REC-2006-A fractionated extract of podophyllum hexandrum protects cellular DNA from radiation-induced damage by reducing the initial damage and enhancing its repair in vivo

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Chaudhary, Pankaj ^a,b   Shukla, Sandeep Kumar ^a   Sharma, Rakesh Kumar ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; BETA GLOBIN; CELL DNA; EPIPODOPHYLLOTOXIN; FLAVONOID; GALLIC ACID; HYDROXYL RADICAL; PLANT EXTRACT; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; POLYPHENOL; QUERCETIN; REC 2006; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; GAMMA RADIATION; GENE AMPLIFICATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PODOPHYLLUM HEXANDRUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; RHIZOME; THYMOCYTE; WHOLE BODY RADIATION;

EID: 80052693571     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nep212     Document Type: Article

References (44)

1. Von Sonntag C. V., The Chemical Basis of Radiation Biology 1987 London, UK Taylor and Francis
2. Meyn R. E., Milas L., Ang K. K., The role of apoptosis in radiation oncology International Journal of Radiation Biology 2009 85 2 107 115
3. Sangsuwan T., Haghdoost S., The nucleotide pool, a target for low-dose -ray-induced oxidative stress Radiation Research 2008 170 6 776 783
4. Pouget J.-P., Mather S. J., General aspects of the cellular response to low- and high-LET radiation European Journal of Nuclear Medicine 2001 28 4 541 561 (Pubitemid 32260923)
5. Natrajan A. T., Berni A., Marimuthu K. M., Palitti F., The type and yield of ionizing radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells Mutation Research 2008 642 80 85
6. Cooke M. S., Evans M. D., Dizdaroglu M., Lunec J., Oxidative DNA damage: mechanisms, mutation, and disease FASEB Journal 2003 17 10 1195 1214 (Pubitemid 36775767)
7. Brown P. E., Mechanism of action of aminothiol radioprotectore Nature 2001 28 363 364
8. Nair C. K. K., Parida D. K., Nomura T., Radioprotectors in radiotherapy Journal of Radiation Research 2001 42 1 21 37 (Pubitemid 33658568)
9. Bump E. A., Malaker K., Radioprotectors: Chemical, Biological, and Clinical Perspectives 1998 Boca Raton, Fla, USA CRC Press
10. Jagetia G. C., Radioprotective potential of plants and herbs against the effects of ionizing radiation Journal of Clinical Biochemistry and Nutrition 2007 40 2 74 81 (Pubitemid 46623808)
11. Vrinda B., Uma Devi P., Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin Mutation Research 2001 498 1-2 39 46 (Pubitemid 32973660)
12. Chaudhary P., Shukla S. K., Kumar I. P., Namita I., Afrin F., Sharma R. K., Radioprotective properties of apple polyphenols: an in vitro study Molecular and Cellular Biochemistry 2006 288 1-2 37 46 (Pubitemid 44314438)
13. Shukla S. K., Chaudhary P., Kumar I. P., Samanta N., Afrin F., Gupta M. L., Sharma U. K., Sinha A. K., Sharma Y. K., Sharma R. K., Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides Environmental and Molecular Mutagenesis 2006 47 9 647 656 (Pubitemid 44917676)
14. Kumar M., Samarth R., Kumar M., Selvan S. R., Saharan B., Kumar A., Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice Evidence-Based Complementary and Alternative Medicine 2007 4 3 343 350
15. Veerapur V. P., Prabhakar K. R., Parihar V. K., Kandadi M. R., Ramakrishana S., Mishra B., Satish Rao B. S., Srinivasan K. K., Priyadarsini K. I., Unnikrishnan M. K., Ficus racemosa stem bark extract: a potent antioxidant and a probable natural radioprotector Evidence-Based Complementary and Alternative Medicine 2009 6 3 317 324
16. Han Y., Son S.-J., Akhalaia M., Platonov A., Son H.-J., Lee K.-H., Yun Y.-S., Song J.-Y., Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan Evidence-Based Complementary and Alternative Medicine 2005 2 4 529 536 (Pubitemid 41752490)
17. Kumar R., Singh P. K., Arora R., Chawla R., Sharma R. K., Radioprotective activities of Podophyllum hexandrum: current knowledge of the molecular mechanisms Trees for Life Journal 2009 4 1 9
18. Singh J., Shah N. C., Podophyllum: a review Current Research on Medicinal and Aromatic Plants 1994 16 53 83
19. Wong S.-K., Tsui S.-K., Kwan S.-Y., Su X.-L., Lin R.-C., Identification and characterization of Podophyllum emodi by API-LC/MS/MS Journal of Mass Spectrometry 2000 35 11 1246 1251
20. Chatterjee A., Pakrashi S. C., The Treatise of Indian Medicinal Plants 1995 New Delhi, India Publication and Information Directorate
21. Arora R., Chawla R., Puri S. C., Sagar R., Singh S., Kumar R., Sharma A. K., Prasad J., Singh S., Kaur G., Chaudhary P., Qazi G. N., Sharma R. K., Radioprotective and antioxidant properties of low-altitude Podophyllum hexandrum (LAPH) Journal of Environmental Pathology, Toxicology and Oncology 2005 24 4 299 314
