Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity

International Immunopharmacology

Volumn 20, Issue 1, 2014, Pages 12-23

  Li, Shiming ^a,b   Lin, Yi Chin ^c   Ho, Chi Tang ^a   Lin, Ping Yi ^d   Suzawa, Michiko ^e   Wang, Hsin Chieh ^c   Chu, Ching Liang ^f   Chen, Der Yuan ^c,g   Lin, Chi Chen ^c,d,g  

^a RUTGERS UNIVERSITY   (United States)

^b HUANGGANG NORMAL UNIVERSITY   (China)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^e Miyauchi Citrus Research Center   (Japan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^g TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Citrus; Contact hypersensitivity (CHS); Dendritic cells; Peels; T cells

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CITRUS FRUIT EXTRACT; GOLD LOTION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; 1 FLUORO 2,4 DINITROBENZENE; CYTOKINE; HAPTEN; IMMUNOLOGIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PLANT MEDICINAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL PROLIFERATION; CONTACT ALLERGY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IMMUNOMODULATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CITRUS; CYTOLOGY; DERMATITIS, ALLERGIC CONTACT; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PHYTOTHERAPY; T LYMPHOCYTE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; CITRUS; CYTOKINES; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; FEMALE; HAPTENS; IMMUNOLOGIC FACTORS; LIPOPOLYSACCHARIDES; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHAGOCYTOSIS; PHYTOTHERAPY; PLANT PREPARATIONS; T-LYMPHOCYTES;

EID: 84895535344     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.02.005     Document Type: Article

References (46)

