Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT

British Journal of Radiology

Volumn 83, Issue 990, 2010, Pages 509-514

  Kitamura, A ^a   Kobayashi, S ^a   Matsushita, T ^a   Fujinawa, H ^b   Murase, Kenya ^a  

^a OSAKA UNIVERSITY   (Japan)

^b I'rom Pharmaceutical Co   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CREATININE; HYDROGEN RICH WATER; UNCLASSIFIED DRUG; URINARY TRACT AGENT; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CLINICAL ASSESSMENT; CONTRAST ENHANCEMENT; CONTROL GROUP; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; EXPERIMENTAL STUDY; INJECTION; KIDNEY DYSFUNCTION; KIDNEY SIZE; MALE; MODEL; MULTIDETECTOR COMPUTED TOMOGRAPHY; NEPHROTOXICITY; NONHUMAN; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CASE-CONTROL STUDIES; CISPLATIN; CONTRAST MEDIA; CREATININE; DISEASE MODELS, ANIMAL; HYDROGEN; KIDNEY; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TOMOGRAPHY, X-RAY COMPUTED; WATER;

EID: 77952915664     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/25604811     Document Type: Article

References (21)

1. Borch RF, Pleasants ME. Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model. Proc Natl Acad Sci USA 1979;76:6611-6614
2. Betteridge DJ. What is oxidative stress? Metabolism 2000;49(2 Suppl 1):3-8.
3. Matsushima H, Yonemura K, Ohishi K, Hishida A. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J Lab Clin Med 1998;131:518-526 (Pubitemid 28278570)
4. Kuhlmann MK, Burkhardt G, Kohler H. Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application. Nephrol Dial Transplant 1997;12:2478-2480 (Pubitemid 27520658)
5. Osman AM, El-Sayed EM, El-Demerdash E, Al-Hyder A, El-Didi M, Attia AS, et al. Prevention of cisplatin-induced nephrotoxicity by methimazole. Pharmacol Res 2000;41:113-119
6. Dickey DT, Wu YJ, Muldoon LL, Neuwelt EA. Protection against cisplatin-induced toxicities by N-acetylcysteine and sodium thiosulfate as assessed at the molecular, cellular, and in vivo levels. J Pharmacol Exp Ther 2005;314:1052-1058
7. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007;13:688-694 (Pubitemid 46889750)
8. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008;373:30-35
9. Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007;361: 670-674 (Pubitemid 47238041)
10. Tsushima Y. Functional CT of the kidney. Eur J Radiol 1999;30:191-197
11. Murase K, Tachibana A, Kusakabe Y, Matsuura R, Miyazaki S. A method for quantitative assessment of renal function using dynamic contrast-enhanced computed tomography: evaluation of drug-induced nephrotoxicity in rats. Med Phys 2008;35:5768-5776
12. Murase K, Kitamura A, Tachibana A, Kusakabe Y, Matsuura R, Miyazaki S. Quantitative assessment of early experimental diabetes in rats using dynamic contrast-enhanced computed tomography. Eur J Radiol (in press).
13. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain barrier transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
14. Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee T-Y. Dynamic CT measurement of cerebral blood flow: a validation study. AJNR Am J Neuroradiol 1999;20:63-73. (Pubitemid 30417673)
15. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 2008;375:346-350
16. Cameron JS. Renal function testing. In: Cameron JS, Davison AM, Grunfeld JP, Kerr D, Ritz E, editors. Oxford textbook of clinical nephrology. Oxford: Oxford University Press, 1992: 24-71.
17. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising antitumor activity in mice. Cancer Chemother Pharmacol 2009;64:753-761
18. Levitt MD, Ingelfinger FJ. Hydrogen and methane production in man. Ann N Y Acad Sci 1968;150:75-81.
19. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 2008;28:137-143 (Pubitemid 351452069)
20. Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P, et al. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res 2009;43:478-484
21. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2009;34:501-508