Effects of exercise on cardiovascular performance in the elderly

Frontiers in Physiology

Volumn 5 FEB, Issue , 2014, Pages

  Vigorito, Carlo ^a   Giallauria, Francesco ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Adrenergic system; Cardiovascular system; Elderly; Exercise; Vascular diseases

Indexed keywords

COLLAGEN FIBER;

AEROBIC CAPACITY; AGED; AGING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PERFORMANCE; CARDIOVASCULAR SYSTEM; COMORBIDITY; EXERCISE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HIGH RISK POPULATION; HUMAN; HYPERTENSION; PHYSICAL ACTIVITY; PROGNOSIS; REVIEW;

EID: 84895459854     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00051     Document Type: Review

References (88)

1. Ades, P. A., and Grunvald, M. H. (1990). Cardiopulmonary exercise testing before and after conditioning in older coronary patients. Am. Heart J. 120, 585-589. doi: 10.1016/0002-8703(90)90015-P.
2. Ades, P. A., Waldmann, M. L., Meyer, W. L., Brown, K. A., Poehlman, E. T., Pendlebury, W. W., et al. (1996). Skeletal muscle and cardiovascular adaptations to exercise conditioning in older coronary patients. Circulation 94, 323-330. doi: 10.1161/01.CIR.94.3.323.
3. Ades, P. A., Waldmann, M. L., Poehlman, E. T., Gray, P., Horton, E. D., Horton, E. S., et al. (1993). Exercise conditioning in older coronary patients. Submaximal lactate response and endurance capacity. Circulation 88, 572-577. doi: 10.1161/01.CIR.88.2.572.
4. Belardinelli, R., Georgiou, D., Cianci, G., and Purcaro, A. (1996). Effects of exercise training on left ventricular filling at rest and during exercise in patients with ischemic cardiomyopathy and severe left ventricular systolic dysfunction. Am. Heart J. 132, 61-70. doi: 10.1016/S0002-8703(96)90391-9.
5. Bhella, P. S., Prasad, A., Heinicke, K., Hastings, J. L., Arbab-Zadeh, A., Adams-Huet, B., et al. (2011). Abnormal hemodynamic response to exercise in heart failure with preserved ejection fraction. Eur. J. Heart Fail. 13, 1296-1304. doi: 10.1093/eurjhf/hfr133.
6. Borlaug, B. A., Melenovsky, V., Russell, S. D., Kessler, K., Pacak, K., Becker, L. C., et al. (2006). Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 114, 2138-2147. doi: 10.1161/CIRCULATIONAHA.106.632745.
7. Brubaker, P. H., Joo, K. C., Stewart, K. P., Fray, B., Moore, B., and Kitzman, D. W. (2006). Chronotropic incompetence and its contribution to exercise intolerance in older heart failure patients. J. Cardiopulm. Rehabil. 26, 86-89. doi: 10.1097/00008483-200603000-00007.
8. Brubaker, P. H., and Kitzman, D. W. (2011). Chronotropic incompetence: causes, consequences, and management. Circulation 123, 1010-1020. doi: 10.1161/CIRCULATIONAHA.110.940577.
9. Cannavo, A., Rengo, G., Liccardo, D., Pagano, G., Zincarelli, C., De Angelis, M. C., et al. (2013a). β 1-Adrenergic receptor and sphingosine-1-phosphate receptor 1 reciprocal down-regulation influences cardiac hypertrophic response and progression toward heart failure: protective role of S1PR1 cardiac gene therapy. Circulation 128, 1612-1622. doi: 10.1161/CIRCULATIONAHA.113.002659.
10. Cannavo, A., Rengo, G., Liccardo, D., Pironti, G., Scimia, M. C., Scudiero, L., et al. (2013b). Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation. Apoptosis 18, 1252-1261. doi: 10.1007/s10495-013-0876-9.
11. Chiappa, G. R., Roseguini, B. T., Vieira, P. J. C., Alves, C. N., Tavares, A., Winkelmann, E. R., et al. (2008). Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. J. Am. Coll. Cardiol. 51, 1663-1671. doi: 10.1016/j.jacc.2007.12.045.
