Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of the exposure of inhabitants of Lleida, Spain

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1436-1442

  Coronel, M B ^a   Marin, S ^a   Tarrago M ^a   Cano Sancho, G ^a   Ramos, A J ^a   Sanchis, V ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

Author keywords

Daily intake; Exposure assessment; Human urine; Ochratoxin ; Ochratoxin A

Indexed keywords

BIOLOGICAL MARKER; MYCOTOXIN; OCHRATOXIN; OCHRATOXIN ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEEDING BEHAVIOR; FEMALE; FOOD CONTAMINATION; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; LONG TERM EXPOSURE; MALE; METABOLITE; QUESTIONNAIRE; RISK ASSESSMENT; SPAIN; TOXIN ANALYSIS; URINALYSIS; URINE LEVEL;

ADOLESCENT; ADULT; CARCINOGENS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; MIDDLE AGED; MYCOTOXINS; OCHRATOXINS; SPAIN; YOUNG ADULT;

EID: 79955656588     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.03.039     Document Type: Article

References (36)

1. Akdemir C., Cemiloglu O., Basaran A., Ozkaya S., Karakaya A. Estimation of ochratoxin A in some Turkish populations: An analysis in urine as a simple, sensitive and reliable biomarker. Food Chem. Toxicol. 2010, 48:877-882.
2. Biasucci, G., Calabrese, G., Di Giuseppe, R., Carrara, G., Colombo, F., Mandelli, B., Maj, M., Bertuzzi, T., Pietri, A., Rossi, F., 2010. The presence of ochratoxin A in cord serum and human milk and its correspondence with maternal dietary habits. Eur. J. Nutr. doi:. doi:10.1007/s00394-010-0130-y.
3. Castegnaro M., Maru V., Maru G., Ruiz-Lopez M.D. High-performance liquid chromatographic determination of ochratoxin A and its 4R-4-Hydroxy metabolite in human urine. Analyst 1990, 115:129-131.
4. Castegnaro M., Maru V., Petkova-Bocharova T., Nikolov I., Bartsch H. Concentrations of ochratoxin A in the urine of endemic nephropathy patients and controls in Bulgaria: lack of detection of 4-hydroxyochratoxin A. Mycotoxins, endemic nephropathy and urinary tract tumours 1991, vol. 115:165-169. IARC Scientific Publications, Lyon.
5. Coronel M.B., Sanchis V., Ramos A.J., Marin S. Assessment of the exposure to ochratoxin A in the province of Lleida, Spain. Food Chem. Toxicol. 2009, 49:2847-2852.
6. Coronel M.B., Sanchis V., Ramos A.J., Marin S. Review. Ochratoxin A: presence in human plasma and intake estimation. Food Sci. Technol. Int. 2010, 16:5-18.
7. Domijan A.M., Peraica M., Miletic-Medved M., Lucic A., Fuchs R. Two different clean-up procedures for liquid chromatographic determination of ochratoxin A in urine. J. Chromatogr. B 2003, 798:317-321.
8. Duarte S.C., Bento J.M.V., Pena A., Lino C.M. Ochratoxin A exposure assessment of the inhabitants of Lisbon during winter 2007/2008 through bread and urine analysis. Food Addit. Contam. 2009, 26:1411-1420.
9. Duarte S., Bento J., Pena A., Lino C.M., Delerue-Matos, Oliva-Teles T., Morais S., Correia M., Oliveira M.B.P.P., Alves M.R., Pereira J.A. Monitoring of ochratoxin A exposure of the Portuguese population through a nationwide urine survey-Winter 2007. Sci. Total Environ. 2010, 408:1195-1198.
10. EFSA, European Food Safety Authority, 2006. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to ochratoxin A in food (Question No. EFSA-Q-2005-154). The EFSA Journal, 365.
11. Erkekoĝlu P., Sabuncuoĝlu S., Aydi{dotless}n S., Şahin G., Giray B. Determination of seasonal variations in serum ochratoxin A levels in healthy population living in some regions of Turkey by enzyme-linked immunosorbent assay. Toxicon 2010, 55:507-513.
12. European Commission. Directorate-General Health and Consumer Protection, 2002. Assessment of dietary intake of ochratoxin A by the population of EU member states. Scientific Cooperation Task Reports. Task 3.2.7.
13. Fazekas B., Tar A., Kováks M. Ochratoxin A content of urine samples of healthy humans in Hungary. Acta Vet. Hung. 2005, 53:35-44.
14. Food Standards Agency, 2002. survey of nuts, nut products and dried tree fruits for mycotoxins. Number 21/02. , visited 15 October 2010. http://www.food.gov.uk.
