Cell encapsulation: Promise and progress

Nature Medicine

Volumn 9, Issue 1, 2003, Pages 104-107

  Orive, Gorka ^a   Hernández, Rosa María ^a   Gascón, Alicia R ^a   Calafiore, Riccardo ^b   Chang, Thomas M S ^c   De Vos, Paul ^d   Hortelano, Gonzalo ^e   Hunkeler, David ^f   Lacík, Igor ^g   Shapiro, A M James ^h   Pedraz, José Luis ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF PERUGIA   (Italy)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e MCMASTER UNIVERSITY   (Canada)

^f AQUA+TECH Specialties SA   (Switzerland)

^g POLYMER INSTITUTE   (Slovakia)

^h UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCATION; POLYMER;

ANIMAL MODEL; BIOCOMPATIBILITY; BIOREACTOR; CELL ENCAPSULATION; CELL TRANSPLANTATION; CELL TYPE; ETHICS; GENETIC ENGINEERING; IMMUNE RESPONSE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; REVIEW;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL TRANSPLANTATION; CELLS, IMMOBILIZED; CLINICAL TRIALS; HUMANS; MEMBRANES, ARTIFICIAL; MICROSPHERES; POLYAMINES; POLYMERS; REPRODUCIBILITY OF RESULTS; STEM CELLS; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 0037236027     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0103-104     Document Type: Review

References (38)

1. Chang, T.M.S. Semipermeable microcapsules. Science 146, 524-525 (1964).
2. Lim, F. & Sun, A.M. Microencapsulated islets as bioartificial endocrine pancreas. Science 210, 908-909 (1980).
3. Sun, Y.L., Ma, X.J., Zhou, D.B., Vacek, I. & Sun, A.M. Normalization of diabetes in spontaneously diabetic cynomologous monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J. Clin. Invest. 98, 1417-1422 (1996).
4. Hortelano, G., Al-Hendy, A., Ofosu, F.A. & Chang, P.L. Delivery of human Factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B. Blood 87, 5095-5103 (1996).
5. Xu, W., Liu, L. & Charles, I.G. Microencapsulated iNOS-expressing cells cause tumor suppression in mice. FASEB J. 16, 213-215 (2002).
6. Prakash, S. & Chang, T.M.S. Microencapsulated genetically engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats. Nature Med. 2, 883-887 (1996).
7. Soon-Shiong, P. et al. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet 343, 950-951 (1994).
8. Hasse, C., Klock, G., Schlosser, A., Zimmermann, U. & Rothmund, M., Parathyroid allotransplantation without immunosuppression. Lancet 351, 1296-1297 (1997).
9. Lanza, R.P., Hayes, J.L. & Chick, W.L. Encapsulated cell technology. Nature Biotechnol. 14, 1107-1111 (1996).
10. Shapiro, A.M.J. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230-238 (2000).
11. Hunkeler, D. et al. Objectively assessing bioartificial organs. Ann. NY Acad. Sci. 944, 456-471 (2001).
12. Anilkumar, A.V., Lacik, I. & Wang, T.G. A novel reactor for making uniform capsules. Biotechnol. Bioeng. 75, 581-589 (2001).
13. Strand, B.L. et al. Poly-L-lysine induces fibrosis on alginate microcapsules via the induction of cytokines. Cell Transplant. 10, 263-275 (2001).
14. Calafiore, R. et al. Transplantation of minimal volume microcapsules in diabetic high mammalians. Ann. NY Acad. Sci. 875, 219-232 (1999).
15. Wang, T. et al. An encapsulation system for the immunoisolation of pancreatic islets. Nature Biotechnol. 15, 358-362 (1997).
16. De Vos, P. et al. Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets. Biomaterials 24, 305-312 (2003).
17. Murphy, F.A. The public health risk of animal organ and tissue transplantation into humans. Science 273, 746-747 (1996).
18. Günzburg, W.H. & Salmons, B. Xenotransplantation: Is the risk of viral infection as great as we thought? Mol. Med. Today 6, 199-208 (2000).
19. Hunkeler, D. Allo transplants xeno: as bioartificial organs move to the clinic. Ann. NY Acad. Sci. 944, 1-6.
20. Bach, F.H. & Fineberg, H.V. Call for a moratorium on xenotransplants. Nature 391, 326 (1998).
21. Aebischer, P., Hottinger, A.F. & Déglon, N. Cellular xenotransplantation. Nature Med. 5, 852 (1999).
22. Hunkeler, D. et al. Bioartificial organs and acceptable risk. Nature Biotechnol. 17, 1045 (1999).
23. Calafiore, R. et al. Cellular support systems for alginate microcapsules containing islets as composite bioartificial pancreas. Ann. NY Acad. Sci. 944, 240-251 (2001).
24. De Vos, P., Hamel, A.F. & Tatarkiewicz, K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 45, 159-173 (2002).
25. De Vos, P. & Marchetti, P. Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets. Trends Mol. Med. 8, 363-366 (2002).
26. US Pharmacopeia and National Formulary (Rockville, Maryland). 1046, 2762-2790 (2002).
27. Check, E. Diabetes trial stirs debate on safety of xenotransplants. Nature 419, 5 (2002).
28. Mares-Guia, M. & Ricordi, C. Hetero-polysaccharide conjugate and methods of making and using the same. US Patent 6,281,341 (2001).
29. King, A. et al. Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerised alginate as a coating. J. Biomed. Mat. Res. (in press).
30. Desai, T.A. Microfabrication technology for pancreatic cell encapsulation. Exp. Opin. Biol. Ther. 2, 633-646 (2002).
31. Pelegrin, M. et al. Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells. Gene Ther. 5, 828-834 (1998).
32. Löhr, M. et al. Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma. Lancet 357, 1591-1592 (2001).
33. Read, T.A. et al. Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nature Biotechnol. 19, 29-34 (2001).
34. Joki, T. et al. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nature Biotechnol. 19, 35-39 (2001).
35. Cirone, P., Bourgeois, J.M., Austin, R.C. & Chang, P.L. A novel approach to tumor suppression with microencapsulated recombinant cells. Hum. Gene Ther. 13, 1157-1166 (2002).
36. Drukker, M. et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc. Natl. Acad. Sci. USA 99, 9864-9869 (2002).
37. Dove, A. Cell-based therapies go live. Nature Biotechnol. 20, 339-343 (2002).
38. Orive, G., Hernández, R.M., Gascón, A.R., Igartua, M. & Pedraz, J.L. Encapsulated cell technology: from research to market. Trends Biotechnol. 20, 382-387 (2002).