Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling

Toxicology Letters

Volumn 184, Issue 3, 2009, Pages 169-175

  Hancock, Karen D ^a   Coleman, Elaine S ^a   Tao, Ya Xiong ^a   Morrison, Edward E ^a   Braden, Tim D ^a   Kemppainen, Barbara W ^a   Akingbemi, Benson T ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Leydig cells; Phytoestrogens; Steroid hormones; Testicular interstitial cells

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CHOLERA TOXIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FORSKOLIN; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LONG EVANS RAT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS;

ADENYLATE CYCLASE; ANIMALS; CELLS, CULTURED; CHOLERA TOXIN; CYCLIC CMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOCRINE DISRUPTORS; ENZYME ACTIVATORS; EPIDERMAL GROWTH FACTOR; FORSKOLIN; GENISTEIN; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; PROTEIN KINASE INHIBITORS; RATS; RATS, LONG-EVANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, LH; SIGNAL TRANSDUCTION; TESTOSTERONE; TYRPHOSTINS;

RATTUS;

EID: 58249139530     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.11.005     Document Type: Article

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