메뉴 건너뛰기




Volumn 299, Issue 1, 2009, Pages 23-31

Leydig cell aging and the mechanisms of reduced testosterone synthesis

Author keywords

Leydig cell; Luteinizing hormone; Steroidogenesis; Testosterone

Indexed keywords

CYTOCHROME P450; HYDROXYSTEROID DEHYDROGENASE;

EID: 58349121828     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.07.016     Document Type: Review
Times cited : (176)

References (102)
  • 1
    • 40549101870 scopus 로고    scopus 로고
    • Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats
    • Abidi P., Leers-Sucheta S., Cortez Y., Han J., and Azhar S. Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats. Aging Cell 7 (2008) 166-178
    • (2008) Aging Cell , vol.7 , pp. 166-178
    • Abidi, P.1    Leers-Sucheta, S.2    Cortez, Y.3    Han, J.4    Azhar, S.5
  • 2
    • 47849100495 scopus 로고    scopus 로고
    • Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway
    • Abidi P., Zhang H., Zaidi S.M., Shen W.J., Leers-Sucheta S., Cortez Y., Han J., and Azhar S. Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway. J. Endocrinol. 198 (2008) 193-207
    • (2008) J. Endocrinol. , vol.198 , pp. 193-207
    • Abidi, P.1    Zhang, H.2    Zaidi, S.M.3    Shen, W.J.4    Leers-Sucheta, S.5    Cortez, Y.6    Han, J.7    Azhar, S.8
  • 3
    • 18844381164 scopus 로고    scopus 로고
    • Cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency
    • Agarwal A.K., and Auchus R.J. Cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency. Endocrinology 146 (2005) 2531-2538
    • (2005) Endocrinology , vol.146 , pp. 2531-2538
    • Agarwal, A.K.1    Auchus, R.J.2
  • 4
    • 33746084479 scopus 로고    scopus 로고
    • Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis
    • Allen J.A., Shankara T., Janus P., Buck S., Diemer T., Hales K.H., and Hales D.B. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. Endocrinology 147 (2006) 3924-3935
    • (2006) Endocrinology , vol.147 , pp. 3924-3935
    • Allen, J.A.1    Shankara, T.2    Janus, P.3    Buck, S.4    Diemer, T.5    Hales, K.H.6    Hales, D.B.7
  • 5
    • 0036217072 scopus 로고    scopus 로고
    • The lutropin/choriogonadotropin receptor, a 2002 perspective
    • Ascoli M., Fanelli F., and Segaloff D.L. The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr. Rev. 23 (2002) 141-174
    • (2002) Endocr. Rev. , vol.23 , pp. 141-174
    • Ascoli, M.1    Fanelli, F.2    Segaloff, D.L.3
  • 6
    • 28744455710 scopus 로고    scopus 로고
    • Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2
    • Asghar M., Banday A.A., Fardoun R.Z., and Lokhandwala M.F. Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2. Free Radic. Biol. Med. 40 (2006) 13-20
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 13-20
    • Asghar, M.1    Banday, A.A.2    Fardoun, R.Z.3    Lokhandwala, M.F.4
  • 7
    • 0037201611 scopus 로고    scopus 로고
    • Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis
    • Azhar S., and Reaven E. Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis. Mol. Cell. Endocrinol. 195 (2002) 1-26
    • (2002) Mol. Cell. Endocrinol. , vol.195 , pp. 1-26
    • Azhar, S.1    Reaven, E.2
  • 8
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman K.B., and Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78 (1998) 547-581
    • (1998) Physiol. Rev. , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 10
    • 0031594725 scopus 로고    scopus 로고
    • Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-d-aspartate
    • Bonavera J.J., Swerdloff R.S., Sinha Hakim A.P., Lue Y.H., and Wang C. Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-d-aspartate. J. Androl. 10 (1998) 93-99
    • (1998) J. Androl. , vol.10 , pp. 93-99
    • Bonavera, J.J.1    Swerdloff, R.S.2    Sinha Hakim, A.P.3    Lue, Y.H.4    Wang, C.5
  • 11
    • 0030955987 scopus 로고    scopus 로고
    • Spontaneous feminization in a 46, XX female patient with congenital lipoid adrenal hyperplasia due to a homozygous frame shift mutation in the steroidogenic acute regulatory protein
    • Bose H.S., Pescovitz O.H., and Miller W.L. Spontaneous feminization in a 46, XX female patient with congenital lipoid adrenal hyperplasia due to a homozygous frame shift mutation in the steroidogenic acute regulatory protein. J. Clin. Endocrinol. Metab. 82 (1997) 1511-15115
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1511-15115
    • Bose, H.S.1    Pescovitz, O.H.2    Miller, W.L.3
  • 13
    • 0026549468 scopus 로고
