Evidence for autoantibody-induced CD4 depletion mediated by apoptotic and non-apoptotic mechanisms in HIV-positive long-term surviving haemophilia patients

Clinical and Experimental Immunology

Volumn 135, Issue 1, 2004, Pages 94-104

  Daniel, V ^a   Sadeghi, M ^a   Naujokat, C ^a   Weimer, R ^a   Huth Kuhne A ^b   Zimmermann, R ^b   Opelz, G ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Kurpfalz Hospital   (Germany)

Author keywords

Apoptotic and non apoptotic lymphocyte depletion mechanisms; Autoantibody induced CD4 depletion; CD8+ blood lymphocytes; Four colour fluorescence flow cytometry; HIV 1 viral load; Long term HIV infected haemophilia patients

Indexed keywords

ANNEXIN; CD3 ANTIGEN; CD4 ANTIGEN; COMPLEMENT COMPONENT C3D; FAS ANTIGEN; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROPIDIUM IODIDE;

ADOLESCENT; ADULT; ANTIBODY DEPENDENT LEUKOCYTE CYTOTOXICITY; APOPTOSIS; ARTICLE; CELL LABELING; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEMOPHILIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN BLOOD LEVEL; INTERMETHOD COMPARISON; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MALE; PHAGOCYTOSIS; PRIORITY JOURNAL; SURVIVAL TIME; VIRUS LOAD;

ADOLESCENT; ADULT; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; APOPTOSIS; AUTOANTIBODIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; HEMOPHILIA A; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOGLOBULIN G; IMMUNOPHENOTYPING; LONGITUDINAL STUDIES; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHAGOCYTOSIS; RNA, VIRAL; VIRAL LOAD;

EID: 0347949509     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02339.x     Document Type: Article

References (25)

1. Quagliarello V. The Acquired Immunodeficiency Syndrome: current status. Yale J Biol Med 1982; 55:443-52 [review].
2. Wang L, Adegboyega PA. Down-regulation of Fas expression in the lymph nodes of patients infected with human immunodeficiency virus. Arch Pathol Lab Med 2002; 126:28-32.
3. + hemophilia patients: results of a 10-year study. Immunol Lett 1995; 47:97-102.
4. + lymphocytes in haemophilia patients; results of a 10-year study. Clin Exp Immunol 1996; 104:4-10.
5. Daniel V, Schimpf K, Opelz G. Lymphocyte autoantibodies and alloantibodies in HIV-positive haemophilia patients. Clin Exp Immunol 1989; 75:178-83.
6. + lymphocytes. Clin Exp Immunol 1999; 115:477-84.
7. + lymphocyte autoantibodies. Vox Sang 1996; 70:86-91.
8. Wang ZQ, Horowitz HW, Orlikowsky T, Dudhane A, Weinstein A, Hoffmann MK. Lymphocyte-reactive autoantibodies in human immunodeficiency virus type 1-infected persons facilitate the deletion of CD8 T cells by macrophages. J Infect Dis 1998; 178:404-12.
9. + T cell depletion in HIV-1-infected patients. Microb Pathog 1998; 25:253-66.
10. Parker SJ, Sadlon TA, Gordon DL. Enhancement of NK cell-mediated antibody-dependent lysis of recombinant gp120-coated CD4 cells by complement. J Infect Dis 1995; 171:186-9.
11. + patients induce apoptosis on normal lymphocytes. Immunology 1997; 92:317-20.
12. + T cell apoptosis in HIV-infected patients. Clin Exp Immunol 1999; 118:412-6.
13. Stricker K, Knipping E, Bohler T, Benner A, Krammer PH, Debatin KM. Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children. Cell Death Differ 1998; 5:222-30.
14. Silvestris F, Grinello D, Del Prete A, Cafforio P, Quarto M, Dammacco F. Anti-Fas (CD95/Apo-I) autoantibodies and soluble Fas levels concur in T cell depletion in HIV type 1 infection. AIDS Res Hum Retroviruses 2001; 17:603-14.
15. Gupta S. Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans. Vaccine 2000; 18:1596-601.
16. Aggarwal S, Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol 1998; 160:1627-37.
17. Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boutet S, Proust JJ. Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mech Ageing Dev 1997; 96:35-46.
18. Mantzioris BX, Berger MF, Sewell W, Zola H. Expression of the Fc receptor for IgG (Fc gamma RII/ (CDw32) by human circulating T and B lymphocytes. J Immunol 1993; 150:5175-84.
19. Mouawad R, Khayat D, Soubrane C. Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in advanced melanoma. Melanoma Res 2000; 10:461-7.
20. + cell count increases and viral load and immune complex decreases. AIDS Res Hum Retroviruses 2001; 17:329-35.
21. Silvestris F, Cocco T, Cafforio P, Calvani N, Dammacco F. Immunogenicity of an eight amino acid domain shared by Fas (CD95/Apo-I) and HIV-1 gp120. I. Structural and antigenic analysis. Mol Med 2000; 6: 494-508.
22. + lymphopenia. Int J Clin Laboratory Res 1998; 28:215-25
23. Silvestris F, Camarda G, Cafforio P, Dammacco F. Upregulation of Fas ligand secretion in non-lymphopenic stages of HIV-1 infection. AIDS 1998; 12:1103-4.
24. + T lymphocytes is not mediated by Fas-Fas ligand. AIDS 1997; 14:1671-80.
25. + patients bind apoptotic T cells in vitro. Eur J Histochem 1997; 41 (Suppl. 2):65-6.