Impairments in glucose tolerance can have a negative impact on cognitive function: A systematic research review

Neuroscience and Biobehavioral Reviews

Volumn 33, Issue 3, 2009, Pages 394-413

  Lamport, Daniel J ^a   Lawton, Clare L ^a   Mansfield, Michael W ^b   Dye, Louise ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Attention; Cognition; Cognitive function; Cognitive performance; Cognitive tests; Glucoregulation; Glucose; Glucose tolerance; Impaired glucoregulation; Impaired glucose tolerance; Memory; Psychomotor

Indexed keywords

INSULIN;

ALERTNESS; ATTENTION; COGNITION; COGNITIVE DEFECT; DISEASE ASSOCIATION; GLUCOSE INTAKE; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROBLEM SOLVING; REVIEW; SEMANTIC MEMORY; SHORT TERM MEMORY; SYSTEMATIC REVIEW; VERBAL MEMORY; WORKING MEMORY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; COGNITION; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; GLUCOSE INTOLERANCE; HUMANS; INSULIN; LONGITUDINAL STUDIES; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SEX FACTORS; YOUNG ADULT;

EID: 59249097298     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2008.10.008     Document Type: Review

References (131)

1. Abdul-Ghani M.A., Jenkinson C.P., Richardson D.K., Tripathy D., and DeFronzo R.A. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance. Diabetes 55 (2006) 1430-1435
2. Allen J.B., Gross A.M., Aloia M.S., and Billingsley C. The effects of glucose on nonmemory cognitive functioning in the elderly. Neuropsychologia 34 (1996) 459-465
3. Allen K., Frier B.M., and Strachan M.W.J. The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. European Journal of Pharmacology 490 (2004) 169-175
4. American Diabetes Association. The expert committee of the diagnosis and classification of diabetes mellitus. Follow up report on the diagnosis of diabetes mellitus. Diabetes Care 26 (2003) 3160-3167
5. Amiel S.A. Nutrition of the brain: macronutrient supply. Proceedings of the Nutrition Society 53 (1994) 401-405
6. Awad N., Gagnon M., Desrochers A., Tsiakas M., and Messier C. Impact of peripheral glucoregulation on memory. Behavioral Neuroscience 116 (2002) 691-702
7. Awad N., Gagnon M., and Messier C. The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. Journal of Clinical and Experimental Neuropsychology 26 (2004) 1044-1080
8. Baker L.D., Watson G.S., Cholerton B., Reger M.A., Chapman D., and Hyde K. Acute intranasal administration improves verbal memory for adults with Alzheimer's disease. Society for Neuroscience Meeting (2003)
9. Balion C.M., Raina P.S., Gerstein H.C., Santaguida P.L., Morrison K.M., Booker L., and Hunt D.L. Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review. Clinical Chemistry and Laboratory Medicine 45 (2007) 1180-1185
10. Banks W., Jaspan J., Huang W., and Kastin A. Transport of insulin across the blood brain barrier: saturability at euglycemic doses of insulin. Peptides 18 (1997) 1423-1429
11. Banks W., Jaspan J., and Kastin A. Effect of diabetes mellitus on the permeability of the blood brain barrier to insulin. Peptides 18 (1997) 1577-1584
12. Banks W., Jaspan J., and Kastin A. Selective physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 18 (1997) 1257-1262
13. Baron A. The coupling of glucose metabolism and perfusion in human skeletal muscle. Diabetes 45 (1996) 105-109
14. Baskin D.G., Stein L.J., Ikeda H., Woods S.C., Figlewicz D.P., Porte D., Greenwood M.R.C., and Dorsa D.M. Genetically obese Zucker rats have abnormally low brain insulin content. Life Sciences 36 (1985) 627-633
