Modification of radiation-induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: An in vitro study in human blood leukocytes

Environmental and Molecular Mutagenesis

Volumn 55, Issue 5, 2014, Pages 436-448

  Srivastava, Nitya N ^a   Shukla, Sandeep K ^a   Yashavarddhan, M H ^a   Devi, Memita ^a   Tripathi, Rajendra P ^a   Gupta, Manju L ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

DNA damage; Non homologous end joining; P53BP1; Podophyllum hexandrum; H2AX

Indexed keywords

DOUBLE STRANDED DNA; G 002M; GAMMA H2AX; HISTONE H2AX; LIGASE; LIGASE IV; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG;

53BP1 GENE; ARTICLE; ATM GENE; CONCENTRATION RESPONSE; DNA MODIFICATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG EFFICACY; FLOW CYTOMETRY; GAMMA RADIATION; GENE; GENE EXPRESSION; HISTONE PHOSPHORYLATION; HUMAN; IN VITRO STUDY; KU80 GENE; LEUKOCYTE; LYMPHOCYTE; MALE; MONOCYTE; NORMAL HUMAN; PODOPHYLLUM HEXANDRUM; PROTEIN PHOSPHORYLATION; RADIATION DOSE DISTRIBUTION; RADIATION INJURY; RADIATION PROTECTION; RADIATION RESPONSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHIZOME; SIGNAL TRANSDUCTION; UPREGULATION;

DNA DAMAGE; NON-HOMOLOGOUS END JOINING; P53BP1; PODOPHYLLUM HEXANDRUM; Γ-H2AX;

ANTIGENS, NUCLEAR; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DRUGS, CHINESE HERBAL; FLAVONOIDS; GAMMA RAYS; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES; LYMPHOCYTES; MALE; MONOCYTES; PHOSPHORYLATION; PODOPHYLLUM; RADIATION-PROTECTIVE AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84894251730     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21853     Document Type: Article

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