Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: Novel mechanisms for orphan nuclear receptor action

Molecular Endocrinology

Volumn 11, Issue 7, 1997, Pages 891-904

  Zhang, Peilin ^a   Mellon, Synthia H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA BINDING PROTEIN; NERVE GROWTH FACTOR;

ADRENAL CORTEX CELL; ARTICLE; DNA SEQUENCE; EARLY RESPONSE GENE; LEYDIG CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

GALLUS GALLUS;

EID: 0030961743     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.7.9940     Document Type: Article

References (63)

1. Picado-Leonard J, Miller WL 1987 Cloning and sequence of the human gene for P450c17 (steroid 17α-hydroxylase/17, 20 lyase): similarity to the gene for P450c21. DNA 6:437-448
2. Givens C, Zhang P, Bair S, Mellon S 1994 Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities. DNA Cell Biol 13:1087-1098
3. Nakajin S, Hall PF, Onoda M 1981 Testicular microsomal cytochrome P-450 for C21 steroid side chain cleavage. Spectral and binding studies. J Biol Chem 256:6134-6139
4. Nakajin S, Hall PF 1981 Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of a C21 steroid side-chain cleavage system (17α-hydroxylase-C17, 20 lyase). J Biol Chem 256:3871-3876
5. Zuber MX, Simpson ER, Waterman MR 1986 Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Science 234:1258-1261
6. Mellon SH, Vaisse C 1989 cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Proc Natl Acad Sci USA 86:7775-7779
7. Namiki M, Kitamura M, Buczko E, Dufau ML 1988 Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration. Biochem Biophys Res Commun 157:705-712
8. Greco TL, Payne AH 1994 Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase, P450 17 alpha-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonads. Endocrinology 135:262-268
9. Johnson D, Sen M 1990 The cytochrome P450c17 α (17 α-hydroxylase/C17, 20 lyase) activity of the junctional zone of the rat placenta. J Endocrinol 125:217-224
10. Durkee TJ, McLean MP, Hales DB, Payne AH, Waterman MR, Khan I, Gibori G 1992 P450(17 alpha) and P450SCC gene expression and regulation in the rat placenta. Endocrinology 130:1309-1317
11. Voutilainen R, Tapanainen J, Chung B, Matteson KJ, Miller WL 1986 Hormonal regulation of P-450 scc (20, 22 desmolase) and P-450c17 (17 α-hydroxylase/17, 10 lyase) in cultured human granulosa cells. J Clin Endocrinol Metab 63:202-207
12. Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL 1987 Cytochrome P450c17 (steroid 17 α-hydroxylase/17, 20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. Proc Natl Acad Sci USA 84:407-411
13. DiBlasio AM, Voutilainen R, Jaffe RB, Miller WL 1987 Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 α-hydroxylase/17, 20-lyase) in cultured human fetal adrenal cells. J Clin Endocrinol Metab 65:170-175
14. Naseeruddin SA, Hornsby PJ 1990 Regulation of 11 beta- and 17 alpha-hydroxylases in cultured bovine adrenocortical cells: 3′, 5′-cyclic adenosine monophosphate, insulin-like growth factor-I, and activators of protein kinase C. Endocrinology 127:1673-1681
15. Lund J, Mason JI, Simpson ER, Waterman MR 1989 Developmental regulation of P-45017 alpha gene expression in fetal bovine adrenal. Endocr Res 15:17-29
16. Staels B, Hum DW, Miller WL 1993 Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal. Mol Endocrinol 7:423-433
17. Mesiano S, Coulter CL, Jaffe RB 1993 Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of functional zonation. J Clin Endocrinol Metab 77:1184-1189
18. Zhang P, Mellon SH 1996 The orphan nuclear receptor steroidogenic factor-1 regulates the cAMP-mediated transcriptional activation of rat cytochrome P450c17. Mol Endocrinol 10:147-158
19. Brentano ST, Picado-Leonard J, Mellon SH, Moore CCD, Miller WL 1990 Tissue-specific, cyclic adenosine 3′,5′-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells. Mol Endocrinol 4:1972-1979
20. Lala DS, Rice DA, Parker KL 1992 Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6:1249-1258
21. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ 1992 Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol 12:4153-4163
22. Cooney AJ, Leng X, Tsai SY, O'Malley BW, Tsai MJ 1993 Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J Biol Chem 268:4152-4160
23. Compagnone NA, Moenter S, Weiner RI, Mellon SH, A novel approach using promoter-directed tumorigenesis produces highly differentiated steroidogenic cell lines that intentionally express a tissue-specific cryptic promoter of unknown function. Program of the 76th Annual Meeting of The Endocrine Society, Anaheim, CA, 1994 (Abstract 793)
24. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J 1991 Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300
25. Wilson TE, Fahrner TJ, Milbrandt J 1993 The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 13:5794-5804
26. Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL 1993 The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 13:861-868
27. Clemens JW, Lala DS, Parker KL, Richards JS 1994 Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells. Endocrinology 134:1499-1508
28. Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL, White BA 1993 Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 7:776-786
29. Bakke M, Lund J 1995 Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3′,5′-monophosphate-responsive sequence in the bovine CYP17 gene. Mol Endocrinol 9:327-339