12. Clemson, L., Fiatarone Singh, M. A., Bundy, A., Cumming, R. G., Manollaras, K., O'Loughlin, P., et al. (2012). Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial. BMJ 345:e4547. doi: 10.1136/bmj.e4547.
13. Cohen-Solal, A. (1996). Cardiopulmonary Exercise Testing in Chronic Heart Failure. Exercise Gas Exchange in Heart Disease. Armonk, NY: Futura Publishing Company.
14. Corbi, G., Conti, V., Russomanno, G., Rengo, G., Vitulli, P., Ciccarelli, A. L., et al. (2012b). Is physical activity able to modify oxidative damage in cardiovascular aging? Oxid. Med. Cell. Longev. 2012:728547. doi: 10.1155/2012/728547.
15. Corbi, G., Conti, V., Scapagnini, G., Filippelli, A., and Ferrara, N. (2012a). Role of sirtuins, calorie restriction and physical activity in aging. Front. Biosci. (Elite Ed.) 4:768-778. doi: 10.2741/417.
16. Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., et al. (2010). Sarcopenia: European consensus on definition and diagnosis. Report of the European working group on sarcopenia in older people. Age Ageing 39, 412-423. doi: 10.1093/ageing/afq034.
17. Desouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., et al. (2000). Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102, 1351-1357. doi: 10.1161/01.CIR.102.12.1351.
18. Dubach, P., Myers, J., Dziekan, G., Goebbels, U., Reinhart, W., Muller, P., et al. (1997). Effect of high intensity exercise training on central hemodynamic responses to exercise in men with reduced left ventricular function. J. Am. Coll. Cardiol. 29, 1591-1598. doi: 10.1016/S0735-1097(97)82540-5.
19. Duscha, B. D., Kraus, W. E., Keteyian, S. J., Sullivan, M. J., Green, H. J., Schachat, F. H., et al. (1999). Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations. J. Am. Coll. Cardiol. 33, 1956-1963. doi: 10.1016/S0735-1097(99)00101-1.
20. Femminella, G. D., Rengo, G., Pagano, G., de Lucia, C., Komici, K., Parisi, V., et al. (2013). β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy? J. Alzheimers Dis. 34, 341-347. doi: 10.3233/JAD-121813.
21. Fleg, J. L., Pina, I. L., Balady, G. J., Chaitman, B. R., Fletcher, B., Lavie, C., et al. (2000). Assessment of functional capacity in clinical and research applications. An Advisory From the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association. Circulation 102, 1591-1597. doi: 10.1161/01.CIR.102.13.1591.
22. Frankel, J. E., Bean, J. F., and Frontera, W. R. (2006). Exercise in the elderly: research and clinical practice. Clin. Geriatr. Med. 22, 239-256. doi: 10.1016/j.cger.2005.12.002.
23. Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., et al. (2001). Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56, M146-M156. doi: 10.1093/gerona/56.3.M146.
24. Frontera, W. R., Meredith, C. N., O'Reilly, K. P., and Evans, W. J. (1990). Strength training and determinants of VO2max in older men. J. Appl. Physiol. 68, 329-333.
25. Fujimoto, N., Prasad, A., Hastings, J. L., Arbab-Zadeh, A., Bhella, P. S., Shibata, S., et al. (2010). Cardiovascular effects of 1 year of progressive and vigorous exercise training in previously sedentary individuals older than 65 years of age. Circulation 122, 1797-1805. doi: 10.1161/CIRCULATIONAHA.110.973784.
26. Fujimoto, N., Prasad, A., Hastings, J. L., Bhella, P. S., Shibata, S., Palmer, D., et al. (2012). Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction. Am. Heart J. 164, 869-877. doi: 10.1016/j.ahj.2012.06.028.
27. Giallauria, F., Acampa, W., Ricci, F., Vitelli, A., Torella, G., Lucci, R., et al. (2013). Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function. Eur. J. Nucl. Med. Mol. Imaging 40, 315-324. doi: 10.1007/s00259-012-2302-x.
28. Giallauria, F., Cirillo, P., Lucci, R., Pacileo, M., De Lorenzo, A., D'Agostino, M., et al. (2008). Left ventricular remodelling in patients with moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and predictive role of N-terminal pro-brain natriuretic peptide. Eur. J. Cardiovasc. Prev. Rehabil. 15, 113-118. doi: 10.1097/HJR.0b013e3282f00990.
