Ochratoxin A in adult population of Lleida, Spain: Presence in blood plasma and consumption in different regions and seasons

Food and Chemical Toxicology

Volumn 49, Issue 10, 2011, Pages 2697-2705

  Coronel, M B ^a   Sanchis, V ^a   Ramos, A J ^a   Marin, S ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

Author keywords

Blood plasma; Daily intake; Exposure assessment; Ochratoxin A; Regions; Seasons

Indexed keywords

OCHRATOXIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD FREQUENCY QUESTIONNAIRE; FOOD INTAKE; GEOGRAPHIC DISTRIBUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; LIMIT OF DETECTION; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; POPULATION EXPOSURE; SEASONAL VARIATION; SEX DIFFERENCE; SPAIN; TOXIN ANALYSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; MIDDLE AGED; OCHRATOXINS; SEASONS; SEX FACTORS; SPAIN; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 80051863242     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.07.045     Document Type: Article

References (58)

1. Abid S., Hassen W., Achour A., Skhiri H., Maaroufi K., Ellouz F., Creppy E., Bacha H. Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic?. Hum. Exp. Toxicol. 2003, 22:77-84.
2. Assaf H., Betbeder A., Creppy E.E., Pallardy M., Azouri H. Ochratoxin A levels in human plasma and foods in Lebanon. Hum. Exp. Toxicol. 2004, 23:495-501.
3. Bauer J., Gareis M. Ochratoxin A in der Nährungsmittelkette. J. Vet. Med. B. 1987, 34:613-627.
4. Breitholtz A., Olsen M., Dahlback A., Hult K. Plasma ochratoxin A levels in three Swedish populations surveyed using an ion-pair HPLC technique. Food Addit. Contam. 1991, 8:183-192.
5. Burdaspal P.A., Legarda T.M. Datos sobre presencia de ocratoxina A en plasma humano en España. Alimentaria 1998, 292:103-109.
6. Coronel M.B., Sanchis V., Ramos A.J., Marin S. Assessment of the exposure to ochratoxin A in the province of Lleida, Spain. Food Chem. Toxicol. 2009, 49:2847-2852.
7. Domijan A.M., Peraica M., Fuchs R., Lucić A., Radić B., Balija M., Bosanac I., Grgičević D. Ochratoxin A in blood of healthy population in Zagreb. Arh. Hig. Rada. Toksiko. 1999, 50:263-271.
8. EFSA (European Food Safety Authority) Opinion of the scientific panel on contaminants in the food chain on a request from the Commission related to ochratoxin A in food (Question n EFSA-Q-2005-154). The EFSA Journal 2006, 365.
9. Erkekoĝlu P., Sabuncuoĝlu S., Aydi{dotless}n S., Şahin G., Giray B. Determination of seasonal variations in serum ochratoxin A levels in healthy population living in some regions of Turkey by enzyme-linked immunosorbent assay. Toxicon 2010, 55:507-513.
10. European Commission, 2002. Directorate-General Health and Consumer Protection. Assessment of dietary intake of ochratoxin A by the population of EU member states. Scientific Cooperation Task Reports. Task 3.2.7.
11. Filali A., Betbeder A.M., Baudrimont I., Benayada A., Soulaymani R., Creppy E.E. Ochratoxin A in human plasma in Morocco: a preliminary survey. Hum. Exp. Toxicol. 2002, 21:241-245.
12. Foods Standards Agency, 2002. Survey of Nuts, Nut Products and Dried Tree Fruit for Mycotoxins (Number 21/02). Available from: http://www.food.gov.uk/science/surveillance/fsis2002/21.
13. Fuchs R., Radić B., Čeović S., Šoštaric B., Hult K. Human exposure to ochratoxin A. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours 1991, 131-134. IARC Press, Lyon. M. Castegnaro, R. Pleština, G. Dirheimer, I.N. Chernozemsky, H. Bartsch (Eds.).
14. Fukal L., Reisnerova H. Monitoring of aflatoxins and ochratoxin A in Czechoslovak human sera by immunoassay. B. Environ. Contam. Toxicol. 1990, 44:345-349.
15. Gilbert J., Brereton P., MacDonald S. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit. Contam. 2001, 18:1088-1093.
16. Golinsky P., Grabarkiewicz-Szczesna J., Chelkowski J., Hult K., Kostecki M. Possible sources of ochratoxin A in Poland. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours 1991, 153-158. IARC Press, Lyon. M. Castegnaro, R. Pleština, G. Dirheimer, I.N. Chernozemsky, H. Bartsch (Eds.).
