Encapsulation of pancreatic islets for transplantation in diabetes: The untouchable islets

Trends in Molecular Medicine

Volumn 8, Issue 8, 2002, Pages 363-366

  De Vos, Paul ^a   Marchetti, Piero ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL MEMBRANE; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; DEVICE; DIABETES MELLITUS; ENCAPSULATION; IMMUNE SYSTEM; INSULIN RELEASE; PANCREAS ISLET TRANSPLANTATION; REVIEW;

ANIMALS; BIOCOMPATIBLE MATERIALS; DIABETES MELLITUS; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL;

ANIMALIA;

EID: 0036319442     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02381-X     Document Type: Review

References (20)

1. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
2. Biocompatibility Issues
3. Considerations for successful transplantation of encapsulated pancreatic islets
4. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets
5. Glucose control and long-term survival in biobreeding/Worcester rats after intraperitoneal implantation of hydrophilic macrobeads containing porcine islets without immunosuppression
6. Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects
7. Insulin secretion by rat islet isografts of a defined endocrine volume after transplantation to three different sites
8. Efficacy of a prevascularized expanded polytetrafluoroethylene solid support system as a transplantation site for pancreatic islets
9. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation
10. Succesful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets
11. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression
12. Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets
13. Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?
14. Humoral response to encapsulated islets
15. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells
16. Alginate polylysine microcapsules as immune barrier: Permeability of cytokines and immunoglobulins over the capsule membrane
17. Microcapsules and their ability to protect islets against cytokine-mediated dysfunction
18. Bovine islets are less susceptible than human islets to damage by human cytokines
19. Entrapment of dispersed pancreatic islet cells in CultiSpher-S macroporous gelatin microcarriers: Preparation, in vitro characterization, and microencapsulation
20. In vitro cultivation of human islets from expanded ductal tissue