Exposure of infants to ochratoxin A with breast milk

Archives of Toxicology

Volumn 88, Issue 3, 2014, Pages 837-846

  Munoz K ^a   Blaszkewicz, M ^b   Campos, V ^c   Vega, M ^c   Degen, G H ^b  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^c UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Biomonitoring; Human milk; Infants' exposure; Mycotoxin; Ochratoxin A

Indexed keywords

OCHRATOXIN;

ANALYSIS; BLOOD; BREAST FEEDING; BREAST MILK; CHEMISTRY; CHILE; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; HUMAN; INFANT; LONGITUDINAL STUDY; MOTHER; NEWBORN; URINE;

BREAST FEEDING; CHILE; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MILK, HUMAN; MOTHERS; OCHRATOXINS;

EID: 84894517537     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1168-4     Document Type: Article

References (62)

1. American Academy of Pediatrics (AAP) (2001) The transfer of drugs and other chemicals into human milk. Paediatrics 108(3):1025-1029
2. American Academy of Pediatrics (AAP) (2005) Breastfeeding and the use of human milk. Paediatrics 115(2):496-506
3. Apostolou E, El-Nezami HS, Ahoka JT, Donohe DD (1998) The evaluation of ochratoxin A in breast milk in Victoria (Australia). Rev Med Vet 149(6):709
4. Bauer J (2013) Longitudinal composition of breast milk with extremely preterm infants compared to premature to term milk. In: Preedy V, Watson RR, Zibadi S (eds) Handbook of dietary and nutritional aspects of human breast milk. Wageningen Academic Publishers, The Netherlands, pp 83-97. ISBN: 978-90-8686-209-2
5. Bauer J, Gareis M (1987) Ochratoxin A in der Nahrungsmittelkette. J Vet Med B 34:613-627
6. Biasucci G, Calabrese G, Di Giuseppe R, Carrara G, Colombo F, Mandelli B, Maj M, Bertuzzi T, Pietri A, Rossi F (2011) The presence of ochratoxin A in cord serum and in human milk and its correspondence with maternal dietary habits. Eur J Nutr 50(3):211-218
7. Blaszkewicz M, Baumhoer G (2010) In: Deutsche Forschungsgemeinschaft DFG. Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Analysen in biologischem Material. Ochratoxin A. Band 2, pp 1-18
8. Breitholtz-Emanuelsson A, Olsen M, Oskarsson A, Palminger I, Hult K (1993) Ochratoxin A in cow's milk and in human milk with corresponding human blood samples. J AOAC Int 76(4):842-846
9. Coronel MB, Marin S, Tarrago M, Cano-Sancho G, Ramos AJ, Sanchis V (2011a) Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of exposure in inhabitants of Lleida, Spain. Food Chem Toxicol 49:1436-1442
10. Coronel MB, Sanchis V, Ramos AJ, Marin S (2011b) Ochratoxin A in adult population of Lleida, Spain: presence in blood plasma and consumption in different regions and seasons. Food Chem Toxicol 49(10):2697-2705
11. Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ (2004) A framework for assessing risks to children from exposure to environmental agents. Environ Health Perspect 112(2):238-256
12. Degen GH (2011) Tools for investigating workplace-related risks from mycotoxin exposure. World Mycotoxin J 4(3):315-327
13. Degen GH, Muñoz K, Hengstler JG (2013) Occurrence of mycotoxins in breast milk. In: Preedy V, Watson RR, Zibadi S (eds) Handbook of dietary and nutritional aspects of human breast milk. Wageningen Academic Publishers, The Netherlands, pp. 813-831. ISBN: 978-90-8686-209-2
14. Dostal A, Jakusova L, Cajdova J, Hudeckova H (2008) Results of the first studies of occurrence of ochratoxin A in human milk in Slovakia. Bratisl Lek Listy 109(6):276-278
15. Duarte SC, Pena A, Lino CM (2011) Human ochratoxin A biomarkers: from exposure to effect. Crit Rev Toxicol 41(3):187-212
16. El-Sayed AAM, Aly SE, Neamat-Allah AA (2002) Human exposure to mycotoxins in Egypt. Mycotoxin Res 18:23-30
17. Emmett PM, Rogers IS (1997) Properties of human milk and their relationship with maternal nutrition. Early Hum Dev 49:7-28
18. European Commission (EC) (2002) Assessment of dietary intake of ochratoxin A by the population of EU member states. Report of the Scientific Cooperation, Task 3.2.7. Directorate-General Health and Consumer Protection, European Commission. Available at URL: europa.eu.int/comm/food/fs/scoop/3.2.7- en.pdf
