Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart

Cardiovascular Research

Volumn 78, Issue 2, 2008, Pages 385-394

  Leosco, Dario ^a   Rengo, Giuseppe ^b,c   Iaccarino, Guido ^a   Golino, Luca ^a   Marchese, Massimo ^a   Fortunato, Francesca ^a   Zincarelli, Carmela ^a,b   Sanzari, Emma ^a   Ciccarelli, Michele ^a,b   Galasso, Gennaro ^a   Altobelli, Giovanna Giuseppina ^a   Conti, Valeria ^d   Matrone, Gianfranco ^a   Cimini, Vincenzo ^a   Ferrara, Nicola ^c,e   Filippelli, Amelia ^d   Koch, Walter J ^b   Rengo, Franco ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c IRCCS   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e UNIVERSITY OF MOLISE   (Italy)

Author keywords

adrenergic receptor; Angiogenesis; Exercise training; Heart failure; Vascular endothelial growth factor

Indexed keywords

BETA ADRENERGIC RECEPTOR;

ADRENERGIC SYSTEM; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE SIZE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; LUNG CONGESTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; CORONARY CIRCULATION; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXERTION; HEART FAILURE; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE II; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 42349083039     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvm109     Document Type: Article

References (41)

1. Anversa P, Beghi C, Kikkawa Y, Olivetti G. Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth. Circ Res 1986;58:26-37.
2. Karam R, Healy BP, Wicker P. Coronary reserve is depressed in postmyocardial infarction reactive cardiac hypertrophy. Circulation 1990;81:238-246.
3. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 2005;115:2108-2118.
4. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K et al. Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts. N Engl J Med 1982;307:205-211.
5. 1-receptor down-regulation in heart failure. Circ Res 1986;59:297-309.
6. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning and heart function. Nature 2002;415:206-212.
7. Petrofski JP, Koch WJ. The β-adrenergic receptor kinase (βARK1) in heart failure. J Mol Cell Cardiol 2003;35:1167-1174.
8. Gros R, Chorazyczewski J, Meek MD, Benovic JL, Ferguson SS, Feldman RD. G-Protein-coupled receptor kinase activity in hypertension: increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension 2000;35:38-42.
9. Ungerer M, Bohm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of β-adrenergic receptor kinase and b1-adrenergic receptors in the failing human heart. Circulation 1993;87:454-463.
10. Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D et al. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 2005;26:1752-1758.
11. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 1995;268:1350-1353.
12. Rockman HA, Chien KR, Choi D-J, Iaccarino G, Hunter JJ, Ross J Jr et al. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of heart failure in gene targeted mice. Proc Natl Acad Sci USA 1998;95:7000-7005.
13. Shah AS, White DC, Emani S, Kypson AP, Lilly RE, Wilson K et al. In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 2001;103:1311-1316.
14. Harding V, Jones L, Lefkowitz RJ, Koch WJ, Rockman HA. Cardiac βARK1 inhibition prolongs survival and augments b blocker therapy in a mouse model of severe heart failure. Proc Natl Acad Sci USA 2001;98:5809-5814.
15. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992;72:369-417.
16. Brown MD. Exercise and coronary vascular remodelling in the healthy heart. Exp Physiol 2003;88:645-658.
17. Leosco D, Rengo G, Iaccarino G, Sanzari E, Golino L, De Lisa G et al. Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats. J Gerontol A Biol Sci Med Sci 2007;62:471-480.
18. Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T. Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. Am J Physiol Heart Circ Physiol 2006;291:H1290-H1298.
19. Gustafsson T, Puntschart A, Kaijser L, Jansson E, Sundberg CJ. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol Heart Circ Physiol 1999;276:H679-H685.
20. Leosco D, Rengo G, Iaccarino G, Filippelli A, Lymperopoulos A, Zincarelli C et al. Exercise and β-blocker treatment ameliorate age-impaired β-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. Am J Physiol Heart Circ Physiol 2007;293:H1596-H1603.
21. Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V et al. Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries. Am J Physiol Heart Circ Physiol 2003;285:H369- H374.
22. de Waard MC, van der Velden J, Bito V, Ozdemir S, Biesmans L, Boontje NM et al. Early exercise training normalizes myofilament function and attenuates left ventricular pump dysfunction in mice with a large myocardial infarction. Circ Res 2007;100:1079-1088.
23. MacDonnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J et al. Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation 2005;111:3420-3428.
24. Xiao RP, Spurgeon HA, O'Connor F, Lakatta EG. Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling. J Clin Invest 1994;94:2051-2059.
25. Musch TI, Moore RL, Leathers DJ, Bruno A, Zelis R. Endurance training in rats with chronic heart failure induced by myocardial infarction. Circulation 1986;74:431-441.
26. 2+-sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovasc Res 2002;54:162-174.
27. Gaudron P, Hu K, Schamberger R, Budin M, Walter B, Ertl G. Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction. Circulation 1994;89:402-412.
28. Kloner RA, Kloner JA. The effect of early exercise on myocardial infarct scar formation. Am Heart J 1983;106:1009-1013.
29. White FC, Bloor CM, McKirnan MD, Carroll SM. Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart. J Appl Physiol 1998;85:1160-1168.
30. Lei L, Zhou R, Zheng W, Christensen LP, Weiss RM, Tomanek RJ. Bradycardia induces Angiogenesis, Increases Coronary Reserve, and Preserves Function of the Postinfarcted Heart. Circulation 2004;110:796-802.
31. Rehman J, Li J, Parvathaneni L, Karlsson G, Panchal VR, Temm CJ et al. Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol 2004;43:2314-2318.
32. Koller A, Huang A, Sun D, Kaley G. Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Role of endothelial nitric oxide and prostaglandins. Circ Res 1995;76:544-550.
33. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2006;6:389-395.
34. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest 2005;115:2128-2138.
35. Shapiro LM, Smith RG. Effect of training of left ventricular structure and function-an echocardiographic study. Br Heart J 1983;50:534- 539.
36. Orenstein TL, Parker TG, Butany JW, Goodman JM, Dawood F, Wen WH et al. Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression. J Clin Invest 1995;96:858-866.
37. Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade. Circulation 1998;98:1783-1789.
38. Georget M, Mateo P, Vandecasteele G, Jurevicius J, Lipskaia L, Defer N et al. Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8). FASEB J 2002;16:1636-1648.
39. Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G et al. Ischemic neoangiogenesis enhanced by beta-2 adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circ Res 2005;97:1182-1189.
40. Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG et al. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007;129:511-522.
41. Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS et al. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest 2006;116:1547- 1560.