Chemical mixtures: Evaluation of risk for child-specific exposures in a multi-stressor environment

Toxicology and Applied Pharmacology

Volumn 233, Issue 1, 2008, Pages 116-125

  Pohl, H R ^a   Abadin, H G ^a  

^a AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

Author keywords

Chemical mixtures; Children's health; Life stages

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ATRAZINE; CARBON MONOXIDE; CHEMICAL AGENT; CHLORINATED HYDROCARBON; CHLORPYRIFOS; COPPER; DICHLOROMETHANE; DIMPYLATE; FORMALDEHYDE; HEXACHLOROBENZENE; LEAD; MANGANESE; MERCURY; METHYL CHLORIDE; METHYLMERCURIC CHLORIDE; NITRATE; NITROGEN DIOXIDE; POLYCHLORINATED BIPHENYL DERIVATIVE; SIMAZINE; VOLATILE ORGANIC COMPOUND; ZINC;

AIR POLLUTANT; ARTICLE; BREAST MILK; CALCULATION; CHILD; CHILD HEALTH; DUST; ENVIRONMENTAL EXPOSURE; HUMAN; INDOOR AIR POLLUTION; OCCUPATIONAL EXPOSURE; PRENATAL EXPOSURE; RISK ASSESSMENT; SOIL POLLUTION; STRESS; WATER CONTAMINATION;

AGE FACTORS; CHILD; ENVIRONMENTAL EXPOSURE; HAZARDOUS SUBSTANCES; HUMANS; RISK FACTORS;

EID: 55649123197     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.01.015     Document Type: Article

References (75)

