Cell encapsulation via microtechnologies

Biomaterials

Volumn 35, Issue 9, 2014, Pages 2651-2663

  Kang, AhRan ^a   Park, JiSoo ^a   Ju, Jongil ^a   Jeong, Gi Seok ^a   Lee, Sang Hoon ^a  

^a Korea University   (South Korea)

Author keywords

Cell encapsulation; Immune protection; Microencapsulation; Microtechnology; Tissue engineering; Transplantation

Indexed keywords

CELL ENCAPSULATION; IMMUNE PROTECTION; MICROENCAPSULATION; MICROTECHNOLOGY; TISSUE ENGINEERING; TRANSPLANTATION;

ANIMALS; CELLS; CELLS, IMMOBILIZED; HUMANS; MICROFLUIDICS; MICROSPHERES; MICROTECHNOLOGY;

EID: 84894977671     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.12.073     Document Type: Review

References (143)

1. Hernández R.M., Orive G., Murua A., Pedraz J.L. Microcapsules and microcarriers for in situ cell delivery. Adv Drug Deliv Rev 2010, 62:711-730.
2. Orive G., Maria Hernández R., Rodríguez Gascón A., Calafiore R., Swi Chang T.M., Vos Pd, et al. History, challenges and perspectives of cell microencapsulation. Trends Biotechnol 2004, 22:87-92.
3. Hunt N.C., Grover L.M. Cell encapsulation using biopolymer gels for regenerative medicine. Biotechnol Lett 2010, 32:733-742.
4. Nicodemus G.D., Bryant S.J. Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng Part B 2008, 14:149-165.
5. Canaple L., Rehor A., Hunkeler D. Improving cell encapsulation through size control. JBiomater Sci Polym Ed 2002, 13:783-796.
6. Uludag H., De Vos P., Tresco P.A. Technology of mammalian cell encapsulation. Adv Drug Deliv Rev 2000, 42:29-64.
7. Weibel D.B., DiLuzio W.R., Whitesides G.M. Microfabrication meets microbiology. Nat Rev Microbiol 2007, 5:209-218.
8. Whitesides G.M., Ostuni E., Takayama S., Jiang X., Ingber D.E. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 2001, 3:335-373.
9. Xia Y., Whitesides G.M. Soft lithography. Annu Rev Mater Sci 1998, 28:153-184.
10. Jang J.Y., Lee D.Y., Park S.J., Byun Y. Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets. Biomaterials 2004, 25:3663-3669.
11. Pukel C., Baquerizo H., Rabinovitch A. Destruction of rat islet cell monolayers by cytokines: synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 1988, 37:133-136.
12. Orive G., Gascón A.R., Hernández R.M., Igartua M., Luis Pedraz J. Cell microencapsulation technology for biomedical purposes: novel insights and challenges. Trends Pharmacol Sci 2003, 24:207-210.
13. Orive G., Hernández R.M., Gascón A.R., Calafiore R., Chang T.M., De Vos P., et al. Cell encapsulation: promise and progress. Nat Med 2003, 9:104-107.
14. Morimoto Y., Takeuchi S. Three-dimensional cell culture based on microfluidic techniques to mimic living tissues. Biomater Sci 2013, 1:257-264.
15. Wang X., Kluge J.A., Leisk G.G., Kaplan D.L. Sonication-induced gelation of silk fibroin for cell encapsulation. Biomaterials 2008, 29:1054-1064.
16. Temenoff J.S., Park H., Jabbari E., Conway D.E., Sheffield T.L., Ambrose C.G., et al. Thermally cross-linked oligo (poly (ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells invitro. Biomacromolecules 2004, 5:5-10.
17. Temenoff J.S., Park H., Jabbari E., Sheffield T.L., LeBaron R.G., Ambrose C.G., et al. Invitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. JBiomed Mater Res Part A 2004, 70:235-244.
18. Kim J., Kim I.S., Cho T.H., Lee K.B., Hwang S.J., Tae G., et al. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 2007, 28:1830-1837.