1. I.A. Hakim, R.B. Harris, and C. Ritenbaugh Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin Nutr Cancer 37 2000 161 168
2. M. Chutia, P. Deka Bhuyan, M.G. Pathak, T.C. Sarma, and P. Boruah Antifungal activity and chemical composition of Citrus reticulata Blanco essential oil against phytopathogens from North East India LWT-Food Sci Technol 42 2009 777 780
3. M. Sawamura, N. Thi Minh Tu, Y. Onishi, E. Ogawa, and H.S. Choi Characteristic odor components of Citrus reticulata Blanco (ponkan) cold-pressed oil Biosci Biotechnol Biochem 68 2004 1690 1697
4. L. Espina, M. Somolinos, S. Lorán, P. Conchello, D. García, and R. Pagán Chemical composition of commercial citrus fruit essential oils and evaluation of their antimicrobial activity acting alone or in combined processes Food Control 22 2011 896 902
5. S.C. Ho, and C.C. Lin Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels J Agric Food Chem 56 2008 7976 7982
6. F. Epifano, S. Genovese, and M. Curini Auraptene: phytochemical and pharmacological properties Phytochem Res Prog 2008 145 162
7. R.K. Upadhyay, P. Dwivedi, and S. Ahmad Screening of antibacterial activity of six plant essential oils against pathogenic bacterial strains Asian J Med Sci 2 2010 152 158
8. E.J. Yang, S.S. Kim, J.Y. Moon, T.-H. Oh, J.S. Baik, and N.H. Lee et al. Inhibitory effects of Fortunella japonica var. margarita and Citrus sunki essential oils on nitric oxide production and skin pathogens Acta Microbiol Immunol Hung 57 2010 15 27
9. E. Yi, and E.S. Yoo A novel bioactive fabric dyed with unripe Citrus grandis Osbeck extract part 1: dyeing properties and antimicrobial activity on cotton knit fabrics Text Res J 80 2010 2117 2123
10. O. Benavente-Garcia, and J. Castillo Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity J Agric Food Chem 56 2008 6185 6205
11. E.M. Kurowska, J.A. Manthey, A. Casaschi, and A.G. Theriault Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin Lipids 39 2004 143 151
12. J.A. Manthey, N. Guthrie, and K. Grohmann Biological properties of citrus flavonoids pertaining to cancer and inflammation Curr Med Chem 8 2001 135 153
13. M. Miyazawa, Y. Okuno, M. Fukuyama, S.-I. Nakamura, and H. Kosaka Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium J Agric Food Chem 47 1999 5239 5244
14. J.M. Roza, Z. Xian-Liu, and N. Guthrie Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects Altern Ther Health Med 13 2007 44
15. H. Xiao, C.S. Yang, S. Li, H. Jin, C.T. Ho, and T. Patel Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis Mol Nutr Food Res 53 2009 398 406
16. C.S. Lai, S. Li, C.B. Liu, Y. Miyauchi, M. Suzawa, and C.T. Ho et al. Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids Mol Nutr Food Res 57 2013 551 555
17. M.H. Pan, S. Li, C.S. Lai, Y. Miyauchi, M. Suzawa, and C.T. Ho Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice Food Sci Human Wellness 1 2012 65 73
18. C.S. Lai, S. Li, Y. Miyauchi, M. Suzawa, C.T. Ho, and M.H. Pan Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors Food Funct 4 2013 944 949
19. T. Etoh, Y.P. Kim, M. Hayashi, M. Suzawa, S. Li, and C.T. Ho et al. Inhibitory effect of a formulated extract from multiple citrus peels on LPS-induced inflammation in RAW 246.7 macrophages Funct Foods Health Dis 3 2013 242 253
20. F. Granucci, I. Zanoni, and P. Ricciardi-Castagnoli Central role of dendritic cells in the regulation and deregulation of immune responses Cell Mol Life Sci 65 2008 1683 1697
21. R.M. Steinman, and H. Hemmi Dendritic cells: translating innate to adaptive immunity Curr Top Microbiol Immunol 311 2006 17 58
22. C. Hivroz, K. Chemin, M. Tourret, and A. Bohineust Crosstalk between T lymphocytes and dendritic cells Crit Rev Immunol 32 2012 139 155
23. R. Förster, A. Braun, and T. Worbs Lymph node homing of T cells and dendritic cells via afferent lymphatics Trends Immunol 33 2012 271 280
24. P. Hubert, N. Jacobs, J.H. Caberg, J. Boniver, and P. Delvenne The cross-talk between dendritic and regulatory T cells: good or evil? J Leukoc Biol 82 2007 781 794
25. D.Y. Chen, P.S. Song, J.S. Hong, C.L. Chu, I.H. Pan, and Y.M. Chen et al. Dextromethorphan inhibits activations and functions in dendritic cells Clin Dev Immunol 2013 125643
26. C.C. Lin, Y.L. Yu, C.C. Shih, K.J. Liu, K.L. Ou, and L.Z. Hong et al. A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells Cancer Immunol Immunother 60 2011 1019 1027
27. R.Y. Huang, Y.L. Yu, W.C. Cheng, C.N. OuYang, E. Fu, and C.L. Chu Immunosuppressive effect of quercetin on dendritic cell activation and function J Immunol 184 2010 6815 6821
28. G.Y. Kim, M.G. Han, and Y.S. Song et al. Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-κB Biol Pharm Bull 27 2004 1656 1662
29. M. Rescigno, M. Martino, C.L. Sutherland, M.R. Gold, and P. Ricciardi-Castagnoli Dendritic cell survival and maturation are regulated by different signaling pathways J Exp Med 188 1998 2175 2180
30. S. Yokoi, H. Niizeki, H. Iida, H. Asada, and S. Miyagawa Adjuvant effect of lipopolysaccharide on the induction of contact hypersensitivity to haptens in mice J Dermatol Sci 53 2009 120 128
31. T. Geldart, and T. Illidge Anti-CD 40 monoclonal antibody Leuk Lymphoma 46 2005 1105 1113
32. A.H. Sharpe, and G.J. Freeman The B7-CD28 superfamily Nat Rev Immunol 2 2002 116 126
33. T.K. Teague, P. Marrack, J.W. Kappler, and A.T. Vella IL-6 rescues resting mouse T cells from apoptosis J Immunol 158 1997 5791 5796
34. O. Dienz, and M. Rincon The effects of IL-6 on CD4 T cell responses Clin Immunol 130 2009 27 33
35. J.K. Yoo, J.H. Cho, S.W. Lee, and Y.C. Sung IL-12 provides proliferation and survival signals to murine CD4 + T cells through phosphatidylinositol 3-kinase/Akt signaling pathway J Immunol 169 2002 3637 3643
36. J. Estaquier, T. Idziorek, W. Zou, D. Emilie, C.M. Farber, and J.M. Bourez et al. T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4 + T cells from human immunodeficiency virus-infected persons J Exp Med 182 1995 1759
37. T. Marth, M. Zeitz, B.R. Ludviksson, W. Strober, and B.L. Kelsall Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells J Immunol 162 1999 7233
38. C. Gasparini, and M. Feldmann NF-κB as a target for modulating inflammatory responses Curr Pharm Des 18 2012 5735 5745
39. M. Rescigno, M. Martino, C.L. Sutherland, M.R. Gold, and P. Ricciardi- Castagnoli Dendritic cell survival and maturation are regulated by different signaling pathways J Exp Med 188 1998 2175 2180
40. G.Y. Kim, M.G. Han, Y.S. Song, B.C. Shin, Y.I. Shin, and H.J. Lee et al. Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4- mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-κB Biol Pharm Bull 27 2004 1656 1662
41. J. Wang, X. Wang, S. Hussain, Y. Zheng, S. Sanjabi, and F. Ouaaz et al. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells J Immunol 178 2007 6777 6788
42. P. Kidd Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease Altern Med Rev 8 2003 223 246
43. M.K. Gately, L.M. Renzetti, J. Magram, A.S. Stern, L. Adorini, and U. Gubler et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses Annu Rev Immunol 16 1998 495 521
44. B. Wang, C. Feliciani, I. Freed, Q. Cai, and D.N. Sauder Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies J Leukoc Biol 70 2001 185 191
45. F. Granucci, and I. Zanoni Role of Toll like receptor-activated dendritic cells in the development of autoimmunity Front Biosci 13 2008 4817 4826
46. G.N. Barber Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses Curr Opin Immunol 23 2011 10 20