15. Baura G.D., Foster D.M., Kaiyala K., Porte Jr. D., Kahn S.E., and Schwartz M.W. Insulin transport from plasma into the central nervous system in inhibited by dexamethasone in dogs. Diabetes 45 (1996) 86-90
16. Benedict C., Hallschmid M., Hatke A., Schultes B., Fehm H.L., Born J., and Kern W. Intranasal insulin improves memory in humans. Psychoneuroendocrinology 29 (2004) 1326-1334
17. Benton D., Ruffin M.P., Lassel T., Nabb S., Messaoudi M., Vinoy S., Desor D., and Lang V. The delivery rate of dietary carbohydrates affects cognitive performance in both rats and humans. Psychopharmacology 166 (2003) 86-90
18. Biessels G.J., Deary I.J., and Ryan C.M. Cognition and diabetes: a lifespan perspective. Lancet Neurology 7 (2008) 184-190
19. Biessels G.J., vab der Heide L.P., Kamal A., Bleys R.L., and Gipsen W.H. Ageing and diabetes: implications for brain function. European Journal of Pharmacology 441 (2002) 1-14
20. Blass J.P., and Gibson G.E. Carbohydrates and acetylcholine synthesis: implications for cognitive disorder. In: Davis K.L., and Berger P.A. (Eds). Brain Acetylcholine and Neuropsychiatric Disease (1979), Plenum Press, New York, NY 215-236
21. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
22. Cervos-Navarro J., and Kater S.B. Selective vulnerability in brain hypoxia. Critical Reviews in Neurobiology 6 (1991) 149-182
23. 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings of the National Academy for Science of the USA 90 (1993) 9898-9900
24. Choeiri C., Staines W., and Messier C. Immunohistochemical localization and quantification of glucose transports in the mouse brain. Neuroscience 111 (2002) 19-34
25. Cohen R. Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87 (1993) S67-S76
26. Convit A. Link between cognitive impairment in insulin resistance: an explanatory model. Neurobiology of Aging 26 (2005) S31-S35
27. Convit A., Wolf O.T., Tarshish C., and de Leon M.J. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proceedings of the National Academy of Science 100 (2003) 2019-2022
28. Craft S., Asthana S., Cook D.G., Baker L.D., Cherrier M., Purganan K., Wait C., Petrova A., Latendresse S., Watson G.S., Newcomer J.W., Schellenberg G.D., and Krohn A.J. Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology 28 (2003) 809-822
29. Craft S., Newcomer J., Kanne S., Dagogo-Jack S., Cryer P., Sheline Y., Luby J., Dagogo-Jack A., and Alderson A. Memory improvement following induced hyperinsulinaemia in Alzheimer's disease. Neurobiology of Aging 17 (1996) 123-130
30. Craft S., Murphy C., and Wemstrom J. Glucose effects on complex memory and nonmemory tasks: the influence of age, sex, and glucoregulatory response. Psychobiology 22 (1994) 95-105
31. Cukeirman T., Gerstein H.C., and Williamson J.D. Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 48 (2005) 2460-2469
32. den Heijer T., Vermeer S.E., van Dijk E.J., Prins N.D., Koudstaal P.J., Hofman A., and Breteler M.M. Type 2 diabetes and atrophy of the medial temporal lobe structures. Diabetologia 46 (2003) 1604-1610
33. Di Bonito P., Di Fraia L., Di Gennaro L., Vitale A., Lapenta M., Scala A., Lardino M.R., Cusati B., Attino L., and Capaldo B. Impact of impaired fasting glucose and other metabolic factors on cognitive function in elderly people. Nutrition, Metabolism, and Cardiovascular Disease 17 (2007) 203-208
34. Donohoe R.T., and Benton D. Glucose tolerance predicts performance on tests of memory and cognition. Physiology and Behavior 71 (2000) 395-401
35. Duelli R., Maurer M.H., Staudt R., Heiland S., Duembgen L., and Kuschinsky W. Increased cerebral glucose utilization and decreased glucose transporter Glut1 during chronic hyperglycemia in rat brain. Brain Research 858 (2000) 338-347