17. Grosso F., Said S., Mabrouk I., Fremy J.M., Castegnaro M., Jemmali M., Dragacci S. New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food Chem. Toxicol. 2003, 41:1133-1140.
18. Hadlock R.M., Wagner G. Vorkommen von Ochratoxin A beim Menschen in Deutschland. Fleischwirtschaft 1993, 73:1079-1080.
19. Hagelberg S., Hult K., Fuchs R. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J. Appl. Toxicol. 1989, 9:91-96.
20. Hald B. Ochratoxin A in human blood in European countries. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours 1991, 159-164. IARC Press, Lyon. M. Castegnaro, R. Pleština, G. Dirheimer, I.N. Chernozemsky, H. Bartsch (Eds.).
21. Hassen W., Abid S., Achour A., Creppy E., Bacha H. Ochratoxin A and β2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the Centre of Tunisia: a hot spot of Ochratoxin A exposure. Toxicology 2004, 199:185-193.
22. Hmaissia-Khlifa K., Ghali R., Mazigh C., Aouni Z., Ghorbel H., Harrzalla K., Machgoul S., Hedhili A. Serum levels of ochratoxin A in healthy subjects and in nephropathic patients in Tunisia. Ann. Biol. Clin. 2008, 66:631-636.
23. Hmaissia-Khlifa K., Ghali R., Aouni Z., Mazigh C., Machgoul S., Hedhili A. Estimation of ochratoxin A in human blood of healthy Tunisian population. Exp. Toxicol. Pathol. 2010, 62:539-542.
24. IARC (International Agency for Research on Cancer) Ochratoxin A. Heterocycl. Aromat. Amines Mycotoxins 1993, 56:26-32.
25. JECFA (Joint FAO/WHO Expert Committee on Food Additives), 2007. Evaluation of certain food additives and contaminants, 68th report of the Joint FAO/WHO Expert Committee on Food Additives, Technical report series n° 947. WHO, Geneva, pp. 208.
26. Jimenez A.M., López A., Gonzalez-Peñas E., Bello J., Betbeder A.M., Creppy E.E. Exposure to ochratoxin A in Europe: comparison with a region of northern Spain. J. Toxicol.-Toxin Rev. 1998, 17:479-491.
27. Khalef A., Zidane C., Charef A., Gharbi A., Tadjerouna M., Betbeder A.M., Creppy E.E. Human ochratoxicosis in Algeria. Human Ochratoxicosis and its Pathologies 1993, 123-127. INSERM/John Libbey Eurotext, Montrouge. E.E. Creppy, M. Castegnaro, G. Dirheimer (Eds.).
28. Klaassen C.D. Distribution, excretion and absorption of toxicants. Casarett and Doull's Toxicology: The Basic Science of Poisons 1986, 33-63. Macmillan Publishing, New York. 3rd ed. C.D. Klaassen, M.O. Amaur, J. Doull (Eds.).
29. Kovács F., Sándor G., Ványi A., Domány S., Zomborszky-Kovács M. Detection of ochratoxin a in human blood and colostrum. Acta Vet. Hung. 1995, 43:393-400.
30. Kuiper-Goodman T., Ominski K., Marquardt R.R., Malcom S., McMullen E., Lombaert G.A., Morton T. Estimating human exposure to ochratoxin A in Canada. Human Ochratoxicosis and its Pathologies 1993, 167-174. INSERM/John Libbey Eurotext, Montrouge. E.E. Creppy, M. Castegnaro, G. Dirheimer (Eds.).
31. Lino C.M., Baeta M.L., Henri M., Dinis A.M.P., Pena A.S., Silveira M.I.N. Levels of ochratoxin A in serum from urban and rural Portuguese populations and estimation of exposure degree. Food Chem. Toxicol. 2008, 46:879-885.
32. Maaroufi K., Achour A., Hammami M., El May M., Betbeder A.M., Ellouz F., Creppy E.E., Bacha H. Ochratoxin A in human blood in relation to nephropathy in Tunisia. Hum. Exp. Toxicol. 1995, 14:609-614.
33. Märtlbauer E., Usleber E., Dietrich R., Schneider E. Ochratoxin A in human blood serum - retrospective long-term data. Mycotox. Res. 2009, 25:175-186.
34. Medina A., Mateo E.M., Roig R.J., Blanquer A., Jiménez M. OTA levels in the plasma of healthy blood donors from Valencia and estimation of exposure degree: comparison with previous national Spanish data. Food Addit. Contam. 2010, 27:1273-1284.
35. Miraglia M., Brera C., Colatosti M. Application of biomarkers to assessment of risk to human health exposure to mycotoxins. Microchem. J. 1996, 54:472-477.
36. Mortensen H.P., Hald B., Madsen A. Feeding experiment with ochratoxin A contaminated barley for bacon and pigs. 5. Ochratoxin A in pig blood. Acta Agr. Scand. 1983, 33:238-239.
