Preliminary study of Ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption

Food and Chemical Toxicology

Volumn 44, Issue 11, 2006, Pages 1884-1889

  Muñoz, Katherine ^a   Vega, Mario ^a   Rios, Gisela ^a   Muñoz, Sara ^a   Madariaga, Ricardo ^b  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b INSTITUTO DE INVESTIGACIONES AGROPECUARIAS   (Chile)

Author keywords

Chile; HPLC; Mycotoxin; Ochratoxin A; Plasma

Indexed keywords

ESTER; MYCOTOXIN; OCHRATOXIN; OCHRATOXIN A METHYL ESTER;

ADULT; AGRICULTURE; ARTICLE; ASPERGILLUS; BLOOD LEVEL; BLOOD SAMPLING; CHILE; CORRELATION COEFFICIENT; EUROPE; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; MALE; NORMAL HUMAN; PENICILLIUM; PURIFICATION; QUESTIONNAIRE; SOLID PHASE EXTRACTION; SOUTH AMERICA; TOXICOKINETICS; BLOOD; EATING; FOOD CONTAMINATION;

ASPERGILLUS; FUNGI; PASSIFLORA SERRATODIGITATA; PENICILLIUM;

AGRICULTURE; CHILE; EATING; FOOD CONTAMINATION; HUMANS; MYCOTOXINS; OCHRATOXINS;

EID: 33750744840     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.06.008     Document Type: Article

References (40)

