Dementia and cognitive decline in type 2 diabetes and prediabetic stages: Towards targeted interventions

The Lancet Diabetes and Endocrinology

Volumn 2, Issue 3, 2014, Pages 246-255

  Biessels, Geert Jan ^a   Strachan, Mark W J ^b   Visseren, Frank L J ^a   Kappelle, L Jaap ^a   Whitmer, Rachel A ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c DIVISION OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; COMORBIDITY; CONGENITAL BLOOD VESSEL MALFORMATION; DEMENTIA; DEPRESSION; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; LIFESTYLE; NEUROIMAGING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; RISK FACTOR; SOCIAL STATUS; TREATMENT OUTCOME; COMPLICATION; DISEASE COURSE; PATHOLOGY; SOCIOECONOMICS;

DEMENTIA; DEPRESSION; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; HUMANS; RISK FACTORS; SOCIOECONOMIC FACTORS;

EID: 84895463355     PISSN: 22138587     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2213-8587(13)70088-3     Document Type: Review

References (106)

1. Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366:2112-2117.
2. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006, 5:64-74.
3. Cheng G, Huang C, Deng H, Wang H Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J 2012, 42:484-491.
4. National Diabetes Fact Sheet Centres for Disease Control and Prevention, (accessed June 23, 2013). http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf.2013.
5. Wild S, Roglic G, Green A, Sicree R, King H Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
6. Yaffe K, Blackwell T, Whitmer RA, Krueger K, Barrett CE Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women. J Nutr Health Aging 2006, 10:293-295.
7. Luchsinger JA Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. Eur J Pharmacol 2008, 585:119-129.
8. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP, Yaffe K Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ 2005, 330:1360.
9. Kloppenborg RP, van den Berg E, Kappelle LJ, Biessels GJ Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. Eur J Pharmacol 2008, 585:97-108.
10. Petersen RC Mild cognitive impairment as a diagnostic entity. J Intern Med 2004, 256:183-194.
11. Luchsinger JA, Reitz C, Patel B, Tang MX, Manly JJ, Mayeux R Relation of diabetes to mild cognitive impairment. Arch Neurol 2007, 64:570-575.
12. Roberts RO, Knopman DS, Geda YE, et al. Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement 2013, published online April 3. 10.1016/S1552-5260(13)00013-7.
13. Xu W, Caracciolo B, Wang HX, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes 2010, 59:2928-2935.
14. Li J, Wang YJ, Zhang M, et al. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 2011, 76:1485-1491.
15. Helzner EP, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 2009, 66:343-348.
16. Sanz CM, Hanaire H, Vellas BJ, Sinclair AJ, Andrieu S Diabetes mellitus as a modulator of functional impairment and decline in Alzheimer's disease. The Real.FR cohort. Diabet Med 2012, 29:541-548.
17. Reijmer YD, van den Berg E, Ruis C, Kappelle LJ, Biessels GJ Cognitive dysfunction in patients with type 2 diabetes. Diabetes Metab Res Rev 2010, 26:507-519.
18. van den Berg E, Kloppenborg RP, Kessels RP, Kappelle LJ, Biessels GJ Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition. Biochim Biophys Acta 2009, 1792:470-481.
19. Ruis C, Biessels GJ, Gorter KJ, van den Donk M, Kappelle LJ, Rutten GE Cognition in the early stage of type 2 diabetes. Diabetes Care 2009, 32:1261-1265.
20. Lamport DJ, Lawton CL, Mansfield MW, Dye L Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review. Neurosci Biobehav Rev 2009, 33:394-413.
21. Crichton GE, Elias MF, Buckley JD, Murphy KJ, Bryan J, Frisardi V Metabolic syndrome, cognitive performance, and dementia. J Alzheimers Dis 2012, 30(suppl 2):S77-S87.
22. van den Berg E, Reijmer YD, de Bresser J, Kessels RP, Kappelle LJ, Biessels GJ A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia 2010, 53:58-65.
23. Yaffe K, Falvey C, Hamilton N, et al. Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Arch Neurol 2012, 69:1170-1175.
24. McEvoy LK, Laughlin GA, Barrett-Connor E, et al. Metabolic syndrome and 16-year cognitive decline in community-dwelling older adults. Ann Epidemiol 2012, 22:310-317.
25. Launer LJ, Andersen K, Dewey ME, et al. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology 1999, 52:78-84.
26. Johnson DK, Storandt M, Morris JC, Galvin JE Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch Neurol 2009, 66:1254-1259.
27. Yau PL, Javier DC, Ryan CM, et al. Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus. Diabetologia 2010, 53:2298-2306.
28. van Harten B, de Leeuw FE, Weinstein HC, Scheltens P, Biessels GJ Brain imaging in patients with diabetes: a systematic review. Diabetes Care 2006, 29:2539-2548.
29. de Bresser J, Tiehuis AM, van den Berg E, et al. Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes. Diabetes Care 2010, 33:1309-1314.
30. Espeland MA, Bryan RN, Goveas JS, et al. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies. Diabetes Care 2013, 36:90-97.
31. Falvey CM, Rosano C, Simonsick EM, et al. Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults. Diabetes Care 2013, 36:677-682.