29. Giallauria, F., Del Forno, D., Pilerci, F., De Lorenzo, A., Manakos, A., Lucci, R., et al. (2005). Improvement of heart rate recovery after exercise training in older people. J. Am. Ger. Soc. 53, 2037-2038. doi: 10.1111/j.1532-5415.2005.00479_4.x.
30. Giannuzzi, P., Temporelli, P. L., Corrà, U., and ELVD-CHF Study Group. (2003). Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) trial. Circulation 108, 554-559. doi: 10.1161/01.CIR.0000081780.38477.FA.
31. Gielen, S., Sandri, M., Kozarez, I., Kratzsch, J., Teupser, D., Thiery, J., et al. (2012). Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig exercise intervention in chronic heart failure and aging catabolism study. Circulation 125, 2716-2727. doi: 10.1161/CIRCULATIONAHA.111.047381.
32. Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Lamb, S. E., Gates, S., Cumming, R. G., et al. (2009). Interventions for preventing falls in older people living in the community. Cochrane Database Syst. Rev. 3:CD007146. doi: 10.1002/14651858.CD007146.
33. Hambrecht, R., Fiehn, E., Yu, J., Niebauer, J., Weigl, C., Hilbrich, L., et al. (1997). Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J. Am. Coll. Cardiol. 29, 1067-1073. doi: 10.1016/S0735-1097(97)00015-6.
34. Hambrecht, R., Gielen, S., Linke, A., Fiehn, E., Yu, J., Walther, C., et al. (2000a). Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial. JAMA 283, 3095-3101. doi: 10.1001/jama.283.23.3095.
35. Hambrecht, R., Niebauer, J., Fiehn, E., Kälberer, B., Offner, B., Hauer, K., et al. (1995). Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J. Am. Coll. Cardiol. 25, 1239-1249. doi: 10.1016/0735-1097(94)00568-B.
36. Hambrecht, R., Wolff, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., et al. (2000b). Effect of exercise on coronary endothelial function in patients with coronary artery disease. N. Engl. J. Med. 342, 454-460. doi: 10.1056/NEJM200002173420702.
37. Harber, M. P., Konopka, A. R., Undem, M. K., Hinkley, J. M., Minchev, K., Kaminsky, L. A., et al. (2012). Aerobic exercise training induces skeletal muscle hypertrophy and age-dependent adaptations in myofiber function in young and older men. J. Appl. Physiol. 113, 1495-1504. doi: 10.1152/japplphysiol.00786.2012.
38. Haykowsky, M., McGavock, J., Vonder Muhll, I., Koller, M., Mandic, S., Welsh, R., et al. (2005). Effect of exercise training on peak aerobic power, left ventricular morphology, and muscle strength in healthy older women. J. Gerontol. A Biol. Sci. Med. Sci. 60, 307-311. doi: 10.1093/gerona/60.3.307.
39. Haykowsky, M. J., Brubaker, P. H., John, J. M., Stewart, K. P., Morgan, T. M., and Kitzman, D. W. (2011). Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J. Am. Coll. Cardiol. 58, 265-274. doi: 10.1016/j.jacc.2011.02.055.
40. Haykowsky, M. J., Brubaker, P. H., Stewart, K. P., Morgan, T. M., Eggebeen, J., and Kitzman, D. W. (2012). Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J. Am. Coll. Cardiol. 60, 120-128. doi: 10.1016/j.jacc.2012.02.055.
41. Haykowsky, M. J., Liang, Y., Pechter, D., Jones, L. W., McAlister, F. A., and Clark, A. M. (2007). A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed. J. Am. Coll. Cardiol. 49, 2329-2336. doi: 10.1016/j.jacc.2007.02.055.
42. Hollmann, W., Strüder, H. K., Tagarakis, C. V., and King, G. (2007). Physical activity and the elderly. Eur. J. Cardiovasc. Prev. Rehabil. 14, 730-739. doi: 10.1097/HJR.0b013e32828622f9.
43. Hornig, B., Maier, V., and Drexler, H. (1996). Physical training improves endothelial function in patients with chronic heart failure. Circulation 93, 210-214. doi: 10.1161/01.CIR.93.2.210.