    • Control of respiration and ATP synthesis in mammalian mitochondria and cells
    • Brown G.C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284 (1992) 1-13
    • (1992) Biochem. J. , vol.284 , pp. 1-13
    • Brown, G.C.1
  • 14
    • 1542329063 scopus 로고    scopus 로고
    • Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells
    • Cao L., Leers-Sucheta S., and Azhar S. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J. Steroid Biochem. Mol. Biol. 88 (2004) 61-67
    • (2004) J. Steroid Biochem. Mol. Biol. , vol.88 , pp. 61-67
    • Cao, L.1    Leers-Sucheta, S.2    Azhar, S.3
  • 15
    • 0030848810 scopus 로고    scopus 로고
    • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
    • Caron K.M., Soo S.C., Wetsel W.C., Stocco D.M., Clark B.J., and Parker K.L. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 11540-11545
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 11540-11545
    • Caron, K.M.1    Soo, S.C.2    Wetsel, W.C.3    Stocco, D.M.4    Clark, B.J.5    Parker, K.L.6
  • 16
    • 33750563633 scopus 로고    scopus 로고
    • cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells
    • Castillo A.F., Maciel F.C., Castilla R., Duarte A., Maloberti P., Paz C., and Podesta E.J. cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells. FEBS J. 273 (2006) 5011-5021
    • (2006) FEBS J. , vol.273 , pp. 5011-5021
    • Castillo, A.F.1    Maciel, F.C.2    Castilla, R.3    Duarte, A.4    Maloberti, P.5    Paz, C.6    Podesta, E.J.7
  • 17
    • 0028558510 scopus 로고
    • Age-related decreased Leydig cell testosterone production in the brown Norway rat
    • Chen H., Hardy M.P., Huhtaniemi I., and Zirkin B.R. Age-related decreased Leydig cell testosterone production in the brown Norway rat. J. Androl. 15 (1994) 551-557
    • (1994) J. Androl. , vol.15 , pp. 551-557
    • Chen, H.1    Hardy, M.P.2    Huhtaniemi, I.3    Zirkin, B.R.4
  • 18
    • 0033592972 scopus 로고    scopus 로고
    • Long term suppression of Leydig cell steroidogenesis prevents Leydig cell aging
    • Chen H., and Zirkin B.R. Long term suppression of Leydig cell steroidogenesis prevents Leydig cell aging. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 14877-14881
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14877-14881
    • Chen, H.1    Zirkin, B.R.2
  • 19
    • 0034899370 scopus 로고    scopus 로고
    • Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?
    • Chen H., Cangello D., Benson S., Folmer J., Zhu H., Trush M.A., and Zirkin B.R. Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?. Exp. Gerontol. 36 (2001) 1361-1373
    • (2001) Exp. Gerontol. , vol.36 , pp. 1361-1373
    • Chen, H.1    Cangello, D.2    Benson, S.3    Folmer, J.4    Zhu, H.5    Trush, M.A.6    Zirkin, B.R.7
  • 20
    • 0036227563 scopus 로고    scopus 로고
    • Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro
    • Chen H., Hardy M.P., and Zirkin B.R. Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro. Endocrinology 143 (2002) 1637-1642
    • (2002) Endocrinology , vol.143 , pp. 1637-1642
    • Chen, H.1    Hardy, M.P.2    Zirkin, B.R.3
  • 21
    • 0347318172 scopus 로고    scopus 로고
    • Leydig cell gene expression: effects of age and caloric restriction
    • Chen H., Irizarry R.A., Luo L., and Zirkin B.R. Leydig cell gene expression: effects of age and caloric restriction. Exp. Gerontol. 39 (2004) 31-43
    • (2004) Exp. Gerontol. , vol.39 , pp. 31-43
    • Chen, H.1    Irizarry, R.A.2    Luo, L.3    Zirkin, B.R.4
  • 22
    • 4644300593 scopus 로고    scopus 로고
    • Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells
    • Chen H., Liu J., Luo L., and Zirkin B.R. Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells. Endocrinology 145 (2004) 4441-4446
    • (2004) Endocrinology , vol.145 , pp. 4441-4446
    • Chen, H.1    Liu, J.2    Luo, L.3    Zirkin, B.R.4
  • 24
    • 33846422789 scopus 로고    scopus 로고
    • Cyclooxygenases in rat Leydig cells: effects of luteinizing hormone and aging
    • Chen H., Luo L., Liu J., and Zirkin B.R. Cyclooxygenases in rat Leydig cells: effects of luteinizing hormone and aging. Endocrinology 148 (2007) 735-742
    • (2007) Endocrinology , vol.148 , pp. 735-742
    • Chen, H.1    Luo, L.2    Liu, J.3    Zirkin, B.R.4
  • 25
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M., Blasco M.A., and Serrano M. Cellular senescence in cancer and aging. Cell 130 (2007) 223-233
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 28
    • 0036220150 scopus 로고    scopus 로고
    • Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells
    • Culty M., Luo L., Yao Z.X., Chen H., Papadopoulos V., and Zirkin B.R. Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J. Androl. 23 (2002) 439-447
    • (2002) J. Androl. , vol.23 , pp. 439-447
    • Culty, M.1    Luo, L.2    Yao, Z.X.3    Chen, H.4    Papadopoulos, V.5    Zirkin, B.R.6
  • 29
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    • D'Autréaux B., and Toledano M.B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell. Biol. 8 (2007) 813-824
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 813-824
    • D'Autréaux, B.1    Toledano, M.B.2
  • 30
    • 0037330172 scopus 로고    scopus 로고
    • Immune-endocrine interactions and Leydig cell function: the role of cytokines
    • Diemer T., Hales D.B., and Weidner W. Immune-endocrine interactions and Leydig cell function: the role of cytokines. Andrologia 35 (2003) 55-63
    • (2003) Andrologia , vol.35 , pp. 55-63
    • Diemer, T.1    Hales, D.B.2    Weidner, W.3
  • 31
    • 0020472981 scopus 로고
    • Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein
    • Dix C.J., Schumacher M., and Cooke B.A. Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein. Biochem. J. 202 (1982) 739-745
    • (1982) Biochem. J. , vol.202 , pp. 739-745
    • Dix, C.J.1    Schumacher, M.2    Cooke, B.A.3
  • 32
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Dröge, W.1
  • 33
    • 0019132846 scopus 로고
    • Hormone-induced guanyl nucleotide binding and activation of adenylate cyclase in the Leydig cell
    • Dufau M.L., Baukal A.J., and Catt K.J. Hormone-induced guanyl nucleotide binding and activation of adenylate cyclase in the Leydig cell. Proc. Natl. Acad. Sci. U.S.A. 77 (1980) 5837-5841
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 5837-5841
    • Dufau, M.L.1    Baukal, A.J.2    Catt, K.J.3
  • 35
    • 28444437064 scopus 로고    scopus 로고
    • Membranes are more mosaic than fluid
    • Engelman D.M. Membranes are more mosaic than fluid. Nature 438 (2005) 578-580
    • (2005) Nature , vol.438 , pp. 578-580
    • Engelman, D.M.1
  • 36
    • 0025882945 scopus 로고
    • Acute action of luteinizing hormone on mouse Leydig cells: accumulation of mitochondrial phosphoproteins and stimulation of testosterone synthesis
    • Epstein L.F., and Orme-Johnson N.R. Acute action of luteinizing hormone on mouse Leydig cells: accumulation of mitochondrial phosphoproteins and stimulation of testosterone synthesis. Mol. Cell. Endocrinol. 81 (1991) 113-126
    • (1991) Mol. Cell. Endocrinol. , vol.81 , pp. 113-126
    • Epstein, L.F.1    Orme-Johnson, N.R.2
  • 37
    • 0020555750 scopus 로고
    • Effect of luteinizing hormone on Leydig cell structure and testosterone secretion
    • Ewing L.L., Wing T.Y., Cochran R.C., Kromann N., and Zirkin B.R. Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 112 (1983) 1763-1769
    • (1983) Endocrinology , vol.112 , pp. 1763-1769
    • Ewing, L.L.1    Wing, T.Y.2    Cochran, R.C.3    Kromann, N.4    Zirkin, B.R.5
  • 38
    • 33750943634 scopus 로고    scopus 로고
    • Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats
    • Fardoun R.Z., Asghar M., and Lokhandwala M. Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats. Am. J. Physiol. Renal Physiol. 291 (2006) F945-F951
    • (2006) Am. J. Physiol. Renal Physiol. , vol.291
    • Fardoun, R.Z.1    Asghar, M.2    Lokhandwala, M.3
  • 39
    • 0023502450 scopus 로고
    • Cyclic AMP mediated modification of cholesterol traffic in Leydig tumor cells
    • Freeman D.A. Cyclic AMP mediated modification of cholesterol traffic in Leydig tumor cells. J. Biol. Chem. 262 (1987) 13061-13068
    • (1987) J. Biol. Chem. , vol.262 , pp. 13061-13068
    • Freeman, D.A.1
  • 40
    • 0023062991 scopus 로고
    • G-proteins: transducers of receptor-generated signals
    • Gilman A.G. G-proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56 (1987) 615-649
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 615-649
    • Gilman, A.G.1
  • 41
    • 0034190297 scopus 로고    scopus 로고
    • Protein kinase C signaling and oxidative stress
    • Gopalakrishna R., and Jaken S. Protein kinase C signaling and oxidative stress. Free Radic. Biol. Med. 28 (2000) 1349-1361
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1349-1361
    • Gopalakrishna, R.1    Jaken, S.2
  • 42
    • 0031736458 scopus 로고    scopus 로고
    • Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?
