Physical activity and the elderly

European Journal of Preventive Cardiology

Volumn 14, Issue 6, 2007, Pages 730-739

  Hollmann, Wildor ^a   Strüder, Heiko K ^a   Tagarakis, Christos V m ^a   King, Gerard ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

ageing; brain and physical activity; physical performance capacity

Indexed keywords

AEROBIC CAPACITY; AGE DISTRIBUTION; AGING; BRAIN FUNCTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; DEPRESSION; DIABETES MELLITUS; ELDERLY CARE; ENDURANCE; EXERCISE; FALLING; FRACTURE; HEART INFARCTION; HEART OUTPUT; HUMAN; HYPERTENSION; LIFE EXPECTANCY; MOTOR UNIT; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE STRENGTH; NERVOUS SYSTEM DEVELOPMENT; OBESITY; OSTEOARTHRITIS; OSTEOPOROSIS; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SKELETAL MUSCLE; STROKE; SYSTOLIC BLOOD PRESSURE;

AGE FACTORS; AGED; AGING; CARDIOVASCULAR DISEASES; DISEASE PROGRESSION; HUMANS; MIDDLE AGED; MOTOR ACTIVITY; RISK FACTORS;

EID: 36749048224     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/HJR.0b013e32828622f9     Document Type: Review

References (149)

1. Department of Health. National service framework for older people. London: The Stationery Office; 2001.
2. Booth FW, Gordon SE, Carlson CHJ, Hamilton MT. Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol 2000; 88: 774–787.
3. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV. The relation between insulin sensitivity and the fatty-acid-composition of skeletal-muscle-phospholipids. N Engl J Med 1993; 328: 238–244.
4. De Groot L, Verheijden MW, de Henauw ST, Schroll M, van Staveren WA. Lifestyle, nutritional status, health, and mortality in elderly people across Europe: a review of the longitudinal results of the SENECA study. J Gerontol: Med Sci 2004; 59A: 1277–1284.
5. Gill THM, Allore H, Guo Z. The deleterious effects of bed rest among community-living older persons. J Gerontol: Med Sci 2004; 59A: 755–761.
6. Greenleaf JE. Physiology of prolonged bed rest. NASA Tech Memorandum 1988; 101010: 1–8.
7. Hollmann W, Hettinger TH. Sports medicine - fundamentals for work, training and preventive medicine [in German]. Stuttgart: Schattauer; 2000.
8. American College of Sports Medicine. Position stand on exercise and physical activity for older adults. Med Sci Sports Exerc 1998; 30: 992–1008.
9. Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand 1960; 49 (Suppl 169): 11.
10. Astrand I, Astrand PO, Hallback I, Kilbom A. Reduction in maximal oxygen intake with age. J Appl Physiol 1973; 35: 649–654.
11. Hollmann W. Maximum and continuous work capacity in athletes [in German]. Barth: München; 1963.
12. Hollmann W. Diminution of cardio-pulmonary capacity in the course of life and its prevention by participation in sports. Tokyo: University of Tokyo Press; 1966.
13. Hollmann W. Physical activity as a prevention for cardiovascular diseases [in German]. Stuttgart: Hippokrates; 1965.
14. Robinson S. Experimental studies of physical fitness in relation to age. Arbeitsphysiol 1938; 10: 251–323.
15. Hollmann W, Liesen H, Rost R, Kawahats K. Physical performance and trainability in the elderly [in German]. Z Gerontol 1978; 11: 312–318.
16. Chesky JA, Rockstein M. Reduced myocardial actomyosin adenosine triphosphatase activity in the aging male Fischer rat. Cardiovasc Res 1977; 11: 242–246.
17. Ehsani AA, Ogawa T, Miller TR, Spina RJ, Jilka SM. Exercise training improves left ventricular systolic function in older men. Circulation 1991; 83: 96–103.
18. Lakatta EG, Levy D. Arterial and cardiac aging: major chairholders in cardiovascular disease enterprises. Part II: The aging heart in health: links to heart disease. Circulation 2003; 107: 346–354.
19. Lakatta EG. Arterial and cardiac aging: major chairholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation 2003; 107: 490–497.
20. Lompre AM, Lambert F, Lakatta EG, Schwartz K. Expression of sarcoplasmic reticulum Ca2+-ATPase and calsequestrin genes in rat heart during ontogenic development and aging. Circ Res 1991; 69: 1380–1388.