36. Dunstan D.W., Zimmet P.Z., Welborn T.A., de Courten M.P., Cameron A.J., Sicree R.A., Dwyer T., Colagiuri S., Jolley D., Knuiman M., Atkins R., and Shaw J.E. The rising prevalence of diabetes and impaired glucose tolerance: the Australian diabetes, obesity, and lifestyle study. Diabetes Care 25 (2002) 829-834
37. Elias P.K., Elias M.F., D'Agostino R.B., Cupples L.A., Wilson P.W., Silbershatz H., and Wolf P.A. NIDDM and blood pressure risk factors for poor cognitive performance: the Framingham study. Diabetes Care 20 (1997) 1388-1395
38. Elias M.F., Elias P.K., Sullivan L.M., Wolf P.A., and D'Agostino R.B. Obesity, diabetes and cognitive deficit: the Framingham heart study. Neurobiology of Aging 26 (2005) s11-s16
39. Folstein M., Folstein S., and McHugh P.R. 'Mini-Mental State'. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12 (1975) 189-198
40. Fontbonne A., Berr C., Ducimetiere P., and Alperovitch A. Changes in cognitive abilities over a 4 year period are unfavorably affected in elderly diabetic subjects. Diabetes Care 24 (2001) 366-370
41. Fuh J.-L., Wang S.-J., Hwut C.-M., and Lu S.-R. Glucose tolerance status and cognitive impairment in early middle-aged women. Diabetic Medicine 24 (2007) 788-791
42. Gabir M., Hanson R.I., Dabelea D., Imperatore G., Roumain J., Bennett P.H., and Knowler W.C. The 1997 American Diabetes Association and 1999 World Health Organisation criteria for hyperglycaemia in the diagnosis and prediction of diabetes. Diabetes Care 23 (2000) 1108-1112
43. Gibson G.E., Blass J.P., and Jenden D.J. Measurement of acetylcholine turnover with glucose used as a precursor: evidence for compartmentation of glucose metabolism in the brain. Journal of Neurochemistry 30 (1978) 71-76
44. Gold P.E. Role of glucose in regulating the brain and cognition. American Journal of Clinical Nutrition 61 (1995) S987-S995
45. Gradman T.J., Laws A., Thompson L.W., and Reaven G.M. Verbal learning and/or memory improves with glycaemic control in older subjects with non-insulin-dependent diabetes mellitus. Journal of the American Geriatrics Society 41 (1993) 1305-1312
46. Harris M.I., Flegal K.M., Cowie C.C., Eberhardt M.S., Goldstein D.E., Little R.R., Wiedmeyer H.M., and Byrd-Holt D.D. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults. Diabetes Care 21 (1998) 518-524
47. Helkala E., Lakka T., Vanhanen M., Tuomainen T.-P., Ehnholm C., Kaplan G.A., and Salonen J.T. Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample. Diabetic Medicine 18 (2001) 991-997
48. Hiltunen L.A., Keinanen-Kiukaanniemi S.M., and Laara E.M. Glucose tolerance and cognitive impairment in an elderly population. Public Health 115 (2001) 197-200
49. Hoyland A., Lawton C.L., and Dye L. Acute effects of macronutrient manipulations on cognitive test performance in healthy young adults: a systematic research review. Neuroscience and Biobehavioral Reviews 32 (2007) 72-85
50. Jacob R.J., Fan X., Evans M.L., Dziura J., and Sherwin R.S. Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier. Metabolism 51 (2002) 1522-1524
51. Jacobsen A.M., Musen G., Ryan C.M., Cleary P., Waberski B., Burwood A., Weinger K., Bayless M., Dahms W., and Harth J. Long term effects of diabetes and its long term treatment on cognitive function. New England Journal of Medicine 356 (2007) 1842-1852
52. Jacobson L., and Sapolsky R.M. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocorticol axis. Endocrine Reviews 12 (1991) 118-134
53. Kaiyala K.J., Prigeon R.L., Kahn S.E., Woods S.C., and Schwartz M.W. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 49 (2000) 1525-1533