    • Grzywacz F.W., Chen H., Allegretti J., and Zirkin B.R. Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?. J. Androl. 19 (1998) 625-630
    • (1998) J. Androl. , vol.19 , pp. 625-630
    • Grzywacz, F.W.1    Chen, H.2    Allegretti, J.3    Zirkin, B.R.4
  • 43
    • 1842587828 scopus 로고    scopus 로고
    • Cell biology of Leydig cells in the testis
    • Haider S.G. Cell biology of Leydig cells in the testis. Int. Rev. Cytol. 233 (2004) 181-241
    • (2004) Int. Rev. Cytol. , vol.233 , pp. 181-241
    • Haider, S.G.1
  • 44
    • 0037206398 scopus 로고    scopus 로고
    • Testicular macrophage modulation of Leydig cell steroidogenesis
    • Hales D.B. Testicular macrophage modulation of Leydig cell steroidogenesis. J. Reprod. Immunol. 57 (2002) 3-18
    • (2002) J. Reprod. Immunol. , vol.57 , pp. 3-18
    • Hales, D.B.1
  • 45
    • 33144490305 scopus 로고    scopus 로고
    • Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
    • Hansen J.M., Go Y.M., and Jones D.P. Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annu. Rev. Pharmacol. Toxicol. 46 (2006) 215-234
    • (2006) Annu. Rev. Pharmacol. Toxicol. , vol.46 , pp. 215-234
    • Hansen, J.M.1    Go, Y.M.2    Jones, D.P.3
  • 46
    • 33646701679 scopus 로고    scopus 로고
    • Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells
    • Hanukoglu I. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug Metab. Rev. 38 (2006) 171-196
    • (2006) Drug Metab. Rev. , vol.38 , pp. 171-196
    • Hanukoglu, I.1
  • 47
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men, Baltimore Longitudinal Study of Aging
    • Harman S.M., Metter E.J., Tobin J.D., Pearson J., and Blackman M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men, Baltimore Longitudinal Study of Aging. J. Endocrinol. Metab. 86 (2001) 724-731
    • (2001) J. Endocrinol. Metab. , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 48
    • 20844451376 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria
    • Hauet T., Yao Z.X., Bose H.S., Wall C.T., Han Z., Li W., Hales D.B., Miller W.L., Culty M., and Papadopoulos V. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria. Mol. Endocrinol. 19 (2005) 540-554
    • (2005) Mol. Endocrinol. , vol.19 , pp. 540-554
    • Hauet, T.1    Yao, Z.X.2    Bose, H.S.3    Wall, C.T.4    Han, Z.5    Li, W.6    Hales, D.B.7    Miller, W.L.8    Culty, M.9    Papadopoulos, V.10
  • 49
    • 0025016027 scopus 로고
    • Sources of cholesterol for testosterone biosynthesis in murine Leydig cells
    • Hou J.W., Collins D.C., and Schleicher R.L. Sources of cholesterol for testosterone biosynthesis in murine Leydig cells. Endocrinology 127 (1990) 2047-2055
    • (1990) Endocrinology , vol.127 , pp. 2047-2055
    • Hou, J.W.1    Collins, D.C.2    Schleicher, R.L.3
  • 50
    • 0017352531 scopus 로고
    • Gonadotropin-induced regulation of luteinizing hormone receptors and desensitization of testicular 3′:5′-cyclic AMP and testosterone responses
    • Hsueh A.J., Dufau M.L., and Catt K.J. Gonadotropin-induced regulation of luteinizing hormone receptors and desensitization of testicular 3′:5′-cyclic AMP and testosterone responses. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 592-595
    • (1977) Proc. Natl. Acad. Sci. U.S.A. , vol.74 , pp. 592-595
    • Hsueh, A.J.1    Dufau, M.L.2    Catt, K.J.3
  • 51
    • 0242353364 scopus 로고    scopus 로고
    • Membrane organization of luteinizing hormone receptors differs between actively signaling and desensitized receptors
    • Hunzicker-Dunn M., Barisas G., Song J., and Roess D.A. Membrane organization of luteinizing hormone receptors differs between actively signaling and desensitized receptors. J. Biol. Chem. 278 (2003) 42744-42749
    • (2003) J. Biol. Chem. , vol.278 , pp. 42744-42749
    • Hunzicker-Dunn, M.1    Barisas, G.2    Song, J.3    Roess, D.A.4
  • 52
    • 0024380688 scopus 로고
    • Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation
    • Inoue Y., and Rebois R.V. Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation. J. Biol. Chem. 264 (1989) 8504-8508
    • (1989) J. Biol. Chem. , vol.264 , pp. 8504-8508
    • Inoue, Y.1    Rebois, R.V.2
  • 53
    • 0019961652 scopus 로고
    • How is the level of free arachidonic acid controlled in mammalian cells?