30. Michael MD, Kilgore MW, Morohashi K, Simpson ER 1995 Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J Biol Chem 270:13561-13566
31. Fitzpatrick SL, Richards JS 1994 Identification of a cyclic adenosine 3′,5′-monophosphate-response element in the rat aromatase promoter that is required for transcriptional activation in rat granulosa cells and R2C Leydig cells. Mol Endocrinol 8:1309-1319
32. Zhang P, Rodriguez H, Mellon SH 1995 Transcriptional regulation of P450scc gene expression in neural and in steroidogenic cells: implications for regulation of neurosteroidogenesis. Mol Endocrinol 9:1571-1582
33. Lund J, Ahlgren R, Wu DH, Kagimoto M, Simpson ER, Waterman MR 1990 Transcriptional regulation of the bovine CYP17 (P-450(17)α) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE). J Biol Chem 265:3304-3312
34. Ahlgren R, Simpson ER, Waterman MR, Lund J 1990 Characterization of the promoter/regulatory region of the bovine CYP11A (P-450 scc) gene. Basal and cAMP-dependent expression. J Biol Chem 265:3313-3319
35. Rodriguez HR, Hum D, Staels B, Miller WL 1997 Transcription of the human genes for P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells. J Clin Endocrinol Metab 82:365-371
36. Hum DW, Aza-Blanc P, Miller WL 1995 Characterization of placental transcriptional activation of the human gene for P450scc. DNA Cell Biol 14:451-463
37. Moore CCD, Hum DW, Miller WL 1992 Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3′,5′-monophosphate response element in the human gene for P450scc. Mol Endocrinol 6:2045-2058
38. Yamamoto T, Chapman BM, Johnson DC, Givens CR, Mellon SH, Soares MJ 1996 Cytochrome P450c17 gene expression in differentiating rat trophoblast cells. J Endocrinol 150:161-168
39. Chang SF, Chung BC 1995 Difference in transcriptional activity of two homologous CYP21A genes. Mol Endocrinol 9:1330-1336
40. Crawford PA, Sadovsky Y, Woodson K, Lee SL, Milbrandt J 1995 Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 15:4331-4336
41. Kagawa N, Ogo A, Takahashi Y, Iwamatsu A, Waterman MR 1994 A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1. J Biol Chem 269:18716-18719
42. Le Dréan Y, Liu D, Wong AOL, Xiong F, Hew CL 1996 Steroidogenic factor 1 and estradiol receptor act in synergism to regulate the expression of the salmon gonadotropin II§ subunit gene. Mol Endocrinol 10:217-229
43. Forman BM, Umesono K, Chen J, Evans RM 1995 Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541-550
44. Hum DW, Miller WL 1993 Transcriptional regulation of human genes for steroidogenic enzymes. Clin Chem 39:333-340
45. Hum DW, Staels B, Black SM, Miller WL 1993 Basal transcriptional activity and cyclic adenosine 3′,5′-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells. Endocrinology 132:546-552
46. Moore CCD, Brentano ST, Miller WL 1990 Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements. Mol Cell Biol 10:6013-6023
47. Momoi K, Waterman MR, Simpson ER, Zanger UM 1992 3′,5′-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1. Mol Endocrinol 6:1682-1690
48. Zanger UM, Lund J, Simpson ER, Waterman MR 1991 Activation of transcription in cell-free extracts by a novel cAMP-responsive sequence from the bovine CYP17 gene. J Biol Chem 266:11417-11420
49. Morohashi K, Zanger UM, Honda S, Hara M, Waterman MR, Omura T 1993 Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Mol Endocrinol 7:1196-1204
50. Hashimoto T, Morohashi K, Takayama K, Honda S, Wada T, Handa H, Omura T 1992 Cooperative transcription activation between Ad1, a CRE-like element, and other elements in the CYP11B gene promoter. J Biochem 112:573-575
51. Yamamoto T, Roby KF, Kwok SC, Soares MJ 1994 Transcriptional activation of cytochrome P450 side chain cleavage enzyme expression during trophoblast cell differentiation. J Biol Chem 269:6517-6523
52. Zanger UM, Kagawa N, Lund J, Waterman MR 1992 Distinct biochemical mechanisms for cAMP-dependent transcription of CYP17 and CYP21. FASEB J 6:719-723
53. Youngblood GL, Payne AH 1992 Isolation and characterization of the mouse P450 17 α-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3′,5′-monophosphate in MA-10 Leydig cells. Mol Endocrinol 6:927-934
54. Fevold HR, Ivanovitch JD, Zanger UM, Waterman MR 1993 The sequence of the 5′-end of the rat CYP17 gene, the transcription initiation site and a comparison with the homologous genes of other species. Mol Cell Endocrinol 95:95-100
55. Chen CT, Guo IC, Chung BC 1995 Regulation of cholesterol side-chain cleavage cytochrome P450 in mouse testis Leydig cell line I-10. DNA Cell Biol 14:803-810
56. Guo IC, Tsai HM, Chung BC 1994 Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 (P450scc) gene in adrenal Y1 and placental JEG-3 cells. J Biol Chem 269:6362-6369
57. Manley JL, Fire A, Cano A, Sharp PA, Gefter ML 1980 DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proc Natl Acad Sci USA 77:3855-3859
58. Galas DJ, Schmitz A 1978 DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res 5:3157-3170
59. Yasumura Y, Buonassisi V, Sato G 1966 Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype. Cancer Res 26:529-535
60. Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108:88-95
61. Brasier AR, Tate JE, Habener JF 1989 Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 7:1116-1122
62. Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
63. Lin D, Harikrishna JA, Moore CCD, Jones KL, Miller WL 1991 Missense mutation serine 106 → proline causes 17 α hydroxylase deficiency. J Biol Chem 266:15992-15998