19. Williams C.G., Kim T.K., Taboas A., Malik A., Manson P., Elisseeff J. Invitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng 2003, 9:679-688.
20. Nuttelman C.R., Tripodi M.C., Anseth K.S. Invitro osteogenic differentiation of human mesenchymal stem cells photoencapsulated in PEG hydrogels. JBiomed Mater Res Part A 2004, 68:773-782.
21. Salinas C.N., Cole B.B., Kasko A.M., Anseth K.S. Chondrogenic differentiation potential of human mesenchymal stem cells photoencapsulated within poly (ethylene glycol)-arginine-glycine-aspartic acid-serine thiol-methacrylate mixed-mode networks. Tissue Eng 2007, 13:1025-1034.
22. Sawhney A.S., Pathak C.P., Hubbell J.A. Bioerodible hydrogels based on photopolymerized poly (ethylene glycol)-co-poly (alpha.-hydroxy acid) diacrylate macromers. Macromolecules 1993, 26:581-587.
23. Rice M.A., Anseth K.S. Encapsulating chondrocytes in copolymer gels: bimodal degradation kinetics influence cell phenotype and extracellular matrix development. JBiomed Mater Res Part A 2004, 70:560-568.
24. Bryant S.J., Bender R.J., Durand K.L., Anseth K.S. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotechnol Bioeng 2004, 86:747-755.
25. Bryant S.J., Anseth K.S. Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly (ethylene glycol) hydrogels. JBiomed Mater Res Part A 2002, 59:63-72.
26. Park Y., Lutolf M.P., Hubbell J.A., Hunziker E.B., Wong M. Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly (ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Tissue Eng 2004, 10:515-522.
27. McKinnon D.D., Kloxin A.M., Anseth K.S. Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons. Biomater Sci 2013, 1:460-469.
28. Baroli B. Photopolymerization of biomaterials: issues and potentialities in drug delivery, tissue engineering, and cell encapsulation applications. JChem Technol Biotechnol 2006, 81:491-499.
29. Foo C.T.W.P., Lee J.S., Mulyasasmita W., Parisi-Amon A., Heilshorn S.C. Two-component protein-engineered physical hydrogels for cell encapsulation. PNAS 2009, 106:22067-22072.
30. Li R.H., Altreuter D.H., Gentile F.T. Transport characterization of hydrogel matrices for cell encapsulation. Biotechnol Bioeng 1996, 50:365-373.
31. Emerich D.F., Winn S.R., Christenson L., Palmatier M.A., Gentile F.T., Sanberg P.R. Anovel approach to neural transplantation in Parkinson's disease: use of polymer-encapsulated cell therapy. Neurosci Biobehav Rev 1992, 16:437-447.
32. Mikos A.G., Papadaki M.G., Kouvroukoglou S., Ishaug S.L., Thomson R.C. Mini-review: Islet transplantation to create a bioartificial pancreas. Biotechnol Bioeng 1994, 43:673-677.
33. Zielinski B.A., Aebischer P. Chitosan as a matrix for mammalian cell encapsulation. Biomaterials 1994, 15:1049-1056.
34. Yasuhara T., Shingo T., Muraoka K., Kobayashi K., Takeuchi A., Yano A., et al. Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease. JNeurosurg 2005, 102:80-89.
35. Broadhead K.W., Biran R., Tresco P.A. Hollow fiber membrane diffusive permeability regulates encapsulated cell line biomass, proliferation, and small molecule release. Biomaterials 2002, 23:4689-4699.
36. Lindner M.D., Winn S.R., Baetge E., Hammang J.P., Gentile F.T., Doherty E., et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp Neurol 1995, 132:62-76.
37. Emerich D.F., Winn S.R., Harper J., Hammang J.P., Baetge E.E., Kordower J.H. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons. JComp Neurol 1994, 349:148-164.
38. Aebischer P., Wahlberg L., Tresco P., Winn S. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution. Biomaterials 1991, 12:50-56.
39. Wu F.J., Peshwa M.V., Cerra F.B., Hu W.-S. Entrapment of hepatocyte spheroids in a hollow fiber bioreactor as a potential bioartificial liver. Tissue Eng 1995, 1:29-40.