44. Hundley, W. G., Bayram, E., Hamilton, C. A., Hamilton, E. A., Morgan, T. M., Darty, S. N., et al. (2007). Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction. Am. J. Physiol. Heart Circ. Physiol. 292, H1427-H1434. doi: 10.1152/ajpheart.00567.2006.
45. Jette, M., Heller, R., Landry, F., and Blumchen, G. (1991). Randomized 4-week exercise program in patients with impaired left ventricular function. Circulation 84, 1561-1567. doi: 10.1161/01.CIR.84.4.1561.
46. Keteyian, S. J., Levine, A. B., Brawner, C. A., Kataoka, T., Rogers, F. J., Schairer, J. R., et al. (1996). Exercise training in patients with heart failure. A randomized, controlled trial. Ann. Intern. Med. 124, 1051-1057. doi: 10.7326/0003-4819-124-12-199606150-00004.
47. Konopka, A. R., Trappe, T. A., Jemiolo, B., Trappe, S. W., and Harber, M. P. (2011). Myosin heavy chain plasticity in aging skeletal muscle with aerobic exercise training. J. Gerontol. A Biol. Sci. Med. Sci. 66A, 835-841. doi: 10.1093/gerona/glr088.
48. Lakatta, E. G., and Levy, D. (2003). Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation 107, 346-354. doi: 10.1161/01.CIR.0000048893.62841.F7.
49. Laoutaris, I. D., Adamopoulos, S., Manginas, A., Panagiotakos, D. B., Kallistratos, M. S., Doulaptsis, C., et al. (2013). Benefits of combined aerobic/resistance/inspiratory training in patients with chronic heart failure. A complete exercise model? A prospective randomised study. Int. J. Cardiol. 167, 1967-1972. doi: 10.1016/j.ijcard.2012.05.019.
50. Leosco, D., Rengo, G., Iaccarino, G., Golino, L., Marchese, M., Fortunato, F., et al. (2008). Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart. Cardiovasc. Res. 78, 385-394. doi: 10.1093/cvr/cvm109.
51. Levy, N. W., Ng, M., Martin, P., and Zieske, H. (1966). Sympathetic and parasympathetic interactions upon the left ventricle of the dog. Circ. Res. 19, 5-10. doi: 10.1161/01.RES.19.1.5.
52. Liu, C. J., and Latham, N. K. (2009). Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst. Rev. 3:CD002759. doi: 10.1002/14651858.CD002759.pub2.
53. Magnusson, G., Gordon, A., Kaijser, L., Sylvén, C., Isberg, B., Karpakka, J., et al. (1996). High intensity knee extensor training in patients with chronic heart failure. Major skeletal muscle improvement. Eur. Heart J. 17, 1048-1055. doi: 10.1093/oxfordjournals.eurheartj.a015001.
54. Mangione, K. K., Miller, A. H., and Naughton, I. V. (2010). Cochrane review: improving physical function and performance with progressive resistance strength training in older adults. Phys. Ther. 90, 1711-1715. doi: 10.2522/ptj.20100270.
55. Marciano, C., Galderisi, M., Gargiulo, P., Acampa, W., D'Amore, C., Esposito, R., et al. (2012). Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease. Eur. J. Nucl. Med. Mol. Imaging 39, 1199-1206. doi: 10.1007/s00259-012-2117-9.
56. McGuire, D. K., Levine, B. D., Williamson, J. W., Snell, P. G., Blomqvist, C. G., Saltin, B., et al. (2001). A 30-year follow-up of the Dallas bedrest and training study: II. Effect of age on cardiovascular adaptation to exercise training. Circulation 104, 1358-1366. doi: 10.1161/hc3701.096099.
57. Mühlberg, W., and Sieber, C. (2004). Sarcopenia and frailty in geriatric patients: implications for training and prevention. Z. Gerontol. Geriatr. 37, 2-8. doi: 10.1007/s00391-004-0203-8.
58. Nechwatal, R. M., Duck, C., and Gruber, G. (2002). Physical training as interval or continuous training in chronic heart failure for improving functional capacity, hemodynamics and quality of life: a controlled study. Z. Kardiol. 91, 328-337. doi: 10.1007/s003920200034.
