The use of DNA double-strand break quantification in radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 2, 2001, Pages 373-377

  McMillan, Trevor J ^a   Tobi, Simon ^a   Mateos, Santiago ^b   Lemon, Catherine ^c  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF SEVILLE   (Spain)

^c MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Damage; Double strand break; Radiation; Repair

Indexed keywords

CANCER RADIOTHERAPY; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL; UTERINE CERVIX CARCINOMA;

CELL CYCLE; CELL DEATH; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; NEOPLASMS; RADIATION TOLERANCE; RADIATION, IONIZING; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 0035254209     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01467-X     Document Type: Conference Paper

References (17)

1. Responses of radiosensitive repair-proficient cell lines to restriction endonucleases
2. Repair of x-ray-induced DNA double strand breaks in specific Not I restriction fragments in human fibroblasts; Joining of correct and incorrect ends
3. Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 125IdUrd
4. The comet assay in clinical practice
5. Chromatin structure and cellular radiosensitivity; A comparison of two human tumour cell lines
6. The role of DNA single- and double-strand breaks in cell killing by ionizing radiation
7. Study of DNA double-strand break induction in different chromatin substrates of radioresistant and radiosensitive human tumour cell lines
8. Differences between a human bladder carcinoma cell line and its radiosensitive clone in the formation of radiation-induced DNA double-strand breaks in different chromatin substrates
9. Menage a trois; Double strand break repair, V(D)J recombination and DNA- PK
10. A surfeit of RAD51-like genes?
11. DNA double-strand break induction and rejoining as determinants of human tumour cell radiosensitivity. A pulsed-field gel electrophoresis study
12. Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells
13. Pulsed-field gel electrophoresis in the measurement of DNA double-strand break repair in xrs-6 and CHO cell lines; DNA degradation under some conditions interferes with the assessment of DSB rejoining
14. Repair of radiation-induced DNA double-strand breaks in human fibroblasts is consistent with a continuous spectrum of repair probability
15. Fibroblast radiosensitivity measured using the comet DNA-damage assay correlayes with clonogenic survival parameters
16. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines
17. Molecular determinants of radiosensitivity in mammalian cells