Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids

Molecular Nutrition and Food Research

Volumn 57, Issue 3, 2013, Pages 551-555

  Lai, Ching Shu ^a   Li, Shiming ^b   Liu, Cheng Bin ^c   Miyauchi, Yutaka ^d   Suzawa, Michiko ^d   Ho, Chi Tang ^b   Pan, Min Hsiung ^a  

^a NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^b RUTGERS UNIVERSITY   (United States)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d Miyauchi Citrus Research Center   (Japan)

Author keywords

Aberrant crypt foci; Azoxymethane; Citrus peel; Gold lotion

Indexed keywords

ANTINEOPLASTIC AGENT; AZOXYMETHANE; CYCLOOXYGENASE 2; FLAVONOID; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; ORNITHINE DECARBOXYLASE; PLANT EXTRACT; PTGS2 PROTEIN, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ABERRANT CRYPT FOCUS; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CITRUS; COLON TUMOR; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; PATHOLOGY;

ABERRANT CRYPT FOCI; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AZOXYMETHANE; CITRUS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; FLAVONOIDS; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED ICR; NITRIC OXIDE SYNTHASE TYPE II; ORNITHINE DECARBOXYLASE; PLANT EXTRACTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

CITRUS; MUS;

EID: 84875054047     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200606     Document Type: Article

References (23)

1. Yang, X., Kang, S. M., Jeon, B. T., Kim, Y. D. et al., Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J. Sci. Food Agric. 2011, 91, 1925-1927.
2. Callaway, T. R., Carroll, J. A., Arthington, J. D., Edrington, T. S. et al., Escherichia coli O157: H7 populations in ruminants can be reduced by orange peel product feeding. J. Food Prot. 2011, 74, 1917-1921.
3. Ho, S. C., Lin, C. C., Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels. J. Agric. Food Chem. 2008, 56, 7976-7982.
4. Yang, E. J., Kim, S. S., Moon, J. Y., Oh, T. H. et al., Inhibitory effects of Fortunella japonica var. margarita and Citrus sunki essential oils on nitric oxide production and skin pathogens. Acta Microbiol. Immunol. Hung. 2010, 57, 15-27.
5. Li, S., Lo, C. Y., Ho, C. T., Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. J. Agric. Food Chem. 2006, 54, 4176-4185.
6. Li, S., Pan, M. H., Lo, C. Y., Tan, D. et al., Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones. J. Functional Foods 2009, 1, 12.
7. Walle, T., Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? Semin. Cancer Biol. 2007, 17, 354-362.
8. Miyamoto, S., Yasui, Y., Ohigashi, H., Tanaka, T. et al., Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Chem. Biol. Interact. 2010, 183, 276-283.
9. Fan, K., Kurihara, N., Abe, S., Ho, C. T. et al., Chemopreventive effects of orange peel extract (OPE) I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. J. Med. Food 2007, 10, 11-17.
10. Lai, C. S., Tsai, M. L., Cheng, A. C., Li, S. et al., Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mol. Nutr. Food Res. 2011, 55, 278-290.
11. Takayama, T., Katsuki, S., Takahashi, Y., Ohi, M. et al., Aberrant crypt foci of the colon as precursors of adenoma and cancer. N. Engl. J. Med. 1998, 339, 1277-1284.
12. Takahashi, M., Wakabayashi, K., Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci. 2004, 95, 475-480.
13. Otori, K., Sugiyama, K., Hasebe, T., Fukushima, S., Esumi, H., Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res. 1995, 55, 4743-4746.
14. Pan, M. H., Lai, C. S., Wu, J. C., Ho, C. T., Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol. Nutr. Food Res. 2011, 55, 32-45.
15. Bing, R. J., Miyataka, M., Rich, K. A., Hanson, N. et al., Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. Clin. Cancer Res. 2001, 7, 3385-3392.
16. Niho, N., Kitamura, T., Takahashi, M., Mutoh, M. et al., Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. Cancer Sci. 2006, 97, 1011-1014.
17. Vanamala, J., Leonardi, T., Patil, B. S., Taddeo, S. S. et al., Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 2006, 27, 1257-1265.
18. Tanaka, T., Makita, H., Kawabata, K., Mori, H. et al., Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis 1997, 18, 957-965.
19. Suzuki, R., Kohno, H., Murakami, A., Koshimizu, K. et al., Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats. Biofactors 2004, 22, 111-114.
20. Su, J. D., Yen, J. H., Li, S., Weng, C. Y. et al., 3′, 4′-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic. Biol. Med. 2012, 52, 126-141.
21. Breinholt, V., Lauridsen, S. T., Dragsted, L. O., Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. Xenobiotica 1999, 29, 1227-1240.
22. Obermeier, M. T., White, R. E., Yang, C. S., Effects of bioflavonoids on hepatic P450 activities. Xenobiotica 1995, 25, 575-584.
23. Siess, M. H., Leclerc, J., Canivenc-Lavier, M. C., Rat, P. et al., Heterogenous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes. Toxicol. Appl. Pharmacol. 1995, 130, 73-78.