40. Nyberg S.L., Shatford R.A., Peshwa M.V., White J.G., Cerra F.B., Hu W.S. Evaluation of a hepatocyte-entrapment hollow fiber bioreactor: a potential bioartificial liver. Biotechnol Bioeng 1993, 41:194-203.
41. Wu F.J., Friend J.R., Lazar A., Mann H.J., Remmel R.P., Cerra F.B., et al. Hollow fiber bioartificial liver utilizing collagen-entrapped porcine hepatocyte spheroids. Biotechnol Bioeng 1996, 52:34-44.
42. Altman J., Houlbert D., Callard P., McMillan P., Solomon B., Rosen J., et al. Long-term plasma glucose normalization in experimental diabetic rats with macroencapsulated implants of benign human insulinomas. Diabetes 1986, 35:625-633.
43. Lacy P.E., Hegre O.D., Gerasimidi-Vazeou A., Gentile F.T., Dionne K.E. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets. Science 1991, 254:1782-1784.
44. Lanza R.P., Borland K.M., Lodge P., Carretta M., Sullivan S.J., Muller T.E., et al. Treatment of severely diabetic pancreatectomized dogs using a diffusion-based hybrid pancreas. Diabetes 1992, 41:886-889.
45. Lanza R.P., Butler D.H., Borland K.M., Staruk J.E., Faustman D.L., Solomon B.A., et al. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. PNAS 1991, 88:11100-11104.
46. Visted T., Bjerkvig R., Enger P.Ø. Cell encapsulation technology as a therapeutic strategy for CNS malignancies. Neuro Oncol 2001, 3:201-210.
47. Sakai S., Mu C., Kawabata K., Hashimoto I., Kawakami K. Biocompatibility of subsieve-size capsules versus conventional-size microcapsules. JBiomed Mater Res Part A 2006, 78:394-398.
48. De Vos P., Hamel A., Tatarkiewicz K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 2002, 45:159-173.
49. Lee M.-K., Bae Y.H. Cell transplantation for endocrine disorders. Adv Drug Deliv Rev 2000, 42:103-120.
50. De Vos P., De Haan B., Van Schilfgaarde R. Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules. Biomaterials 1997, 18:273-278.
51. De Vos P., De Haan B., Wolters G.H., Van Schilfgaarde R. Factors influencing the adequacy of microencapsulation of rat pancreatic islets1. Transplantation 1996, 62:888-893.
52. De Vos P., Marchetti P. Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets. Trends Mol Med 2002, 8:363-366.
53. Fritschy W.M., Wolters G.H., Van Schilfgaarde R. Effect of alginate-polylysine-alginate microencapsulation on invitro insulin release from rat pancreatic islets. Diabetes 1991, 40:37-43.
54. Lim F., Sun A.M. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980, 210:908-910.
55. O'Shea G.M., Goosen M.F., Sun A.M. Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane. Biochim Biophys Acta, Mol Cell Res 1984, 804:133-136.
56. Winn S.R., Tresco P.A., Zielinski B., Greene L.A., Jaeger C.B., Aebischer P. Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells. Exp Neurol 1991, 113:322-329.
57. Read T.-A., Sorensen D.R., Mahesparan R., Enger P.Ø., Timpl R., Olsen B.R., et al. Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nat Biotechnol 2001, 19:29-34.
58. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J.M., Wong V., Lindsay R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 1994, 265:1107-1110.
59. Emerich D.F., Winn S.R., Hantraye P.M., Peschanski M., Chen E.-Y., Chu Y., et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 1997, 386:395-399.
60. Spuch C., Antequera D., Portero A., Orive G., Hernández R.M., Molina J.A., et al. The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer's disease. Biomaterials 2010, 31:5608-5618.
61. Simpson N.E., Grant S.C., Gustavsson L., Peltonen V.-M., Blackband S.J., Constantinidis I. Biochemical consequences of alginate encapsulation: a NMR study of insulin-secreting cells. Biomaterials 2006, 27:2577-2586.