32. Saczynski JS, Siggurdsson S, Jonsson PV, et al. Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study. Diabetes Care 2009, 32:1608-1613.
33. Maillard P, Seshadri S, Beiser A, et al. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol 2012, 11:1039-1047.
34. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013, 12:822-838.
35. Luitse MJA, Biessels GJ, Rutten GEHM, Kappelle LJ Diabetes, hyperglycaemia, and acute ischaemic stroke. Lancet Neurol 2012, 11:261-271.
36. Manschot SM, Brands AM, van der Grond J, et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 2006, 55:1106-1113.
37. Cordonnier C, Al-Shahi SR, Wardlaw J Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007, 130:1988-2003.
38. Reijmer YD, Leemans A, Brundel M, Kappelle LJ, Biessels GJ Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes. Diabetes 2013, 62:2112-2115.
39. Musen G, Jacobson AM, Bolo NR, et al. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes 2012, 61:2375-2379.
40. Plassman BL, Williams JW, Burke JR, Holsinger T, Benjamin S Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Ann Intern Med 2010, 153:182-193.
41. Barnes DE, Yaffe K The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011, 10:819-828.
42. Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology 2004, 63:1181-1186.
43. Umegaki H, Iimuro S, Shinozaki T, et al. Risk factors associated with cognitive decline in the elderly with type 2 diabetes: pooled logistic analysis of a 6-year observation in the Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int 2012, 12(suppl 1):110-116.
44. Bruce DG, Davis WA, Casey GP, et al. Predictors of cognitive decline in older individuals with diabetes. Diabetes Care 2008, 31:2103-2107.
45. Johnson ML, Parikh N, Kunik ME, et al. Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus. Alzheimers Dement 2012, 8:437-444.
46. Manschot SM, Biessels GJ, de Valk HW, et al. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007, 50:2388-2397.
47. van den Berg E, Dekker JM, Nijpels G, et al. Blood pressure levels in pre-diabetic stages are associated with worse cognitive functioning in patients with type 2 diabetes. Diabetes Metab Res Rev 2009, 25:657-664.
48. Anstey KJ, Cherbuin N, Budge M, Young J Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev 2011, 12:e426-e437.
49. Abbatecola AM, Lattanzio F, Spazzafumo L, et al. Adiposity predicts cognitive decline in older persons with diabetes: a 2-year follow-up. PLoS ONE 2010, 5:e10333.
50. Bruce DG, Davis WA, Casey GP, et al. Predictors of cognitive impairment and dementia in older people with diabetes. Diabetologia 2008, 51:241-248.
51. Reitz C Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations. J Alzheimers Dis 2012, 30(suppl 2):S127-S145.
52. Prince M, Acosta D, Ferri CP, et al. Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. Lancet 2012, 380:50-58.
53. Rusanen M, Kivipelto M, Quesenberry CP, Zhou J, Whitmer RA Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch Intern Med 2011, 171:333-339.
54. Devore EE, Kang JH, Okereke O, Grodstein F Physical activity levels and cognition in women with type 2 diabetes. Am J Epidemiol 2009, 170:1040-1047.
55. Devore EE, Stampfer MJ, Breteler MM, et al. Dietary fat intake and cognitive decline in women with type 2 diabetes. Diabetes Care 2009, 32:635-640.
56. Katon W, Lyles CR, Parker MM, Karter AJ, Huang ES, Whitmer RA Association of depression with increased risk of dementia in patients with type 2 diabetes: the Diabetes and Aging Study. Arch Gen Psychiatry 2012, 69:410-417.
57. Katon WJ, Lin EH, Williams LH, et al. Comorbid depression is associated with an increased risk of dementia diagnosis in patients with diabetes: a prospective cohort study. J Gen Intern Med 2010, 25:423-429.
58. Koekkoek PS, Rutten GE, Ruis C, et al. Mild depressive symptoms do not influence cognitive functioning in patients with type 2 diabetes. Psychoneuroendocrinology 2013, 38:376-386.
59. Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 2010, 53:2480-2486.
60. Roy T, Lloyd CE Epidemiology of depression and diabetes: a systematic review. J Affect Disord 2012, 142(suppl):S8-21.
61. Sinclair AJ, Girling AJ, Bayer AJ Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study. Diabetes Res Clin Pract 2000, 50:203-212.
62. Parikh NM, Morgan RO, Kunik ME, et al. Risk factors for dementia in patients over 65 with diabetes. Int J Geriatr Psychiatry 2011, 26:749-757.
63. Peila R, Rodriguez BL, Launer LJ Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 2002, 51:1256-1262.
64. Xu WL, von Strauss E, Qiu CX, Winblad B, Fratiglioni L Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study. Diabetologia 2009, 52:1031-1039.
65. van den Berg E, de Craen AJ, Biessels GJ, Gussekloo J, Westendorp RG The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study. Diabetologia 2006, 49:2015-2023.
66. Yaffe K, Falvey CM, Hamilton N, et al. Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus. JAMA Intern Med 2013, 173:1300-1306.
67. Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP, Selby JV Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009, 301:1565-1572.