37. Muñoz K., Vega M., Rios G., Muñoz S., Madariaga R. Preliminary study of Ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption. Food Chem. Toxicol. 2006, 44:1884-1889.
38. Ostry V., Malir F., Roubal T., Skarkova J., Ruprich J., Cerna M., Creppy E.E. Monitoring of mycotoxin biomarkers in the Czech Republic. Mycotox. Res. 2005, 21:49-52.
39. Pacin A.M., Ciancio Bovier E.V., Motta E., Resnik S.L., Villa D., Olsen M. Survey of Argentinean human plasma for ochratoxin A. Food Addit. Contam. 2008, 25:635-641.
40. Palli D., Miraglia M., Saieva C., Masala G., Cava E., Colatosti M., Corsi A.M., Russo A., Brera C. Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidem. Biomar. 1999, 8:265-269.
41. Peraica M., Domijan A., Fuchs R., Lucić A., Radić B. The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol. Lett. 1999, 110:105-112.
42. Peraica M., Domijan A., Matasǐn M., Lucić A., Radić B., Delaš F., Horvat M., Bosanac I., Balija M., Grgičević D. Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities. Arch. Toxicol. 2001, 75:410-414.
43. Pérez de Obanos A., López de Ceraín A., Jiménez A.M., González E., Bello J. Ochratoxin A in human plasma: new data of exposition in Spain. Rev. Toxicol. 2001, 18:19-23.
44. Petkova-Bocharova T., Castegnaro M. Ochratoxin A in human blood in relation to endemic nephropathy and urinary tract tumours in Bulgaria. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours 1991, 135-137. IARC Press, Lyon. M. Castegnaro, R. Pleština, G. Dirheimer, I.N. Chernozemsky, H. Bartsch (Eds.).
45. Petkova-Bocharova T., Castegnaro M., Pfohl-Leszkowicz A., Garren L., Grosso F., Nikolov I., Vrabcheva T., Dragacci S., Chernozemsky I.N. Analysis of ochratoxin A in serum and urine of inhabitants from an area with Balkan endemic nephropathy: a one-month follow-up study. Facta Univ. 2003, 10:62-68.
46. Quintana Guzmán E.M., Antillón Guerrero F., Azofeifa Chaves J. Determinación de ocratoxina A en plasma humano y en café por un método de ELISA. Arch. Latinoam. Nutr. 2007, 57:168-172.
47. Radić B., Fuchs R., Peraica M., Lucić A. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicol. Lett. 1997, 91:105-109.
48. Rosner H., Rohrmann B., Peiker G. Ochratoxin A in human serum. Arch. Lebensmittelhyg. 2000, 51:104-107.
49. Ruprich J., Ostry V. Health risk assessment of the mycotoxin ochratoxin A to humans: Czech Republic - Brno - 1991/92. Cent. Eur. J. Public Health. 1993, 1:86-93.
50. Sangare-Tigori B., Moukha S., Kouadio J.H., Dano D.S., Betbeder A.-M., Achour A., Creppy E.E. Ochratoxin A in human blood in Abidjan, Côte d'Ivoire. Toxicon 2006, 47:894-900.
51. Scott P.M., Kanhere S.R., Lau B.P., Lewis D.A., Hayward S., Ryan J.J., Kuiper-Goodman T. Survey of Canadian human blood plasma for ochratoxin A. Food Addit. Contam. 1998, 15:555-562.
52. Solti L., Salamon F., Barna-Vetró I., Gyöngyösi Á., Szabó E., Wölfling A. Ochratoxin A content of human sera determined by a sensitive ELISA. J. Anal. Toxicol. 1997, 21:44-48.
53. Studer-Rohr, I., 1995. Ochratoxin A in Humans, Exposure, Kinetics and Risk Assessment PhD Thesis Dissertation ETH No. 11071, Swiss Federal Institute of Technology, Zurich.
54. Studer-Rohr I., Schlatter J., Dietrich D.D. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch. Toxicol. 2000, 74:499-510.
55. Tápai K., Téren J., Mesterházy Á. Ochratoxin A in the sera of blood donors and ill persons. Cereal Res. Commun. 1997, 25:307-308.
56. Thuvander A., Paulsen J.E., Axberg K., Johansson N., Vidnes A., Enghardt-Barbieri H., Trygg K., Lund-Larsen K., Jahrl S., Widenfalk A., Bosnes V., Alexander J., Hult K., Olsen M. Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem. Toxicol. 2001, 39:1145-1151.
57. Ueno Y., Maki S., Lin J., Furuya M., Sugiura Y., Kawamura O. A 4-year study of plasma ochratoxin A in a selected population in Tokyo by immunoassay and immunoaffinity column-linked HPLC. Food Chem. Toxicol. 1998, 36:445-449.
58. Zimmerli B., Dick R. Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data. J. Chromatogr. Biomed. 1995, 666:85-99.