62. Ennis W., James D.T. Asimple apparatus for producing droplets of uniform size from small volumes of liquids. Science 1950, 112:434-436.
63. Sparks R.E., Salemme R.M., Meier P.M., Litt M.H., Lindan O. Removal of waste metabolites in uremia by microencapsulated reactants. Trans ASAIO 1969, 15:353-358.
64. Nebel R.L., Bame J., Saacke R., Lim F. Microencapsulation of bovine spermatozoa. JAnim Sci 1985, 60:1631.
65. Cell encapsulation technology and therapeutics 1999, Springer. W.M. Kühtreiber (Ed.).
66. Wolters G.H., Fritschy W.M., Gerrits D., Van Schilfgaarde R. Aversatile alginate droplet generator applicable for microencapsulation of pancreatic islets. JAppl Biomater 1992, 3:281-286.
67. Zimmermann H., Hillgärtner M., Manz B., Feilen P., Brunnenmeier F., Leinfelder U., et al. Fabrication of homogeneously cross-linked, functional alginate microcapsules validated by NMR-, CLSM-and AFM-imaging. Biomaterials 2003, 24:2083-2096.
68. Klokk T., Melvik J. Controlling the size of alginate gel beads by use of a high electrostatic potential. JMicroencapsul 2002, 19:415-424.
69. Zimmermann H., Shirley S.G., Zimmermann U. Alginate-based encapsulation of cells: past, present, and future. Curr Diab Rep 2007, 7:314.
70. Haeberle S., Naegele L., Burger R., Stetten Fv, Zengerle R., Ducrée J. Alginate bead fabrication and encapsulation of living cells under centrifugally induced artificial gravity conditions. JMicroencapsul 2008, 25:267-274.
71. Haeberle S., Zengerle R., Ducrée J. Centrifugal generation and manipulation of droplet emulsions. Microfluid Nanofluid 2007, 3:65-75.
72. Tsuda Y., Morimoto Y., Takeuchi S. Monodisperse cell-encapsulating peptide microgel beads for 3D cell culture. Langmuir 2009, 26:2645-2649.
73. Morimoto Y., Tan W.-H., Takeuchi S. Three-dimensional axisymmetric flow-focusing device using stereolithography. Biomed Microdevices 2009, 11:369-377.
74. Morimoto Y., Tan W.-H., Tsuda Y., Takeuchi S. Monodisperse semi-permeable microcapsules for continuous observation of cells. Lab Chip 2009, 9:2217-2223.
75. Tan W.H., Takeuchi S. Monodisperse alginate hydrogel microbeads for cell encapsulation. Adv Mater 2007, 19:2696-2701.
76. Um E., Lee D.-S., Pyo H.-B., Park J.-K. Continuous generation of hydrogel beads and encapsulation of biological materials using a microfluidic droplet-merging channel. Microfluid Nanofluid 2008, 5:541-549.
77. Nichol J.W., Koshy S.T., Bae H., Hwang C.M., Yamanlar S., Khademhosseini A. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 2010, 31:5536-5544.
78. Koh W.-G., Revzin A., Pishko M.V. Poly (ethylene glycol) hydrogel microstructures encapsulating living cells. Langmuir 2002, 18:2459-2462.
79. Du Y., Lo E., Ali S., Khademhosseini A. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. PNAS 2008, 105:9522-9527.
80. Aubin H., Nichol J.W., Hutson C.B., Bae H., Sieminski A.L., Cropek D.M., et al. Directed 3D cell alignment and elongation in microengineered hydrogels. Biomaterials 2010, 31:6941-6951.
81. Panda P., Ali S., Lo E., Chung B.G., Hatton T.A., Khademhosseini A., et al. Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 2008, 8:1056-1061.
82. Khademhosseini A., Eng G., Yeh J., Fukuda J., Blumling J., Langer R., et al. Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. JBiomed Mater Res Part A 2006, 79:522-532.
83. Shepard J.A., Stevans A.C., Holland S., Wang C.E., Shikanov A., Shea L.D. Hydrogel design for supporting neurite outgrowth and promoting gene delivery to maximize neurite extension. Biotechnol Bioeng 2012, 109:830-839.