21. Harridge SD, Bottinelli R, Canepari M, Pellegrino MA, Reggiani C, Esbjornsson M, Saltin B. Whole-muscle and single-fibre contractile properties and myosin heavy chain isoforms in humans. Pflügers Arch 1996; 432: 913–920.
22. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA 1997; 94: 4318–4323.
23. Bhatnagar GM, Walford GD, Beard ES, Humphreys S, Lakatta EG. ATPase activity and force production in myofibrilles and twitch characteristics in intact muscle from neonatal, adult, and senescent rat myocardium. J Mol Cell Cardiol 1984; 16: 203–218.
24. Carrier L, Boheler KR, Chassagne C, de la Bastie D, Wisnewsky C, Lakatta EG, Schwartz K. Expression of the sarcomeric actin isogenes in the rat heart with development of senescence. Circ Res 1992; 70: 999–1005.
25. Cleland SJ, Petrie JR, Ueda S, Elliott HL, Connell JM. Insulin as a vascular hormone: implications for the pathophysiology of cardiovascular disease. Clin Exp Pharmacol Physiol 1998; 25: 175–184.
26. Holubarsch CH, Goulett RP, Litten RZ, Martin BJ, Mulieri LA, Alpert NR. The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium. Circ Res 1985; 56: 78–86.
27. Tate CHA, Hyek MF, Taffet GE. Mechanisms for the responses of cardiac muscle to physical activity in old age. Med Sci Sports Exerc 1994; 26 (No 5): 561–567.
28. Liesen H, Dufaux B, Heck H, Mader A, Rost R, Lötzerich S, Hollmann W. Physical stress and training in the elderly [in German]. Dtsch Z Sportmed 1979; 30: 218–225.
29. Liesen H, Heikkinen E, Suominen H, Michel D. Effects of a 12-month endurance training on metabolic muscular performance in untrained men [in German]. Sportarzt Sportmed 1975; 2: 26–33.
30. Suominen H, Heikkinen E, Liesen H, Michel D, Hollmann W. Effects of 8 weeks' endurance training on skeletal muscle metabolism in 56-70-year-old sedentary men. Eur J Appl Physiol 1977; 37: 173–180.
31. Liesen H, Hollmann W. Increased physical performance and metabolic muscular adaptations after endurance training in the elderly [in German]. Gereatr 1976; 6: 150–156.
32. Philippi H, Hollmann W, Liesen H. Effects of a local aerobic training on the blood circulation in the muscle and on the local aerobic endurance performance of men and women [in German]. Sportarzt Sportmed 1973; 2: 30–36.
33. Wahren J, Saltin B, Jorfeldt L, Pernow B. Influence of age on the local circulatory adaptation to leg exercise. Scand J Clin Lab Invest 1974; 33: 79–86.
34. Williamson JR, Hoffmann PL, Kohrt WM, Spina RJ, Coggan AR, Holloszy JO. Endurance exercise training decreases capillary basement membrane width in older non-diabetic and diabetic adults. J Appl Physiol 1996; 80: 747–754.
35. Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, et al. Effect of aging and physical activity on left ventricular compliance. Circulation 2004; 110: 1799–1805.
36. Bean JF, Vora A, Frontera WR. Benefits of exercise for community-dwelling older adults. Arch Phys Med Rehabil 2004; 85 (Suppl 3): S31–S44.
37. Blair SN, Kohl HW, Paffenbarger RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality: a prospective study of healthy men and women. J Am Med Ass 1989; 262: 2395–2401.
38. Bouchard C, Rankinen T, Changon YC, Rice T, Perusse L, Gagnon J, et al. Genomic scan for maximal oxygen uptake and its response to training in the heritage family study. J Appl Physiol 2000; 88: 551–559.
39. Brown MD. Exercise and coronary vascular remodelling in the healthy heart. Exper Physiol 2003; 88: 645–658.
40. Gates PE, Moreau KL, Eskurza I, Seals DR. Aging and cardiovascular function with acute and habitual exercise. Eur Rev Aging Physical Activity 2005; 2: 35–46.
41. Haskell WL. Sports, exercise and health [in German]. Orthopäde 2000; 29: 930–935.
42. Hubert HB, Bloch DA, Oehlert JW, Fries JF. Lifestyle habits and compression of morbidity. J Gerontol Med Sci 2002; 57A: M347–M351.