1. ACGIH. 2000 TLV sand BELs. Threshold limit values for chemical substances and physical agents and biological entities. American Conference of Governmental Industrial Hygienists. Cincinnati, OH (2000) 80-82
2. Anderson T.D., and Lydy M.J. Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides. Environ. Toxicol. Chem. 21 (2002) 1507-1514
3. ATSDR. 2000. Summary Report for the ATSDR Soil-Pica Workshop, June 2000, Agency for Toxic Substances and Disease Registry, Atlanta, GA, http://www.atsdr.cdc.gov/child/soilpica.html.
4. ATSDR. Interaction Profile for Persistent Chemicals found in Breast Milk. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2004)
5. ATSDR. Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2004)
6. ATSDR. Interaction Profile for Lead, Manganese, Zinc, and Copper. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2004)
7. ATSDR. Toxicological Profile for Arsenic-Draft for Public Comment. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2005)
8. ATSDR. Interaction Profile for Chlorpyrifos, Lead, Mercury, and Methylmercury. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2006)
9. ATSDR. Interaction Profile for Atrazine, Deethylatrazine, Diazinon, Nitrate, and Simazine. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2006)
10. ATSDR. Interaction profile for Carbon Monoxide, Formaldehyde, Methylene Chloride, Nitrogen Dioxide, and Tetrachloroethylene. Agency for Toxic Substances and Disease Registry, Atlanta, GA (2007)
11. ATSDR. ATSDR Public Health Assessment Guidance Manual (2007), Agency for Toxic Substances and Disease Registry, Atlanta, GA. http://www.atsdr.cdc.gov/HAC/phamanual/foreword.html http://www.atsdr.cdc.gov/HAC/phamanual/foreword.html
12. Aylward L.L., and Hays S.M. Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels. J. Expo. Anal. Environ. Epidemiol. 12 (2002) 319-328
13. Belden J.B., and Lydy M.J. Impact of atrazine on organophosphate insecticide toxicity. Environ Toxicol Chem 19 9 (2000) 2266-2274
14. Bemis J.C., and Seegal R.F. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environ. Health Perspect. 107 (1999) 879-885
15. Binder S., Sokal D., and Maughn D. The use of tracer elements in estimating the amount of soil ingested by young children. Arch. Environ. Health 41 (1986) 341-345
16. Bruckner J.V. Differences in sensitivity of children and adults to chemical sensitivity: the National Academy Report. Reg. Tox. and Pharm. 31 (2000) 1-6
17. Clausing P., Brunekreff B., and Van Wijen J.H. A method for estimating soil ingestion by children. Int. Arch. Occup. Environ. Health 59 (1987) 73-82
18. Clewell H.J., Teeguarden J., McDonald T., Sarangapani R., Lawrence G., Covington T., Gentry R., and Shipp A. Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences in tissue dosimetry. Crit. Rev. Tox. 32 5 (2002) 329-389
19. Cova D., Nebuloni C., Arnoldi A., et al. N-nitrosation of triazines in human gastric juice. J. Agric. Food Chem. 44 (1996) 2852-2855
20. De Freitas C.U., De Capitani E.M., Gouveia N., Simonetti M.H., Silva M.R.P., Kira C.S., Sakuma A.M., Carvalho M.F.H., Duran M.C., Tiglea P., and de Abreu M.H. Lead exposure in an urban community: investigation of risk factors and assessment of the impact of lead abatement measures. Environ. Res. 103 (2007) 338-344
21. DeRosa C.T., Hansen H., Wilbur S., Pohl H.R., El-Masri H.A., and Mumtaz M.M. Interactions. In: Bingham E., Cohrssen B., and Powell C. (Eds). Patty's Toxicology vol. 1 (2001), John Wiley & Sons, Inc., New York 233-284
22. Duggan M.J., and Inskip M.J. Childhood exposure to lead in surface dust and soil: a community health problem. Public Health Rev. 13 (1985) 1-54
23. Eisenbrand G., Ungerer O., and Preussmann R. Formation of N-nitroso compounds from agricultural chemicals and nitrite. In: Bogovski P., Walker E.A., and Davis W. (Eds). N-nitroso compounds in the environment (1975), International Agency for Research on Cancer, Switzerland 71-74
24. Ellenhorn M.J., and Barceloux D.G. Nitrates, nitrites, and methemoglobinemia in Medical Toxicology: Diagnosis and Treatment of Human Poisoning (1988), Elsevier, New York 844
25. EPA. Guidelines for the health risk assessment of chemical mixtures. U.S. Environmental protection Agency. Fed. Reg. 51 (1986) 34014-34025
26. EPA. Risk assessment guidance for superfund. Volume I. Human health evaluation manual (1989), Washington, DC. U.S. Environmental Protection Agency. Office of Emergency and Remedial Response EPA/540/1-89/001