54. Kalmijn S., Feskens E.J., Launer L.J., Stijnen T., and Kromhout D. Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia 38 (1995) 1096-1102
55. Kanaya A.M., Barrett-Connor E., Gildengorin G., and Yaffe K. Change in cognitive function by glucose tolerance status in older adults. Archives of Internal Medicine 164 (2004) 1327-1333
56. Kaplan R.J., Greenwood C.E., Winocur G., and Wolever T.M.S. Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates. American Journal of Clinical Nutrition 72 (2000) 825-836
57. Katz A., Nambi S.S., Mather K., Baron A.D., Follman D.A., Sullivan G., and Quon M.J. Quantitative insulin sensitivity check index: a simple accurate method for measuring insulin sensitivity in humans. Journal of Clinical Endocrinology and Metabolism 85 (2000) 2402-2410
58. Kern W., Peters A., Fruehwald-Schultes B., Wellhoener P., Deininger E., Born J., and Fehm H.L. Improving influence of insulin on cognitive functions in humans. Neuroendocrinology 74 (2001) 270-280
59. Kerr M., and Small D. Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development. Journal of Neuroscience Research 80 (2005) 151-159
60. Kirschbaum C., Wolf O.T., May M., Wippich W., and Hellhammer D.H. Stress and treatment inducing elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sciences 58 (1996) 1475-1483
61. Kumari M., Brunner E., and Fuhrer R. Minireview: mechanism by which the metabolic syndrome and diabetes impair memory. Journals of Gerontolgy. Series A, Biological Sciences and Medical Sciences 55 (2000) B228-232
62. Kumari M., and Marmot M. Diabetes and cognitive function in a middle-aged cohort. Neurology 65 (2005) 1597-1603
63. Laakso M., Edelman S.V., Brechtel G., and Baron A.D. Impaired insulin-mediated skeletal muscle blood flow in patients with DM. Diabetes 41 (1992) 1076-1083
64. Levitan E.B., Song Y., Ford E.S., and Liu S. Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. JAMA 293 (2005) 194-202
65. Lindeman R.D., Romero L.J., LaRue A.S., Lillian-Yau H.C., Schade D., Koehler K., Baumgartner R.N., and Garry P.J. A biethnic community survey of cognition in participants with type 2 diabetes, impaired glucose tolerance, and normal glucose tolerance. Diabetes Care 24 (2001) 1567-1572
66. Lupien S., DeLeon M., Desanti S., Convit A., Tarshish C., Nair N.P., McEwen B., Hauger R.L., and Meaney M.J. Stress induced declarative memory impairment in health elderly subjects: relationship to cortisol reactivity. Journal of Clinical Endocrinology and Metabolism 82 (1997) 2070-2075
67. Mattson M.P., Gurthrie P.B., and Kater S.B. Intrinsic factors in the selective vulnerability of hippocampal pyramidal neurons. Progress in Clinical and Biological Research 317 (1989) 333-351
68. McCall A.L. The impact of diabetes on the CNS. Diabetes 41 (1992) 557-570
69. McEwen B.S. Possible mechanisms for atrophy of the human hippocampus. Molecular Psychiatry 2 (1997) 255-263
70. McNay E.C., and Gold P.E. Age-related differences in hippocampal extracellular fluid glucose concentration during behavior testing and following systemic glucose administration. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56 (2001) B66-B71
71. McNay E.C., McCartney R.C., and Gold P.E. Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood. Neurobiology of Learning and Memory 75 (2001) 325-337
72. McNay E.C., Fries T.M., and Gold P.E. Decreases in rat extracellular hippocampal glucose concentrations associated with cognitive demand during a spatial task. Proceedings of the National Academy for Science of the USA 97 (2000) 2881-2885