    • Irvine R.F. How is the level of free arachidonic acid controlled in mammalian cells?. Biochem. J. 204 (1982) 3-16
    • (1982) Biochem. J. , vol.204 , pp. 3-16
    • Irvine, R.F.1
  • 54
    • 0036792481 scopus 로고    scopus 로고
    • High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex
    • Jefcoate C. High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex. J. Clin. Invest. 110 (2002) 881-890
    • (2002) J. Clin. Invest. , vol.110 , pp. 881-890
    • Jefcoate, C.1
  • 55
    • 0032054602 scopus 로고    scopus 로고
    • Identification of a carboxylesterase as the major protein bound by molinate
    • Jewell W.T., and Miller M.G. Identification of a carboxylesterase as the major protein bound by molinate. Toxicol. Appl. Pharmacol. 149 (1998) 226-234
    • (1998) Toxicol. Appl. Pharmacol. , vol.149 , pp. 226-234
    • Jewell, W.T.1    Miller, M.G.2
  • 57
    • 0035066997 scopus 로고    scopus 로고
    • Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid
    • Karbownik M., Garcia J.J., Lewiński A., and Reiter R.J. Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid. J. Bioenerg. Biomembr. 33 (2001) 73-78
    • (2001) J. Bioenerg. Biomembr. , vol.33 , pp. 73-78
    • Karbownik, M.1    Garcia, J.J.2    Lewiński, A.3    Reiter, R.J.4
  • 58
    • 0942298219 scopus 로고    scopus 로고
    • Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men
    • Keenan D.M., and Veldhuis J.D. Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R381-R389
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 59
    • 0037223063 scopus 로고    scopus 로고
    • Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization
    • Kohout T.A., and Lefkowitz R.J. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol. Pharmacol. 63 (2003) 9-18
    • (2003) Mol. Pharmacol. , vol.63 , pp. 9-18
    • Kohout, T.A.1    Lefkowitz, R.J.2
  • 60
    • 9144219652 scopus 로고    scopus 로고
    • A lipid peroxidation-derived inflammatory mediator. Identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages
    • Kumagi T., Matsukawa N., Kaneko Y., Kusumi Y., Mitsumata M., and Uchida K. A lipid peroxidation-derived inflammatory mediator. Identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J. Biol. Chem. 279 (2004) 48389-48396
    • (2004) J. Biol. Chem. , vol.279 , pp. 48389-48396
    • Kumagi, T.1    Matsukawa, N.2    Kaneko, Y.3    Kusumi, Y.4    Mitsumata, M.5    Uchida, K.6
  • 62
    • 0027275205 scopus 로고
    • Age-related decline in the steroidogenic capacity of isolated rat Leydig cells: a defect in cholesterol mobilization and processing
    • Liao C., Reaven E., and Azhar S. Age-related decline in the steroidogenic capacity of isolated rat Leydig cells: a defect in cholesterol mobilization and processing. J. Steroid Biochem. Mol. Biol. 46 (1993) 39-47
    • (1993) J. Steroid Biochem. Mol. Biol. , vol.46 , pp. 39-47
    • Liao, C.1    Reaven, E.2    Azhar, S.3
  • 63
    • 33845977384 scopus 로고    scopus 로고
    • Protein-protein interactions mediate mitochondrial cholesterol transport and biosynthesis
    • Liu J., Rone M.B., and Papadopoulos V. Protein-protein interactions mediate mitochondrial cholesterol transport and biosynthesis. J. Biol. Chem. 281 (2006) 38879-38893
    • (2006) J. Biol. Chem. , vol.281 , pp. 38879-38893
    • Liu, J.1    Rone, M.B.2    Papadopoulos, V.3
  • 64
    • 0029827114 scopus 로고    scopus 로고
    • Are Leydig cell steroidogenic enzymes differentially regulated with aging?
