Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: Post hoc epidemiologic analysis of the ACCORD trial

Diabetes Care

Volumn 35, Issue 4, 2012, Pages 787-793

  Punthakee, Zubin ^a   Miller, Michael E ^b   Launer, Lenore J ^c   Williamson, Jeff D ^b   Lazar, Ronald M ^d   Cukierman Yaffee, Tali ^e   Seaquist, Elizabeth R ^f   Ismail Beigi, Faramarz ^g   Sullivan, Mark D ^h   Lovato, Laura C ^b   Bergenstal, Richard M ⁱ   Gerstein, Hertzel C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e TEL AVIV UNIVERSITY   (Israel)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ INTERNATIONAL DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GLYCEMIC CONTROL; HIGH RISK POPULATION; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MENTAL CAPACITY; MENTAL HEALTH; MENTAL TEST; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PREDICTION; RISK ASSESSMENT;

ADULT; AGED; AGED, 80 AND OVER; CLINICAL TRIALS AS TOPIC; COGNITION; COGNITION DISORDERS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOGLYCEMIA; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84862081563     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-1855     Document Type: Article

References (33)

1. American Diabetes Association. Standards of medical care in diabetes - 2009. Diabetes Care 2009;32(Suppl. 1):S13-S61
2. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Organization of Diabetes Care. Canadian Journal of Diabetes 2008;32:S20-S24
3. International Diabetes Federation. Education. In Global Guideline for Type 2 Diabetes. Brussels, International Diabetes Federation, 2005, p. 15-18
4. McGuire LC, Ford ES, Ajani UA. The impact of cognitive functioning on mortality and the development of functional disability in older adults with diabetes: the second longitudinal study on aging. BMC Geriatr 2006;6:8
5. Sinclair AJ, Girling AJ, Bayer AJ. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study. Diabetes Res Clin Pract 2000;50:203-212
6. Buse JB, Bigger JT, Byington RP, et al.; ACCORD Study Group. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am J Cardiol 2007;99(12A):21i-33i
7. Gerstein HC, Riddle MC, Kendall DM, et al.; ACCORD Study Group. Glycemia treatment strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol 2007;99(12A):34i-43i
8. Williamson JD, Miller ME, Bryan RN, et al.; ACCORD Study Group. The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods. Am J Cardiol 2007;99(12A):112i- 122i
9. Rosano C, Simonsick EM, Harris TB, et al. Association between physical and cognitive function in healthy elderly: the health, aging and body composition study. Neuroepidemiology 2005;24:8-14 (Pubitemid 39664101)
10. Pavlik VN, de Moraes SA, Szklo M, Knopman DS, Mosley TH Jr, Hyman DJ. Relation between cognitive function and mortality in middle-aged adults: the atherosclerosis risk in communities study. Am J Epidemiol 2003;157:327-334 (Pubitemid 36193935)
11. Swan GE, Carmelli D, LaRue A. Performance on the digit symbol substitution test and 5-year mortality in the Western Collaborative Group Study. Am J Epidemiol 1995;141:32-40
12. Proust-Lima C, Amieva H, Dartigues JF, Jacqmin-Gadda H. Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studies. Am J Epidemiol 2007;165:344-350 (Pubitemid 46174759)
13. Lezak MD. Memory I: tests. In Neuropsychological Assessment. New York, Oxford University Press, 1995, p. 429-498
14. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935;18:643-662
15. Tombaugh TN, McIntyre NJ. The minimental state examination: a comprehensive review. J Am Geriatr Soc 1992;40:922-935
16. Cukierman-Yaffe T, Gerstein HC, Williamson JD, et al.; Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Investigators. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care 2009;32:221-226
17. Miller ME, Bonds DE, Gerstein HC, et al.; ACCORD Investigators. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ 2010;340:b5444
18. Patel A, MacMahon S, Chalmers J, et al.; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560-2572 (Pubitemid 351831357)
19. Gerstein HC, Miller ME, Byington RP, et al.; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358:2545-2559 (Pubitemid 351831356)
20. Kodl CT, Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev 2008;29:494-511 (Pubitemid 351831510)
21. Brumback T, Cao D, King A. Effects of alcohol on psychomotor performance and perceived impairment in heavy binge social drinkers. Drug Alcohol Depend 2007;91:10-17 (Pubitemid 47385028)
22. Lukas SE, Lex BW, Slater JP, Greenwald NE, Mendelson JH. A microanalysis of ethanol-induced disruption of body sway and psychomotor performance in women. Psychopharmacology (Berl) 1989;98:169-175 (Pubitemid 19137727)
23. Heishman SJ, Stitzer ML, Bigelow GE. Alcohol and marijuana: comparative dose effect profiles in humans. Pharmacol Biochem Behav 1988;31:649-655 (Pubitemid 19274262)
24. Beydoun MA, Kaufman JS, Sloane PD, Heiss G, Ibrahim J. n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study. Public Health Nutr 2008;11:17-29 (Pubitemid 350233687)
25. Hoyer WJ, Stawski RS, Wasylyshyn C, Verhaeghen P. Adult age and digit symbol substitution performance: a meta-analysis. Psychol Aging 2004;19:211-214 (Pubitemid 38338279)
26. Lee DM, Tajar A, Ulubaev A, et al.; EMAS study group. The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men. Int J Geriatr Psychiatry 2009;24:1257-1266
27. MacDonald SW, Hultsch DF, Strauss E, Dixon RA. Age-related slowing of digit symbol substitution revisited: what do longitudinal age changes reflect? J Gerontol B Psychol Sci Soc Sci 2003;58:187-194
28. Wielgos CM, Cunningham WR. Age-related slowing on the Digit Symbol task: longitudinal and cross-sectional analyses. Exp Aging Res 1999;25:109-120 (Pubitemid 29149055)
29. de Galan BE, Zoungas S, Chalmers J, et al.; ADVANCE Collaborative Group. Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Diabetologia 2009;52:2328-2336
30. Austin EJ, Deary IJ. Effects of repeated hypoglycemia on cognitive function: a psychometrically validated reanalysis of the Diabetes Control and Complications Trial data. Diabetes Care 1999;22:1273-1277 (Pubitemid 29350236)
31. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-986
32. Cox DJ, Kovatchev B, Koev D, et al. Hypoglycemia anticipation, awareness and treatment training (HAATT) reduces occurrence of severe hypoglycemia among adults with type 1 diabetes mellitus. Int J Behav Med 2004;11:212-218 (Pubitemid 40082768)
33. Misono AS, Cutrona SL, Choudhry NK, et al. Healthcare information technology interventions to improve cardiovascular and diabetes medication adherence. Am J Manag Care 2010;16(Suppl. HIT):SP82-SP92