Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression

Toxicology in Vitro

Volumn 28, Issue 4, 2014, Pages 647-656

  Liu, Qing ^a   Wang, Yajun ^a   Gu, Jianhong ^a   Yuan, Yan ^a   Liu, Xuezhong ^a   Zheng, Wanglong ^a   Huang, Qinyi ^a   Liu, Zongping ^a   Bian, Jianchun ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

Leydig cells; Nur77; Steroidogenic enzymes; Testosterone; Zearalenone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; CYCLIC AMP; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; NUCLEAR RECEPTOR NUR77; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; NR4A1 PROTEIN, MOUSE; ZEARALENONE;

17BETA HSD GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING KINETICS; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; HORMONE INHIBITION; HORMONE RECEPTOR INTERACTION; LEYDIG CELL; LHR GENE; LONG TERM EXPOSURE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; P450C17 GENE; P450SCC GENE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TESTOSTERONE SYNTHESIS; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; LEYDIG CELLS; MALE; MICE; MICE, INBRED ICR; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; RECEPTORS, ESTROGEN; RECEPTORS, LH; SIGNAL TRANSDUCTION; TESTOSTERONE; ZEARALENONE;

EID: 84894665264     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.01.013     Document Type: Article

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