Levels of ochratoxin A in serum from urban and rural Portuguese populations and estimation of exposure degree

Food and Chemical Toxicology

Volumn 46, Issue 3, 2008, Pages 879-885

  Lino, C M ^a   Baeta, M L ^a   Henri, M ^a   Dinis, A M P ^a   Pena, A S ^a   Silveira, M I N ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

HPLC; Ochratoxin A; Portugal; Serum; Spectrofluorimeter detection

Indexed keywords

BORON TRIFLUORIDE; CHLOROFORM; OCHRATOXIN; PHOSPHORIC ACID;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; POPULATION RESEARCH; PORTUGAL; RURAL AREA; SEX RATIO; SPECTROFLUOROMETRY; URBAN AREA;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENVIRONMENTAL EXPOSURE; HUMANS; MYCOTOXINS; OCHRATOXINS; RURAL POPULATION; SPECTROMETRY, FLUORESCENCE; URBAN POPULATION;

EID: 38649140511     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.10.012     Document Type: Article

References (35)

1. Assaf H., Betbeder A.-M., Creppy E.E., Pallardy M., and Azouri H. Ochratoxin A levels in human plasma and foods in Lebanon. Hum. Exper. Toxicol. 23 (2004) 495-501
2. Breitholtz A., Olsen M., Dahlback A., and Hult K. Plasma ochratoxin A levels in three Swedish populations surveyed using an ion-pair HPLC technique. Food Addit. Contam. 8 (1991) 183-192
3. Breitholtz-Emanuelson A., Olsen M., Oskarsson A., Palminger I., and Hult K. Ochratoxin A in cow's milk and in human milk with corresponding human blood samples. J. AOAC Int. 76 (1993) 842-846
4. Brera C., Caputi R., Miraglia M., Iavicoli I., Salerno A., and Carelli G. Exposure assessment to mycotoxins in workplaces: aflatoxins and ochratoxin A occurence in airborne dusts and human sera. Microchem. J. 73 (2002) 167-173
5. Castegnaro M., Mohr U., Pfohl-Leszkowicz A., Estéve J., Steinmann J., Tillmann T., Michelon J., and Bartsch H. Sex-and strain specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction. Int. J. Cancer 77 (1998) 70-75
6. Castellari M., Fabbri S., Fabiani A., Amati A., and Galassi S. Comparison of different immunoaffinity clean-up procedures for high-performance liquid chromatographic analysis of ochratoxin A in wines. J. Chromatogr. A 888 (2000) 129-136
7. Creppy, E., Castegnaro, M., Grosse, Y., Mérieux, J., Manier, C., Moncharmont, P., Waller, C., 1993. Coloque INSERM/John Libbey Eurotext Ltd., Montrouge, France, vol. 231, pp. 147-158.
8. Dragacci S., Grosso F., Bire R., Fremy J.M., and Coulon S. A French monitoring programme for determining of ochratoxin A occurrence in pig kidneys. Nat. Toxins 7 (1999) 167-173
9. EU, 2002. Assessment of dietary intake of ochratoxin A by the population of EU member states (report for SCOOP task 3.2.7.). .
10. Fillali A., Betbeder A.M., Baudrimont I., Benayada A., Soulaymani R., and Creppy E.E. Ochratoxin A in human plasma in Morocco: a preliminary survey. Hum. Exp. Toxicol. 21 (2002) 241-245
11. Gareis M., Wolff J., Bresch H., Engel G., Rosner H., Majeurs P., Scheurer R., and Bodechtel C.C. The German ochratoxin A project: contamination of foods and consumer exposure. Mycotoxins 51 (2001) 31-35
12. Grosso F., Said S., Mabrouk I., Fremy J.M., Castegnaro M., Jemmali M., and Dagracci S. New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food Chem. Toxicol. 41 (2003) 1133-1140
13. Hald B. Ochratoxin A in human blood in European countries in mycotoxins, endemic nephropathy and urinary tract tumors. IARC 115 (1991) 159-164
14. 2-microglobulinuria in healthy individuals and chronic interstitial nephropathy patients in the Centre of Tunisia: a hot spot of ochratoxin A exposure. Toxicology 199 (2004) 185-193
15. Hill A.R.C., and Reynolds S.L. Guidelines for in-house validation of analytical methods for pesticide residues in food and animal feeds. Analyst 124 (1999) 953-958
