The human 3β-hydroxysteroid dehydrogenase/Δ5- Δ4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells

Endocrinology

Volumn 146, Issue 2, 2005, Pages 861-869

  Martin, Luc J ^a   Tremblay, Jacques J ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CELL NUCLEUS RECEPTOR; CELL NUCLEUS RECEPTOR NUR77; UNCLASSIFIED DRUG; 3 BETA HYDROXYSTEROID OXIDOREDUCTASE DELTA(5) 3 KETOSTEROID ISOMERASE; 3 BETA-HYDROXYSTEROID OXIDOREDUCTASE-DELTA(5) 3-KETOSTEROID ISOMERASE; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; CELL RECEPTOR; CYCLIC AMP; DNA BINDING PROTEIN; MULTIENZYME COMPLEX; NUCLEAR RECEPTOR NUR77; STEROID DELTA ISOMERASE; STEROID RECEPTOR; TRANSCRIPTION FACTOR;

ADRENAL CELL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; HORMONE SYNTHESIS; HUMAN; LEYDIG CELL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STEROIDOGENESIS; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; MALE; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEYDIG CELLS; MALE; MICE; MULTIENZYME COMPLEXES; PROGESTERONE REDUCTASE; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RESPONSE ELEMENTS; STEROID ISOMERASES; TRANSCRIPTION FACTORS;

EID: 12344335015     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0859     Document Type: Article

References (58)