73. McVeigh G.E., Brennan G.M., Johnston G.D., McDermott B.J., McGrath L.T., Henry W.R., Andrews J.W., and Hayes J.R. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35 (1992) 771-776
74. Meneilly G.S., Cheung E., Tessier D., Yakura C., and Tuokko H. The effect of improved glycaemic control on cognitive functions in the elderly patient with diabetes. Journal of Gerontology 48 (1993) M117-M121
75. Messier C. Glucose improvement of memory: a review. European Journal of Pharmacology 490 (2004) 33-57
76. Messier C. Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging. Neurobiology of Aging 26 (2005) S26-S30
77. Messier C., and Teutenberg K. The role of insulin, insulin growth, and insulin-degrading enzyme in brain aging and Alzheimer's disease. Neural Plasticity 12 (2005) 311-328
78. Messier C., Desrochers A., and Gagnon M. Effect of glucose, glucose regulation, and word imagery value on human memory. Behavioral Neuroscience 113 (1999) 431-438
79. Messier C., Durkin T., Mrabet O., and Destrade C. Memory-improving action of glucose: indirect evidence for a facilitation of hippocampal acetylcholine synthesis. Behavioral Brain Research 39 (1990) 135-143
80. Messier C., Gagnon M., and Knott V. Effect of glucose and peripheral glucose regulation on memory in the elderly. Neurobiology of Aging 18 (1997) 297-304
81. Messier C., Tsiakas M., Gagnon M., Desrochers A., and Awad N. Effect of age and glucoregulation on cognitive performance. Neurobiology of Aging 24 (2003) 985-1003
82. Mooradian A.D. Pathophysiology of central nervous system complications in diabetes mellitus. Clinical Neuroscience 4 (1997) 322-326
83. Mooradian A.D., and Morin A.M. Brain uptake of glucose in diabetes mellitus: the role of glucose transporters. American Journal of Medical Science 301 (1991) 172-177
84. Mudher A., and Lovestone S. Alzheimer's disease-do tauists and baptists finally shake hands?. Trends in Neuroscience 25 (2002) 22-26
85. Mussell M., Hewer W., Kulzer B., Bergis K., and Rist F. Effects of improved glycaemic control maintained for 3 months on cognitive function in patients with type 2 diabetes. Diabetic Medicine 21 (2004) 1253-1256
86. Nabb S., and Benton D. The influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance. Physiology and Behavior 87 (2006) 16-23
87. Naor M., Steingruber H., Westhoff K., Schottenfeld-Naor Y., and Gries A.F. Cognitive function in elderly non-insulin dependent diabetic patients before and after treatment for metabolic control. Journal of Diabetes and Its Complications 11 (1997) 40-46
88. Papanikolaou P., Palmer H., Binns M.A., Jenkins D.J.A., and Greenwood C.E. Better cognitive performance following a low-glycaemic-index compared with a high-glycaemic-index carbohydrate meal in adults with type 2 diabetes. Diabetologia 49 (2006) 855-862
89. Pelia R., Rodriguez B.L., and Launer L.J. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies-the Honolulu-Asia aging study. Diabetes 51 (2002) 1256-1262
90. Pelligrino D.A., LaManna J.C., Duckrow R.B., Bryan R.J., and Harik S.I. Hyperglycemia and blood-brain barrier glucose transport. Journal of Cerebral Blood Flow and Metabolism 12 (1992) 887-889
91. Plat L., Byrne M.M., Sturis J., Polonsky K.S., Mockel J., Fery F., and Van Cauter E. Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans. American Journal of Physiology 271 (1996) E36-42
92. Radzuik J. Insulin sensitivity and its measurements: structural commonalities among the methods. The Journal of Clinical Endocrinology and Metabolism 85 (2000) 4426-4433
93. Ragozzino M.E., Pal S.N., Unik K., Stefani M.R., and Gold P.E. Modulation of hippocampal acetylcholine release and spontaneous alternation scores by intrahippocampal glucose injections. Journal of Neuroscience 18 (1998) 1595-1601