59. Paolillo, S., Rengo, G., Pagano, G., Pellegrino, T., Savarese, G., Femminella, G. D., et al. (2013). Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study. Diabetes Care 36, 2395-2401. doi: 10.2337/dc12-2147.
60. Peterson, M. D., and Gordon, P. M. (2011). Resistance exercise for the aging adult: clinical implications and prescription guidelines. Am. J. Med. 124, 194-198. doi: 10.1016/j.amjmed.2010.08.020.
61. Peterson, M. D., Rhea, M. R., Sen, A., and Gordon, P. A. (2010). Resistance exercise for muscular strength in older adults: a meta-analysis. Ageing Res. Rev. 9, 226-237. doi: 10.1016/j.arr.2010.03.004.
62. Piepoli, M. F., Guazzi, M., Boriani, G., Cicoira, M. A., Corrà, U., Dalla Libera, L., et al. (2010). Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II. Eur. J. Cardiovasc. Prev. Rehabil. 17, 643-648. doi: 10.1097/HJR.0b013e32833f3aa5.
63. Pina, I. L., Apstein, C. S., Balady, G. J., Belardinelli, R., Chaitman, B. R., Duscha, B. D., et al. (2003). Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation 107, 1210-1225. doi: 10.1161/01.CIR.0000055013.92097.40.
64. Pollock, M. L., Carroll, J. F., Graves, J. E., Leggett, S. H., Braith, R. W., Limacher, M., et al. (1991). Injuries and adherence to walk/jog and resistance training programs in the elderly. Med. Sci. Sports Exerc. 23, 1194-1200. doi: 10.1249/00005768-199110000-00014.
65. Prasad, A., Popovic, Z. B., Arbab-Zadeh, A., Fu, Q., Palmer, D., Dijk, E., et al. (2007). The effects of aging and physical activity on Doppler measures of diastolic function. Am. J. Cardiol. 99, 1629-1636. doi: 10.1016/j.amjcard.2007.01.050.
66. Pu, C., Johnson, M., Forman, D., Piazza, L., and Fiatarone, M. (1997). High intensity progressive resistance training in older women with chronic heart failure. Med. Sci. Sports Exerc. 29, S148. doi: 10.1097/00005768-199705001-00845.
67. Rengo, F., Parisi, V., Rengo, G., Femminella, G. D., Rengo, C., Zincarelli, C., et al. (2012d). Instruments for geriatric assessment: new multidimensional assessment approaches. J. Nephrol. 25(Suppl. 19), S73-S78. doi: 10.5301/jn.5000164.
68. Rengo, G., Cannavo, A., Liccardo, D., Zincarelli, C., de Lucia, C., Pagano, G., et al. (2013). Vascular endothelial growth factor blockade prevents the beneficial effects of β-blocker therapy on cardiac function, angiogenesis and remodeling in heart failure. Circ. Heart Fail. 6, 1259-1267. doi: 10.1161/CIRCHEARTFAILURE.113.000329.
69. Rengo, G., Galasso, G., Femminella, G. D., Parisi, V., Zincarelli, C., Pagano, G., et al. (2014). Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure. Eur. J. Prev. Cardiol. 21, 4-11. doi: 10.1177/2047487313491656.
70. Rengo, G., Lymperopoulos, A., Zincarelli, C., Femminella, G., Liccardo, D., Pagano, G., et al. (2012b). Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2)-adrenoceptor-catecholamine production axis in heart failure. Br. J. Pharmacol. 166, 2430-2440. doi: 10.1111/j.1476-5381.2012.01972.x.
71. Rengo, G., Perrone-Filardi, P., Femminella, G. D., Liccardo, D., Zincarelli, C., de Lucia, C., et al. (2012c). Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside. Circ. Heart Fail. 5, 385-391. doi: 10.1161/CIRCHEARTFAILURE.112.966895.
72. Rengo, G., Zincarelli, C., Femminella, G. D., Liccardo, D., Pagano, G., de Lucia, C., et al. (2012a). Myocardial β (2)-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure. Br. J. Pharmacol. 166, 2348-2361. doi: 10.1111/j.1476-5381.2012.01954.x.
73. Rinaldi, B., Corbi, G., Boccuti, S., Filippelli, W., Rengo, G., Leosco, D., et al. (2006). Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart. Exp. Gerontol. 41, 764-770. doi: 10.1016/j.exger.2006.05.008.