19. European Food Safety Authority (EFSA) (2006) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food. EFSA J 365:1-56
20. FAO/WHO (Food and Agriculture Organisation/World Health Organisation) (2001) Ochratoxin A. In: Safety evaluation of certain mycotoxins in food, prepared by the 56th meeting of the joint FAO/WHO expert committee on food additives (JECFA). WHO food additives series 47. World Health Organisation, Geneva, Switzerland, pp 281-387
21. Fleishaker JC (2003) Models and methods for predicting drug transfer into human milk. Adv Drug Deliv Rev 55(5):643-652
22. Galvano F, Pietri A, Bertuzzi T, Gagliardi L, Ciotti S, Luisi S, Bognanno M, La Fauci L, Iacopino AM, Nigro F, Li Volti G, Vanella L, Giammanco G, Tina GL, Gazzolo D (2008) Maternal dietary habits and mycotoxin occurrence in human mature milk. Mol Nutr Food Res 52(4):496-501
23. Gareis M, Märtlbauer E, Bauer J, Gedek B (1988) Bestimmung von Ochratoxin A in Muttermilch. Zeitschr Lebensm Unters Forsch 186:114-117
24. Gilbert J, Brereton P, MacDonald S (2001) Assessment of dietary exposure to ochratoxin A in the UK using duplicate diet approach and analysis of urine and plasma samples. Food Addit Contam 18(12):1088-1093
25. Gobierno de Chile (2010a) Lactancia materna en Chile, contenidos técnicos para profesionales de la salud. (Breastfeeding in Chile, technical guide for health workers). Ministerio de Salud. Available at URL: www.minsal.gob.cl/portal/url/item/822bfc84b3242b25e04001011e017693.pdf
26. Gobierno de Chile (2010b) Norma de programas alimentarios en Chile. (Standard food programs in Chile). Ministerio de Salud. Available at URL: www.redsalud.gov.cl/portal/url/item/93ac93874415cad0e04001011f012383.pdf
27. Gürbay A, Girgin G, Atasayar Sabuncuoglu S, Sahin G, Yurdakök M, Yigit S, Tekinalp G (2010) Ochratoxin A: is it present in breast milk samples obtained from mothers from Ankara, Turkey. J Appl Toxicol 30(4):329-333
28. Hassan A, Sheashaa H, Abdel Fattah M, Ibrahim A, Gaber O, Sobh M (2006) Study of Ochratoxin A as an environmental risk that causes renal injury in breast-fed Egyptian infants. Pediatr Nephrol 21:102-105
29. Ito S, Alcorn J (2003) Xenobiotic transporter expression and function in the human mammary gland. Adv Drug Deliv Rev 55:653-665
30. Jonsyn F (1999) Intake of aflatoxins and ochratoxins by infants in Sierra Leone: possible effects on the general health of these children. J Nutr Environ Med 9:15-22
31. Jonsyn F, Maxwell SM, Hendrickse R (1995) Ochratoxin A and aflatoxins in breast milk samples from Sierra Leone. Mycopathologia 131:121-126
32. Kovács F, Sándor G, Ványi A, Domány S, Zomborszky-Kovács M (1995) Detection of ochratoxin A in human blood and colostrum. Acta Vet Hung 43(4):393-400
33. Kuiper-Goodman T, Hilts C, Billiard SM, Kiparissis Y, Richrad IDK, Hayward S (2010) Health risk assessment of ochratoxin A for all age-sex strata in a market economy. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27(2):212-240
34. Leotsinidis M, Alexopoulos A, Kostopoulou-Farri E (2005) Toxic and essential trace elements in human milk from Greek lactating women: association with dietary habits and other factors. Chemosphere 61:238-247
35. Lino CM, Baeta ML, Henri M, Dinis AMP, Pena AS, Silverira MIN (2008) Levels of ochratoxin A from urban and rural Portuguese populations an estimation of exposure degree. Food Chem Toxicol 46:879-885
36. Makri A, Goveia M, Balbus J, Parkin R (2004) Children's susceptibility to chemicals: a review by developmental stage. J Toxicol Environ Health B Crit Rev 7(6):417-435
37. Mally A, Dekant W (2009) Mycotoxins and the kidney: models of action for renal tumour formation by ochratoxin A in rodents. Mol Nutr Food Res 53:467-478
38. Märtlbauer E, Usleber E, Dietrich R, Schneider E (2009) Ochratoxin A in human blood serum-retrospective long-term data. Mycotox Res 25:175-186
39. Micco C, Miraglia M, Brera C, Corneli S, Ambruzzi A (1995) Evaluation of ochratoxin A level in human milk in Italy. Food Addit Contam 12(3):351-354