27. EPA. 2002. The grouping of a series of triazine pesticides based on a common mechanism of toxicity. Washington, DC: U.S. Environmental Protection Agency. Office of Pesticides Programs. http://www.epa.gov/oppsrrd1/cumulative/triazines/triazinescommonmech.pdf.
28. EPA, 2007. Indoor air quality. U.S. Environmental protection Agency www.epa.gov/iaq (searched October 2007).
29. EPA (U.S. Environmental Protection Agency). Estimated per capita water ingestion in the United States (2000), Office of Science and Technology, Office of Water, Washington, DC
30. Fay, M., 2007. Environmental pollutant mixtures in completed exposure pathways at hazardous waste sites. Env. Tox. Pharm. (in press).
31. Fine D.H., Roundbehler D.P., Belcher, et al. N-nitroso compounds in air and water. In: environmental N-nitroso compounds analysis and formation: proceedings of a working conference held at the Polytechnical Institute, Tallinn, Estonian SSR, 1-3. WHO: Lyon, France. IARC Sci. Publ. 14 (1976) 401-408
32. Flora S.J.S., Jain V.K., Behari J.R., et al. Protective role of trace metals in lead intoxication. Toxicol. Lett. 13 (1982) 51-56
33. Flora S.J.S., Coulombe R.A., Sharma R.P., et al. Influence of dietary protein deficiency on lead-copper interaction in rats. Ecotoxicol. Environ. Saf. 18 (1989) 75-82
34. Ginsberg G., Hattis D., Miller R., and Sonawane B. Pediatric pharmacokinetic data: implications for environmental risk assessment for children. Pediatrics 113 4 (2004) 973-983
35. Gough M. Human exposures from dioxin in soil - a meeting report. J. Toxicol. Environ. Health 32 (1991) 205-245
36. Hamula C., Wang Z., Zhang H., Kwon E., Li X.F., Gabos S., and Le X.C. Chromium on the hands of children after playing in playgrounds built from chromated copper arsenate (CCA)-treated wood. Environ. Health Perspect. 114 3 (2006) 460-465
37. Hapke H.J., Youssef S., and Omer O.H. Modification of the alkylphosphate toxicity in lead-contaminated rats (in German). Dtsch. Tieraerztl. Wochenschr. 85 11 (1978) 441-444
38. Houstek J., Belusa M., Bircak J., et al. Detske lekarstvi [Czech] (1982), Avicenum, Prague 276
39. Institoris L., Siroki O., Desi I., et al. Immunotoxicology examination of repeated dose combined exposure by dimethoate and two heavy metals in rats. Hum. Exp. Toxicol. 18 2 (1999) 88-94
40. Ishidate M. Application of chromosomal aberration tests in vitro to the primary screening for chemicals with carcinogenic and/or genetic hazards. In: Garattini S. (Ed). Tests courts de cancérogénèse: Quo vadis? (1983), Centre de Recherches Clin-Midy, Montpellier 57-79
41. Ishidate M., Sofuni T., and Yoshikawa K. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens. GANN Monogr. Cancer Res. 27 (1981) 95-108
42. Jacobson J.L., and Jacobson S.W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N. Engl. J. Med. 335 11 (1996) 783-789
43. Kavlock R.J., Daston G.P., DeRosa C., Fenner-Crisp P., Gray L.E., Kaattari S., Lucier G., Luster M., Mae M.J., Maczka C., Miller R., Moore J., Rolland R., Scott G., Sheehan D.M., Sinks T., and Tilson H.A. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the US EPA-sponsored workshop. Environ. Health Perspect. 104 Suppl 4 (1996) 715-740
44. Kearney P.C., Oliver J.E., Helling C.S., et al. Distribution, movement, persistence, and metabolism of N-nitrosoatrazine in soils and a model aquatic ecosystem. J. Agric. Food Chem. 25 (1977) 1177-1181
45. Kies C., and Ip S.W. Lead bioavailability to humans from diets containing constant amounts of lead: impact of supplemental copper, zinc and iron. Trace Subst. Environ. Health 24 (1990) 177-184
46. Krull I.S., Mills K., Hoffman G., et al. The analysis of N-nitrosoatrazine and N-nitrosocarbaryl in whole mice. J. Anal. Toxicol. 4 5 (1980) 260-262
47. Kurppa K., Kivisto H., and Vainio H. Dichloromethane and carbon monoxide inhalation: carboxyhemoglobin addition, and drug metabolizing enzymes in rat. Int. Arch. Occup. Environ. Health 49 (1981) 83-87
48. Lanphear B.P., Succop P., Roda S., and Henningsen G. The effect of soil abatement on blood led levels in children living near a former smelting and millkng operation. Public Health Reports 118 (2003) 83-90
49. Layton D.W. Metabolically consistent breathing rates or use in dose assessments. Health Physics 64 1 (1993) 23-36
50. Meisner L.F., Roloff B.D., and Belluck D.A. In vitro effects of N-nitrosoatrazine on chromosome breakage. Arch. Environ. Contam. Toxicol. 24 (1993) 108-112
51. Mirvish S.S., Gannett P., Babcook D.M., et al. N-nitrosoatrazine: synthesis, kinetics of formation, and NMR spectra and other properties. J. Agric. Food Chem. 39 7 (1991) 1205-1210