43. Paffenbarger RS, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. New Engl J Med 1986; 314: 605–613.
44. Sharma S. Athlete's heart: effect of age, sex, ethnicity and sporting discipline. Exper Physiol 2003; 88: 665–669.
45. Taylor AH, Cable NT, Faulkner G, Hillsdon M, Narici M, Van der Bij AK. Physical activity and older adults: a review of health benefits and the effectiveness of interventions. J Sports Sci 2004; 22: 703–725.
46. US Department of Health and Human Services (USDHHS) Physical activity and health: a report of the surgeon general (executive summary). Pittsburgh, Pennsylvania: Superintendent of Documents.
47. Lexell J, Taylor CC, Sjörström M. What is the cause of the aging atrophy? Total number, size and proportion of different fibre types studied in whole vastus lateralis muscle from 15-83-year-old men. J Neurol Sci 1988; 84: 275–283.
48. Doherty TJ. Physiology of aging: invited review: aging and sarcopenia. J Appl Physiol 2003; 95: 1717–1727.
49. Porter MN, Vandervoort AA, Lexell J Aging of human muscle: structure, function and adaptability Scand J Med Sci Sports 1995; 5: 129–137.
50. Phillips SK, Brook KM, Siddle NC, Bruce SA, Woledge RC. Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clin Sci 1992; 84: 95–102.
51. Vandervoort AA, Kramer JE, Wharran ER. Eccentric knee strength of elderly females. J Gerontol 1990; 45: B125–131.
52. Klitgaard H, Zhou M, Schiaffino S, Betto R, Salviati G, Saltin B. Aging alters the myosin heavy chain composition of single fibres from human skeletal muscle. Acta Physiol Scand 1990; 140: 55–62.
53. Kawamura Y, O'Brian PC, Okazaki H, Dyck PJ. Lumbar motoneurons of man. II. Numbers and diameter distributions of large-and intermediate-diameter cytons in‘motoneurons columns' of spinal cord of man. J Neuropathol Exp Neurol 1977; 36: 860–866.
54. Tomlinson BE, Irving D. The numbers of limb motoneurons in the human lumbosacral cord throughout life. J Neurol Sci 1977; 34: 213–220.
55. Aniansson A, Grimby G, Hedberg M. Compensatory muscle fibre hypertrophy in elderly men. J Appl Physiol 1992; 73: 812–816.
56. Aniansson A, Sperling L, Rundgren A, Lehnberg E. Muscle function in 75-year-old men and women, a longitudinal study. Scand J Rehabil Med 1983; 9 (Suppl 9): 92–101.
57. Barton E, Morris C. Mechanisms and strategies to counter muscle atrophy [review article]. J Gerontol: Med Sci 2003; 58A (No 10): 923–926.
58. Frontera WR, Meredith CN, O'Reilly KP, Knuttgen WG, Ivans WJ. Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988; 64: 1038–1044.
59. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. JAMA 1990; 263: 3029–3034.
60. Fiatarone MA, O'Neill EF, Doyleryan N, Clements KM, Solares GR, Nelson ME, et al. Exercise training and supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769–1775.
61. Sherman LA, Hirshman MF, Cormot M, March-And-Brustel AL, Goodyear LJ. Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle. Endocrinol 1996; 137: 266–273.
62. Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S. Type IIx myosin heavy chain transcripts are expressed in type IIb fibres of human skeletal muscle. Am J Physiol 1994; 267: C1723–C1728.
63. Andersen P, Henriksson J. Training induced changes in the subgroups of human type II skeletal muscle fibres. Acta Physiol Scand 1977; 99: 123–125.
64. Karlsson J, Diamant B, Volkers K, Lund B. Muscle fibre types, ubiquinone content and exercise capacity in hypertension and effort angina. Ann Med 1991; 23: 339–344.
65. Larsson L, Li X, Yu F, Degens H. Age-related changes in contractile properties and expression of myosin isoforms in single skeletal muscle cells. Muscle Nerve 1997; 5 (Suppl 5): 74–78.
66. Saltin B, Helge JW. Skeletal muscles, physical activity and health [in German]. Orthopäde 2000; 29: 941–947.
67. Saltin B, Gollnick P. Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of physiology: skeletal muscle 1983. PP 555–631.