16. Hubner L. Validation of analytical methods: review and strategy. LC-GC Int. 11 (1998) 96-105
17. IARC Monographs on the evaluation of carcinogenic risks of chemicals to humans. 1993, vol. 56: Some naturally occurring substances: some food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC, Lyon.
18. Jimenez A.M., Cerain A.L., González-Penas E., Bello J., Betbeder A.M., and Creppy E.E. Exposure to ochratoxin A in Europe: comparison with a region of northern Spain. J. Toxicol.-Toxin Rev. 17 (1998) 479-491
19. Kane A., Diop N., and Diack T.S. Natural occurrence of ochratoxin A in food and feed in Senegal. IARC Monographs on mycotoxins, endemic nephropathy and urinary tract tumours. IARC (1991) 93-96
20. Leitner A., Zoller P., Paolill O.A., Stroka J., Papadopoulou-Bouraoui A., Jaborek Anklam E., and Lindner W. Comparison of methods for the determination of ochratoxin A in wine. Anal. Chim. Acta 453 (2002) 33-41
21. Marquardt R.R., and Frolich A.A. A review of recent advances in understanding ochratoxicosis. J. Anim. Sci. 70 (1992) 3968-3988
22. Moreno Guillamont E., Lino C.M., Baeta M.L., Pena A.S., Silveira M.I.N., and Mañes J. A comparative study of extraction apparatus in HPLC analysis of ochratoxin A in muscle. Anal. Bioanal. Chem. 383 (2005) 570-575
23. Palli D., Miraglia M., Saieva C., Masala G., Cava E., Colatosti M., Corsi A.M., Russo A., and Brera C. Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidem. Biom. Prevent 8 (1999) 265-269
24. Pena A., Cerejo F., Lino C.M., and Silveira M.I. Determination of ochratoxin A in portugueses rice samples by high performance liquid chromatography with fluorescence detection. Anal. Bioanal. Chem. 382 (2005) 1288-1293
25. Pena A., Seifrtova M., Lino C., Silveira I., and Solich P. Estimation of ochratoxin A in Portuguese population: new data on the occurrence in human urine by high performance liquid chromatography with fluorescence detection. Food Chem. Toxicol. 44 (2006) 1449-1454
26. Peraica M., Domijan A.-M., Fuchs R., Lucic A., and Radic B. The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol. Lett. 110 (1999) 105-112
27. Peraica M., Domijan A.-M., Matasin M., Lucic A., Radic B., Delas F., Horvat M., Bosanac I., Balija M., and Grgicevic D. Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities. Arch. Toxicol. 75 (2001) 410-414
28. Petkova-Bocharova T., Castegnaro M., Pfohl-Leszkowicz A., Garren L., Grosso F., Nikolov I., Vrabcheva T., Dragacci S., and Chernozemsky I.N. Facta Univer. 10 (2003) 62-68
29. Scott P.M., Kanhere S.R., Lau B.P.-Y., Lewis D.A., Hayward S., and Kuiper-Goodman T. Survey of Canadian human blood plasma for ochratoxin A. Food Addit. Contam. 15 (1998) 555-562
30. Singare-Tigori B., Moukha S., Kouadio J.H., Dano D.S., Betbeder A.-M., Achour A., and Creppy E.E. Ochratoxin A in human blood in Abidjan, Côte d'Ivoire. Toxicon 47 (2006) 894-900
31. Swartz M.E., and Krull I.S. Validation of chromatographic methods. Pharma. Tech. 22 (1998) 104-120
32. Thuvander A., Paulsen J.E., Axberg K., Johansson N., Vidnes A., Enghardt-Barbieri H., Trygg K., Lund-Larsen K., Jahrl S., Widenfalk A., Bosnes V., Alexander Y., Hult K., and Olsen M. Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem. Toxicol. 39 (2001) 1145-1151
33. Valenta H. Chromatographic methods for the determination of ochratoxin A in animal and human tissues and fluids. J. Chromatogr. A 815 (1998) 72-92
34. Visconti A., Pascale M., and Centonze G. Determination of ochratoxin A in domestic and imported beers in Italy by immunoaffinity clean-up and liquid chromatography. J. Chromatogr. A 888 (2000) 321-326
35. Zimmerli B., and Dick R. Determination of ochratoxin A at ppb level in human blood, serum, milk and some foodstuffs by HPLC with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data. J. Chromatogr. B Biomed. Appl. 666 (1995) 85-99