15. Gilbert J., Brereton P., MacDonald S. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach, analysis of urine, plasma samples. Food Addit. Contam. 2001, 18:1088-1093.
16. Haftenberger M., Heuer T., Heidemann C., Kube F., Krems C., Mensink G.B.M. Relative validation of a food frequency questionnaire for national health and nutrition monitoring. Nutr. J. 2010, 9:36.
17. Hassan A., Sheashaa H.A., Fattah M.F.A., Ibrahim A.Z., Gaber O.A., Sobh M.A. Study of ochratoxin A as an environmental risk that causes renal injury in breast-fed Egyptian infants. Pediatr. Nephrol. 2006, 21:102-105.
18. Ochratoxin A. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Naturally Occurring Substances. Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins 1993, 56:26-32. IARC, International Agency for Research on Cancer.
19. 68th Meeting. Evaluation of certain food additives and contaminants 2007, JECFA, Joint FAO/WHO Expert Committee on Food Additives, WHO, Geneva, 208.
20. Jonsyn-Ellis F.E. Aflatoxins and ochratoxins in urine samples of school children in Mokonde, Southern Sierra Leone. J. Nutr. Environ. Med. 2000, 10:225-231.
21. Kane A., Creppy E.E., Roth A., Röschenthaler R., Dirheimer G. Distribution of the [3H]-label from low doses of radioactive ochratoxin A ingested in rats, and evidence for DNA single-strand breaks caused in liver and kidneys. Arch. Toxicol. 1986, 58:219-224.
22. Kühn I., Valenta H., Rohr J. Determination of ochratoxin A in bile of swine by high-performance liquid chromatography. J. Chromatogr. B 1995, 668:333-337.
23. Li S., Marquardt R.R., Frohlich A.A. Identification of ochratoxins and some of their metabolites in bile and urine of rats. Food Chem. Toxicol. 2000, 38:141-152.
24. Manique R., Pena A., Lino C.M., Moltó J.C., Mañes J. Ochratoxin A in the morning and afternoon portions of urine from Coimbra and Valencian populations. Toxicon 2008, 51:1281-1287.
25. Märtlbauer E., Usleber E., Dietrich R., Schneider E. Ochratoxin A in human blood serum-retrospective long-term data. Mycotox. Res. 2009, 25:175-186.
26. Muñoz K., Campos V., Blaszkewicz M., Vega M., Alvarez A., Neira J., Degen G. Exposure to neonates to ochratoxin A: first biomonitoring results in human milk (colostrum) from Chile. Mycotox. Res. 2010, 26:59-67.
27. Muñoz K., Blaszkewicz M., Degen G.H. Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. J. Chromatogr. B 2010, 878:2623-2629.
28. Pascale M., Visconti A. Rapid method for the determination of ochratoxin A in urine by immunoaffinity column clean-up and high-performance liquid chromatography. Mycopathologia 2000, 152:91-95.
29. Patel S., Hazel C.M., Winterton A.G.M., Gleadle A.E. Survey of ochratoxin A in UK retail coffees. Food Addit. Contam. A 1997, 14:217-222.
30. Pena A., Seifrtová M., Lino C., Silveira I., Solich P. Estimation of ochratoxin A in Portuguese population: New data on the occurrence in human urine by high performance liquid chromatography with fluorescence detection. Food Chem. Toxicol. 2006, 44:1449-1454.
31. Petkova-Bocharova T., Castegnaro M., Pfohl-Leszkowicz A., Garren L., Grosso F., Nikolov I., Vrabcheva T., Dragacci S., Chernozemsky I.N. Analysis of OTA in serum and urine of inhabitants from an area with BEN: a one month follow up study. Facta Univ. 2003, 10:62-68.
32. Ringot D., Chango A., Schneider Y.-J., Larondelle Y. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem. Biol. Interact. 2006, 159:18-46.
33. Støren O., Holm H., Størmer F.C. Metabolism of ochratoxin A by rats. Appl. Environ. Microbiol. 1982, 44:785-789.
34. Studer-Rohr I., Schlatter J., Dietrich D.D. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch. Toxicol. 2000, 74:499-510.
35. Trinidad Rodríguez I., Fernández Ballart J., Cucó Pastor G., Biarnés Jordà E., Arija Val V. Validation of a short questionnaire on frequency of dietary intake: Reproducibility and validity. Nutr. Hosp. 2008, 23:242-252.
36. Willet W.C., Sampson L., Stampfer M.J., Rosner B., Bain C., Witschi J., Hennekens C.H., Speizer F.E. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am. J. Epidemiol. 1985, 122:51-65.