40. Muñoz K (2012) Development of biomonitoring methods for the mycotoxin ochratoxin A and their application to assess infants' exposure with human milk. Dissertation, Technische Universität Dortmund
41. Muñoz K, Vega M, Rios G, Muñoz S, Madariaga R (2006) Preliminary study of ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption. Food Chem Toxicol 44:1884-1889
42. Muñoz K, Blaszkewicz M, Degen GH (2010a) Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. J Chromatogr B 878:2623-2629
43. Muñoz K, Campos V, Blaszkewicz M, Vega M, Alvarez A, Neira J, Degen GH (2010b) Exposure of neonates to ochratoxin A: first biomonitoring results in human milk (colostrum) from Chile. Mycotox Res 26:59-67
44. Muñoz K, Wollin KM, Kalhoff H, Degen GH (2013) Zum Vorkommen des Mykotoxins Ochratoxin A in Muttermilchproben aus Deutschland. Gesundheitswesen 75:1-4
45. Navas S, Sabino M, Rodriguez-Amaya D (2005) Aflatoxin M1 and ochratoxin A in human milk bank in the city of Sao Paulo, Brazil. Food Addit Contam 22(5):457-462
46. Palli D, Miraglia M, Saieva C, Masala G, Cava E, Colatosti M, Corsi AM, Russo A, Brera C (1999) Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidemiol Biomarkers 8(3):265-269
47. Pohl HR, Abadin HG (2008) Chemical mixtures: evaluation of risks for child-specific exposures in a multi-stressor environment. Toxicol Appl Pharmacol 233:116-125
48. Postupolski J, Karlowski K, Kubik P (2006) Ochratoxin A and foetal blood and in maternal milk. Rocz Panstw Zakl Hig 57(1):23-30
49. Schwenk M, Gundert-Remy U, Heinemeyer G, Olejniczak K, Stahlmann R, Kaufmann W, Bolt HM, Greim H, von Keutz E, Gelbke HP, DGPT (2003) Children as a sensitive subgroup and their role in regulatory toxicology: DGPT workshop report. Arch Toxicol 77(1):2-6
50. Scott PM (2005) Biomarkers of human exposure to ochratoxin A. Food Addit Contam 1:99-107
51. Sikorski R, Paszkowski T, Radomanski T, Niewladowska P, Semeniuk S (1990) Human colostrum as a source of organohalogen xenobiotics for a breast-fed neonate. Reprod Toxicol 4:17-20
52. Skaug MA, Størmer FC, Saugstad OD (1998) Ochratoxin A: a naturally occurring mycotoxin found in human milk samples from Norway. Acta Paediatr 87:1275-1278
53. Skaug M, Helland I, Solvoll K, Saugstad O (2001) Presence of ochratoxin A in human milk in relation to dietary intake. Food Addit Contam 18(4):321-327
54. Stojkovic R, Hult K, Gamulin S, Plestina R (1984) High affinity binding of ochratoxin A to plasma constituents. Biochem Int 9:33-38
55. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) (1996) Toxicological evaluation of certain Food Addit Contam in food: ochratoxin A. Forty-fourth meeting. WHO Food Addit Ser 35:363-376
56. The Nordic Working Group on Food Toxicology and Risk Evaluation (NNT) (1991) Health evaluation of ochratoxin A in food products. Nordiske Seminar og Arbejdsrapporter 545. Nordic Council of Ministers, Copenhagen, Denmark (cited as Olsen M et al. 1991 in Kuiper-Goodman REVIEW)
57. Thuvander A, Paulsen JE, Axberg K, Johansson K, Vidnes A, Enghardt-Barbieri H, Trygg K, Lund-Larsen K, Jahrl S, Widenfalk A, Bosnes V, Alexander J, Hult K, Olsen M (2001) Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem Toxicol 39:1145-1151
58. Tonon KM, Reiter MGR, Scussel VM (2013) Mycotoxins levels in human milk: a menace to infants and children health. Curr Nutr Food Sci 1:33-42
59. Turconi G, Guarcello M, Livieri Ch, Comizzoli S, Maccarini L, Castellazzi A, Pietri A, Piva G, Roggi C (2004) Evaluation of xenobiotics in human milk and ingestion by the newborn: an epidemiological survey in Lombardy (Northern Italy). Eur J Nutr 43:191-197
60. van Egmond HP, Schothorst RC, Jonker MA (2007) Regulations relating to mycotoxins in food: perspectives in a global and European context. Anal Bioanal Chem 389(1):147-157
61. Zimmerli B, Dick R (1995) Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data. J Chromatogr B Biomed Appl 666:85-99
62. Zwart L, Haenen H, Vesantvoort C, Wolterink G, van Engelen J, Sips A (2004) Role of biokinetics in risk assessment of drugs and chemicals in children. Regul Toxicol Pharmacol 39:282-309