22. Chawla R., Arora R., Singh S., Sagar R. K., Sharma R. K., Kumar R., Sharma A., Tripathi R. P., Puri S. C., Khan H. A., Shawl A. S., Sultan P., Krishan T., Qazi G. N., Podophyllum hexandrum offers radioprotection by modulating free radical flux: role of aryl-tetralin lignans Evidence-Based Complementary and Alternative Medicine 2006 3 4 503 511 (Pubitemid 44899989)
23. Goel H. C., Prasad J., Sharma A., Singh B., Antitumor and radioprotective action of Podophyllum hexandrum Indian Journal of Experimental Biology 1998 36 583 587
24. Sankhwar S., Gupta M. L., Gupta V., Verma S., Suri K. A., Devi M., Podophyllum hexandrum -mediated survival protection and restoration of other cellular injuries in lethally irradiated mice Evidence-Based Complementary and Alternative Medicine 2009
25. Gupta M. L., Tyagi S., Flora S. J. S., Agrawala P. K., Chaudhary P., Puri S. C., Protective efficacy of semi purified fraction of high altitude Podophyllum hexandrum rhizomes in lethally irradiated Swiss albino mice Cellular and Molecular Biology 2007 53 29 41 (Pubitemid 350164303)
26. Lennartz M., Coquerelle T., Hagen U., Modification of end-groups in DNA strand breaks of irradiated thymocytes during early repair International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 1975 28 2 181 185
27. Gaertner C., Sexauer C., Hagen U., Repair of radiation induced DNA strand breaks in thymocytes International Journal of Radiation Biology 1977 32 3 293 296 (Pubitemid 8172917)
28. Chakrov S., Stoilov P., Alexandrov A., Russev G., Repair pattern in the -globin gene cluster of human fibroblast after UV irradiation European Journal of Biochemistry 1997 248 669 675 (Pubitemid 27400019)
29. Chakalova L., Russev G., Transcriptionally active and inactive mouse b-globin gene loci are repaired at similar rates after ultraviolet irradiation European Journal of Biochemistry 1999 261 667 673 (Pubitemid 29226063)
30. Milano J., Day B. J., A catalytic antioxidant metalloporpyrin blocks hydrogen peroxide induced mitochondrial DNA damage Nucleic Acids Research 2000 28 968 973 (Pubitemid 30085324)
31. Sestili P., Martinelli C., Stocchi V., The fast halo assay: an improved method to quantify genomic DNA strand breakage at the single-cell level Mutation Research 2006 607 2 205 214 (Pubitemid 44107787)
32. Milano J., Day B. J., A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide-induced mitochondrial DNA damage Nucleic Acids Research 2000 28 4 968 973 (Pubitemid 30085324)
33. Williams D. R., Rapley R., Rapley R., Agarose gel electrophoresis The Nucleic Acid Protocols Handbook 2000 Totowa, NJ, USA Humana Press 67 70
34. Shimada K., Fujikawa K., Yahara K., Nakamura T., Antioxidative properties of xanthan on the autoxidation of soyabean oil in cyclodextrin emulsion Journal of Agricultural and Food Chemistry 1992 40 945 948
35. Gutteridge J. M. C., Thiobarbituric acid-reactivity following iron-dependent free-radical damage to amino acids and carbohydrates FEBS Letters 1981 128 2 343 346 (Pubitemid 11043854)
36. Rao U. M., Source of superoxide anion radical in aerobic mixtures consisting of NAD(P)H, 5-methylphenazinium methyl sulfate and nitroblue tetrazolium chloride Free Radical Biology and Medicine 1989 7 513 519 (Pubitemid 20022609)
37. Prieto P., Pineda M., Aguilar M., Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E1 Analytical Biochemistry 1999 269 337 341 (Pubitemid 29201033)
38. Singleton V. L., Rossi J. A., Colorimetry of total phenolics with phosphomolybdic acid-phosphotungstic acid reagents American Journal of Enology and Viticulture 1965 16 144 158
39. Zhishen J., Mengcheng T., Jianming W., The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals Food Chemistry 1999 64 555 559 (Pubitemid 29060787)
40. Yakes F. M., Van Houten B., Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress Proceedings of the National Academy of Sciences of the United States of America 1997 94 2 514 519 (Pubitemid 27053665)
41. Kalinowski D. P., Illenye S., Van Houten B., Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay Nucleic Acids Research 1992 20 13 3485 3494
42. Gao K., Henning S. M., Niu Y., Youssefian A. A., Seeram N. P., Xu A., Heber D., The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells Journal of Nutritional Biochemistry 2006 17 2 89 95 (Pubitemid 43082142)
43. Zhang X. G., Xu P., Li Q., Yu C. H., Zhang Y., Chen S. H., Effect of tea polyphenols on cytokine gene expression in rats with alcoholic liver disease Hepatobiliary and Pancreatic Diseases International 2006 5 268 272 (Pubitemid 43826921)
44. Mariappan D., Winkler J., Partihiben V., Doss M. X., Hescheler J., Sachinidis A., Dietary small molecules and large-scale gene expression studies: an experimental approach for understanding their beneficial effects on the development of malignant and non-malignant proliferative diseases Current Medicinal Chemistry 2006 13 1481 1489 (Pubitemid 43821701)