84. McGuigan A.P., Bruzewicz D.A., Glavan A., Butte M., Whitesides G.M. Cell encapsulation in sub-mm sized gel modules using replica molding. PLoS One 2008, 3:e2258.
85. Bruzewicz D.A., McGuigan A.P., Whitesides G.M. Fabrication of a modular tissue construct in a microfluidic chip. Lab Chip 2008, 8:663-671.
86. Matsunaga Y.T., Morimoto Y., Takeuchi S. Molding cell beads for rapid construction of macroscopic 3D tissue architecture. Adv Mater 2011, 23:H90-H94.
87. Parka J., Randallb C., Kalinina Y., Pandeya S., Graciasa D. Abio-artificial pancreas created using cell encapsulation in self-assembled microcontainers on alginate sheet. μTAS 2011.
88. Lee K.H., No D.Y., Ryoo J.H., Wong S.F. Diffusion-mediated in situ alginate encapsulation of cell spheroids using microscale concave well and nanoporous membrane. Lab Chip 2011, 11:1168-1173.
89. Lee B.R., Hwang J.W., Choi Y.Y., Wong S.F., Hwang Y.H., Lee D.Y., et al. In situ formation and collagen-alginate composite encapsulation of pancreatic islet spheroids. Biomaterials 2012, 33:837-845.
90. Park D.Y., Moon C.H., Kang E., No D.Y., Ju J., Lee S.-H. One-stop microfiber spinning and fabrication of a fibrous cell-encapsulated scaffold on a single microfluidic platform. Biofabrication 2013, [Accepted].
91. Puppi D., Dinucci D., Bartoli C., Mota C., Migone C., Dini F., et al. Development of 3D wet-spun polymeric scaffolds loaded with antimicrobial agents for bone engineering. JBioact Compat Polym 2011, 26:478-492.
92. Mazzitelli S., Capretto L., Carugo D., Zhang X., Piva R., Nastruzzi C. Optimised production of multifunctional microfibres by microfluidic chip technology for tissue engineering applications. Lab Chip 2011, 11:1776-1785.
93. Yamada M., Sugaya S., Naganuma Y., Seki M. Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking. Soft Matter 2012, 8:3122-3130.
94. Su J., Zheng Y., Wu H. Generation of alginate microfibers with a roller-assisted microfluidic system. Lab Chip 2009, 9:996-1001.
95. Hwang C.M., Khademhosseini A., Park Y., Sun K., Lee S.-H. Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering. Langmuir 2008, 24:6845-6851.
96. Hwang C., Park Y., Park J., Lee K., Sun K., Khademhosseini A., et al. Controlled cellular orientation on PLGA microfibers with defined diameters. Biomed Microdevices 2009, 11:739-746.
97. Lee B.R., Lee K.H., Kang E., Kim D.-S., Lee S.-H. Microfluidic wet spinning of chitosan-alginate microfibers and encapsulation of HepG2 cells in fibers. Biomicrofluidics 2011, 5:022208.
98. Lee K.H., Shin S.J., Park Y., Lee S.-H. Synthesis of cell-laden alginate hollow fibers using microfluidic chips and microvascularized tissue-engineering applications. Small 2009, 5:1264-1268.
99. Sugiura S., Oda T., Aoyagi Y., Satake M., Ohkohchi N., Nakajima M. Tubular gel fabrication and cell encapsulation in laminar flow stream formed by microfabricated nozzle array. Lab Chip 2008, 8:1255-1257.
100. Kang E., Jeong G.S., Choi Y.Y., Lee K.H., Khademhosseini A., Lee S.-H. Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. Nat Mater 2011, 10:877-883.
101. Jun Y., Kang A.R., Lee J.S., Jeong G.S., Ju J., Lee D.Y., et al. 3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage. Biomaterials 2013, 34:3784-3794.
102. Onoe H., Okitsu T., Itou A., Kato-Negishi M., Gojo R., Kiriya D., et al. Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Nat Mater 2013, 12:584-590.