74. Salazar, N. C., Vallejos, X., Siryk, A., Rengo, G., Cannavo, A., Liccardo, D., et al. (2013). GRK2 blockade with betaARKct is essential for cardiac beta2-adrenergic receptor signaling towards increased contractility. Cell Commun. Signal. 11, 64. doi: 10.1186/1478-811X-11-64.
75. Sarto, P., Balducci, E., Balconi, G., Fiordaliso, F., Merlo, L., Tuzzato, G., et al. (2007). Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J. Card. Fail. 13, 701-708. doi: 10.1016/j.cardfail.2007.06.722.
76. Sattelmair, J. R., Pertman, J. H., and Forman, D. E. (2009). Effects of physical activity on cardiovascular and noncardiovascular outcomes in older adults. Clin. Geriatr. Med. 25, 677-702. doi: 10.1016/j.cger.2009.07.004.
77. Savarese, G., Trimarco, B., Dellegrottaglie, S., Prastaro, M., Gambardella, F., Rengo, G., et al. (2013). Natriuretic peptide-guided therapy in chronic heart failure: a meta-analysis of 2,686 patients in 12 randomized trials. PLoS ONE 8:e58287. doi: 10.1371/journal.pone.0058287.
78. Spina, R. J., Ogawa, T., Kohrt, W. M., Martin, W. H.III., Holloszy, J. O., and Ehsani, A. A. (1993). Differences in cardiovascular adaptations to endurance exercise training between older men and women. J. Appl. Physiol. 75, 849-855.
79. Spina, R. J., Turner, M. J., and Ehsani, A. A. (1998). Beta-adrenergic-mediated improvement in left ventricular function by exercise training in older men. Am. J. Physiol. 274, H397-H404.
80. Stratton, J. R., Cerqueira, M. D., Schwartz, R. S., Levy, W. C., Veith, R. C., Kahn, S. E., et al. (1992). Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation 86, 504-512. doi: 10.1161/01.CIR.86.2.504.
81. Stratton, J. R., Dunn, J. F., Adamopoulos, S., Kemp, G. J., Coats, A. J., and Rajagopalan, B. (1994). Training partially reverses skeletal muscle metabolic abnormalities during exercise in heart failure. J. Appl. Physiol. 76, 1575-1582.
82. Sullivan, M. J., Green, H. J., Cobb, F. R. (1990). Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure. Circulation 81, 518-527. doi: 10.1161/01.CIR.81.2.518.
83. Sullivan, M. J., Higginbotham, M. B., and Cobb, F. R. (1988). Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects. Circulation; 78:506-515. doi: 10.1161/01.CIR.78.3.506.
84. Tyni-Lenne, R., Gordon, A., Jansson, E., Bermann, G., and Sylven, C. (1997). Skeletal muscle endurance training improves peripheral oxidative capacity, exercise tolerance, and health-related quality of life in women with chronic congestive heart failure secondary to either ischemic cardiomyopathy or idiopathic dilated cardiomyopathy. Am. J. Cardiol. 80, 1025-1029. doi: 10.1016/S0002-9149(97)00597-3.
85. Van der Meer, S., Zwerink, M., van Brussel, M., van der Valk, P., Wajon, E., and van der Palen, J. (2012). Effect of outpatient exercise training programmes in patients with chronic heart failure: a systematic review. Eur. J. Cardiovasc. Prev. Rehabil. 19, 795-803. doi: 10.1177/1741826711410516.
86. Vigorito, C., Incalzi, R. A., Acanfora, D., Marchionni, N., Fattirolli, F., and Gruppo Italiano di Cardiologia Riabilitativa e Preventiva. (2003). Raccomandazioni per la riabilitazione cardiovascolare del paziente molto anziano. [Recommandations for cardiovascular rehabilitation in the very elderly]. Monaldi Arch. Chest Dis. 60, 25-39.
87. Wilson, J. R., Mancini, D. M., and Dunkman, W. B. (1993). Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure. Circulation 87, 470-475. doi: 10.1161/01.CIR.87.2.470.
88. Wisloff, U., Stoylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø, Haram, P. M., et al. (2007). Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115, 3086-3094. doi: 10.1161/CIRCULATIONAHA.106.675041.