    • Luo L., Chen H., and Zirkin B.R. Are Leydig cell steroidogenic enzymes differentially regulated with aging?. J. Androl. 17 (1996) 509-515
    • (1996) J. Androl. , vol.17 , pp. 509-515
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 65
    • 10844285662 scopus 로고    scopus 로고
    • Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging
    • Luo L., Chen H., and Zirkin B.R. Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging. J. Androl. 26 (2005) 25-31
    • (2005) J. Androl. , vol.26 , pp. 25-31
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 66
    • 33644534186 scopus 로고    scopus 로고
    • Aging and the brown Norway rat leydig cell antioxidant defense system
    • Luo L., Chen H., Trush M.A., Show M.D., Anway M.D., and Zirkin B.R. Aging and the brown Norway rat leydig cell antioxidant defense system. J. Androl. 27 (2006) 240-247
    • (2006) J. Androl. , vol.27 , pp. 240-247
    • Luo, L.1    Chen, H.2    Trush, M.A.3    Show, M.D.4    Anway, M.D.5    Zirkin, B.R.6
  • 67
    • 0036176556 scopus 로고    scopus 로고
    • Andropause: clinical implications of the decline in serum testosterone levels with aging in men
    • Matsumoto A.M. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J. Gerontol. A Biol. Sci. Med. Sci. 57 (2002) M76-M99
    • (2002) J. Gerontol. A Biol. Sci. Med. Sci. , vol.57
    • Matsumoto, A.M.1
  • 68
    • 0030899883 scopus 로고    scopus 로고
    • Biogerontologic theories
    • McClearn G.E. Biogerontologic theories. Exp. Gerontol. 32 (1997) 3-10
    • (1997) Exp. Gerontol. , vol.32 , pp. 3-10
    • McClearn, G.E.1
  • 69
    • 34250859711 scopus 로고    scopus 로고
    • Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis
    • Midzak A.S., Liu J., Zirkin B.R., and Chen H. Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis. Endocrinology 148 (2007) 2583-2590
    • (2007) Endocrinology , vol.148 , pp. 2583-2590
    • Midzak, A.S.1    Liu, J.2    Zirkin, B.R.3    Chen, H.4
  • 70
    • 18844367746 scopus 로고    scopus 로고
    • Regulation of steroidogenesis by electron transfer
    • Miller W.L. Regulation of steroidogenesis by electron transfer. Endocrinology 146 (2005) 2544-2550
    • (2005) Endocrinology , vol.146 , pp. 2544-2550
    • Miller, W.L.1
  • 71
    • 0037016682 scopus 로고    scopus 로고
    • The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation
    • Min L., Galet C., and Ascoli M. The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation. J. Biol. Chem. 277 (2002) 702-710
    • (2002) J. Biol. Chem. , vol.277 , pp. 702-710
    • Min, L.1    Galet, C.2    Ascoli, M.3
  • 73
    • 0034804050 scopus 로고    scopus 로고
    • Reactive oxygen species up-regulates cyclooxygenase-2, p53, and Bax mRNA expression in bovine luteal cells
    • Nakamura T., and Sakamoto K. Reactive oxygen species up-regulates cyclooxygenase-2, p53, and Bax mRNA expression in bovine luteal cells. Biochem. Biophys. Res. Commun. 284 (2001) 201-210
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 201-210
    • Nakamura, T.1    Sakamoto, K.2
  • 74
    • 37549016836 scopus 로고    scopus 로고
    • Heterotrimeric G protein activation by G-protein-coupled receptors
    • Oldham W.M., and Hamm H.E. Heterotrimeric G protein activation by G-protein-coupled receptors. Nat. Rev. Mol. Cell. Biol. 9 (2008) 60-71
    • (2008) Nat. Rev. Mol. Cell. Biol. , vol.9 , pp. 60-71
    • Oldham, W.M.1    Hamm, H.E.2
  • 75
    • 4744346615 scopus 로고    scopus 로고
    • The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology
    • Ostrom R.S., and Insel P.A. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br. J. Pharmacol. 143 (2004) 235-245
    • (2004) Br. J. Pharmacol. , vol.143 , pp. 235-245
    • Ostrom, R.S.1    Insel, P.A.2
  • 76
    • 0027447948 scopus 로고
    • Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function
    • Papadopoulos V. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr. Rev. 14 (1993) 222-240
    • (1993) Endocr. Rev. , vol.14 , pp. 222-240
    • Papadopoulos, V.1
  • 77
    • 0031451871 scopus 로고    scopus 로고
    • Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line
    • Papadopoulos V., Amri H., Li H., Boujrad N., Vidic B., and Garnier M. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J. Biol. Chem. 272 (1997) 32129-32135
    • (1997) J. Biol. Chem. , vol.272 , pp. 32129-32135
