Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8304-8315

  Yamada, Masumi ^a   Utoh, Rie ^b   Ohashi, Kazuo ^b   Tatsumi, Kohei ^b   Yamato, Masayuki ^b   Okano, Teruo ^b   Seki, Minoru ^a  

^a CHIBA UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Alginate; Co culture; Hepatocyte; Microencapsulation

Indexed keywords

ALBUMIN SECRETION; ALGINATE LYASE; ANISOTROPIC HYDROGELS; ASSESSMENT TOOL; BIOARTIFICIAL LIVER DEVICES; CELL CULTIVATION; CELL-CELL INTERACTION; COCULTURE; DRUG DEVELOPMENT; FEEDER CELLS; HEPATIC FUNCTION; HEPATOCYTES; HYDROGEL FIBERS; LIVER TISSUE ENGINEERING; LIVER-SPECIFIC FUNCTIONS; LONG-TERM PRESERVATION; MICROENCAPSULATION; MICROFIBERS; MICROFLUIDIC CHANNEL; MONOLAYER CULTURE; MULTIPLE CELL TYPES; OXYGEN TENSION; RAT HEPATOCYTES; SODIUM ALGINATES; UREA SYNTHESIS;

ALGINATE; ANISOTROPY; ARTIFICIAL ORGANS; CELL CULTURE; CELLS; ENCAPSULATION; GENE EXPRESSION; MONOLAYERS; TISSUE ENGINEERING; UREA;

HYDROGELS;

ALBUMIN; ALGINIC ACID; UREA;

ANIMAL CELL; ANISOTROPIC HYDROGEL MICROFIBER; ANISOTROPY; ARTICLE; CELL ENCAPSULATION; CELL INTERACTION; CELL VIABILITY; COCULTURE; CULTURE MEDIUM; FEEDER CELL; GENE EXPRESSION; HYDROGEL; LIVER CELL; LIVER FUNCTION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; UREA CYCLE;

ALGINATES; ANIMALS; CELL CULTURE TECHNIQUES; GLUCURONIC ACID; HEPATOCYTES; HEXURONIC ACIDS; HYDROGEL; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SWISS 3T3 CELLS; TISSUE ENGINEERING;

RATTUS;

EID: 84866169463     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.068     Document Type: Article

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