang L, Wong XH, Li G, Proc Intl Soc Mag Reson Med 2001 9 1446
7. Evaluation of early reperfusion and i.v. tPA therapy using diffusion-and perfusion-weighted MRI. Marks MP, Tong DC, Beaulieu C, Albers GW, deCrespigny A, Moseley MR, Neurology 1999 52 1792 1798 10371525 (Pubitemid 29260891)
8. Characterization and evolution of diffusion MNRE imaging abnormalities in Stroke patients undergoing intra-arterial thrombolysis. Schaefer POW, Hassankhani A, Putman C, Sorensen GA, Schwamm L, Koroshez W, Gonzalez GR, ANJR 2004 25 951 957 (Pubitemid 38765872)
9. Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent. Tanaka M, Folia Pharmacol Jpn 2002 119 301 308 10.1254/fpj.119.301 (Pubitemid 34496216)
10. A post-marketing drug use survey of a neuroprotecive drug Radicut injection 30 mg(non-proprietary name: edaravone) for acute ischemic stroke. Kageyama M, Toriyama S, Tsubosita A, Muraki S, Yamada T, Ishibashi A, J New Rem Clin 2009 58 1212 1226
11. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S, Nat Med 2007 13 688 694 10.1038/nm1577 17486089 (Pubitemid 46889750)
12. Concept of branch atheromatous disease. Takagi M, Neurol Med 2008 69 542 549
13. Acute Cerebral Infarction: Quantification of Spin-Density and T2 Shine-through Phenomena on Diffusion-weighted MR Images. Burdett JH, Elster AD, Ricci PE, Radiology 1999 212 333 339 10429687 (Pubitemid 29356549)
14. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Edaravone Acute Infarction Study Group, Cerebrovasc Dis 2003 15 222 229 12715790
15. Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one. Yamamoto Y, Kuwahara T, Watanabe K, Watanabe K, Redox Report 1996 2 333 338 (Pubitemid 126684602)
16. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Zhang N, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y, Urabe T, Stroke 2005 36 2220 2225 10.1161/01.STR.0000182241.07096.06 16166574 (Pubitemid 41429250)
17. Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, Saito KI, J Pharmacol Exp Ther 1997 281 921 927 9152402 (Pubitemid 27203828)
18. Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation. Yoshida H, Metoki N, Ishikawa A, Imaizumi T, Matsumiya T, Tanji K, Ota K, Ohyama C, Satoh K, Neurosci Res 2010 66 284 289 10.1016/j.neures.2009.11.011 19954754
19. Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. Zhang W, Sato K, Hayashi T, Omori N, Nagano I, Kato S, Horiuchi S, Abe K, Neurol Res 2004 26 342 348 10.1179/016164104225014058 15142331 (Pubitemid 38620058)
20. The Novel Antioxidant Edaravone: From Bench to Bedside. Watanabe T, Tahara M, Todo S, Cardiovascular Therapeutics 2008 26 101 114 10.1111/j.1527-3466.2008.00041.x 18485133 (Pubitemid 351952827)
21. A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? Lapchak PA, Expert Opinion on Pharmacotherapy 2010 11 1753 1763 10.1517/14656566.2010.493558 20491547
22. Therapeutic antioxidant medical gas. Nakao A, Sugimoto R, Billiar TR, McCurry KR, J Clin Biochem Nutr 2009 44 1 13 10.3164/jcbn.08-193R 19177183
23. Supplementation of hydrogen-rich water improves lipid andd glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nsksmura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T, Nur Res 2008 28 137 143 (Pubitemid 351452069)
24. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A, Am I transplant 2008 8 2015 2024
25. Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N, Oncol Res 2008 17 247 255 10.3727/096504008786991620 19192719
26. Oral administration of hydrogen water prevents chronic allograft nephropathy in rat renal transplantation. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billar R, Nakao A, Kidney Int 2010 77 101 109 10.1038/ki.2009.421 19907413
27. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billar TR, McCurry KR, J Heart Lung Transplant 2010 29 544 553 10.1016/j.healun.2009.10.011 20036162
28. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G, Shock 2010 34 90 97 19997046
29. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ, Liver Int 2010 30 958 968 10.1111/j.1478-3231.2010.02254.x 20492513
30. A novel bioactive hemodialysis system using dissolved dihydrogen(H2) produced by water electrolysis: a clinical trial. Nakayama M, Nakao H, Hamada H, Itami N, Nakazawa R, Ito S, Nephrol Dial Transplant 2010 25 3026 3033 10.1093/ndt/gfq196 20388631
31. Hydrogen-rich saline protects against spinal cord injury in rats. Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zang ZH, Yuan HB, Sun XJ, Neurochem Res 2010 35 1111 1118 10.1007/s11064-010-0162-y 20354783
32. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido M, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu y, Noda M, PloS One 2009 30 1 10 e7247
33. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ, Brain Res 2010 1328 152 161 20171955
34. Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome - An Open Label Pilot Study. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N, J Clin Biochem Nutr 2010 46 140 149 10.3164/jcbn.09-100 20216947
35. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular disease. Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M, Recent Patents on Cardiovascular Drug Discovery 2006 1 85 93 10.2174/157489006775244191 18221078