Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection

Biomaterials

Volumn 34, Issue 33, 2013, Pages 8122-8130

  Jun, Yesl ^a   Kim, Min Jun ^b   Hwang, Yong Hwa ^b   Jeon, Eun Ae ^b   Kang, Ah Ran ^a   Lee, Sang Hoon ^a   Lee, Dong Yun ^b  

^a Korea University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Collagen Alginate composite (CAC); Immunoprotection; Islet encapsulation; Microfluidics; Xenotransplantation

Indexed keywords

COLLAGEN-ALGINATE COMPOSITE (CAC); EXTRACELLULAR MATRIX COMPONENTS; IMMUNOPROTECTION; ISLET ENCAPSULATIONS; MICROFLUIDIC PLATFORMS; POLYDIMETHYLSILOXANE PDMS; TYPE 1 DIABETES MELLITUS; XENOTRANSPLANTATION;

ALGINATE; COLLAGEN; FIBERS; FLUIDIC DEVICES; GLUCOSE; MAMMALS; SILICONES;

MICROFLUIDICS;

ALGINIC ACID;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENCAPSULATION; EXTRACELLULAR MATRIX; GLUCOSE BLOOD LEVEL; IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MALE; MICROENVIRONMENT; MICROFLUIDICS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SURVIVAL TIME; XENOTRANSPLANTATION;

MUS;

COLLAGEN-ALGINATE COMPOSITE (CAC); IMMUNOPROTECTION; ISLET ENCAPSULATION; MICROFLUIDICS; XENOTRANSPLANTATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICROFLUIDICS; MICROSCOPY, ELECTRON, SCANNING; RATS, SPRAGUE-DAWLEY;

EID: 84881667053     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.079     Document Type: Article

References (35)