103. Schmidt C.E., Leach J.B. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003, 5:293-347.
104. Gomez N., Lu Y., Chen S., Schmidt C.E. Immobilized nerve growth factor and microtopography have distinct effects on polarization versus axon elongation in hippocampal cells in culture. Biomaterials 2007, 28:271-284.
105. Kang E., Choi Y.Y., Chae S.K., Moon J.H., Chang J.Y., Lee S.-H. Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds. Adv Mater 2012, 24:4271-4277.
106. Kang E., Shin S.-J., Lee K.H., Lee S.-H. Novel PDMS cylindrical channels that generate coaxial flow, and application to fabrication of microfibers and particles. Lab Chip 2010, 10:1856-1861.
107. Jun Y., Kim M.J., Hwang Y.H., Jeon E., Kang A.R., Lee S.-H., et al. Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection. Biomaterials 2013, 34:8122-8130.
108. Yamada M., Utoh R., Ohashi K., Tatsumi K., Yamato M., Okano T., et al. Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions. Biomaterials 2012, 33:8304-8315.
109. Alwan A. Global status report on noncommunicable diseases 2010 2011, World Health Organization.
110. Fox I.J., Chowdhury J.R. Hepatocyte transplantation. Am J Transplant 2004, 4:7-13.
111. Ohashi K., Park F., Kay M.A. Hepatocyte transplantation: clinical and experimental application. JMol Med 2001, 79:617-630.
112. Hoshikawa A., Nakayama Y., Matsuda T., Oda H., Nakamura K., Mabuchi K. Encapsulation of chondrocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering. Tissue Eng 2006, 12:2333-2341.
113. Betre H., Ong S.R., Guilak F., Chilkoti A., Fermor B., Setton L.A. Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. Biomaterials 2006, 27:91-99.
114. Hong Y., Song H., Gong Y., Mao Z., Gao C., Shen J. Covalently crosslinked chitosan hydrogel: properties of invitro degradation and chondrocyte encapsulation. Acta Biomater 2007, 3:23-31.
115. Suri S., Schmidt C.E. Cell-laden hydrogel constructs of hyaluronic acid, collagen, and laminin for neural tissue engineering. Tissue Eng Part A 2010, 16:1703-1716.
116. Li H., Wijekoon A., Leipzig N.D. 3D differentiation of neural stem cells in macroporous photopolymerizable hydrogel scaffolds. PLoS One 2012, 7:e48824.
117. Balakrishnan B., Jayakrishnan A. Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials 2005, 26:3941-3951.
118. Siti-Ismail N., Bishop A.E., Polak J.M., Mantalaris A. The benefit of human embryonic stem cell encapsulation for prolonged feeder-free maintenance. Biomaterials 2008, 29:3946-3952.
119. Chia S., Wan A., Quek C., Mao H., Xu X., Shen L., et al. Multi-layered microcapsules for cell encapsulation. Biomaterials 2002, 23:849-856.
120. Chia S.-M., Leong K.W., Li J., Xu X., Zeng K., Er P.-N., et al. Hepatocyte encapsulation for enhanced cellular functions. Tissue Eng 2000, 6:481-495.
121. Wells G., Fisher M., Sefton M. Microencapsulation of viable hepatocytes in HEMA-MMA microcapsules: a preliminary study. Biomaterials 1993, 14:615-620.
122. De Vos P., De Haan B., Wolters G., Strubbe J., Van Schilfgaarde R. Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets. Diabetologia 1997, 40:262-270.
123. Goosen M.F., O'Shea G.M., Gharapetian H.M., Chou S., Sun A.M. Optimization of microencapsulation parameters: semipermeable microcapsules as a bioartificial pancreas. Biotechnol Bioeng 1985, 27:146-150.
124. Chang P., Hortelano G., Awrey D., Tse M. Growth of recombinant fibroblasts in alginate microcapsules. Biotechnol Bioeng 1994, 43:925-933.
