3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage

Biomaterials

Volumn 34, Issue 15, 2013, Pages 3784-3794

  Jun, Yesl ^a   Kang, Ah Ran ^a   Lee, Jae Seo ^a   Jeong, Gi Seok ^a   Ju, Jongil ^a   Lee, Dong Yun ^b   Lee, Sang Hoon ^a  

^a Korea University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Co culture; Concave microwell array; Hepatocytes; Islet encapsulation; Pancreatic islets; Type 1 diabetes mellitus (T1DM)

Indexed keywords

COCULTURE; CONCAVE MICROWELL; DIABETES MELLITUS; HEPATOCYTES; ISLET ENCAPSULATIONS; PANCREATIC ISLET;

CELLS; CYTOLOGY; MICROCHANNELS; MORPHOLOGY; OPTICAL MICROSCOPY; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; THREE DIMENSIONAL; TRANSMISSION ELECTRON MICROSCOPY; UREA;

THREE DIMENSIONAL COMPUTER GRAPHICS;

ALBUMIN; CYTOCHROME P450; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL HYBRIDIZATION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN RELEASE; LIVER CELL; MALE; MICROSCOPY; NONHUMAN; PANCREAS ISLET CELL; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; XENOTRANSPLANTATION;

ANIMALS; CELL SHAPE; CELL SIZE; COCULTURE TECHNIQUES; CRYOULTRAMICROTOMY; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; ISLETS OF LANGERHANS; LIVER; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; SPHEROIDS, CELLULAR;

RATTUS;

EID: 84874964749     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.02.010     Document Type: Article

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