1. Shapiro A.M., Lakey J.R., Ryan E.A., Korbutt G.S., Toth E., Warnock G.L., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. NEngl J Med 2000, 343:230-238.
2. Moberg L., Johansson H., Lukinius A., Berne C., Foss A., Kallen R., et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002, 360:2039-2045.
3. Rossini A.A., Greiner D.L., Mordes J.P. Induction of immunologic tolerance for transplantation. Physiol Rev 1999, 79:99-141.
4. Chapman J.R. Chronic calcineurin inhibitor nephrotoxicity-lest we forget. Am J Transplant 2011, 11:693-697.
5. Ryan E.A., Paty B.W., Senior P.A., Bigam D., Alfadhli E., Kneteman N.M., et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005, 54:2060-2069.
6. Muellerklieser W., Freyer J.P., Sutherland R.M. Influence of glucose and oxygen-supply conditions on the oxygenation of multicellular spheroids. Brit J Cancer 1986, 53:345-353.
7. Sakata N., Obenaus A., Chan N., Mace J., Chinnock R., Hathout E. Factors affecting islet graft embolization in the liver of diabetic mice. Islets 2009, 1:26-33.
8. Lum Z.P., Krestow M., Tai I.T., Vacek I., Sun A.M. Xenografts of rat islets into diabetic mice - an evaluation of new smaller capsules. Transplantation 1992, 53:1180-1183.
9. DeVos P., DeHaan B., Pater J., VanSchilfgaarde R. Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat isletallografts. Transplantation 1996, 62:893-899.
10. Dolnik V., Liu S., Jovanovich S. Capillary electrophoresis on microchip. Electrophoresis 2000, 21:41-54.
11. Beebe D.J., Mensing G.A., Walker G.M. Physics and applications of microfluidics in biology. Annu Rev Biomed Eng 2002, 4:261-286.
12. Dittrich P.S., Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat Rev Drug Discov 2006, 5:210-218.
13. El-Ali J., Sorger P.K., Jensen K.F. Cells on chips. Nature 2006, 442:403-411.
14. Kang E., Shin S.J., Lee K.H., Lee S.H. Novel PDMS cylindrical channels that generate coaxial flow, and application to fabrication of microfibers and particles. Lab a Chip 2010, 10:1856-1861.
15. Lee K.H., Shin S.J., Kim C.B., Kim J.K., Cho Y.W., Chung B.G., et al. Microfluidic synthesis of pure chitosan microfibers for bio-artificial liver chip. Lab a Chip 2010, 10:1328-1334.
16. Hwang C.M., Khademhosseini A., Park Y., Sun K., Lee S.H. Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering. Langmuir 2008, 24:6845-6851.
17. Kang E., Jeong G.S., Choi Y.Y., Lee K.H., Khademhosseini A., Lee S.H. Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. Nat Mater 2011, 10:877-883.
18. Lee B.R., Hwang J.W., Choi Y.Y., Wong S.F., Hwang Y.H., Lee D.Y., et al. In situ formation and collagen-alginate composite encapsulation of pancreatic islet spheroids. Biomaterials 2012, 33:837-845.
19. Jung Y.S., Jeong J.H., Yook S., Im B.H., Seo J., Hong S.W., et al. Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model. Biomaterials 2012, 33:295-303.
20. Lee B.R., Lee K.H., Kang E., Kim D.S., Lee S.H. Microfluidic wet spinning of chitosan-alginate microfibers and encapsulation of HepG2 cells in fibers. Biomicrofluidics 2011, 5:22208.
21. Mikos A.G., Papadaki M.G., Kouvroukoglou S., Ishaug S.L., Thomson R.C. Mini-review: islet transplantation to create a bioartificial pancreas. Biotechnol Bioeng 1994, 43:673-677.
22. Marchetti P., Del Prato S., Lupi R., Del Guerra S. The pancreatic beta-cell in human Type 2 diabetes. Nutr Metab Cardiovas 2006, 16:S3-S6.
23. Nanji S.A., Shapiro A.M.J. Advances in pancreatic islet transplantation in humans. Diabetes Obes Metab 2006, 8:15-25.
24. Thomas F.T., Contreras J.L., Bilbao G., Ricordi C., Curiel D., Thomas J.M. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation. Surgery 1999, 126:299-304.
25. Wang R.N., Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. JEndocrinol 1999, 163:181-190.
26. Perfetti R., Henderson T.E., Wang Y.H., MontroseRafizadeh C., Egan J.M. Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix. Pancreas 1996, 13:47-54.
27. Pinkse G.G.M., Bouwman W.P., Jiawan-Lalai R., Terpstra O.T., Bruijn J.A., de Heer E. Integrin signaling via RGD peptides and anti-beta 1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 2006, 55:312-317.
28. Salvay D.M., Rives C.B., Zhang X.M., Chen F., Kaufman D.B., Lowe W.L., et al. Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation 2008, 85:1456-1464.
29. Jalili R.B., Rezakhanlou A.M., Hosseini-Tabatabaei A., Ao Z.L., Warnock G.L., Ghahary A. Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal. JCell Physiol 2011, 226:1813-1819.
30. Hammar E., Parnaud G., Bosco D., Perriraz N., Maedler K., Donath M., et al. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes 2004, 53:2034-2041.
31. Ryan E.A., Lakey J.R., Rajotte R.V., Korbutt G.S., Kin T., Imes S., et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001, 50:710-719.
32. Lanza R.P., Hayes J.L., Chick W.L. Encapsulated cell technology. Nat Biotechnol 1996, 14:1107-1111.
33. Kang E., Choi Y.Y., Chae S.K., Moon J.H., Chang J.Y., Lee S.H. Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds. Adv Mater 2012, 24:4271-4277.
34. Takei T., Kishihara N., Sakai S., Kawakami T. Novel technique to control inner and outer diameter of calcium-alginate hydrogel hollow microfibers, and immobilization of mammalian cells. Biochem Eng J 2010, 49:143-147.
35. Mazzitelli S., Capretto L., Carugo D., Zhang X., Piva R., Nastruzzi C. Optimised production of multifunctional microfibres by microfluidic chip technology for tissue engineering applications. Lab a Chip 2011, 11:1776-1785.