68. Lexell J, Downham JD. What is the effect of aging on type II muscle fibres? J Neurol Sci 1992; 107: 250–257.
69. Orlander J, Aniansson A. Effects of physical training on skeletal muscle metabolism and ultrastructure in 70 to 75-year-old men. Acta Physiol Scand 1979; 109: 149–154.
70. Shono N, Mizuno M, Nishida H, Higaki Y, Urata H, Tanaka H, et al. Decreased skeletal muscle capillarization is related to higher serum levels of LDL cholesterol and apolipoprotein P in men. Metabolism 1999; 48: 1267–1271.
71. Schön EA, Hollmann W, Leresen H, Waterloh E. Electron microscopical results on the m. vastus lateralis of untrained people and marathon runners and the relationships to maximal oxygen uptake and lactate accumulation [in German]. Bad Nauheim: Deutscher Sportärzte-Kongress; 1978.
72. Helge JW, Kiens B. Muscle enzyme activity in men: role of substrate availability and training. Am J Physiol 1997; 272: R1620–R1624.
73. Kliwer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992; 358: 771–774.
74. Andersson A, Sjödin A, Olsson R, Vessby B. Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am J Physiol 1998; 274: E432–E438.
75. Lindgarde F, Saltin B. Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middle-aged men. Diabetologica 1981; 20: 134–138.
76. Blair SN, Brodney S. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc 1999; 31: 5646–5662.
77. Andersen JL, Schiaffino S. Mismatch between myosin heavy chain mRNA and protein distribution in human skeletal muscle fibres. Am J Physiol 1997; 272: C1881–C1889.
78. Frisk-Holmberg M, Essen B, Fredrikson M, Strom G, Wibell L. Muscle fibre composition in relation to blood pressure response to isometric exercise in normotensive and hypertensive subjects. Acta Med Scand 1983; 213: 21–26.
79. Krotkiewski M, Lithell H, Shono N, Wysocki M, Holm G. High blood pressure and muscle morphology/metabolism: causal relationship or only associated factors? Clin Physiol 1998; 18: 203–213.
80. Laughlin MH. Endothelium-mediated control of coronary vascular tone after chronic exercise training. Med Sci Sports Exerc 1995; 27: 1135–1144.
81. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109–142.
82. Celermajer DS, Sörensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994; 24: 471–476.
83. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal and endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22–27.
84. Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997; 95: 1119–1121.
85. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 1996; 334: 150–154.
86. Gaenzer H, Sturm W, Neumayr G. Pronounced postprandial lipemia impairs endothelium-dependent dilatation of the brachial artery in men. Cardiovasc Res 2001; 52: 509–516.
87. Cooke JP, Tsao PS. Is NO an endogenous anti-artherogenic molecule? Arterioscler Thromb 1994; 14: 653–655.
88. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 1135–1143.
89. Rinder MR, Spina RJ, Ehsani AA. Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol 2000; 88: 761–766.
90. Hambrecht R, Niebauer J, Marburger C, Grunze M, Kalberer B, Hauer K, et al. Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol 1993; 22: 468–477.
91. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998; 98: 2709–2715.
92. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454–460.
93. Bloch W, Schmidt A. Sport and free radicals/antioxidants [in German]. Blickpunkt Der Mann 2004; 3: 13–18.
94. Woodman CR, Müller JM, Laughlin MH, Price EM. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol 1997; 273: H2575–H2579.
95. Marcell TJ. Sarcopenia: causes, consequences, and preventions [review article]. J Gerontol: Med Sci 2003; 58A (No 10): 911–916.
96. Moyna NM, Estrada E, LaRocha GM, Sarnoski C, Wark A, Meckes CL, et al. Endothelial function in adolescence with type 2 diabetes. Med Sci Sport Exerc 2001; 33: S395.
97. Morgan TE, Cobb LA, Short FA, Ross R, Gunn DR. Effects of long-term exercise on human muscle mitochondria. Adv Exp Biol Med 1971; 11: 87–95.
98. Carmeli E. The molecular basis of aging skeletal muscle and physical activity. Eur Rev Aging Phys Activity 2005; 2: 57–66.
99. Coyle EF, Martin WH III, Sinacore DR, Joyner MJ, Hagberg JM, Holloszy JO. Time course of loss of adaptations after stopping prolonged intense endurance training. J Appl Physiol 1984; 57: 1857–1864.
100. Kirwan JP, Kohrt WM, Wojta DM, Bourey RE, Holloszy JP. Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year old men and women. J Gerontol 1993; 48: M84–M90.