68. Bruce DG, Davis WA, Casey GP, et al. Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study. Diabetologia 2009, 52:1808-1815.
69. de Galan BE, Zoungas S, Chalmers J, et al. Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Diabetologia 2009, 52:2328-2336.
70. Punthakee Z, Miller ME, Launer LJ, et al. Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care 2012, 35:787-793.
71. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E Alzheimer's disease. Lancet 2011, 377:1019-1031.
72. Schneider JA, Arvanitakis Z, Bang W, Bennett DA Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007, 69:2197-2204.
73. Craft S, Cholerton B, Baker LD Insulin and Alzheimer's disease: untangling the web. J Alzheimers Dis 2013, 33(suppl 1):S263-S275.
74. Ahtiluoto S, Polvikoski T, Peltonen M, et al. Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 2010, 75:1195-1202.
75. Nelson PT, Smith CD, Abner EA, et al. Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta 2009, 1792:454-469.
76. Thambisetty M, Metter EJ, Yang A, et al. Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore longitudinal study of aging. JAMA Neurol 2013, published online July 29. 10.1001/jamaneurol.2013.284.
77. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F Amylin deposition in the brain: a second amyloid in Alzheimer's disease?. Ann Neurol 2013, published online June 22. 10.1002/ana.23956.
78. Westermark P, Andersson A, Westermark GT Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiol Rev 2011, 91:795-826.
79. Jack CR, Knopman DS, Jagust WJ, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010, 9:119-128.
80. Pendlebury ST, Rothwell PM Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol 2009, 8:1006-1018.
81. Pantoni L Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010, 9:689-701.
82. Feinkohl I, Keller M, Robertson CM, et al. Clinical and subclinical macrovascular disease as predictors of cognitive decline in older patients with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care 2013, 36:2779-2786.
83. Luchsinger JA, Tang MX, Stern Y, Shea S, Mayeux R Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol 2001, 154:635-641.
84. Heringa SM, Bouvy WH, van den Berg E, Moll AC, Kappelle LJ, Biessels GJ Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review. J Cereb Blood Flow Metab 2013, 33:983-995.
85. Ding J, Strachan MW, Reynolds RM, et al. Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 2010, 59:2883-2889.
86. Sommerfield AJ, Deary IJ, Frier BM Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care 2004, 27:2335-2340.
87. Ryan CM, Freed MI, Rood JA, Cobitz AR, Waterhouse BR, Strachan MW Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 2006, 29:345-351.
88. Banks WA, Owen JB, Erickson MA Insulin in the brain: there and back again. Pharmacol Ther 2012, 136:82-93.
89. Zhao WQ, Townsend M Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 2009, 1792:482-496.
90. Marioni RE, Strachan MW, Reynolds RM, et al. Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 2010, 59:710-713.
91. Beaudry JL, Riddell MC Effects of glucocorticoids and exercise on pancreatic beta-cell function and diabetes development. Diabetes Metab Res Rev 2012, 28:560-573.
92. de Quervain DJ, Aerni A, Schelling G, Roozendaal B Glucocorticoids and the regulation of memory in health and disease. Front Neuroendocrinol 2009, 30:358-370.
93. Reynolds RM, Strachan MW, Labad J, et al. Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care 2010, 33:714-720.
94. Hsu CC, Wahlqvist ML, Lee MS, Tsai HN Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J Alzheimers Dis 2011, 24:485-493.
95. Imfeld P, Bodmer M, Jick SS, Meier CR Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study. J Am Geriatr Soc 2012, 60:916-921.
96. Ott A, Stolk RP, Van Harskamp F, Pols HA, Hofman A, Breteler MM Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology 1999, 53:1937-1942.
97. Seaquist ER, Miller ME, Fonseca V, et al. Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND. J Diabetes Complications 2013, 27:485-491.
98. Launer LJ, Miller ME, Williamson JD, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol 2011, 10:969-977.
99. Koekkoek PS, Ruis C, van den Donk M, et al. Intensive multifactorial treatment and cognitive functioning in screen-detected type 2 diabetes-the ADDITION-Netherlands study: a cluster-randomized trial. J Neurol Sci 2012, 314:71-77.
100. Matthews FE, Arthur A, Barnes LE, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 2013, published online July 17. 10.1016/S0140-6736(13)61570-6.
101. Jack CR, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013, 12:207-216.
102. Exalto LG, Biessels GJ, Karter AJ, et al. Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study. Lancet Diabetes Endocrinol 2013, published online Aug 20. http://dx.doi.org/10.1016/S2213-8587(13)70048-2.
103. McClean PL, Parthsarathy V, Faivre E, Holscher C The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011, 31:6587-6594.
104. Holscher C Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochem Soc Trans 2011, 39:891-897.
105. Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012, 69:29-38.
106. Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012, 55:1577-1596.