94. Ragozzino M.E., Unick K.E., and Gold P.E. Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 4693-4698
95. Reagan L.P., Rosell D.R., Alves S.E., Hoskin E.K., McCall A.L., Charron M.J., and McEwen B.S. GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. Brain Research 932 (2002) 129-134
96. Reger M.A., Watson G.S., Frey W.H., Baker L.D., Cholerton B., Keeling M.L., Belongia D.A., Fishel M.A., Plymate S.R., Schellenberg G.D., Cherrier M.M., and Craft S. Effects of intranasal insulin on cognition in memory impaired older adults: modulation by APOE genotype. Neurobiology of Aging 27 (2006) 451-458
97. Riby L.M. The impact of age and task domain on cognitive performance: a meta-analytic review of the glucose facilitation effect. Brain Impairment 5 (2004) 145-165
98. Rolandsson O., Backestrom A., Eriksson S., Hallmans G., and Nilsson L.-G. Increased glucose levels are associated with episodic memory in nondiabetic women. Diabetes 57 (2008) 440-443
99. Rush D.K. Scopolamine amnesia of passive avoidance: a deficit of information acquisition. Behavioral and Neural Biology 50 (1988) 255-274
100. Rusted J.M., and Warburton D.M. Effects of Scopolamine on verbal memory-a retrieval or acquisition deficit. Neuropsychobiology 21 (1989) 76-83
101. Ryan C.M. Diabetes, ageing, and cognitive decline. Neurobiology of Aging 26 (2005) S21-S25
102. Ryan C.M., and Geckle M.O. Circumscribed cognitive dysfunction in middle-aged adults with type 2 diabetes. Diabetes Care 23 (2000) 1486-1493
103. Ryan C.M., and Geckle M.O. Why is learning and memory dysfunction in type 2 diabetes limited to older adults?. Diabetes Metabolic Research and Reviews 16 (2000) 308-315
104. Ryan C.M., Strachan M.W.J., Rood J.A., Waterhouse B.R., and Fried M.I. Diabetes 53 Suppl. 2 (2004) A25
105. Santaguida P.L., Balion C., Hunt D., Morrison K., Gerstein H., Paina P., Booker L., and Yazdi H. Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose. Summary, Evidence Report/Technology Assessment No. 128 (2005), AHRQ publication. Agency for Healthcare Research and Quality, Rockville, MD
106. Scott R., Kritz-Silverstein D., Barrett-Connor E., and Wiederholt W.C. The association of non-insulin dependent diabetes mellitus and cognitive function in an older cohort. Journal of the American Geriatrics Society 46 (1998) 1217-1222
107. Seaquist E.R., Damberg G.S., Tkac I., and Gruetter R. The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans. Diabetes 50 (2001) 2203-2209
108. Sekikawa A., Eguchi H., Tominaga M., Igarashi K., Abe T., Manaka H., Sasaki H., Fukuyama H., Kato T., Kiyohara Y., and Fujishima M. Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in a rural area of Japan: the Funagata diabetes study. Journal of Diabetes and Its Complications 14 (2000) 78-83
109. Silver I.A., and Erecinska M. Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation of oxygen supply in normo-, hypo-, and hyperglycemic animals. Journal of Neuroscience 14 (1994) 5068-5076
110. Simpson I.A., Appel N.M., Hokari M., Oki J., Holman G.D., Maher F., Koehler-Stec E.M., Vannucci S.J., and Smith Q.R. Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. Journal of Neurochemistry 72 (1999) 238-247
111. Stevenson E., Williams C., Nute M., Swaile P., and Tsui M. The effect of the glycemic index of an evening meal on the metabolic response to a standard high glycemic index breakfast and subsequent exercise in men. International Journal of Sports Nutrition and Exercise Metabolism 15 (2005) 308-322