125. Levee M.G., Lee G.M., Paek S.H., Palsson B.O. Microencapsulated human bone marrow cultures: a potential culture system for the clonal outgrowth of hematopoietic progenitor cells. Biotechnol Bioeng 1994, 43:734-739.
126. Sakai S., Kawabata K., Ono T., Ijima H., Kawakami K. Development of mammalian cell-enclosing subsieve-size agarose capsules (<100μm) for cell therapy. Biomaterials 2005, 26:4786-4792.
127. Edd J.F., Di Carlo D., Humphry K.J., Köster S., Irimia D., Weitz D.A., et al. Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip 2008, 8:1262-1264.
128. Kim C., Lee K.S., Kim Y.E., Lee K.-J., Lee S.H., Kim T.S., et al. Rapid exchange of oil-phase in microencapsulation chip to enhance cell viability. Lab Chip 2009, 9:1294-1297.
129. Kim C., Chung S., Kim Y.E., Lee K.S., Lee S.H., Oh K.W., et al. Generation of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid. Lab Chip 2011, 11:246-252.
130. Wu L., Chen P., Dong Y., Feng X., Liu B.-F. Encapsulation of single cells on a microfluidic device integrating droplet generation with fluorescence-activated droplet sorting. Biomed Microdevices 2013, 1-8.
131. Capretto L., Mazzitelli S., Luca G., Nastruzzi C. Preparation and characterization of polysaccharidic microbeads by a microfluidic technique: application to the encapsulation of Sertoli cells. Acta Biomater 2010, 6:429-435.
132. Allazetta S., Hausherr T.C., Lutolf M.P. Microfluidic synthesis of cell-type-specific artificial extracellular matrix hydrogels. Biomacromolecules 2013, 14:1122-1131.
133. Köster S., Angile F.E., Duan H., Agresti J.J., Wintner A., Schmitz C., et al. Drop-based microfluidic devices for encapsulation of single cells. Lab Chip 2008, 8:1110-1115.
134. Eun Y.-J., Utada A.S., Copeland M.F., Takeuchi S., Weibel D.B. Encapsulating bacteria in agarose microparticles using microfluidics for high-throughput cell analysis and isolation. ACS Chem Biol 2010, 6:260-266.
135. Kumachev A., Greener J., Tumarkin E., Eiser E., Zandstra P.W., Kumacheva E. High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation. Biomaterials 2011, 32:1477-1483.
136. Choi C.-H., Jung J.-H., Rhee Y.W., Kim D.-P., Shim S.-E., Lee C.-S. Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed Microdevices 2007, 9:855-862.
137. Oh H.-J., Kim S.-H., Baek J.-Y., Seong G.-H., Lee S.-H. Hydrodynamic micro-encapsulation of aqueous fluids and cells via 'on the fly' photopolymerization. JMicromech Microeng 2006, 16:285.
138. Wu M.-H., Pan W.-C. Development of microfluidic alginate microbead generator tunable by pulsed airflow injection for the microencapsulation of cells. Microfluid Nanofluid 2010, 8:823-835.
139. Sugiura S., Oda T., Aoyagi Y., Matsuo R., Enomoto T., Matsumoto K., et al. Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules. Biomed Microdevices 2007, 9:91-99.
140. Sugiura S., Oda T., Izumida Y., Aoyagi Y., Satake M., Ochiai A., et al. Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials 2005, 26:3327-3331.
141. Hu M., Kurisawa M., Deng R., Teo C.-M., Schumacher A., Thong Y.-X., et al. Cell immobilization in gelatin-hydroxyphenylpropionic acid hydrogel fibers. Biomaterials 2009, 30:3523-3531.
142. Takei T., Kishihara N., Sakai S., Kawakami K. Novel technique to control inner and outer diameter of calcium-alginate hydrogel hollow microfibers, and immobilization of mammalian cells. Biochem Eng J 2010, 49:143-147.
143. Sakai S., Liu Y., Mah E.J., Taya M. Horseradish peroxidase/catalase-mediated cell-laden alginate-based hydrogel tube production in two-phase coaxial flow of aqueous solutions for filament-like tissues fabrication. Biofabrication 2013, 5:015012.