Structure-based non-canonical amino acid design to covalently crosslink an antibody-antigen complex

Journal of Structural Biology

Volumn 185, Issue 2, 2014, Pages 215-222

  Xu, Jianqing ^a   Tack, Drew ^b   Hughes, Randall A ^b   Ellington, Andrew D ^b   Gray, Jeffrey J ^a  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Antibody; Binding affinity; Computer aided design; Crosslinking; L DOPA; Non canonical amino acid; Rosetta; Structure based design

Indexed keywords

ANTIBODY; BINDING AFFINITY; COMPUTER-AIDED DESIGN; CROSSLINKING; L-DOPA; NON-CANONICAL AMINO ACID; ROSETTA; STRUCTURE-BASED DESIGN;

ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; COMPUTER SIMULATION; CROSS-LINKING REAGENTS; ESCHERICHIA COLI; LEVODOPA; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; SOFTWARE;

EID: 84894965507     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2013.05.003     Document Type: Article

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