Biological effects of electrolyzed water in hemodialysis

Nephron - Clinical Practice

Volumn 112, Issue 1, 2009, Pages

  Nakayama, Masaaki ^a   Kabayama, Shigeru ^c   Nakano, Hirofumi ^d   Zhu, Wan Jun ^a,c   Terawaki, Hiroyuki ^a   Nakayama, Keisuke ^a   Katoh, Kiyoshi ^b   Satoh, Toshinobu ^b   Ito, Sadayoshi ^a,b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c Nihon Trim Co Ltd   (Japan)

^d Graduate School of Medicine   (Japan)

Author keywords

Electrolyzed water; Hemodialysis; Methylglyoxal; Neutrophils; Oxidative stress

Indexed keywords

HYDROGEN PEROXIDE; LUMINOL; METHYLGUANIDINE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CELL FUNCTION; CELL VIABILITY; CHEMOLUMINESCENCE; CLINICAL ARTICLE; ELECTROLYSIS; FEMALE; HEMODIALYSIS; HUMAN; KIDNEY DISEASE; MALE; NEUTROPHIL; PRIORITY JOURNAL; REVERSE OSMOSIS;

ADULT; AGED; CHEMILUMINESCENT MEASUREMENTS; CYTOCHROMES C; ELECTRODES; ELECTROLYSIS; FEASIBILITY STUDIES; FEMALE; HEMODIALYSIS SOLUTIONS; HEMODYNAMICS; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NEUTROPHILS; OSMOSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRUVALDEHYDE; RENAL DIALYSIS; RESPIRATORY BURST; SUPEROXIDES; WATER;

EID: 63349111405     PISSN: 16602110     EISSN: None     Source Type: Journal    
DOI: 10.1159/000210569     Document Type: Article

References (26)

1. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM: The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002;62:1524-1538.
2. Becker BN, Himmelfarb J, Henrich WL, Hakim RM: Reassessing the cardiac risk profile in chronic hemodialysis patients: a hypothesis on the role of oxidant stress and other non-traditional cardiac risk factors. J Am Soc Nephrol 1997;8:475-486.
3. Morena M, Delbosc S, Dupuy AM, Canaud B, Cristol JP: Overproduction of reactive oxygen species in end-stage renal disease patients: a potential component of hemodialysis-associated inflammation. Hemodial Int 2005;9:37-46.
4. Wratten ML, Tetta C, Ursini F, Sevanian A: Oxidant stress in hemodialysis: prevention and treatment strategies. Kidney Int Suppl 2000;76:S126-S132.
5. Himmelfarb J, Lazarus JM, Hakim R: Reactive oxygen species production by monocytes and polymorphonuclear leukocytes during dialysis. Am J Kidney Dis 1991;17:271-276.
6. Nakayama K, Terawaki H, Nakayama M, Iwabuchi M, Sato T, Ito S: Reduction of serum antioxidative capacity during hemodialysis. Clin Exp Nephrol 2007;11:218-224.
7. Morena M, Cristol JP, Bosc JY, Tetta C, Forret G, Leqer CL, et al: Convective and diffusive losses of vitamin C during haemodiafiltration session: a contributive factor to oxidative stress in haemodialysis patients. Nephrol Dia l Transpla nt 2002;17:422-427.
8. Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, Hayashi H, Otsubo K, Morisawa S, Katakura Y: Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochem Biophys Res Commun 1997;234:269-274.
9. Hiraoka A, Takemoto M, Suzuki T, Shinohara A, Chiba M, Shirao M, Yoshimura Y: Studies on the properties and real existence of aqueous solution systems that a re assumed to have antioxidant activities by the action of 'active hydrogen'. J Healt h Sci 2004;50:456-465.
10. Kim MJ, Kim HK: Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci 2006;79:2288-2292.
11. Kim MJ, Jung KH, Uhm YK, Leem KH, Kim HK: Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull 2007;30:234-236.
12. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007;13:688-694.
13. Huang KC, Yang CC, Lee KT, Chien CT: Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int 2003;64:704-714.
14. Huang KC, Yang CC, Hsu SP, Lee KT, Liu HW, Morisawa S, Otsubo K, Chien CT: Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney Int 2006;70:391-398.
15. Nakayama M, Kabayama S, Terawaki H, Nakayama K, Kato K, Sato T, Ito S: Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int 2007;11:322-327.
16. Sela S, Shurtz-Swirski R, Cohen-Mazor M, Mazor R, Chezar J, Shapiro G, Hassan K, Shkolnik G, Geron R, Kristal B: Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease. J Am Soc Nephrol 2005;16:2431-2438.
17. Crouch SPM, Kozlowski R, Slater KJ, Fletcher J: The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immunol Meth 1993;160:81-88.
18. Ward RA, McLeish KR: Polymorphonuclear leukocyte oxidative burst is enhanced in patients with chronic renal insufficiency. J Am Soc Nephrol 1995;5:1697-1702.
19. Odani H, Shinzato T, Matsumoto Y, Usami J, Maeda K: Increase in three alpha, beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun 1999;256:89-93.
20. Nakayama K, Nakayama M, Iwabuchi M, Terawaki H, Sato T, Kohno M, Ito S: Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients. Am J Nephrol 2008;28:871-878.
21. Thornalley PJ, Langborg A, Minhas HS: Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J 1999;15:109-116.
22. Biswas A, Wang B, Miyagi M, Nagaraj RH: Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alpha A-crystallin. Biochem J 2008;409:771-777.
23. Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Rabbani N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M: High glucose increases angiopoietin-2transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 2007;282:31038-31045.
24. Nakayama M, Nakayama K, Zhu WJ, Shirota Y, Terawaki H, Sato T, Kohno M, Ito S: Polymorphonuclear leukocyte injury by methylglyoxal and hydrogen peroxide: a possible pathological role for enhanced oxidative stress in chronic kidney disease. Nephrol Dial Transplant 2008;23:3096-3102.
25. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007;13:688-694.
26. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S: Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2008, E-pub ahead of print.