    • Papadopoulos, V.1    Amri, H.2    Li, H.3    Boujrad, N.4    Vidic, B.5    Garnier, M.6
  • 79
    • 0028831877 scopus 로고
    • Regulation of expression of steroidogenic enzymes in Leydig cells
    • Payne A.H., and Youngblood G.L. Regulation of expression of steroidogenic enzymes in Leydig cells. Biol. Reprod. 52 (1995) 217-225
    • (1995) Biol. Reprod. , vol.52 , pp. 217-225
    • Payne, A.H.1    Youngblood, G.L.2
  • 80
    • 10644266103 scopus 로고    scopus 로고
    • Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
    • Payne A.H., and Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr. Rev. 25 (2004) 947-970
    • (2004) Endocr. Rev. , vol.25 , pp. 947-970
    • Payne, A.H.1    Hales, D.B.2
  • 81
    • 0030024408 scopus 로고    scopus 로고
    • Induction of lipid peroxidation during steroidogenesis in the rat testis
    • Peltola V., Huhtaniemi I., Metsa-Ketela T., and Ahotupa M. Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 137 (1996) 105-112
    • (1996) Endocrinology , vol.137 , pp. 105-112
    • Peltola, V.1    Huhtaniemi, I.2    Metsa-Ketela, T.3    Ahotupa, M.4
  • 82
    • 0023813845 scopus 로고
    • The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate
    • Platts E.A., Schulster D., and Cooke B.A. The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate. Biochem. J. 253 (1988) 895-899
    • (1988) Biochem. J. , vol.253 , pp. 895-899
    • Platts, E.A.1    Schulster, D.2    Cooke, B.A.3
  • 83
    • 0021361841 scopus 로고
    • Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured Leydig cells. Role in steroidogenic desensitization
    • Quinn P.G., and Payne A.H. Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured Leydig cells. Role in steroidogenic desensitization. J. Biol. Chem. 259 (1984) 4130-4135
    • (1984) J. Biol. Chem. , vol.259 , pp. 4130-4135
    • Quinn, P.G.1    Payne, A.H.2
  • 84
    • 0028961947 scopus 로고
    • Characteristics of mitotic cells in developing and adult testes with observations on cell lineages
    • Russell L.D., de França L.R., Hess R., and Cooke P. Characteristics of mitotic cells in developing and adult testes with observations on cell lineages. Tissue Cell 27 (1995) 105-128
    • (1995) Tissue Cell , vol.27 , pp. 105-128
    • Russell, L.D.1    de França, L.R.2    Hess, R.3    Cooke, P.4
  • 85
    • 0028130155 scopus 로고
    • Leydig cells: endocrine, paracrine, and autocrine regulation
    • Saez J.M. Leydig cells: endocrine, paracrine, and autocrine regulation. Endocr. Rev. 15 (1994) 574-626
    • (1994) Endocr. Rev. , vol.15 , pp. 574-626
    • Saez, J.M.1
  • 86
    • 0242290164 scopus 로고    scopus 로고
    • Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal
    • Shen W.J., Patel S., Natu V., Hong R., Wang J., Azhar S., and Kraemer F.B. Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. J. Biol. Chem. 278 (2003) 43870-43876
    • (2003) J. Biol. Chem. , vol.278 , pp. 43870-43876
    • Shen, W.J.1    Patel, S.2    Natu, V.3    Hong, R.4    Wang, J.5    Azhar, S.6    Kraemer, F.B.7
  • 87
    • 33645520326 scopus 로고    scopus 로고
    • Luteinizing hormone receptors translocate to plasma membrane microdomains after binding of human chorionic gonadotropin
    • Smith S.M., Lei Y., Liu J., Cahill M.E., Hagen G.M., Barisas B.G., and Roess D.A. Luteinizing hormone receptors translocate to plasma membrane microdomains after binding of human chorionic gonadotropin. Endocrinology 147 (2006) 1789-1795
    • (2006) Endocrinology , vol.147 , pp. 1789-1795
    • Smith, S.M.1    Lei, Y.2    Liu, J.3    Cahill, M.E.4    Hagen, G.M.5    Barisas, B.G.6    Roess, D.A.7
  • 88
    • 0034891121 scopus 로고    scopus 로고
    • Lipid peroxidation in aging and age-dependent diseases
    • Spiteller G. Lipid peroxidation in aging and age-dependent diseases. Exp. Gerontol. 36 (2001) 1425-1457
    • (2001) Exp. Gerontol. , vol.36 , pp. 1425-1457
    • Spiteller, G.1
  • 89
    • 0030047248 scopus 로고    scopus 로고
    • Regulation of the acute production of steroids in steroidogenic cells
    • Stocco D.M., and Clark B.J. Regulation of the acute production of steroids in steroidogenic cells. Endocr. Rev. 17 (1996) 221-244
    • (1996) Endocr. Rev. , vol.17 , pp. 221-244
    • Stocco, D.M.1    Clark, B.J.2
  • 90
    • 0035047848 scopus 로고    scopus 로고