112. Stewart R., and Liolitsa D. Type II diabetes mellitus, cognitive impairment and dementia. Diabetic Medicine 16 (1999) 93-112
113. Stolar M. Diabetic complications-atherosclerotic, cardiovascular, and cerebrovascular disease. Diabetes Mellitus in the Elderly (1990) 151-154
114. Strachan M.W. Insulin and cognitive function. The Lancet 18 (2003) 1253
115. Strachan M.W. Insulin and cognitive function in humans: experimental data and therapeutic considerations. Biochemical Society Transactions 33 (2005) 1037-1040
116. Strachan M.W., Dreary I.J., Ewing F.M., and Frier B.M. Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care 20 (1997) 435-438
117. Tripathy D., Carlsson M., Almgren P., Isoma B., Taskinen M.R., Tuomi T., and Groop L.C. Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia study. Diabetes 49 (2000) 975-980
118. Vanhanen M., Koivisto K., Karjalainen L., Helkala E.-L., Laakso M., Soininen H., and Riekkinen P. Risk for non-insulin-dependant diabetes in the normoglycaemic elderly is associated with impaired cognitive function. Neuroreport 8 (1997) 1527-1530
119. Vanhanen M., Koivisto K., Kuusisto J., Mykkanen L., Helkala E.-L., Hanninen T., Riekkinen P., Soininen H., and Laakso M. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care 21 (1998) 398-402
120. Vanhanen M., Kuusisto J., Koivisto K., Mykkanen L., Helkala E.L., Hanninen T., Reikkinen P., Soininen H., and Laasko M. Type-2 diabetes and cognitive function in a non-demented population. Acta Neurologica Scandinavica 100 (1999) 97-101
121. Watson G.S., Peskind E.R., Asthana S., Purganan K., Wait C., Chapman D., Schwartz M.W., Plymate S., and Craft S. Insulin increases CSF Abeta42 levels in normal older adults. Neurology 60 (2003) 1899-1903
122. Watson G.S., Reger M.A., Baker L.D., NcNeely M.J., Fujimoto W.Y., Kahn S.E., Boyko E.J., Leonetti D.L., and Craft S. Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose tolerance. Diabetes Care 29 (2006) 135-136
123. Watson G.S., Reger M.A., Cholerton B.A., Asthana S., Baker L.D., Rhoads K., Plymate S., Fishel M., Kahn S., and Craft S. Insulin increases CSF A[beta] 42 levels in normal older adults. Neurology 60 (2004) 1899-1903
124. Williams J.W., Zimmet P.Z., Shaw J.E., de Courten M.P., Cameron A.J., Chitson P., Tuomilehto J., and Alberti K.G. Gender differences in the prevalence of impaired fasting glycaemia and impaired glucose tolerance in Mauritius. Does sex matter?. Diabetic Medicine 20 (2003) 915-920
125. Wolever T.M., Jenkins D.J., Ocana A.M., Rao V.A., and Collier G.R. Second meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. American Journal of Clinical Nutrition 48 (1988) 1041-1047
126. Wolkowitz O.M., Reus V.I., Weingartner H., Thompson K., Breier A., Doran A., Rubinow D., and Pickar D. Cognitive effects of corticosteroids. American Journal of Psychiatry 147 (1990) 1297-1303
127. World Health Organisation. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications (1999), World Health Organisation
128. World Health Organization. Definition and Diagnosis of Diabetes and Intermediate Hyperglycaemia (2006), World Health Organisation
129. Yaffe K., Blackwell T., Kanaya A.M., Davidowitz N., Barrett-Connor E., and Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 63 (2004) 658-663
130. Zagar A.H., Khan A.R., Masoodi S.R., Laway B.A., Wani A.I., Bashir M.A., and Dar F.I. Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in the Kashmir valley of the Indian subcontinent. Diabetes Research and Clinical Practice 47 (2000) 135-146
131. Zimmet P., Albert K.G., and Shaw P. Global and social implications of the diabetes epidemic. Nature 414 (2001) 782-787