1. Álvarez L., Gil A.G., Ezpeleta O., García Jalón J.A., and López de Cerain A. Immunotoxic effects of Ochratoxin A in wistar rats after oral administration. Food Chem. Toxicol. 42 (2004) 825-834
2. Assaf H., Betbeder A.M., Creppy E.E., Pallardy M., and Azouri H. Ochratoxin A levels in human plasma and foods in Lebanon. Hum. Exp. Toxicol. 23 (2004) 495-501
3. Blesa J., Soriano J.M., Moltó J.C., and Mañes J. Concentration of Ochratoxin A in wines from supermarkets and stores of Valencian Community (Spain). J. Chromatogr. A 1054 (2004) 397-401
4. Blumenthal C.Z. Production of toxic metabolites Aspergillus niger, Aspergillus oryzae and Trichoderma reesei: justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi. Regul. Toxicol. Pharmacol. 39 (2004) 214-228
5. Breitholtz-Emanuelsson A., Olsen M., Oskarsson A., Palminger I., and Hult K. Ochratoxin A in cow's milk and in human milk with corresponding human blood samples. J. AOAC Int. 76 (1993) 842-846
6. CENSO nacional de Población, 2002. Estadísticas demográficas para población total, por sexo e índice de masculinidad, según división político administrativa y área urbana-rural. Gobierno de Chile, Cuadro 1.1, pp. 13-19.
7. Chan Ch.Ch., Lee Y.C., Lam H., and Zhang X.-M. Method validation for HPLC analysis of related substances in pharmaceutical drug products. Analytical Method Validation and Instrument Performance Verification (2004), John Wiley & Sons, USA 27-49
8. Dortant P.M., Peters-Volleberg G.W.M., Van Loveren H., Marquardt R.R., and Speijers G.J.A. Age-related differences in the toxicity of Ochratoxin A in female rats. Food Chem. Toxicol. 39 (2001) 55-65
9. European Commission, 2002. Assessment of dietary intake of Ochratoxin A by the population of European Union Members states. Directorate General-Health and consumer protection. Report on tasks for scientific cooperation. Report of experts participating in Task 3.2.7, pp. 18-19.
10. Fazecas B., Tar A., and Kovacs M. Ochratoxin a content of urine samples of healthy humans in Hungary. Acta Vet. Hung. 53 (2005) 35-44
11. Fuchs R., and Hult K. Ochratoxin A in blood and its pharmacokinetic properties. Food Chem. Toxicol. 30 (1992) 201-204
12. Gautier J.C., Holzhaeuser D., Markovic J., Gremaud E., Schilter B., and Turesky R.J. Oxidative damage and stress response from Ochratoxin A exposure in rats. Free Radical Biol. Med. 30 10 (2001) 1089-1098
13. Grosso F., Saïd S., Mabrouk I., Fremy J.M., Castegnaro M., Jemmali M., and Dragacci S. New data on the occurrence of Ochratoxin A in human sera from patients affected or not by renal disease in Tunisia. Food Chem. Toxicol. 41 (2003) 1133-1140
14. Harris J., and Mantle P. Biosynthesis of ochratoxins by Aspergillus ochraceus. Phytochemistry 58 (2001) 709-716
15. IARC, 1993. Ochratoxin A. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monograph on the Evaluation of Carcinogenic Risk to Humans. Lyon, vol. 56, pp. 489-521.
16. Jorgensen K., and Petersen A. Content of Ochratoxin A in paired kidney and meat samples from healthy Danish slaughter pigs. Food Addit. Contam. 19 (2002) 562-567
17. Li S., Marquardt R.R., Frohlich A.A., Vitti T.G., and Crow G. Pharmacokinetics of Ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145 (1997) 82-90
18. Li S., Marquardt R.R., and Frohlich A.A. Identification of ochratoxins and some of their metabolites in bile and urine of rats. Food Chem. Toxicol. 38 (2000) 141-152
19. Lioi M.B., Santoro A., Barbieri R., Salzano S., and Ursini M.V. Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes. Mutat. Res. 557 (2004) 19-27
20. Luhe A., Hildebrand H., and Bach U. A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays. Toxicol. Sci. 73 2 (2003) 315-328
21. Mally A., Keim-Heusler H., Amberg A., Kurz M., Zepnik H., Mantle P., Völkel W., Hard G., and Dekant W. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol. Appl. Pharmacol. 206 (2005) 43-53
22. a Edición, Madrid, pp. 111-155.
23. Official Journal of the European Communities, 2002. Commission Regulation (EC) No 472/2002 of 17 March 2002 Amending Regulation (EC) No 466/2001 setting maximum levels of certain contaminants in foodstuff. L75, 18-20.
24. Official Journal of the European Communities, 2005. Commission Regulation (EC) No 123/2005 of 26 January of 2005 amending Regulation (EC) No 466/2001 as regard ochratoxin A. L25, 3-5.
25. Omar R.F., Gelboin H.V., and Rahimtula A.D. Effect of cytochrome P450 induction on the metabolism and toxicity of ochratoxin A. Biochem. Pharmacol. 51 (1996) 207-216
26. Pittet A. Natural occurrence of mycotoxins in foods and feeds an updated review. Rev. Med. Vet. 149 6 (1998) 479-492
27. Pohland A.E., Nesheim S., and Friedman L. Ochratoxin A: a review. J. Pure Appl. Chem. 64 (1992) 1029-1046
28. Rizzo A., Eskola M., and Atroshi F. Ochratoxin A in cereals, foodstuffs and human plasma. Eur. J. Plant Pathol. 108 7 (2002) 631-637
29. Schaaf G.J., Nijmeierjer S.M., Maas R.F.M., Roestenberg P., De Groene E.M., and Fink-Gremmels J. The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells. Biochim. Biophys. Acta 1588 (2002) 149-158
30. Scott P.M., Kanhere S.R., Lau B.P., Lewis D.A., Hayward S., Ryan J.J., and Kuiper-Goodman T. Survey of Canadian human blood plasma for ochratoxin A. Food Addit. Contam 15 (1998) 555-562
31. Serra R., Mendonça C., Abrunhosa L., Pietri A., and Venancio A. Determination of ochratoxin A in wine grapes: comparison of extractive procedures and method validation. Anal. Chim. Acta 513 (2004) 41-47
32. Solfrizzo M., Avantaggiato G., and Visconti A. Use of various clean-up procedures for the analysis of ochratoxin A in cereals. J. Chromatogr. A 815 1 (1998) 67-73
33. Studer-Rohr I., Dietrich D.R., Schlatter J., and Schlatter C. The occurrence of ochratoxin A in coffee. Food Chem. Toxicol. 33 (1995) 341-355
34. Thuvander A., Paulsen J.E., Axberg K., Johansson N., Vidnes A., Enghardt-Barbieri H., Trygg K., Lund-Larsen K., Jahrl S., Widenfalk A., Bosnes V., Alexander J., Hult K., and Olsen M. Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem. Toxicol 39 (2001) 1145-1151
35. Thuvander A., Paulsen J.E., Axberg K., Johansson N., Vidnes A., Enghardt-Barbieri H., Tressou J., Leblanc J.-Ch., Feinberg M., and Bertail P. Statistical methodology to evaluate food exposure to a contaminant and influence of sanitary limits: application to ochratoxin A. Regul. Toxicol. Pharmacol. 40 (2004) 252-263
36. Ueno Y., Maki S., Lin J., Furuya M., Sugiura Y., and Kawamura O. A 4-year study of plasma ochratoxin A in a selected population in Tokyo by inmunoassay and immunoaffinity column-linked HPLC. Food Chem. Toxicol. 36 (1998) 445-449
37. Valenta H., and Goll M. Determination of ochratoxin A in regional samples of cow's milk from Germany. Food Addit. Contam. 13 (1996) 669-676
38. Veselá D., Veselý D., and Jelïnek R. Toxic effects of ochratoxin A and citrinin, alone and in combination, on chicken embryos. Appl. Environ. Microbiol. 45 1 (1983) 91-93
39. Visconti A., Pascale M., and Centonze G. Determination of ochratoxin A in domestic and imported beers in Italy by immunoaffinity clean-up and liquid chromatography. J. Chromatogr. A 888 (2000) 321-326
40. Zimmerli B., and Dick R. Determination of ochratoxin A at the ppt levels in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with fluorescence detection and immunoaffinity column clean-up: methodology and Swiss data. J. Chromatogr. B 666 (1995) 85-99