101. Rogers MA, King DS, Hagberg JM, Ehsani AA, Holloszy JO. Effect of 10 days of physical inactivity on glucose tolerance in master athletes. J Appl Physiol 1990; 68: 1833–1837.
102. Lipman RL, Raskin P, Love T, Triebwasser J, Lecocq FR, Schnure JJ, Glucose intolerance during decreased physical activity in man. Diabetes 1972; 21: 101–107.
103. Smorawinski J, Kaciuba-Uscilko H, Nazar K, Kubala P, Kaminska E, Ziemba AW, et al. Effects of 3-day bed rest on metabolic, hormonal and circulatory response to an oral glucose load in endurance or strength trained athletes and untrained subjects. J Physiol Pharmacol 2000; 51: 279–289.
104. Hutber CA, Hardie DG, Winder WW. Electrical stimulation inactivates muscle acethyl-CoA carboxylase and increases AMP-activated protein kinase. Am J Physiol 1997; 272: E262–E266.
105. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 1999; 276: E1–E18.
106. Goodyear LJ, Kahn BB. Exercise glucose transport and insulin sensitivity. Ann Rev Med 1998; 49: 235–261.
107. Yarasheski KE. Exercise, aging, and muscle protein metabolism. [review article]. J Gerontol Med Sci 2003; 58A (No 10): 918–922.
108. Roubenoff R. Sarcopenia: effects on body composition and function. J Gerontol: Med Sci 2003; 58A (No 11): 1012–1017.
109. Yarasheski KE, Zachwieja JJ, Bier DM. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol 1993; 265: E210–E214.
110. Sagiv M, Amir R. Genes and the response of elderly to physical activity. Eur Rev Aging Physical Activity 2005; 2: 4–5.
111. Barry BK, Carson RG. The consequences of resistance training for movement control in older adults. [review article]. J Gerontol Med Sci 2004; 59A (No 7): 730–754.
112. Lambert CP, Sullivan DH, Evans WJ. Effects of testosterone replacement and/or resistance training on interleucin-6, tumor necrosis factor-alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial. J Gerontol Med Sci 2003; 58A: 165–170.
113. Taffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleucin-6 and C-reactive protein and physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol Med Sci 2000; 55A: M709–M715.
114. Visser M, Pahor M, Taffe DR, Goodpaster BH, Simonsick EM, Newman AB, et al. Relationship of interleucin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women. The Health ABC study. J Gerontol Med Sci 2002; 57A: M326–M332.
115. Roth SM, Martel GF, Ivey FM, Lemmer JT, Metter EJ, Hurley BF, et al. Skeletal muscle satellite cell populations in healthy young and older men and women. Anat Rec 2000; 260: 351–358.
116. Roth SM, Martel GF, Ivey FM, Lemmer JT, Tracy BL, Metter EJ, et al. Skeletal muscle satellite cell characteristics in young and older men and women after heavy resistance strength training. J Gerontol Biol Sci 2001; 56A: B240–B247.
117. Booth FW, Weeden STH, Tseng BS. Effect of aging on human skeletal muscle and motor function. Med Sci Sports Exerc 1994; 26 (No 5): 556–560.
118. Booth FW, Shanely RA. The biochemical basis of the health effects of exercise: an integrative view. Proc Nutr Soc 2004; 63: 199–203.
119. Seeman E. Physiology of aging - invited review: pathogenesis of osteoporosis. J Appl Physiol 2003; 95: 2142–2451.
120. Bhasin S. Testosterone supplementation for aging-associated sarcopenia [review article]. J Gerontol: Med Sci 2003; 58A (No 11): 1002–1008.
121. Gruenewald DA, Matsumoto AV. Testosterone supplementation therapy for older men: potential benefits and risks. JAGS 2003; 51: 101–115.
122. Close J, Ellis M, Hooper R, Glucksman E, Jackson S, Swift C. Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. Lancet 1999; 353: 93–97.
123. Tinetti ME. Preventing falls in elderly persons. N Engl J Med 2003; 348: 42–49.
124. Friedman D. Event-related brain potential investigations of memory and aging. Biol Psychol 2000; 54: 175–206.
125. Haug H, Barmwater U, Eggers R, Fischer D, Kuhl S, Sass NL. Anatomical changes in aging brain: morphometric analysis of the human prosencephalon. In: Cervos-Navarro J, Sarkander HI, editors. Neuropharmacology of aging. New York: Raven Press; 1983. Vol 21: pp. 1–12.