1. 4 isomerase gene family. Endocr Rev, in press
2. Kojima I, Kojima K, Kreutter D, Rasmussen H1984 The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways. J Biol Chem 259:14448-14457
3. 5-3β-hydroxysteroid dehydrogenase-isomerase activity in rat adrenocortical cells by corticotropin. Endocrinology 111:427-433
4. 5-4-isomerase expression by adrenocorticotropin in bovine adrenocortical cells. Endocrinology 128:139-145
5. Bird IM, Imaishi K, Pasquarette MM, Rainey WE, Mason JI 1996 Regulation of 3β-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. J Endocrinol 150(Suppl):S165-S173
6. 2+-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells. J Clin Endocrinol Metab 83:1592-1597
7. 5-4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Endocrinology 130:2007-2015
8. 5-4-isomerase, 17α-hydroxylase/C17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells. Endocrinology 129:1429-1435
9. 4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester. J Biol Chem 272:7960-7967
10. Peng N, Kim JW, Rainey WE, Carr BR, Attia GR 2003 The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3Β-hydroxysteroid dehydrogenase type II. J Clin Endocrinol Metab 88:6020-6028
11. 4 isomerase gene: activation by prolactin. Mol Endocrinol 13:1084-1093
12. 4 isomerase gene. J Steroid Biochem Mol Biol 82:55-63
13. 4- isomerase expression in human adrenocortical carcinoma cells: evidence for a Stat5-dependent mechanism. Endocrinology 144:1847-1853
14. Gingras S, Simard J, Groner B, Pfitzner E 1999 p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Res 27:2722-2729
15. Wang ZN, Bassett M, Rainey WE 2001 Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11β-hydroxylase. J Mol Endocrinol 27:255-258
16. Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, Carreau S, Ando S, Simpson ER, Clyne CD 2004 Differential expression of steroidogenic factor-1 /adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology 145:2186-2196
17. Liu DL, Liu WZ, Li QL, Wang HM, Qian D, Treuter E, Zhu C 2003 Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary. Biol Reprod 69:508-517
18. Hinshelwood MM, Repa JJ, Shelton JM, Richardson JA, Mangelsdorf DJ, Mendelson CR 2003 Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol Cell Endocrinol 207:39-45
19. Falender AE, Lanz R, Malenfant D, Belanger L, Richards JS 2003 Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Endocrinology 144:3598-3610
20. Yamazaki T, Kanzaki M, Kamidono S, Fujisawa M 2004 Effect of erythropoietin on Leydig cell is associated with the activation of Stat5 pathway. Mol Cell Endocrinol 213:193-198
21. Russell DL, Richards JS 1999 Differentiation-dependent prolactin responsiveness and stat (signal transducers and activators of transcription) signaling in rat ovarian cells. Mol Endocrinol 13:2049-2064
22. Fayard E, Auwerx J, Schoonjans K 2004 LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol 14:250-260
23. Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
24. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res 57: 19-36
25. Val P, Lefrancois-Martinez AM, Veyssiere G, Martinez A 2003 SF-1 a key player in the development and differentiation of Steroidogenic tissues. Nucl Recept 1:8
26. Eells JB, Witta J, Otridge JB, Zuffova E, Nikodem VM 2000 Structure and function of the Nur77 receptor subfamily, a unique class of hormone nuclear receptor. Curr Genomics 1:135-152
27. Giguere V 1999 Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725
28. Song KH, Park JI, Lee MO, Soh J, Lee K, Choi HS 2001 LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells. Endocrinology 142:5116-5123
29. Davis IJ, Lau LF 1994 Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol Cell Biol 14:3469-3483
30. Park JI, Park HJ, Choi HS, Lee K, Lee WK, Chun SY 2001 Gonadotropin regulation of NGFI-B messenger ribonucleic acid expression during ovarian follicle development in the rat. Endocrinology 142:3051-3059
31. Park JI, Park HJ, Lee YI, Seo YM, Chun SY 2003 Regulation of NGFI-B expression during the ovulatory process. Mol Cell Endocrinol 202:25-29
32. Wilson TE, Fahrner TJ, Milbrandt J 1993 The orphan receptors NGFI-B and Steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 13:5794-5804
33. Philips A, Lesage S, Gingras R, Maira MH, Gauthier Y, Hugo P, Drouin J 1997 Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol Cell Biol 17:5946-5951
34. Maira M, Martens C, Philips A, Drouin J 1999 Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol Cell Biol 19:7549-7557
35. Zetterstrom RH, Solomin L, Mitsiadis T, Olson L, Perlmann T 1996 Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol Endocrinol 10:1656-1666
36. 2α-induced expression of 20α- hydroxysteroid dehydrogenase involves the transcription factor NUR77. J Biol Chem 275:37202-37211
37. Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE 2004 The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol 18:279-290
38. Song KH, Park YY, Park KC, Hong CY, Park JH, Shong M, Lee K, Choi HS 2004 The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol 18: 1929-1940
39. Tremblay JJ, Viger RS 1999 Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. Mol Endocrinol 13:1388-1401
40. Tremblay JJ, Viger RS 2001 GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements. Endocrinology 142:977-986
41. Galarneau L, Pare JF, Allard D, Hamel D, Levesque L, Tugwood JD, Green S, Belanger L 1996 The α1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol Cell Biol 16:3853-3865
42. Mayr B, Montminy M 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609
43. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG 1997 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387:677-684
44. Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108:88-95
45. Tremblay JJ, Viger RS 2003 A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4. J Biol Chem 278:42637-42642
46. Daggett MA, Rice DA, Heckert LL 2000 Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region. Biol Reprod 62:670-679
47. Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K 2004 Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor α. Mol Cell Biol 24:2593-2604
48. Maira M, Martens C, Batsche E, Gauthier Y, Drouin J 2003 Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol 23: 763-776
49. Sohn YC, Kwak E, Na Y, Lee JW, Lee SK 2001 Silencing mediator of retinoid and thyroid hormone receptors and activating signal cointegrator-2 as transcriptional coregulators of the orphan nuclear receptor Nur77. J Biol Chem 276:43734-43739
50. Enyeart JJ, Boyd RT, Enyeart JA 1996 ACTH and All differentially stimulate steroid hormone orphan receptor mRNAs in adrenal cortical cells. Mol Cell Endocrinol 124:97-110
51. Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL 1993 The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 13:861-868
52. Kelly SN, McKenna TJ, Young LS 2004 Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal. J Endocrinol 181:355-365
53. Bassett MH, Suzuki T, Sasano H, De Vries CJ, Jimenez PT, Carr BR, Rainey WE 2004 The orphan nuclear receptor NGFIB regulates transcription of 3β-hydroxysteroid dehydrogenase: implications for the control of adrenal functional zonation. J Biol Chem 279:37622-37630
54. Crawford PA, Sadovsky Y, Woodson K, Lee SL, Milbrandt J 1995 Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 15:4331-4336
55. Nomura M, Kawabe K, Matsushita S, Oka S, Hatano O, Harada N, Nawata H, Morohashi K 1998 Adrenocortical and gonadal expression of the mammalian Ftz-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control. J Biochem 124:217-224
56. Boerboom D, Pilon N, Behdjani R, Silversides DW, Sirois J 2000 Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process. Endocrinology 141:4647-4656
57. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA 1999 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3:521-526
58. Yao TP, Ku G, Zhou N, Scully R, Livingston DM 1996 The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci USA 93:10626-10631