    • StAR protein and the regulation of steroid hormone biosynthesis
    • Stocco D.M. StAR protein and the regulation of steroid hormone biosynthesis. Annu. Rev. Physiol. 63 (2001) 193-213
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 193-213
    • Stocco, D.M.1
  • 91
    • 0041816090 scopus 로고    scopus 로고
    • Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
    • Thomas J.L., Duax W.L., Addlagatta A., Brandt S., Fuller R.R., and Norris W. Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase. J. Biol. Chem. 278 (2003) 35483-35490
    • (2003) J. Biol. Chem. , vol.278 , pp. 35483-35490
    • Thomas, J.L.1    Duax, W.L.2    Addlagatta, A.3    Brandt, S.4    Fuller, R.R.5    Norris, W.6
  • 92
    • 0014621744 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
    • Veech R.L., Eggleston L.V., and Krebs H.A. The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem. J. 115 (1969) 609-619
    • (1969) Biochem. J. , vol.115 , pp. 609-619
    • Veech, R.L.1    Eggleston, L.V.2    Krebs, H.A.3
  • 93
    • 21644441621 scopus 로고    scopus 로고
    • Role of the GATA family of transcription factors in andrology
    • Viger R.S., Taniguchi H., Robert N.M., and Tremblay J.J. Role of the GATA family of transcription factors in andrology. J. Androl. 25 (2004) 441-452
    • (2004) J. Androl. , vol.25 , pp. 441-452
    • Viger, R.S.1    Taniguchi, H.2    Robert, N.M.3    Tremblay, J.J.4
  • 94
    • 0027146119 scopus 로고
    • Reproductive aging in the male Brown-Norway rat: a model for human
    • Wang C., Leung A., and Sinha-Hikim A.P. Reproductive aging in the male Brown-Norway rat: a model for human. Endocrinology 133 (1993) 2773-2781
    • (1993) Endocrinology , vol.133 , pp. 2773-2781
    • Wang, C.1    Leung, A.2    Sinha-Hikim, A.P.3
  • 95
    • 0037169833 scopus 로고    scopus 로고
    • Interaction between arachidonic acid and cAMP signaling pathways enhances steroidogenesis and StAR gene expression in MA-10 Leydig tumor cells
    • Wang X.J., Dyson M.T., Mondillo C., Patrignani Z., Pignataro O., and Stocco D.M. Interaction between arachidonic acid and cAMP signaling pathways enhances steroidogenesis and StAR gene expression in MA-10 Leydig tumor cells. Mol. Cell. Endocrinol. 188 (2002) 55-63
    • (2002) Mol. Cell. Endocrinol. , vol.188 , pp. 55-63
    • Wang, X.J.1    Dyson, M.T.2    Mondillo, C.3    Patrignani, Z.4    Pignataro, O.5    Stocco, D.M.6
  • 96
    • 0042388754 scopus 로고    scopus 로고
    • Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression
    • Wang X.J., Dyson M.T., Jo Y., Eubank D.W., and Stocco D.M. Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. J. Steroid Biochem. Mol. Biol. 85 (2003) 159-166
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.85 , pp. 159-166
    • Wang, X.J.1    Dyson, M.T.2    Jo, Y.3    Eubank, D.W.4    Stocco, D.M.5
  • 98
    • 0014082605 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
    • Williamson D.H., Lund P., and Krebs H.A. The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem. J. 103 (1967) 514-527
    • (1967) Biochem. J. , vol.103 , pp. 514-527
    • Williamson, D.H.1    Lund, P.2    Krebs, H.A.3
  • 99
    • 0027326817 scopus 로고
    • Plasma membrane changes in the rat corpus luteum induced by oxygen radical generation
    • Wu X., Yao K., and Carlson J.C. Plasma membrane changes in the rat corpus luteum induced by oxygen radical generation. Endocrinology 133 (1993) 491-495
    • (1993) Endocrinology , vol.133 , pp. 491-495
    • Wu, X.1    Yao, K.2    Carlson, J.C.3
  • 100
    • 33746108825 scopus 로고    scopus 로고
    • Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP
    • Yang T., Zhang A., Pasumarthy A., Zhang L., Warnock Z., and Schnermann J.B. Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP. Am. J. Physiol. Renal Physiol. 291 (2006) F891-F895
    • (2006) Am. J. Physiol. Renal Physiol. , vol.291
    • Yang, T.1    Zhang, A.2    Pasumarthy, A.3    Zhang, L.4    Warnock, Z.5    Schnermann, J.B.6
  • 101
    • 0036860195 scopus 로고    scopus 로고
    • Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging
    • Yeo E.J., and Park S.C. Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging. Mech. Ageing Dev. 123 (2002) 1563-1578
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1563-1578
    • Yeo, E.J.1    Park, S.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.