126. Haug H, Eggers R. Morphometry of the human cortex cerebry and corpus striatum during aging. Neurobiol Aging 1991; 12: 336–338.
127. Albert MS, Duffy FH, Naeser M. Nonlinear changes in cognition with age and their neuropsychologic correlates. Can J Psychol 1987; 41: 141–157.
128. Golomb J, DeLeon MJ, Kluger A, George AE, Jorshish C, Ferris SH. Hippocampal atrophy in normal aging: an association with recent memory impairment. Arch Neurol 1993; 50: 967–973.
129. Squire LR. Memoryand brain. New York: Oxford University Press; 1987.
130. Hollmann W, Strüder HK. Brain, psyche and physical activity [in German]. Orthopäde 2000; 29: 948–956.
131. Hollmann W, Strüder HK. The biological basis of physical performance and trainability of the different motor demands in the elderly. Eur Rev Aging Phys Activity, Ann Ref 2005; 2: 35–48.
132. Hollmann W, Strüder HK, Tagarakis CVM. Physical Activity enhances brain-health and -performance. Review and own results [in German]. Nervenheilkunde 2003; 22: 467–474.
133. Schmidt D, Krause BJ, Herzog H, Strüder HK, Klose C, Wouters E, et al. Age-dependent changes in activation patterns during encoding and retrieval of visually presented word-pair associates. NeuroImage 1999; 9: 908–915.
134. Schmidt D, Krause BJ, Herzog H, Strüder HK, Hautzel H, Klose C, et al. Influence of memory load on the change of regional cerebral blood flow during verbal working memory in elderly subjects. NeuroImage 1999; 9: 907–913.
135. Strüder HK, Hollmann W, Platen P, Rost R, Weicker H, Kirchhof O, Weber K. Neuroendocrine system and mental function in sedentary and endurance-trained elderly males. Int J Sports Med 1999; 20: 159–166.
136. Strüder HK, Hollmann W, Platen P, Rost R, Weicker H, Weber K. Hypothalamic-pituitary-adrenal and -gonadal axis function after exercise in sedentary and endurance trained elderly males. Eur J Appl Physiol 1998; 77: 285–287.
137. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky KA. Prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Int Med 2001; 161: 1703–1708.
138. Butler RN, Forette F, Greengross BS. Maintaining cognitive health in an aging society. JRSH 2004; 124: 119–121.
139. Tong L, Shen H, Perreau VM, Balazs R, Cotman CW. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 2001; 8: 1046–1056.
140. Eriksson PS, Perfilieva E, Björk-Eriksson TH, Alborn AM, Nordborg C, Peterson DA, Gage FH. Neurogenesis in the adult human hippocampus. Nat Med 1998; 4: 1313–1317.
141. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 2001; 58: 498–504.
142. Churchill JD, Galvez R, Colcombe ST, Swain RA, Kramer AF, Greenough WT. Exercise, experience and the aging brain. Neurobiol Aging 2002; 23: 941–955.
143. Verghese J, Lipton R, Katz B, Hall MJ, Derby CB, Kuslansky CA, et al. Leisure activities and the risk of dementia in the elderly. N Engl J Med 2003; 348: 2508–2516.
144. Fabre C, Chamari K, Mucci P, Masse-Biron J, Prefaut C. Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med 2002; 23: 415–421.
145. Cotman CW, Berchtold NC. Exercise: a behavioural intervention to enhance brain health and plasticity. Trends Neurosci 2002; 25: 295–301.
146. Fillit HM, Butler RN, O'Connell HW, Albert MS, Birren JE, Cotman CW, et al. Achieving and maintaining cognitive vitality with aging. [review]. Mayo Clin Proc 2002; 77: 681–696.
147. Hogan M. Physical and cognitive activity and exercise for older adults: a review. Int J Aging Hum Dev 2005; 60: 95–126.
148. Kramer AF, Bherer L, Colcombe STJ, Dong W, Greenough WT. Environmental influence on cognitive and brain plasticity during aging [review article]. J Gerontol Med Sci 2004; 59A (No 9): 940–957.
149. Rogers RL, Meyer JS, Mortel KF. After reaching retirement age physical activity sustains cerebral perfusion and cognition. JAGS 1990; 38: 123–128.