52. Mumtaz M.M., and Durkin P.R. A weight-of-evidence approach for assessing interactions in chemical mixtures. Toxicol. Ind. Health 8 (1992) 377-406
53. Mumtaz M.M., De Rosa C.T., and Durkin P.R. Approaches and challenges in risk assessments of chemical mixtures. In: Yang R.S.H. (Ed). Toxicology of chemical mixtures: case studies, mechanisms and novel approaches (1994), Academic Press, New York, NY 565-597
54. Nagymajtenyi L., Schultz H., Papp A., et al. Developmental neurotoxicology effects of lead and dimethoate in animal experiments. Neurotoxicology 19 4-5 (1998) 617-622
55. Nagymajtenyi L., Desi I., Papp A., et al. Experimentally induced functional changes of the nervous system caused by subchronic combined administration of heavy metals and on organophosphate pesticide. Cent. Eur. J. Public Health 8 (2000) 64-65
56. NAS. Water quality critera 1972. Section III. Freshwater aquatic life and wildlife: mixtures of two or more toxicants. National Academy of Sciences. National Academy of Engineering (1974) NTIS PB 236 199, ii-xix, 1-4, 106-108, 122-123
57. NRC. Mixtures. Drinking water and health, vol. 9 (1989), National Academy of Sciences, National Research Council, National Academy Press, Washington DC 93-107, 121-132, 168-170
58. OSHA. Occupational Safety and Health Administration 29 CFR 1910. 1000. Air contaminants; Rule. Fed. Reg. 58 124 (1993) 35338-35351
59. OSHA, 2001. Occupational Safety and Health Administration. OSHA regulations (Standards - 29 CFRAir contaminants. 1910.1000. http://www.osha-slc.gov/Osh.Std_data/1910_1000.html.
60. Pohl H., and Abadin H. Utilizing uncertainty factors in minimal risk levels derivation. Regul. Toxicol. Pharmacol. 22 2 (1995) 180-188
61. Pohl H.R., Roney N., Wilbur S., Hansen H., and De Rosa C.T. Six interaction profiles for simple mixtures. Chemosphere 53 2 (2003) 183-197
62. Pohl H.R., McClure P., and De Rosa C.T. Persistent chemicals found in breast milk and their possible interactions. Environ. Toxicol. Pharmacol. 18 (2004) 259-266
63. Pohl H.R., van Engelen J., Wilson J., and Sips A. Risk assessment of chemicals and pharmaceuticals in the pediatric population: a workshop report. Regul. Toxicol. Pharmacol. 42 1 (2005) 83-95
64. Pohl H.R., Abadin H.G., Jones D., and De Rosa C.T. The role of exposure versus body burden data in deriving health guidance values. J. Toxicol. Environ. Health B, 10 (2007) 401-415
65. Roney N., and Colman J. Interaction profile for lead, manganese, zinc, and copper. Environ. Toxicol. Pharmacol. 18 (2004) 231-234
66. Schecter A., Startin J., Wright C., et al. Dioxins in U.S. food and estimated daily intake. Chemosphere 29 9-11 (1994) 2261-2265
67. Schecter A., Startin J., Wright C., Kelly M., Papke O., Lis A., Ball M., and Olson J.R. Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake. Environ. Health Perspect. 102 11 (1994) 962-966
68. Sjodin A., Jones R.S., Focant J.F., Lapeza C., Wang R.Y., McGahee III E.E., Zhang Y., Turner W.E., Slazyk B., Needham L.L., and Patterson Jr. D.G. Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environ. Health Perspect. 112 (2004) 654-658
69. Smolen J.M., and Stone A.T. Divalent metal ion-catalyzed hydrolysis of phosphorothionate ester pesticides and their corresponding oxonates. Environ. Sci. Technol. 31 (1997) 1664-1673
70. Squillace P.J., Scott J.C., Moran M.J., Nolan T., and Koplin D.W. VOCs, pesticides, nitrate, and their mixtures in groundwater used for drinking water in the United States. Environ. Sci. Technol. 36 (2002) 1923-1930
71. Tanimura T., Ema M., and Kihara T. Effects of combined treatment with methylmercury and polychlorinated biphenyls (PCBs) on the development of mouse offspring. In: Persuad T.V.N. (Ed). Neural and behavioral teratology (1980), University Park Press, Baltimore, MD 163-198
72. WHO (World Health Organization). Principles for evaluating health risks from chemicals during infancy and early childhood: the need for special approach. Environmental Health Criteria 59 (1986), WHO/IPCS, Geneva, Switzerland
73. Wilbur S., Hansen H., Pohl H.R., Colman J., and McClure P. Using ATSDR's guidance manual for the assessment of joint toxic action of chemical mixtures. Environ. Toxicol. Pharmacol. 18 (2004) 223-230
74. Winneke G. The neurotoxicity of dichloromethane. Neurobehav. Toxicol. Teratol. 3 (1981) 391-395
75. Wolfe N.L., Zepp R.G., Gordon J.A., et al. N-nitrosamine formation from atrazine. Bull. Environ. Contam. Toxicol. 15 3 (1976) 342-347